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A Temporal Continuity to the Vertical
A Temporal Continuity to the Vertical

... terms of 4 radially oriented components: pyramidal cell arrays, apical dendritic bundles, myelinated axon bundles of projection neurons, and double-bouquet cell axon bundles of inhibitory interneurons. Each of these features has been shown to exhibit minicolumnar-scale periodicity in various species ...
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Brain Mechanisms of Memory and Cognition
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Isodirectional Tuning of Adjacent Interneurons and Pyramidal Cells
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... Investigations of spatially tuned neuronal activity promise to elucidate the respective roles of afferent organization and local cortical circuitry in the processes underlying regional cortical function. Directionally selective activity has been observed in many areas of the brain, from the visual ( ...
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The bed nucleus of the stria terminalis (BNST), a structure
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PSY105 Neural Networks 2/5
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Towards understanding of the cortical network underlying
Towards understanding of the cortical network underlying

... functions and how the properties of single neurons and their synaptic connections with neighbouring neurons combine to form local circuits and to exhibit the function of each cortical area. We will discuss some new methodological innovations that tackle these challenges. Keywords: inferior temporal ...
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Brain lateralisation: a question of spatial frequency?

... activity directly under it Forward problem: Knowing where the dipoles are and the distribution of the conduction in the brain, we could calculate the voltage variation recorded at one point of the surface Inverse problem: Infinite number of solutions Source localisation algorithms uses sets of prede ...
Vocal Control Neuron Incorporation Decreases with Age in the Adult
Vocal Control Neuron Incorporation Decreases with Age in the Adult

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Electrophysiological recordings from behaving animals—going

... The main limitation of the freely behaving intracellular recording method is the low success rates. To reach such a recording one must start with an anesthetized animal, once a stable recording is achieved the electrode is anchored to the skull, only then the animal can be removed from the stereotax ...
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How Many Cell Types Does It Take to Wire a Brain?

... via the Cx3cr1 fractalkine receptor (left). Microglia prune elements (center) and then return to a resting state near maintained elements (right). (B) In an alternative model, fractalkine signaling globally activates microglia, but a more local, ...
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Chapter 19 study Questions key

... display renewed fear of the CS if they are tested in context A, but display no fear if tested in context B. In contrast, rats with damage to the hippocampus do not display renewed fear to the CS when tested in context A. 14. What is the role of NMDA receptors in fear extinction? What is the experime ...
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... needed to selectively prioritize information that is relevant to ongoing behavior at the expense of irrelevant distracting information. This selection process is often referred to as ‘attention’. A variety of attention-related modulatory effects on neural processing across the visual system have bee ...
Illusions: A Moving Experience
Illusions: A Moving Experience

... is inserted between the first patch and the motion-detecting neuron but not between the second (right) patch and the same neuron. If the target moves rightward in the receptive field, the activity from the second patch of retina will arrive at the motion-detecting neuron at the same time as the delaye ...
Axonal conduction properties of antidromically identified neurons in
Axonal conduction properties of antidromically identified neurons in

... circuits. Even within the same lamina, nearby cells may participate in different circuits. Thus, anatomical findings have shown that neurons within the same neuropil may receive quite different patterns of thalamocortical inputs, and, at least in the case of efferent neurons, these patterns vary acc ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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