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A- A- A- K+ A - How Your Brain Works
A- A- A- K+ A - How Your Brain Works

... can have a large variety of gated ion channels which will open transiently in the presence of certain stimuli or chemical signals. These gated channels may be permeable to Na+, Cl- or Ca++. • When these gated channels open, the voltage across the membrane will change to reflect the new permeabilitie ...
Gamma band activity in the nuclei of the Reticular Activating System
Gamma band activity in the nuclei of the Reticular Activating System

... (~20-100 Hz). Gamma frequency oscillations have been proposed to participate in conscious perception, problem solving, memory, and rapid eye movement (REM) sleep. It has been suggested that such coherent activation occurs at cortical or thalamocortical levels, and that electrical coupling may play a ...
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IN SEARCH OF PRINCIPLES IN INTEGRATIVE BIOLOGY

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The biology of time across different scales

... mondegreen ‘kiss the sky’ versus ‘kiss this guy’. The brain’s ability to process complex temporal patterns on this timescale is well demonstrated by the fact that language can be reduced to a purely temporal code, as occurs in Morse code. In addition to processing on this subsecond scale, animals pr ...
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R24Summary Statement - University of Illinois Archives

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The Nervous System
The Nervous System

... neuron to neuron across gaps called synapses. A sending neuron synthesizes neurotransmitter molecules and bundles them into packages; when the neuron becomes electrically excited, it releases the neurotransmitter molecules into the synapse. Once in the synapse, each molecule may: Dock on a receptor ...
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... Kinds of Neurons  Sensory Neurons (a.k.a. Afferent Neurons) carry incoming information from the sense receptors to the CNS.  Motor Neurons (a.k.a. Efferent Neurons) carry outgoing information from the CNS to muscles and glands.  Interneurons connect the two neurons. ...
The Nervous System
The Nervous System

... system are called neurons Sensory neurons carry information (impulses) from the sense organs to the central nervous system (CNS). Motor neurons carry information (impulses) from the central nervous system (CNS) to the muscles and glands. Interneurons, found in the CNS, connect the two. ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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