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Why are brain pathways
Why are brain pathways

... systematic maps (Sm I and Sm II) in the parietal lobe. ...
Tom`s JSNC2000 paper
Tom`s JSNC2000 paper

... room that can only learn about the room when it bumps into the walls, which could be a rather slow process. Therefore, the next attempt will need to deliver feedback continuously, perhaps using more elaborate patterns of stimulation than those used here. Another potential problem may be the simplici ...
Last Lecture http://www.umich.edu/~psycours/345/
Last Lecture http://www.umich.edu/~psycours/345/

... • Optic radiations to • AREA 17; Striate Cortex, Primary visual cortex Retinotopic Map ...
A new view of the motor cortex
A new view of the motor cortex

... example, when sites within one region of the map were stimulated, a hand-to-mouth movement was evoked (Graziano et al., 2002; Graziano et al., 2005). The movement included a closure of the hand into an apparent grip, a turning of the wrist and forearm to direct the hand toward the mouth, a rotation ...
Impaired odour discrimination on desynchronization of odour
Impaired odour discrimination on desynchronization of odour

... neurons5,12. This was directly confirmed with paired intracellular recordings from antennal lobe neurons, showing synchronized membrane-potential oscillations in response to specific odours (Fig. 1e; n ¼ 2 animals). In locusts, the oscillatory synchronization of projection neurons—and thus the resul ...
Impact of thousand-and-one amino acid 2 kinase
Impact of thousand-and-one amino acid 2 kinase

... An understanding of how neurons develop their morphology and their distinct physiology is the key to the elucidation of the mechanisms underlying sophisticated cognitive functions in normal and disease conditions. Evidence suggests that neurodevelopmental disorders with delayed onset, such as autism ...
Study Guide
Study Guide

... • In previous assignments, you have been exposed to various pieces of primary literature, i.e., original articles in which scientists report (for the first time) the experiments they performed and the results they obtained. This week's discussion covers a somewhat different form of scientific writin ...
The Neurobiology of EMDR: Exploring the
The Neurobiology of EMDR: Exploring the

... directly to the amygdala, bypassing even the thalamus (LeDoux, 1986, 1992, 1994). A second signal from the thalamus is routed to the neocortex—the thinking brain. This branching allows the amygdala to respond before the neocortex, which mulls over information through several layers of brain circuit ...
Control of dopaminergic neuron survival by the unfolded protein
Control of dopaminergic neuron survival by the unfolded protein

... lesion by measuring the extent of striatal denervation triggered by 6OHDA (Fig. 1C and Fig. S1C). XBP1 Deficiency Triggers Spontaneous ER Stress in the SNpc. XBP1 is crucial to the function of professional secretory cells, and its deficiency triggers drastic phenotypes associated with a basal ER str ...
InterimSummary The Nature of Learning
InterimSummary The Nature of Learning

... change our nervous system and hence our behavior. We refer to these changes as memories. Although it is convenient to describe memories as if they were notes placed in filing cabinets, this is certainly not the way experiences are reflected within the brain. Experiences are not “stored”; rather, the ...
Control of Muscular Contraction
Control of Muscular Contraction

... 3. Golgi Tendon Organs – Thin capsules of connective tissue which exist where muscle fibre and tendon meet. They cause a muscle to relax if high tensions within the muscle occur. ...
Chapter 2: The Brain and Behavior
Chapter 2: The Brain and Behavior

... FIGURE 2.4 The interior of an axon. The right end of the top axon is at rest. Thus, it has a negative charge inside. An action potential begins when ion channels open and sodium ions (Na+) rush into the axon. In this drawing, the action potential would travel from left to right along the axon. In th ...
Time constants
Time constants

... τ = RC). For a typical spontaneous firing rate of about 5-10 Hz (Koch 1999, p. 412), the membrane time constant may be a small as 1-3 ms (Koch 1999, p. 413), while for zero background activity, it may exceed 100 ms (Koch 1999, p. 77). Another problem is that membrane time constants are usually calcu ...
Gating of Sensory Input by Spontaneous Cortical Activity
Gating of Sensory Input by Spontaneous Cortical Activity

