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Genetics Option - Worked Examples
Genetics Option - Worked Examples

... DNA fingerprinting has been a crucially important breakthrough in crime analysis, enabling forensic scientists to identify a suspect from a tiny sample of blood, semen, saliva or other tissue. Before this, they could only identify blood groups and a few proteins, which could provide only a very roug ...
Isolation and Purification of Total Genomic DNA from Gram
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... DNA for analysis by gel electrophoresis, for PCR, and for a couple restriction digests. • PURITY: What level of contaminants (protein, RNA, etc.) can be tolerated? The purification method must eliminate any contaminants that would interfere with subsequent steps. This depends, of course, on what you ...
Cell cycle and Reproduction - River Dell Regional School District
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Genetic Modification in Food Production

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Beyond Mendel: Molecular genetics, cell division, and sex
Beyond Mendel: Molecular genetics, cell division, and sex

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... A DNA database is a computer that stores information about people’s DNA b. A DNA profile contains detailed information about one person’s DNA 8. This will be your personal opinion based on the discussions you had in class. 9. Might be useful for:  Identifying and prosecuting criminals  Identifying ...
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Lecture 2 - Organic Origins Debate

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... We use four letters to code all the information contained in DNA: A, T, C and G. The letters are used in groups of three. A group is called a codon. DNA contains the information that is needed by your body to make proteins. The different proteins have specific functions, such as making our hearts, h ...
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Techniques of gene therapy

... Once the gene that causes a disease has been identified, the corresponding normal gene must be isolated, unless it is already available because it has been studied for some other purpose. Using an abnormal gene to find its normal counterpart is usually done by exploiting the extensive similarity bet ...
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5.2.3 Genomes and Gene Technologies

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DNA and the Chromosome

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PDF (black and white)

... cross-​pol​linated true-b​reeding plants to carry out his experi​ment. What were Mendel's two experi​ments? In his first experi​ment, Mendel studied 7 charac​ter​istics. He performed crosses ...
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Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
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