Mechanisms of Leptin Action and Leptin Resistance
... and leptin-deficient ob/ob animals (3). The function of short-form LRs is less clear, although proposed roles include the transport of leptin across the blood-brain barrier (BBB) and the production of circulating LR extracellular domain to complex with leptin (10, 11). Many of the effects of leptin r ...
... and leptin-deficient ob/ob animals (3). The function of short-form LRs is less clear, although proposed roles include the transport of leptin across the blood-brain barrier (BBB) and the production of circulating LR extracellular domain to complex with leptin (10, 11). Many of the effects of leptin r ...
Curriculum Vitae - Laureate Institute for Brain Research
... I am collaborating with several investigators at UCSD and other institutions to study the neural basis of psychiatric disorders. Specifically, I am working with Drs. Susan Tapert and Gerhard Schulteis on NIDA supported P-20 Center Grant to examine the role of interoception for drug addiction. Intero ...
... I am collaborating with several investigators at UCSD and other institutions to study the neural basis of psychiatric disorders. Specifically, I am working with Drs. Susan Tapert and Gerhard Schulteis on NIDA supported P-20 Center Grant to examine the role of interoception for drug addiction. Intero ...
In 1978 Mountcastle hypothesized that the smallest functional unit of
... sensorimotor cortical slice experiments allow for analysis of all cortical layers, the applied stimuli is un-natural and does not allow for understanding of how the cortex responds to stimuli when all of the cortical connections are still in tact. Therefore, in order to better assess the response to ...
... sensorimotor cortical slice experiments allow for analysis of all cortical layers, the applied stimuli is un-natural and does not allow for understanding of how the cortex responds to stimuli when all of the cortical connections are still in tact. Therefore, in order to better assess the response to ...
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... known receptors for Slit (Robo2, Robo3 and Syndecan) are enriched where the neuropil emerges along the longitudinal fascicles and remains abundant there through the end of embryogenesis (Johnson et al., 2004; Rajagopalan et al., 2000; Simpson et al., 2000; Steigemann et al., 2004). Such an expressio ...
... known receptors for Slit (Robo2, Robo3 and Syndecan) are enriched where the neuropil emerges along the longitudinal fascicles and remains abundant there through the end of embryogenesis (Johnson et al., 2004; Rajagopalan et al., 2000; Simpson et al., 2000; Steigemann et al., 2004). Such an expressio ...
Clarinet (CLA-‐1), a novel active zone protein required for
... (medium) including CLA-‐1c and d; CLA-‐1S (short) including CLA-‐1e and f (fig. 1H). Each isoform can be ...
... (medium) including CLA-‐1c and d; CLA-‐1S (short) including CLA-‐1e and f (fig. 1H). Each isoform can be ...
Clarinet (CLA-‐1), a novel active zone protein required for synaptic
... (medium) including CLA-‐1c and d; CLA-‐1S (short) including CLA-‐1e and f (fig. 1H). Each isoform can be ...
... (medium) including CLA-‐1c and d; CLA-‐1S (short) including CLA-‐1e and f (fig. 1H). Each isoform can be ...
Neural representation of olfactory mixtures in the honeybee
... by mounting 1-mL plastic syringes in six valve positions, either containing filter paper (1 cm2) without any odor substance (for a pure, constant air-stream) or containing filter paper loaded with 4 lL of pure odor substance. This concentration was chosen because it was used in all our previous behavi ...
... by mounting 1-mL plastic syringes in six valve positions, either containing filter paper (1 cm2) without any odor substance (for a pure, constant air-stream) or containing filter paper loaded with 4 lL of pure odor substance. This concentration was chosen because it was used in all our previous behavi ...
Might the olfactory bulb be an origin of olfactory auras in focal
... of Ancient Greece, master of Galen (130-210 A.D.). The word aura, meaning breeze, was introduced into medical terminology not by a physician or scientist, but by a patient of Galen who so described it (Temkin, 1945). Auras were described by Hughlings Jackson in the late 19th century as “the so-calle ...
