lec39_2013 - Andrew.cmu.edu
... a) mRNA – messenger RNA is copy of the DNA that encodes a gene. mRNA specifies the order of amino acids to be used in making the protein. b) tRNA – transfer RNA is the dictionary the converts the codon to a specific amino acid. One part of the tRNA recognizes the codon, the other part contains the a ...
... a) mRNA – messenger RNA is copy of the DNA that encodes a gene. mRNA specifies the order of amino acids to be used in making the protein. b) tRNA – transfer RNA is the dictionary the converts the codon to a specific amino acid. One part of the tRNA recognizes the codon, the other part contains the a ...
Gene Section TOP1 (topoisomerase (DNA) 1) Atlas of Genetics and Cytogenetics
... (base pair): 39090K-39190K chromosome 20 Local order: centromer to telomer. ...
... (base pair): 39090K-39190K chromosome 20 Local order: centromer to telomer. ...
Classification of protein functions
... • You can see the effects of evolution, not only in the whole organism, but also in its molecules - DNA and protein • For a mutation to have an effect on the phenotype (and be subject to selection) it must (usually) affect the structure or function of a protein • You can learn a lot about evolution ...
... • You can see the effects of evolution, not only in the whole organism, but also in its molecules - DNA and protein • For a mutation to have an effect on the phenotype (and be subject to selection) it must (usually) affect the structure or function of a protein • You can learn a lot about evolution ...
Supplemental Data
... Supplemental Figure S2: PtrR2R3-MYB genes in the Clade 27 have a modified R3 DNA binding domain. (a) Amino acid sequence logo corresponding to the modified region, showing the location of 4 additional residues found in Clade 27 members relative to the remainder of the PtrR2R3-MYB family. (b) DNA seq ...
... Supplemental Figure S2: PtrR2R3-MYB genes in the Clade 27 have a modified R3 DNA binding domain. (a) Amino acid sequence logo corresponding to the modified region, showing the location of 4 additional residues found in Clade 27 members relative to the remainder of the PtrR2R3-MYB family. (b) DNA seq ...
DNA, Proteins, and Biotechnology
... Outline the use of polymerase chain reaction (PCR) to copy and amplify minute quantities of DNA. State that, in gel electrophoresis, fragments of DNA move in an electric field and are separated according to their size. State that gel electrophoresis of DNA is used in DNA profiling. Describe the appl ...
... Outline the use of polymerase chain reaction (PCR) to copy and amplify minute quantities of DNA. State that, in gel electrophoresis, fragments of DNA move in an electric field and are separated according to their size. State that gel electrophoresis of DNA is used in DNA profiling. Describe the appl ...
L27- Cloning
... How do we know which of all these colonies came from a cell that took up a plasmid carrying RPE65? ...
... How do we know which of all these colonies came from a cell that took up a plasmid carrying RPE65? ...
Natural antisense RNAs as mRNA regulatory elements in bacteria: a
... other methods of regulation. First, asRNAs could provide an advantageous control system when a particular protein such as transposase needs to be expressed under very selective circumstances or repressed at a very tight level. Second, asRNAs provide one more level of control in the extensive regulat ...
... other methods of regulation. First, asRNAs could provide an advantageous control system when a particular protein such as transposase needs to be expressed under very selective circumstances or repressed at a very tight level. Second, asRNAs provide one more level of control in the extensive regulat ...
"Basics in Bioinformatics" Gabor Rakhely`s lecture, 18/Feb/2010
... Comparison of primary DNA or protein sequences to other primary or secondary sequences Expecting that the function of the similar sequence is known from experiments !!! Thinking by analogy Assuming that if the sequence is similar, the function is also similar question: what is responsible for the fu ...
... Comparison of primary DNA or protein sequences to other primary or secondary sequences Expecting that the function of the similar sequence is known from experiments !!! Thinking by analogy Assuming that if the sequence is similar, the function is also similar question: what is responsible for the fu ...
Supplementary File 1 – Supplementary Material and Methods Plant
... Ph. infestans PMSE proteins was created and both BlastP and tBlastn searches were performed with an e- ...
... Ph. infestans PMSE proteins was created and both BlastP and tBlastn searches were performed with an e- ...
DNA, RNA and Protein
... determined by the DNA. Three Stages of Translation: Initiation- assemble components to start process Elongation- add amino acids in repeated cycles ...