... a semiautomatic algorithm (http://klustakwik.sourceforge.net) followed by manual clustering (http://klusters.sourceforge.net). Only neurons with firing rates higher than 1 Hz were used in further analysis, resulting in population sizes 17, 26, 32, and 45 for the four rats, respectively. After spike ...
Synapses and Neurotransmitters
Synapses and Neurotransmitters

... Although acetylcholine is considered an excitatory neurotransmitter, there are some cases where it can also be inhibitory. Inhibitory neurotransmitters cause the membrane of the postsynaptic neuron to become more permeable to potassium ions. This leads to a hyperpolarization of the membrane which me ...
Neural Darwinism
Neural Darwinism

... key roles in the development and function of the brain. In this article, I review a population theory of the nervous system aimed at understanding the significance of these processes. Since its original formulation in 1978, considerable evidence has accumulated to support this theory of neuronal gro ...
Nogo Receptor mRNA Expression in Intact and Regenerating CNS
Nogo Receptor mRNA Expression in Intact and Regenerating CNS

... If Nogo-66 is a major factor/molecule responsible for the failure of axonal regeneration in the CNS, its receptor should be expressed by all classes of neuron which do not regenerate after brain and spinal cord injury. Furthermore, since two classes of neuron, Purkinje cells and corticospinal neuron ...
Hypothalamus
Hypothalamus

... neurons exhibit a genetically derived circadian rhythm of neuronal activity in which neuronal activity is high for 12 h of the light dark cycle and low for the remainder. Available evidence supports the conclusion that each SCN neuron is an independent oscillator and that communication between SCN n ...
The Nervous System
The Nervous System

... When skeletal muscles contract, they do so in response to stimuli from the nervous system. We plan our movement in the brain, and the ner vous system transmits that plan to the muscles. At the muscles, the nervous system stimulates contraction but stimulates only those motor units needed for that pa ...
Anterior nuclei
Anterior nuclei

... o Neurons involved in feeding, reproductive, and parenting behavior, thermoregulation Anterior nuclei: regulate appetite and food intake. Medial part lesion causes obesity, lateral part lesion causes anorexia Posterior Hypothalamic Region : Temperature regulation function has been assigned. Responds ...
Impaired intracellular trafficking defines early Parkinson`s disease
Impaired intracellular trafficking defines early Parkinson`s disease

... inherited cases of PD caused by mutations in the gene encoding a-synuclein (SNCA), and genome-wide association studies linking sporadic PD and SNCA [19–21]. Despite controversy regarding the physiological state of asynuclein (Box 1), increasing evidence suggests that the physiological role of a-synu ...
Microscopy of myelination - Formatex Research Center
Microscopy of myelination - Formatex Research Center

... and mark any antibody of that species regardless of the antigen that the primary antibody was raised against; this makes them capable of fluorescently marking a range of targets depending on the researcher's needs. For further details of immunolabelling consult [12]. 2.2.2 Fluorescence Microscopy Fl ...
Modelling the Development of Mirror Neurons for Auditory
Modelling the Development of Mirror Neurons for Auditory

... The correlation-based weight update has the consequence that units that respond to stimuli that consistently co-vary between the sensory and the motor map become more highly activated due to the strengthening Hebbian weights: covarying signals between the maps result in the same responding units on ...
Proceedings of 2013 BMI the Second International Conference on
Proceedings of 2013 BMI the Second International Conference on

... unable to move. Conventional assistive devices for people with severe motor disabilities are inherently limited, often relying on residual motor function for their use. Brain-computer interfaces (BCIs) aim to provide a more powerful signal source by tapping into the rich information content that is ...
Dorsal spinal cord stimulation obtunds the capacity of intrathoracic
Dorsal spinal cord stimulation obtunds the capacity of intrathoracic

... power 1401 data acquisition system) and analyzed using the Spike 2 software package (Cambridge Electronics Design). Ganglionic loci were identified from which action potentials with signal to noise ratios greater than 3:1 could be recorded. The activity generated by individual neuronal somata was id ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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