chapter 12. schizophrenia 12.4 schizophrenia
... complications find increases in patients with schizophrenia. Positive studies include those that compare patients with matched controls, with their own well siblings, and even with a monozygotic twin discordant for schizophrenia. On the other hand, several impressive negative reports, including pros ...
... complications find increases in patients with schizophrenia. Positive studies include those that compare patients with matched controls, with their own well siblings, and even with a monozygotic twin discordant for schizophrenia. On the other hand, several impressive negative reports, including pros ...
Reprint
... the organismal soma, the intracellular cytoplasm (excluding cytoplasmic DNA), and the proteins and methyl-groups associated with the DNA molecule. Nongenetic inheritance thus comprises mechanisms whereby the environment within which an ancestor’s genes reside influences development in descendants (Ta ...
... the organismal soma, the intracellular cytoplasm (excluding cytoplasmic DNA), and the proteins and methyl-groups associated with the DNA molecule. Nongenetic inheritance thus comprises mechanisms whereby the environment within which an ancestor’s genes reside influences development in descendants (Ta ...
... novel junctions created by ligation of sequences that were in close proximity through specific interactions. To determine if the Kcnq1 promoter associated with specific DNA sequences in the neonatal heart, we performed an unbiased, systematic 3C scan extending 12.6 kb upstream of the promoter, spann ...
1 Prenatal Nicotine Exposure as a Teratogen in
... cigarette smoke is made up of over 4000 compounds; nicotine, in particular, is the likely candidate for causing prenatal damage. Smoking during pregnancy is the cause for 161,000 prenatal deaths and 4800 infant deaths in the United States each year (145). Over half of these deaths are associated wit ...
... cigarette smoke is made up of over 4000 compounds; nicotine, in particular, is the likely candidate for causing prenatal damage. Smoking during pregnancy is the cause for 161,000 prenatal deaths and 4800 infant deaths in the United States each year (145). Over half of these deaths are associated wit ...
Name
... Expected Phenotypes of Offspring: _______________________ a. If you mated these same cats four more times and obtained a total of forty offspring would you expect the results to be a close approximation of the expected ration? Explain. ...
... Expected Phenotypes of Offspring: _______________________ a. If you mated these same cats four more times and obtained a total of forty offspring would you expect the results to be a close approximation of the expected ration? Explain. ...
Genetics Problems II
... Expected Phenotypes of Offspring: _______________________ a. If you mated these same cats four more times and obtained a total of forty offspring would you expect the results to be a close approximation of the expected ration? Explain. ...
... Expected Phenotypes of Offspring: _______________________ a. If you mated these same cats four more times and obtained a total of forty offspring would you expect the results to be a close approximation of the expected ration? Explain. ...
Genomic imprinting in the development and evolution of
... that substantial progress is best facilitated by studies that integrate genetic data with aspects of neurophysiology, neuroanatomy, cognition, and behaviour (Goldberg & Weinberger, 2004). The only major discipline largely missing from integrative, genetically-based studies of mental disorders is evo ...
... that substantial progress is best facilitated by studies that integrate genetic data with aspects of neurophysiology, neuroanatomy, cognition, and behaviour (Goldberg & Weinberger, 2004). The only major discipline largely missing from integrative, genetically-based studies of mental disorders is evo ...
Schizophrenia: A Complex Disorder That Has Stymied Research
... there are often devastating effects on the psychological and financial resources of the patient, family, and larger community. Patients with schizophrenia also tend to have major impairments in social, occupational, and cognitive functioning, which represent a significant health care burden. More sp ...
... there are often devastating effects on the psychological and financial resources of the patient, family, and larger community. Patients with schizophrenia also tend to have major impairments in social, occupational, and cognitive functioning, which represent a significant health care burden. More sp ...
The genetic epidemiology of idiopathic scoliosis
... The standard of care for scoliosis has not changed significantly in the past three decades, from initiating observation to bracing and to spinal fusion surgery as a last resort [10]. The healthcare costs of bracing, hospitalization, surgery, and chronic back pain are substantial. An understanding of ...
