Bi-202-Lester-PsychiatricDrugs
... 1. “The mood-elevating effects of fluoxetine [Prozac] are not evident after initial exposure to the drug but require its continued use for several weeks. This delayed effect suggests that it is not the inhibition of serotonin transporters per se, but some adaptation to sustained increases in seroton ...
... 1. “The mood-elevating effects of fluoxetine [Prozac] are not evident after initial exposure to the drug but require its continued use for several weeks. This delayed effect suggests that it is not the inhibition of serotonin transporters per se, but some adaptation to sustained increases in seroton ...
Antidepressant
... MAO exists in two forms, A and B which are encoded by separate genes. Both forms of MAO are found mostly in the outer membranes of mitochondria in both neurones and glial cells. 5-HT and NA - metabolized by MAO A ...
... MAO exists in two forms, A and B which are encoded by separate genes. Both forms of MAO are found mostly in the outer membranes of mitochondria in both neurones and glial cells. 5-HT and NA - metabolized by MAO A ...
Autacoids
... A- 5-HT 1D Receptor Agonists: (sumatriptan, rizatriptan, naratriptan, zolmetriptan) are indole derivatives structurally similar to serotonin. These mimic the actions of serotonin at this auto-receptor presynaptic neurotransmitter release release of serotonin &/or NE serotonin/NE-induced va ...
... A- 5-HT 1D Receptor Agonists: (sumatriptan, rizatriptan, naratriptan, zolmetriptan) are indole derivatives structurally similar to serotonin. These mimic the actions of serotonin at this auto-receptor presynaptic neurotransmitter release release of serotonin &/or NE serotonin/NE-induced va ...
Quick Reference for Antidepressants
... Norepinephrine and Dopamine Reuptake Inhibitor IR: Increase 100 mgs every 3 to 4 days up to 150 mg bid SR: up to 300 mg/day given as 150 mg twice daily XL: up to 300 mg/day not to exceed 450 mg/day ...
... Norepinephrine and Dopamine Reuptake Inhibitor IR: Increase 100 mgs every 3 to 4 days up to 150 mg bid SR: up to 300 mg/day given as 150 mg twice daily XL: up to 300 mg/day not to exceed 450 mg/day ...
Anaesthetic implications of psychoactive drugs
... A rare but significant side-effect of both the typical and the atypical antipsychotic drugs is the neuroleptic malignant syndrome. First described in the 1960s, it is characterized by hyperthermia, autonomic dysfunction, and muscle rigidity. Relevant to the anaesthetist is that the differential diag ...
... A rare but significant side-effect of both the typical and the atypical antipsychotic drugs is the neuroleptic malignant syndrome. First described in the 1960s, it is characterized by hyperthermia, autonomic dysfunction, and muscle rigidity. Relevant to the anaesthetist is that the differential diag ...
Medication Alternatives for the Elderly
... Due to strong anticholinergic and sedative properties, amitriptyline and doxepin are rarely the antidepressant of choice in the elderly ...
... Due to strong anticholinergic and sedative properties, amitriptyline and doxepin are rarely the antidepressant of choice in the elderly ...
Drug Intoxication and Withdrawal - CA
... DA and NE reuptake inhibitor, nicotinic antagonist Chemically similar to stimulants Antidepressant, no wt gain or sexual dysfunction Abused intranasally; high similar to cocaine, but less intense • Seizure with high doses (>600 mg/d) • WD rare; anxiety, lethargy, irritability • Tx: gradual taper ...
... DA and NE reuptake inhibitor, nicotinic antagonist Chemically similar to stimulants Antidepressant, no wt gain or sexual dysfunction Abused intranasally; high similar to cocaine, but less intense • Seizure with high doses (>600 mg/d) • WD rare; anxiety, lethargy, irritability • Tx: gradual taper ...
App-Cutter - MD Slimdown
... efficacy of 5-HTP in reducing appetite and food intake in obese healthy and non-insulin-dependent diabetic individuals.[1,2,3] A 2006 study in mice concluded, “5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.”[4] Vitamins B6 and C are important cofactors in the 5-HTP to se ...
... efficacy of 5-HTP in reducing appetite and food intake in obese healthy and non-insulin-dependent diabetic individuals.[1,2,3] A 2006 study in mice concluded, “5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.”[4] Vitamins B6 and C are important cofactors in the 5-HTP to se ...