... of Ancient Greece, master of Galen (130-210 A.D.). The word aura, meaning breeze, was introduced into medical terminology not by a physician or scientist, but by a patient of Galen who so described it (Temkin, 1945). Auras were described by Hughlings Jackson in the late 19th century as “the so-calle ...
Associated Bodywork & Massage Professionals
... The neurotransmitter is received by the receptor site on the cell membrane of the postsynaptic neuron’s dendrites. ...
... The neurotransmitter is received by the receptor site on the cell membrane of the postsynaptic neuron’s dendrites. ...
Mechanisms of Sleep Control - UCLA Integrative Center for
... The most caudal region implicated in NREM sleep control is the region of the nucleus of the solitary tract. Low-frequency stimulation of this structure can produce short-latency sleep onset (Magnes et al., 1961). Stimulation of the baroreceptor afferents to this area can also produce rapid sleep ons ...
... The most caudal region implicated in NREM sleep control is the region of the nucleus of the solitary tract. Low-frequency stimulation of this structure can produce short-latency sleep onset (Magnes et al., 1961). Stimulation of the baroreceptor afferents to this area can also produce rapid sleep ons ...
Cerebral cortical hypoplasia with abnormal morphology of pyramidal
... (TomoVision, Montreal, Canada) based on image contrast as well as the user’s knowledge of the anatomy. Other cerebral regions listed above were also segmented. Boundaries of each region were determined in reference with the procedure of Dorr and coauthors (2008). Segmented images were then analyzed ...
... (TomoVision, Montreal, Canada) based on image contrast as well as the user’s knowledge of the anatomy. Other cerebral regions listed above were also segmented. Boundaries of each region were determined in reference with the procedure of Dorr and coauthors (2008). Segmented images were then analyzed ...
State transitions between wake and sleep, and within the
... H. Merica, R.D. Fortune the polysomnography and spindle-defined sleep onset that often involves an alternation between stage 1 ‘sleep’ and wake before the occurrence of the stage 1 episode that ends with sleep onset. This episode, often referred to as the sleep onset period, marks a period of gradua ...
... H. Merica, R.D. Fortune the polysomnography and spindle-defined sleep onset that often involves an alternation between stage 1 ‘sleep’ and wake before the occurrence of the stage 1 episode that ends with sleep onset. This episode, often referred to as the sleep onset period, marks a period of gradua ...
Decreased cohesin in the brain leads to defective synapse
... density of processes on MBP-positive oligodendrocytes was lower in CdLS brains (Fig. 7 C), suggesting defective myelin formation. Iba1-positive cells were slightly rounder in CdLS brains, which suggested that microglia might have been activated (Fig. 7 D). Additionally, the number of GFAP-positive ...
... density of processes on MBP-positive oligodendrocytes was lower in CdLS brains (Fig. 7 C), suggesting defective myelin formation. Iba1-positive cells were slightly rounder in CdLS brains, which suggested that microglia might have been activated (Fig. 7 D). Additionally, the number of GFAP-positive ...
Recasting the Smooth Pursuit Eye Movement System
... findings indicate that this view needs to be reconsidered. Rather than being controlled primarily by areas in extrastriate cortex specialized for processing visual motion, pursuit involves an extended network of cortical areas, and, of these, the pursuit-related region in the frontal eye fields appe ...
... findings indicate that this view needs to be reconsidered. Rather than being controlled primarily by areas in extrastriate cortex specialized for processing visual motion, pursuit involves an extended network of cortical areas, and, of these, the pursuit-related region in the frontal eye fields appe ...
Theta phase shift in spike timing and modulation of gamma oscillation
... and gold plated to reduce the impedance to the 250- to 300-k⍀ range (measured at 1 kHz; BAK Electronics IMP-1). Details of the surgical procedure were as presented previously (Takahashi et al. 2009a, 2009b). Briefly, rats were anesthetized with a mixture of ketamine (100 mg/kg ip) and xylazine (7 mg ...