... The standard of care for scoliosis has not changed significantly in the past three decades, from initiating observation to bracing and to spinal fusion surgery as a last resort [10]. The healthcare costs of bracing, hospitalization, surgery, and chronic back pain are substantial. An understanding of ...
Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
... inactivation of FMR1 in the newly established iPSC clones [34]. This led to the conclusion that transcription factor reprogramming may incorrectly hypermethylate this region provided that the CGGs are sufficiently long. Furthermore, it highlighted the distinction between FXS hESCs and iPSCs in disea ...
... inactivation of FMR1 in the newly established iPSC clones [34]. This led to the conclusion that transcription factor reprogramming may incorrectly hypermethylate this region provided that the CGGs are sufficiently long. Furthermore, it highlighted the distinction between FXS hESCs and iPSCs in disea ...
this PDF file - E-Journal Faculty of Medicine Universitas
... gene. This enzyme plays an important role in the metabolism of folate and homocysteine. In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate int ...
... gene. This enzyme plays an important role in the metabolism of folate and homocysteine. In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate int ...
SALSA MLPA KIT ME003-A1 Tumor suppressor-3 - MRC
... islands upstream of genes for which an altered methylation status in one or more types of tumours has been reported in literature. In case interesting results are obtained by users, it is possible to develop methylation kits specific for a certain tumour in collaboration with MRC-Holland. Interpreta ...
... islands upstream of genes for which an altered methylation status in one or more types of tumours has been reported in literature. In case interesting results are obtained by users, it is possible to develop methylation kits specific for a certain tumour in collaboration with MRC-Holland. Interpreta ...
A Novel CpG Island Set Identifies Tissue-Specific
... human genome distinguishes two fractions with distinct properties: a major fraction (;98%), in which CpGs are relatively infrequent (on average 1 per 100 bp) but highly methylated (approximately 80% of all CpG sites), and a minor fraction (,2%) that comprises short stretches of DNA (;1,000 bp) in wh ...
... human genome distinguishes two fractions with distinct properties: a major fraction (;98%), in which CpGs are relatively infrequent (on average 1 per 100 bp) but highly methylated (approximately 80% of all CpG sites), and a minor fraction (,2%) that comprises short stretches of DNA (;1,000 bp) in wh ...
The Effect of Ischemia on Biogenic Amine Concentrations in
... amines are both neurotransmitters and have potent vasoactive properties, for many years there has been considerable speculation about their influences on the development of injury to the CNS. 1 Many experimental stroke models exist,2"4 and many studies have been conducted in which biogenic amine con ...
... amines are both neurotransmitters and have potent vasoactive properties, for many years there has been considerable speculation about their influences on the development of injury to the CNS. 1 Many experimental stroke models exist,2"4 and many studies have been conducted in which biogenic amine con ...
Identifying the genomic determinants of aging and longevity in
... Family-based cohorts: Family-based longevity studies consist of nonagenarians/centenarians (siblings) and their middle-aged offspring. The controls used in these studies are either (age-matched) random individuals from the general population or spouses of the offspring of the long-lived individuals. ...
... Family-based cohorts: Family-based longevity studies consist of nonagenarians/centenarians (siblings) and their middle-aged offspring. The controls used in these studies are either (age-matched) random individuals from the general population or spouses of the offspring of the long-lived individuals. ...
Neuromodulation of Aerobic Exercise—A Review
... that a single session of aerobic exercise (running or cycling, ranging from 20 to 90 min of 40–75% of maximal power output or 40–60% of VO2max or 75% of maximal heart rate) increases BDNF levels and that frequent aerobic training (running, or walking for elderly populations, cycling, ranging from 45 ...
... that a single session of aerobic exercise (running or cycling, ranging from 20 to 90 min of 40–75% of maximal power output or 40–60% of VO2max or 75% of maximal heart rate) increases BDNF levels and that frequent aerobic training (running, or walking for elderly populations, cycling, ranging from 45 ...
