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The Nervous System
The Nervous System

... neuron to neuron across gaps called synapses. A sending neuron synthesizes neurotransmitter molecules and bundles them into packages; when the neuron becomes electrically excited, it releases the neurotransmitter molecules into the synapse. Once in the synapse, each molecule may: Dock on a receptor ...
Nervous MusclesSkeleton
Nervous MusclesSkeleton

... – Largest part; contains nucleus and most of cytoplasm – Most metabolic activities occur here ...
File - kilbane science
File - kilbane science

... response. These set of neurons (receptor, sensory, relay and motor neurons) makeup reflex-arcs. ...
Lentivirus-based genetic manipulations of cortical neurons and their
Lentivirus-based genetic manipulations of cortical neurons and their

... study gene functions in small networks and single neurons in vivo are still lacking. Here, we establish a method for genetic manipulation and subsequent phenotypic analysis of individual cortical neurons in vivo. First, lentiviral vectors are used for neuron-specific gene delivery from ␣-calcium兾cal ...
Optimization of neuronal cultures derived from human
Optimization of neuronal cultures derived from human

... 2% B-27 Supplement (Invitrogen), 500 µM glutamine (Invitrogen), and 6.25 µM glutamate (Sigma). When neurons were co-cultured with glia, medium consisted of Advanced DMEM/F12 plus 1% fetal calf serum. Cultures were analyzed between 2 and 7 weeks in vitro on the MANTRA system or on a fluorescence micr ...
Nervous System I - Laurel County Schools
Nervous System I - Laurel County Schools

... Central Nervous System and Peripheral Nervous System.  Central Nervous System (CNS) composed of the brain and spinal cord  Peripheral nervous system (PNS) composed of the nervous (cranial and spinal) that connects the CNS to other body parts.  Together these systems provide three general functio ...
Nervous System I - Laurel County Schools
Nervous System I - Laurel County Schools

... Central Nervous System and Peripheral Nervous System.  Central Nervous System (CNS) composed of the brain and spinal cord  Peripheral nervous system (PNS) composed of the nervous (cranial and spinal) that connects the CNS to other body parts.  Together these systems provide three general functio ...
Chapter 41
Chapter 41

... In humans, the olfactory epithelium is found on the roof of the nasal cavity. It contains about 100 million specialized olfactory cells with ciliated tips. The cilia extend into the layer of mucus on the epithelial surface of the nasal passageway. Receptor molecules on the cilia bind to compounds th ...
File
File

... Form: The basic cells are called neurons or nerve cells. Because neurons communicate with each other and with muscle and gland cells they can coordinate, regulate, and integrate many body functions. The nervous tissue includes neurological cells. These cells support and bind components of nervous ti ...
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM

... the autonomic nervous system such as smooth muscle around blood vessels. • Proceeds without conscious intention but can be influenced by volition. ...
Nervous System
Nervous System

... synapse & binds to receptor protein on postsynaptic cell 4. Postsynaptic cell is excited or inhibited 5. Neurotransmitter in synapse is deactivated ...
Nervous System
Nervous System

... synapse & binds to receptor protein on postsynaptic cell 4. Postsynaptic cell is excited or inhibited 5. Neurotransmitter in synapse is deactivated ...
NERVOUS SYSTEM GENERALITY – INTRODUCTION
NERVOUS SYSTEM GENERALITY – INTRODUCTION

... spinal ganglia or dorsal root ganglia contain the cell bodies of sensory neurons entering the cord at that region. nerve - a group of fibers (axons) outside the CNS. The spinal nerves contain the fibers of the sensory and motor neurons. A nerve does not contain cell bodies. They are located in the g ...
Brain Organization Simulation System
Brain Organization Simulation System

... The main BOSS project goal is to create a tool for neuroscientists to test large-scale neuron-based models of brain functions such as memory and learning. Traditional laboratory methods reveal details about electrical activity by one neuron or at most a few dozen. Precisely which neurons connect ele ...
Topic 1: Cell biology (15 hours)
Topic 1: Cell biology (15 hours)

... acetylcholine receptors. receptor or effector cells. Guidance: Only chemical synapses are 13. Skill: Analysis of required, not electrical, and they can simply be referred to as synapses. oscilloscope traces 9. When presynaptic neurons are depolarized they release a neurotransmitter showing resting i ...
Trial and Error – Optogenetic techniques offer insight into the
Trial and Error – Optogenetic techniques offer insight into the

... neurons actually calculate prediction error. What inputs do dopamine neurons combine and how do they combine them? To answer these questions, we merged molecular biology, electrophysiology, and computational analysis. We focused on the ventral tegmental area (VTA), a small brainstem nucleus that pro ...
Nervous Tissue - MrsSconyersAnatomy
Nervous Tissue - MrsSconyersAnatomy

...  Compare the basic type of ion channels, and explain how they relate to action potentials and graded potentials.  Describe the factors that maintain a resting membrane potential. ...
Implications in absence epileptic seizures
Implications in absence epileptic seizures

... completely silent during cortical seizures with spike-and-wave patterns (Steriade and ...
Introductory chapter
Introductory chapter

... Two friends, one living in the city and the other on the family farm, describe to one another the experiences of everyday life. The farmer conjures up pastoral images, acres of wheat swaying in a gentle breeze, the sweet smells of spring, and the songs of the birds. The city dweller recounts scenes ...
Composition of the Nervous System
Composition of the Nervous System

... -At the boundaries of this system are sensory cells, which through the process of transduction collect the information about the environment (external and internal) and motor neurons that via excitation – contraction coupling and muscles and glands act upon the environment. In between are the interm ...
They Come From the Cortex - American Association of Sleep
They Come From the Cortex - American Association of Sleep

... cells (see Fig 2) the most common neurons within the cortex, are named such due to their cell body shape. Although they are found in all layers other than layer 1, they are they are most predominant in layers 2, 3, and 5.2 Pyramidal neurons have a cell body, an axon, a single apical dendrite and a n ...
INTEGUMENTARY SYSTEM - Coast Colleges Home Page
INTEGUMENTARY SYSTEM - Coast Colleges Home Page

... Na+ Channels Close, K+ Channels Open & K+ Diffuses Out of Neuron Results In Repolarization (+ outside/- inside) Repolarization Required before another Action Potential Sodium-Potassium Pump moves Na+ out & K+ in (Requires Energy) ...
THE NERVOUS SYSTEM
THE NERVOUS SYSTEM

... cell bodies in CNS are usually called ______________-carrying out metabolic functions/not regenerated __________________small collections of cell bodies outside CNS-in PNS ________________________ are bundles of nerve fibers running through CNS _____________________________________ are bundles of ne ...
INTEGUMENTARY SYSTEM
INTEGUMENTARY SYSTEM

... Na+ Channels Close, K+ Channels Open & K+ Diffuses Out of Neuron Results In Repolarization (+ outside/- inside) Repolarization Required before another Action Potential Sodium-Potassium Pump moves Na+ out & K+ in (Requires Energy) ...
Energy - Brain Mind Forum
Energy - Brain Mind Forum

... The immediate effect of this ‘energy autonomy’ is that neurons display many of the functions associated with living organisms. One important side effect of this is that neurons do not always respond as expected. Thus the reaction of a neuron is always ‘probabilistic’ rather than definable. This can ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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