... and gold plated to reduce the impedance to the 250- to 300-k⍀ range (measured at 1 kHz; BAK Electronics IMP-1). Details of the surgical procedure were as presented previously (Takahashi et al. 2009a, 2009b). Briefly, rats were anesthetized with a mixture of ketamine (100 mg/kg ip) and xylazine (7 mg ...
Document
... Both GluR1 and GluR2 play an important role in synaptic plasticity. It is now known that the underlying physiological correlate for the increase in EPSP size is a postsynaptic upregulation of AMPARs at the membrane, which is accomplished through the interactions of AMPARs with ...
... Both GluR1 and GluR2 play an important role in synaptic plasticity. It is now known that the underlying physiological correlate for the increase in EPSP size is a postsynaptic upregulation of AMPARs at the membrane, which is accomplished through the interactions of AMPARs with ...
Kir2 potassium channels in rat striatum are strategically
... includes the following components: 1) Inwardly rectifying channels show a linear conductance below the K+ equilibrium potential (Fig. 3). 2) The outward conductance in physiological conditions helps to stabilize the resting potential15. 3) Negligible outward currents during depolarization prevent ma ...
... includes the following components: 1) Inwardly rectifying channels show a linear conductance below the K+ equilibrium potential (Fig. 3). 2) The outward conductance in physiological conditions helps to stabilize the resting potential15. 3) Negligible outward currents during depolarization prevent ma ...
Wild type human TDP-43 potentiates ALS-linked mutant TDP
... The identification of mutations in the glycine-rich C terminal region of TDP-43 that enhance protein cleavage, aggregation and neurotoxicity confirmed a pathologenic role for TDP-43 mis-accumulation in ALS and FTLD [6, 7, 8]. TDP-43 positive inclusions have also been identified in patients with path ...
... The identification of mutations in the glycine-rich C terminal region of TDP-43 that enhance protein cleavage, aggregation and neurotoxicity confirmed a pathologenic role for TDP-43 mis-accumulation in ALS and FTLD [6, 7, 8]. TDP-43 positive inclusions have also been identified in patients with path ...
A Systematic Nomenclature for the Insect Brain
... head capsule, penetrated by the esophagus (Fig. S1A). When the optic lobes are separated from this structure, the rest of the brain will be referred to as the central brain (Fig. S1B). We do not recommend midbrain to refer to the central brain, because the former is in longstanding use in vertebrate ...
... head capsule, penetrated by the esophagus (Fig. S1A). When the optic lobes are separated from this structure, the rest of the brain will be referred to as the central brain (Fig. S1B). We do not recommend midbrain to refer to the central brain, because the former is in longstanding use in vertebrate ...
Antagonistic roles of Wnt5 and the Drl receptor in patterning the
... The perception of odors requires that stimulus information be systematically organized in a ‘map’ in the olfactory bulb. Indeed, axons of olfactory receptor neurons (ORNs) expressing a given odorant receptor sort out from other axons and terminate specifically in one of a field of discrete synaptic ...
... The perception of odors requires that stimulus information be systematically organized in a ‘map’ in the olfactory bulb. Indeed, axons of olfactory receptor neurons (ORNs) expressing a given odorant receptor sort out from other axons and terminate specifically in one of a field of discrete synaptic ...
Local Field Potentials Related to Bimanual Movements in the
... analyses in the paper were repeated using the sigma-normalized measure of the “bimanual related” effect (Equation 3 of the companion paper). With the exception which is discussed in the results section (figures 12 and 13), this did not change our results in any appreciable way, and we do not present ...
... analyses in the paper were repeated using the sigma-normalized measure of the “bimanual related” effect (Equation 3 of the companion paper). With the exception which is discussed in the results section (figures 12 and 13), this did not change our results in any appreciable way, and we do not present ...
Modality-Based Organization of Ascending Somatosensory Axons in
... Duncan at University of Wisconsin as previously described (Jackson et ...
... Duncan at University of Wisconsin as previously described (Jackson et ...