- Opus
... Moore, Edmund D. Brodie III and Andy Sih. His research integrates theoretical, experimental and computational approaches to understand the evolutionary genetics of complex traits. He is particularly interested in non-Mendelian inheritance, including genomic imprinting, maternal effects, and social e ...
... Moore, Edmund D. Brodie III and Andy Sih. His research integrates theoretical, experimental and computational approaches to understand the evolutionary genetics of complex traits. He is particularly interested in non-Mendelian inheritance, including genomic imprinting, maternal effects, and social e ...
Chapter_012 - IHMC Public Cmaps (2)
... Mosby items and derived items © 2010, 2006 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2010, 2006 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Anticipation in Huntington`s disease is inherited through the male
... may be particularly difficult in these cases although loss of mother/child pairs through adoption may also occur. If AO showed simple regression to the mean, these two biases would result in a loss of parent/child pairs showing negative anticipation. If. however, as the evidence suggests. fathers wi ...
... may be particularly difficult in these cases although loss of mother/child pairs through adoption may also occur. If AO showed simple regression to the mean, these two biases would result in a loss of parent/child pairs showing negative anticipation. If. however, as the evidence suggests. fathers wi ...
Anticipation in Huntington`s disease is inherited through the male
... may be particularly difficult in these cases although loss of mother/child pairs through adoption may also occur. If AO showed simple regression to the mean, these two biases would result in a loss of parent/child pairs showing negative anticipation. If. however, as the evidence suggests. fathers wi ...
... may be particularly difficult in these cases although loss of mother/child pairs through adoption may also occur. If AO showed simple regression to the mean, these two biases would result in a loss of parent/child pairs showing negative anticipation. If. however, as the evidence suggests. fathers wi ...
The dopamine D4 receptor and the hyperactivity phenotype: a
... repeated testing offers the opportunity to test whether the association between DRD4 and hyperactivity is developmentally robust and obtains at different periods in development. Third, data have been collected via psychiatric interviews with the Study members, dimensional rating scales obtained from ...
... repeated testing offers the opportunity to test whether the association between DRD4 and hyperactivity is developmentally robust and obtains at different periods in development. Third, data have been collected via psychiatric interviews with the Study members, dimensional rating scales obtained from ...
Increased D-amino acid oxidase
... S7. Javitt DC.Glutamate as a therapeutic target in psychiatric disorders. Mol Psychiatry 2004; 9: 984-997. S8. Chumakov I, Blumenfeld M, Guerrasimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiologic data implicating the new human gene G72 and the gene for D-amino acid oxidase i ...
... S7. Javitt DC.Glutamate as a therapeutic target in psychiatric disorders. Mol Psychiatry 2004; 9: 984-997. S8. Chumakov I, Blumenfeld M, Guerrasimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiologic data implicating the new human gene G72 and the gene for D-amino acid oxidase i ...
Imprinting capacity of gamete lineages in C. elegans
... with DNA methylation levels, with the maternally-derived alleles generally being more methylated than the paternally-derived alleles. Although reports of parent-of-origin effects in other organisms have been abundant, accounts of parent-of-origin phenomenon in C. elegans have been very rare. A scree ...
... with DNA methylation levels, with the maternally-derived alleles generally being more methylated than the paternally-derived alleles. Although reports of parent-of-origin effects in other organisms have been abundant, accounts of parent-of-origin phenomenon in C. elegans have been very rare. A scree ...
Behavioral epigenetics
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal (including human) behaviour. It is an experimental science that seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviour, cognition personality, and mental health.Epigenetic gene regulation involves changes other than to the sequence of DNA and includes changes to histones (proteins around which DNA is wrapped) and DNA methylation. These epigenetic changes can influence the growth of neurons in the developing brain as well as modify activity of the neurons in the adult brain. Together, these epigenetic changes on neuron structure and function can have a marked influence on an organism's behavior.