Acute dystonia with concomitant use of amitriptyline and paroxetine
... of angle of mouth, slurring of speech, and up rolling of eyeballs for last two days and admitted in the critical care unit. She was diagnosed as major depressive disorder before three years and on regular treatment from psychiatry unit as per the informant and available records. She was receiving pa ...
... of angle of mouth, slurring of speech, and up rolling of eyeballs for last two days and admitted in the critical care unit. She was diagnosed as major depressive disorder before three years and on regular treatment from psychiatry unit as per the informant and available records. She was receiving pa ...
Neural Transmission - People Server at UNCW
... Selective serotonin reuptake inhibitorsBind to and reduce the effectiveness of the 5-HT transporter SSRIs approved to treat depression, with their generic, or chemical, names followed by available brand names in parentheses: Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac, Prozac Weekl ...
... Selective serotonin reuptake inhibitorsBind to and reduce the effectiveness of the 5-HT transporter SSRIs approved to treat depression, with their generic, or chemical, names followed by available brand names in parentheses: Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac, Prozac Weekl ...
Appropriate Drug Prescribing in Older Adults
... Central re-uptake inhibitor of serotonin and norepinephrine At high doses, can induce serotonin release Numerous case reports of Serotonin Syndrome in patients ...
... Central re-uptake inhibitor of serotonin and norepinephrine At high doses, can induce serotonin release Numerous case reports of Serotonin Syndrome in patients ...
Regina Conde
... these radioglandins is considerably problematic (See Chart 2). In addition to the questionable reliability of radioglandins used, there are also problems regarding the populations evaluated in these studies. Poly-drug users were the subjects used in the experimental group of all of these studies and ...
... these radioglandins is considerably problematic (See Chart 2). In addition to the questionable reliability of radioglandins used, there are also problems regarding the populations evaluated in these studies. Poly-drug users were the subjects used in the experimental group of all of these studies and ...
Pethidine FAQs
... inhibiting serotonin metabolism (MAOIs) and directly stimulating serotonin receptors (bromocryptine, lithium). Specific diagnostic criteria for serotonin syndrome include the presence of three or more of the following signs: mental status changes, confusion, hypomania, agitation, incoordination, myo ...
... inhibiting serotonin metabolism (MAOIs) and directly stimulating serotonin receptors (bromocryptine, lithium). Specific diagnostic criteria for serotonin syndrome include the presence of three or more of the following signs: mental status changes, confusion, hypomania, agitation, incoordination, myo ...
Slide 1
... Acute: Diaphoresis, HTN, tachycardia. Also, numbness in the extremities and intoxication, characterized by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. More prone to physical injury as they can’t feel pain. Psych: resembles schizophrenia: unpredictable and driv ...
... Acute: Diaphoresis, HTN, tachycardia. Also, numbness in the extremities and intoxication, characterized by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. More prone to physical injury as they can’t feel pain. Psych: resembles schizophrenia: unpredictable and driv ...
Abstract
... between ages 20 to 40, although there have been reported cases of Susac syndrome in patients as young as 7 and as old as 72 years of age. Also noted is a slight female predominance. ...
... between ages 20 to 40, although there have been reported cases of Susac syndrome in patients as young as 7 and as old as 72 years of age. Also noted is a slight female predominance. ...
MS_Word ~ 89 KB
... inhibiting serotonin metabolism (MAOIs) and directly stimulating serotonin receptors (bromocryptine, lithium). Specific diagnostic criteria for serotonin syndrome include the presence of three or more of the following signs: mental status changes, confusion, hypomania, agitation, incoordination, myo ...
... inhibiting serotonin metabolism (MAOIs) and directly stimulating serotonin receptors (bromocryptine, lithium). Specific diagnostic criteria for serotonin syndrome include the presence of three or more of the following signs: mental status changes, confusion, hypomania, agitation, incoordination, myo ...
Psychopharmacs - antidepressants
... Duman RS, Heninger GR, Nestler EJ.: A molecular and celllular theory of depression. Arch. Gen. Psychiatry, 54, 1997, pp. 597-606. Kupfer DJ.: Long-term treatment of depression. J. Clin. Psychiat., 52, 1991, Suppl. 5., s. 28 - 33 Janicak PG.: Handbook of psychopharmacology, Baltimore: Williams ...
