Unusual mutations in high functioning fragile X males
... repeat expansions to CGG copy numbers between 45 and 200. They are usually not associated with methylation. Premutations are carried by transmitting males and by some of the transmitting females. Carriers of premutations are generally unaffected and show normal expression of the premutated gene both ...
... repeat expansions to CGG copy numbers between 45 and 200. They are usually not associated with methylation. Premutations are carried by transmitting males and by some of the transmitting females. Carriers of premutations are generally unaffected and show normal expression of the premutated gene both ...
Am I a Warrior? - Erasmus University Thesis Repository
... levels of Cortisol. Autoimmune diseases make the immune system of the body attack the innate organs. When low levels of Cortisol occur the disease attacks the adrenal glands. In this case a patient can take corticosteroids to get the proper level of Cortisol. 2.1.4 Control The release of Cortisol is ...
... levels of Cortisol. Autoimmune diseases make the immune system of the body attack the innate organs. When low levels of Cortisol occur the disease attacks the adrenal glands. In this case a patient can take corticosteroids to get the proper level of Cortisol. 2.1.4 Control The release of Cortisol is ...
Expression analysis of Arc in mouse brain Theresa Köhler
... Arc, an immediate early gene, expressed in the brain of mice encodes the activity regulated cytoskeletal-associated protein (ARC) that is found on dendrites of neurons. It regulates cell development and plays an important role in neuronal plasticity and formation of long-term memory. Arc is induced ...
... Arc, an immediate early gene, expressed in the brain of mice encodes the activity regulated cytoskeletal-associated protein (ARC) that is found on dendrites of neurons. It regulates cell development and plays an important role in neuronal plasticity and formation of long-term memory. Arc is induced ...
history-of-psychology
... The Influence of Behavior on Genes • Drug use, environmental exposure, and eating habits have all been linked to changes in gene expression. While some such influences are harmless or even beneficial, others can be extremely detrimental. Researchers hope to identify these behaviors and their effects ...
... The Influence of Behavior on Genes • Drug use, environmental exposure, and eating habits have all been linked to changes in gene expression. While some such influences are harmless or even beneficial, others can be extremely detrimental. Researchers hope to identify these behaviors and their effects ...
Responses of the Human Brain to Mild Dehydration and
... showed a 0.55% brain volume reduction after 16 hours of thirsting and a 0.72% increase after subsequent rehydration. Similarly, Streitbürger et al14 demonstrated an increase in brain volume on ingestion of 3– 4 L of water; however, they failed to show an effect of dehydration on brain volume by 2 d ...
... showed a 0.55% brain volume reduction after 16 hours of thirsting and a 0.72% increase after subsequent rehydration. Similarly, Streitbürger et al14 demonstrated an increase in brain volume on ingestion of 3– 4 L of water; however, they failed to show an effect of dehydration on brain volume by 2 d ...
single nucleotide polymorphisms and suicidal behaviour
... (TPH) is the key enzyme in biosynthesis of serotonin (Arango et al. 2003). Two isoforms of TPH has been discovered, namely TPH1 and TPH2. TPH2 was only found in central nervous system, mostly in the brain stem. The most extensive study was done by Zill and co-workers that did the screening of 10 SNP ...
... (TPH) is the key enzyme in biosynthesis of serotonin (Arango et al. 2003). Two isoforms of TPH has been discovered, namely TPH1 and TPH2. TPH2 was only found in central nervous system, mostly in the brain stem. The most extensive study was done by Zill and co-workers that did the screening of 10 SNP ...
disrupted brain thyroid hormone homeostasis
... Human postmortem frozen regional brain samples were obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland; donor and the donated brain tissue profiles are presented in Table 1. A total of 11 control and 10 ASD cases were examined. For cerebellar (CB) ...
... Human postmortem frozen regional brain samples were obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland; donor and the donated brain tissue profiles are presented in Table 1. A total of 11 control and 10 ASD cases were examined. For cerebellar (CB) ...
Intervention, integration and translation in obesity research: Genetic
... these conditions. Psychological effects, such as depression, have been identified [10], and many social effects of obesity are also well catalogued [11,12]. There may even be environmental costs to obesity [13]. Recognition of these issues has made obesity into a compelling social, medical and scien ...
... these conditions. Psychological effects, such as depression, have been identified [10], and many social effects of obesity are also well catalogued [11,12]. There may even be environmental costs to obesity [13]. Recognition of these issues has made obesity into a compelling social, medical and scien ...
– findings from cross-species Anxiety genetics genome-wide approaches
... Anxiety disorders are complex diseases, which often occur in combination with major depression, alcohol use disorder, or general medical conditions. Anxiety disorders were the most common mental disorders within the EU states in 2010 with 14% prevalence. Anxiety disorders are triggered by environmen ...
