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Local anaesthetics
Local anaesthetics

... stabilise these channels in this configuration. This prevents their change to rested-closed and activated-open states in response to nerve impulse. Sodium channels in the inactivated-closed state are not permeable to sodium ions and thus conduction of nerve impulses in the form of action potential c ...
Nervous System
Nervous System

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Brain and Nervous System
Brain and Nervous System

...  That is created by depolarizing current. ...
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... A fibers. Motor impulses to skeletal muscles are also carried by A fibers. These types of impulses relay information about the external surroundings and how the body will respond to external stimuli. The speed with which these impulses are carried could reduce the incidence of injury to the body by ...
6-8_TissueDamageRegen_SteinÁN
6-8_TissueDamageRegen_SteinÁN

... system (CNS) by the functional mechanisms and especially the extent and speed. When an axon is damaged, the distal segment undergoes Wallerian degeneration, losing its myelin sheath. The proximal segment can either die by apoptosis or undergo the chromatolytic reaction, which is an attempt at repair ...
The Nervous System
The Nervous System

... electrical signals to communicate with other cells • An impulse is: an electrical signal travelling through a neuron • A nerve is: a bundle of neurons • Sensory neurons: carry impulses from receptors (e.g. in skin) to the central nervous system (brain/spinal cord) • Motor neurons: carry impulses fro ...
SC&SN-07
SC&SN-07

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Artificial Eye.pdf - 123SeminarsOnly.com
Artificial Eye.pdf - 123SeminarsOnly.com

... At present, two general strategies have been pursued. The "Epiretinal" approach involves a semiconductor-based device placed above the retina, close to or in contact with the nerve fiber layer retinal ganglion cells. The information in this approach must be captured by a camera system before transmi ...
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Part 1 - Kirkwood Community College

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9.01 - Neuroscience & Behavior Fall 2003 Massachusetts Institute of Technology
9.01 - Neuroscience & Behavior Fall 2003 Massachusetts Institute of Technology

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EMG/ Nerve Conduction Studies

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Notes of Neuronal Firing

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Chapter 2: Introduction to Physiology of Perception
Chapter 2: Introduction to Physiology of Perception

... Figure 2.7 (a) When a nerve fiber is at rest, there is a difference in charge of -70 mV between the inside and the outside of the fiber. This difference is measured by the meter on the left; the difference in charge measured by the meter is displayed on the right. ...
Name________________________ Midterm #1 Biology 3330, Fall
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... found? __________ e). Thien has access to mouse models of this disease, and their nervous systems. Describe how he could identify these neurons. ...
Unit V - Sensation and Perception
Unit V - Sensation and Perception

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Nociceptin mediated microvascular inflammation during sepsis
Nociceptin mediated microvascular inflammation during sepsis

... these diseases is very important and is likely to reveal novel drug targets that may be developed into medicines aimed at sufferers from these diseases. This project is part of our on-going research into the molecular mechanisms underlying neurodegenerative diseases and will focus on the role of axo ...
BIOL241Neurophys11bJUL2012
BIOL241Neurophys11bJUL2012

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02QUIZ02 ( 44K)
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Autonomic Nervous System
Autonomic Nervous System

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Cranial Nerves
Cranial Nerves

... pathways are composed of 3 major neurons: the primary, the secondary, and the tertiary (see Figure 2). The cell bodies of primary neurons are usually located outside the CNS in sensory ganglia. They are homologous with the dorsal root ganglia of the spinal cord. The cell bodies of secondary neurons ...
Synapse
Synapse

... • It is a state of partial hyperpolarization which occurs in the postsynaptic membrane due to single presynaptic impulse ...
Communication within the Nervous System
Communication within the Nervous System

... The Neural Membrane • Moves 3 Na+ outside for every 2 K+ inside ...
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Rheobase



Rheobase is a measure of membrane excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ""rhe"" translates to current or flow, and ""basi"" means bottom or foundation: thus the rheobase is the minimum current that will produce an action potential or muscle contraction.Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied. These variables are inversely related: as the strength of the applied current increases, the time required to stimulate the membrane decreases (and vice versa) to maintain a constant effect. Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.The strength-duration curve was first discovered by G. Weiss in 1901, but it was not until 1909 that Louis Lapicque coined the term ""rheobase"". Many studies are being conducted in relation to rheobase values and the dynamic changes throughout maturation and between different nerve fibers. In the past strength-duration curves and rheobase determinations were used to assess nerve injury; today, they play a role in clinical identification of many neurological pathologies, including as Diabetic neuropathy, CIDP, Machado-Joseph Disease, and ALS.
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