... Duman RS, Heninger GR, Nestler EJ.: A molecular and celllular theory of depression. Arch. Gen. Psychiatry, 54, 1997, pp. 597-606. Kupfer DJ.: Long-term treatment of depression. J. Clin. Psychiat., 52, 1991, Suppl. 5., s. 28 - 33 Janicak PG.: Handbook of psychopharmacology, Baltimore: Williams ...
File
... • Classes of antidepressants • First-line agents • Selective serotonin reuptake inhibitors (SSRIs) • Newer atypical antidepressants (SNRIs, NRIs, ...
... • Classes of antidepressants • First-line agents • Selective serotonin reuptake inhibitors (SSRIs) • Newer atypical antidepressants (SNRIs, NRIs, ...
DRUG INTERACTIONS AND ANESTHESIA
... ♦ Nitroglycerin (NTG) adsorbs to, absorbs into, and penetrates the wall of plastic container or infusion set. Polyethylene reduces NTG concentration by 15%, PVC up to 70%. It remains possible that changes in hemodynamic status could occur in patients on NTG if a change in container type (i.e., from ...
... ♦ Nitroglycerin (NTG) adsorbs to, absorbs into, and penetrates the wall of plastic container or infusion set. Polyethylene reduces NTG concentration by 15%, PVC up to 70%. It remains possible that changes in hemodynamic status could occur in patients on NTG if a change in container type (i.e., from ...
Chapter 20 - Back in the Game Chiropractic Wellness
... Back in the Game Sports Medicine is a clinic dedicated to the treatment of physical injuries to the body. Caring for an injured body involves more than making the diagnosis; it's about understanding and treating the cause to prevent future injuries. The clinic addresses variety of injuries to the bo ...
... Back in the Game Sports Medicine is a clinic dedicated to the treatment of physical injuries to the body. Caring for an injured body involves more than making the diagnosis; it's about understanding and treating the cause to prevent future injuries. The clinic addresses variety of injuries to the bo ...
the presentation handout here.
... ⊕ No one AD or AD class consistently out performs another ⊕ Side effects are different among ADs ⊕ Different actions don’t predict treatment response ...
... ⊕ No one AD or AD class consistently out performs another ⊕ Side effects are different among ADs ⊕ Different actions don’t predict treatment response ...
... studies. Dependence-Milnacipran produces physical dependence, as evidenced by the emergence of withdrawal symptoms following drug discontinuation, similar to other SNRIs and SSRIs. These withdrawal symptoms can be severe. Thus, Savella should be tapered and not abruptly discontinued after extended u ...
Discontinuation syndrome (powerpoint file)
... • 20% of individuals taking antidepressants for at least 6 weeks and then stopping abruptly (rare under 6 – 8 weeks). • More frequent in antidepressants with short half lives (Paroxetine, Sertraline) • Occurs less frequently - dose reduction, missed doses, when swapping from one antidepressant to an ...
... • 20% of individuals taking antidepressants for at least 6 weeks and then stopping abruptly (rare under 6 – 8 weeks). • More frequent in antidepressants with short half lives (Paroxetine, Sertraline) • Occurs less frequently - dose reduction, missed doses, when swapping from one antidepressant to an ...
Substance Abuse PPT
... – Norepinephrine depletion causes person to sleep 12-18 hours – Then, sleep disturbances with rebound REM, anergia, decreased libido, depression, suicidality, anhedonia, poor concentration and cocaine craving ...
... – Norepinephrine depletion causes person to sleep 12-18 hours – Then, sleep disturbances with rebound REM, anergia, decreased libido, depression, suicidality, anhedonia, poor concentration and cocaine craving ...
Clinical Pharmacology Notes
... irreversible nervous system and brain damage, e.g., loss of motor control, numbness in limbs, blindness, and inability to speak. Methaemoglobinaemia can be caused either by a genetic defect in red cell metabolism or haemoglobin structure, or acquired by a variety of drugs and toxins. Common drugs d ...
... irreversible nervous system and brain damage, e.g., loss of motor control, numbness in limbs, blindness, and inability to speak. Methaemoglobinaemia can be caused either by a genetic defect in red cell metabolism or haemoglobin structure, or acquired by a variety of drugs and toxins. Common drugs d ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.