... Anxiety disorders are complex diseases, which often occur in combination with major depression, alcohol use disorder, or general medical conditions. Anxiety disorders were the most common mental disorders within the EU states in 2010 with 14% prevalence. Anxiety disorders are triggered by environmen ...
Stress and Atopic Disorders: Asthma and the Seasonal
... asthmatic response11. In one working paradigm T-helper (Th) cells have been phenotypically divided into two profiles of differentiated cell function having different profiles of cytokine release upon activation (e.g., Th1 and Th2)12. Th1 cells tend to express interleukin-2 (IL-2) and interferon gamm ...
... asthmatic response11. In one working paradigm T-helper (Th) cells have been phenotypically divided into two profiles of differentiated cell function having different profiles of cytokine release upon activation (e.g., Th1 and Th2)12. Th1 cells tend to express interleukin-2 (IL-2) and interferon gamm ...
What is the Gene Trying to Do?
... of secondary importance, or because inclusion of these features would preclude a useful mathematical treatment. It is therefore appropriate, in considering the validity of the FTNS as a theorem, to consider the assumptions upon which it is based. These are either explicit or implicit in the developm ...
... of secondary importance, or because inclusion of these features would preclude a useful mathematical treatment. It is therefore appropriate, in considering the validity of the FTNS as a theorem, to consider the assumptions upon which it is based. These are either explicit or implicit in the developm ...
KAIE LOKK Comparative genome-wide DNA methylation
... The human genome contains about 29 million CpG dinucleotides where a cytosine base is followed by a guanine base. Cytosine in the CpG dinucleotide can exist in either a methylated or unmethylated state. DNA methyltransferase (DNMT) enzymes can add a methyl group to cytosine to form 5-methylcytosine ...
... The human genome contains about 29 million CpG dinucleotides where a cytosine base is followed by a guanine base. Cytosine in the CpG dinucleotide can exist in either a methylated or unmethylated state. DNA methyltransferase (DNMT) enzymes can add a methyl group to cytosine to form 5-methylcytosine ...
Identification of Genetic and Epigenetic Risk Factors for Psoriasis
... 3.1.1 Human genetic variations ..........................................................................55 3.1.2 Genetic Variants in the PSORS1 Region ...................................................56 3.1.3 Experimental assessment of regulatory SNPs............................................58 ...
... 3.1.1 Human genetic variations ..........................................................................55 3.1.2 Genetic Variants in the PSORS1 Region ...................................................56 3.1.3 Experimental assessment of regulatory SNPs............................................58 ...
University of Birmingham Immunolabelling of human metaphase
... overview of the distribution of histone modifications across human metaphase chromosomes. Using metaphase chromosome spreads from lymphoblastoid cell lines (LCL) of normal karyotype and antisera to some key histone modifications, we showed that different histone modifications gave consistent and cle ...
... overview of the distribution of histone modifications across human metaphase chromosomes. Using metaphase chromosome spreads from lymphoblastoid cell lines (LCL) of normal karyotype and antisera to some key histone modifications, we showed that different histone modifications gave consistent and cle ...
Cytokines, prostaglandins and nitric oxide in the regulation of stress
... markedly changed in the hypothalamus. These findings support the theory that significant dysfunction of cellular signaling pathways in the PFC and the hippocampus is critical to the pathogenesis of depression. Chronic psychogenic stressors can induce persistent activation of the neuroendocrine HPA a ...
... markedly changed in the hypothalamus. These findings support the theory that significant dysfunction of cellular signaling pathways in the PFC and the hippocampus is critical to the pathogenesis of depression. Chronic psychogenic stressors can induce persistent activation of the neuroendocrine HPA a ...
COMTemplating the Future of Psychiatric Medicine
... than the "Met" allele.6 Individuals who are homozygous for (have 2 copies of) the Val allele (Val/Val) are thus expected to have decreased DA concentration in the DLPFC compared with Met homozygotes (Met/Met). Heterozygotes (carrying 1 Val and 1 Met allele; Val/Met) have COMT enzyme activity that is ...
... than the "Met" allele.6 Individuals who are homozygous for (have 2 copies of) the Val allele (Val/Val) are thus expected to have decreased DA concentration in the DLPFC compared with Met homozygotes (Met/Met). Heterozygotes (carrying 1 Val and 1 Met allele; Val/Met) have COMT enzyme activity that is ...
Effects of turmeric (Curcuma longa) on the expression
... d and stated that turmeric might have some positive effects on liver enzymes that directly or indirectly reflect a healthier liver. The above findings demonstrate the possible mode of action of TMP as an antioxidant. SOD. Superoxide dismutase catalyzes the conversion of superoxide anions to hydrogen ...
... d and stated that turmeric might have some positive effects on liver enzymes that directly or indirectly reflect a healthier liver. The above findings demonstrate the possible mode of action of TMP as an antioxidant. SOD. Superoxide dismutase catalyzes the conversion of superoxide anions to hydrogen ...