... determined by the DNA. Three Stages of Translation: Initiation- assemble components to start process Elongation- add amino acids in repeated cycles ...
simulating protein analysis using gel electrophoresis
... the three-dimensional protein structure while leaving the primary structure of amino acids intact. Finally more chemicals are added to stabilize the proteins in their denatured state. 2. The muscle tissue from each species is now a ‘soup’ of proteins, water and other chemicals. It contains a number ...
... the three-dimensional protein structure while leaving the primary structure of amino acids intact. Finally more chemicals are added to stabilize the proteins in their denatured state. 2. The muscle tissue from each species is now a ‘soup’ of proteins, water and other chemicals. It contains a number ...
Classification of Amino Acids
... Establishment of pH gradient Gel containing a mixture of low molecular weight organic acids and bases (ampholytes) with different pI value Application of electric field Each protein migrates until it reaches the pH corresponding to its pI ...
... Establishment of pH gradient Gel containing a mixture of low molecular weight organic acids and bases (ampholytes) with different pI value Application of electric field Each protein migrates until it reaches the pH corresponding to its pI ...
Proteins
... Proteins • Proteins are organic molecules composed of polypeptides, or long chains of amino acids. • Proteins play structural roles in organisms, such as being a receptor in cells. Muscles and hairs are made of protein. • Proteins act as enzymes. Enzymes are very sensitive to their surrounding envi ...
... Proteins • Proteins are organic molecules composed of polypeptides, or long chains of amino acids. • Proteins play structural roles in organisms, such as being a receptor in cells. Muscles and hairs are made of protein. • Proteins act as enzymes. Enzymes are very sensitive to their surrounding envi ...
Regulation of Transcription
... of a group of genes (i.e. heat shock proteins) A single gene may be regulated by a number of independent transcription factors (i.e. metallothionine) Eukaryotic regulation does not seem to involve repression To achieve high levels of expression, several different transcription factors binding to dif ...
... of a group of genes (i.e. heat shock proteins) A single gene may be regulated by a number of independent transcription factors (i.e. metallothionine) Eukaryotic regulation does not seem to involve repression To achieve high levels of expression, several different transcription factors binding to dif ...
Presentation (PowerPoint File) - IPAM
... a PE and a PPE protein: express complex, and determine its structure Research of Shuishu Wang and Michael Strong ...
... a PE and a PPE protein: express complex, and determine its structure Research of Shuishu Wang and Michael Strong ...
Cancer Biology – How a cell responds to DNA Damage
... that catalyzes the addition of phosphate to the retinoblastoma protein (Rb). When Rb is not phosphorylated, it binds to the E2F protein and prevents it from working. After phosphorylation, E2F is released and can then bind to DNA and drive the production of select RNAs that code for specific protein ...
... that catalyzes the addition of phosphate to the retinoblastoma protein (Rb). When Rb is not phosphorylated, it binds to the E2F protein and prevents it from working. After phosphorylation, E2F is released and can then bind to DNA and drive the production of select RNAs that code for specific protein ...
included data sources
... The Euretos Knowledge Platform is an innovative bioinformatics platform used by some of the world’s largest pharma & biotech companies, academic hospitals and ...
... The Euretos Knowledge Platform is an innovative bioinformatics platform used by some of the world’s largest pharma & biotech companies, academic hospitals and ...
Protein Physics
... •The 3D structure of proteins has been shown already in 1860 by Hoppe-Zeiler. •Hemoglobin crystals: in a crystal each atom occupies a unique place. •The question whether the structure of a protein in a crystal is the same as in •solution has been solved by NMR. Where proteins can be seen live in sol ...
... •The 3D structure of proteins has been shown already in 1860 by Hoppe-Zeiler. •Hemoglobin crystals: in a crystal each atom occupies a unique place. •The question whether the structure of a protein in a crystal is the same as in •solution has been solved by NMR. Where proteins can be seen live in sol ...
proteinS
... Amino acids are derivatives of carboxylic acids formed by substitution of -hydrogen for amino functional group. ...
... Amino acids are derivatives of carboxylic acids formed by substitution of -hydrogen for amino functional group. ...
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA.The process of gene expression is used by all known life - eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses - to generate the macromolecular machinery for life.Several steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-translational modification of a protein. Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism. Gene regulation may also serve as a substrate for evolutionary change, since control of the timing, location, and amount of gene expression can have a profound effect on the functions (actions) of the gene in a cell or in a multicellular organism.In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable trait. The genetic code stored in DNA is ""interpreted"" by gene expression, and the properties of the expression give rise to the organism's phenotype. Such phenotypes are often expressed by the synthesis of proteins that control the organism's shape, or that act as enzymes catalysing specific metabolic pathways characterising the organism.