Pierre MADL Div. of Material Sciences Dep
... that an organism can pass on characteristics that it acquired during its lifetime to its offspring (also known as based on heritability of acquired characteristics or "soft inheritance"). It is named for the French biologist Jean-Baptiste Lamarck, who incorporated the action of soft inheritance into ...
... that an organism can pass on characteristics that it acquired during its lifetime to its offspring (also known as based on heritability of acquired characteristics or "soft inheritance"). It is named for the French biologist Jean-Baptiste Lamarck, who incorporated the action of soft inheritance into ...
ChromatinDB: a database of genome-wide
... Fig. 1. (A) Graphical display of histone and histone modification patterns for promoter regions bound by the Gcn5 histone acetyltransferase. ChromatinDB was used to display ChIP-microarray data for 135 selected promoter regions. The log base-2 of the average enrichment ratio for each of 22 histone m ...
... Fig. 1. (A) Graphical display of histone and histone modification patterns for promoter regions bound by the Gcn5 histone acetyltransferase. ChromatinDB was used to display ChIP-microarray data for 135 selected promoter regions. The log base-2 of the average enrichment ratio for each of 22 histone m ...
reproductive cell fate transition in plants - Development
... indicates that small-RNA-dependent DNA methylation pathways acting in the nucellus surrounding the MMC play a key role both during MMC specification (Olmedo-Monfil et al., 2010; Singh et al., 2011) and later for the initiation of female gametophyte development (Tucker et al., 2012). In addition, SMC ...
... indicates that small-RNA-dependent DNA methylation pathways acting in the nucellus surrounding the MMC play a key role both during MMC specification (Olmedo-Monfil et al., 2010; Singh et al., 2011) and later for the initiation of female gametophyte development (Tucker et al., 2012). In addition, SMC ...
reproductive cell fate transition in plants - Development
... KEY WORDS: Arabidopsis, Plant reproduction, Megaspore mother cell, Heterochromatin, Chromatin modifications, Histone variants ...
... KEY WORDS: Arabidopsis, Plant reproduction, Megaspore mother cell, Heterochromatin, Chromatin modifications, Histone variants ...
Supplementary Discussion References
... transcription which made up to 50 µg of cRNA. The unfragmented cRNA was tested by running on an Agilent electropherogram to measure the size distribution. The median size (nucleotide length) of the cRNA is reported in Supplementary Table 1. If a sample gave low amounts of cRNA by spectrophotometer o ...
... transcription which made up to 50 µg of cRNA. The unfragmented cRNA was tested by running on an Agilent electropherogram to measure the size distribution. The median size (nucleotide length) of the cRNA is reported in Supplementary Table 1. If a sample gave low amounts of cRNA by spectrophotometer o ...
Genetics of anxiety disorders: the complex road from DSM to DNA
... specific variants for which the same allele has been associated with a given anxiety disorders in more than one study at a statistical threshold of Pr.01. Candidate gene studies of gene–environment interaction have begun to appear, but this remains an under-utilized strategy for genetic studies of a ...
... specific variants for which the same allele has been associated with a given anxiety disorders in more than one study at a statistical threshold of Pr.01. Candidate gene studies of gene–environment interaction have begun to appear, but this remains an under-utilized strategy for genetic studies of a ...
The evolution of genomic imprinting and X
... while the two neighbouring genes from this region, which are imprinted in humans and mice, appeared to be bi-allelically expressed (Suzuki et al., 2007). Although other scenarios are possible, it would appear that PEG10 imprinting occurred first (prior to therian radiation), then other genes from th ...
... while the two neighbouring genes from this region, which are imprinted in humans and mice, appeared to be bi-allelically expressed (Suzuki et al., 2007). Although other scenarios are possible, it would appear that PEG10 imprinting occurred first (prior to therian radiation), then other genes from th ...
Document
... Histone acetylation regulates transcription activation • It has long been known that histones in vivo are acetylated, and as early as in the 60’s, Vincent Allfrey has suggested that histone acetylation (and methylation) regulate RNA synthesis • e.g. by the 70’s, Allfrey et al showed that drugs that ...
... Histone acetylation regulates transcription activation • It has long been known that histones in vivo are acetylated, and as early as in the 60’s, Vincent Allfrey has suggested that histone acetylation (and methylation) regulate RNA synthesis • e.g. by the 70’s, Allfrey et al showed that drugs that ...
Behavioral epigenetics
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal (including human) behaviour. It is an experimental science that seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviour, cognition personality, and mental health.Epigenetic gene regulation involves changes other than to the sequence of DNA and includes changes to histones (proteins around which DNA is wrapped) and DNA methylation. These epigenetic changes can influence the growth of neurons in the developing brain as well as modify activity of the neurons in the adult brain. Together, these epigenetic changes on neuron structure and function can have a marked influence on an organism's behavior.