Corticosteroid–serotonin interactions in the
... irritability and a feeling of being unable to cope which may ultimately result in depression. Depression is probably the most common stress-related disorder. However, repeated stress per se is not sufficient to cause depression. Interactions between a genetic predisposition and some environmental str ...
... irritability and a feeling of being unable to cope which may ultimately result in depression. Depression is probably the most common stress-related disorder. However, repeated stress per se is not sufficient to cause depression. Interactions between a genetic predisposition and some environmental str ...
Stress and Glucocorticoids Affect the Expression of Brain
... and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons following stress. To begin investigating this possibility, we examined the effects of immobiliza ...
... and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons following stress. To begin investigating this possibility, we examined the effects of immobiliza ...
Alcoholism - University of Colorado-MCDB
... Alcohol dependence is a complex disorder that combines alcohol abuse – continued drinking despite negative consequences – with physical symptoms of tolerance, withdrawal and uncontrollable craving for alcohol. The heritability of alcohol dependence is estimated to be between 38% and 64%. This means ...
... Alcohol dependence is a complex disorder that combines alcohol abuse – continued drinking despite negative consequences – with physical symptoms of tolerance, withdrawal and uncontrollable craving for alcohol. The heritability of alcohol dependence is estimated to be between 38% and 64%. This means ...
References
... shown. Its location is at the opposite end on chromosome 5 from where OspIge5.1 is ...
... shown. Its location is at the opposite end on chromosome 5 from where OspIge5.1 is ...
Ambiguity aversion and familiarity bias
... A gene is the basic unit of heredity in a living organism. The gene concept is an empirical construct preceding the molecular biology era and based on breeding experiments in plants (first by Gregor Mendel in 1866) and animals. At the beginning of the 20th century Mendel’s genes were identified with ...
... A gene is the basic unit of heredity in a living organism. The gene concept is an empirical construct preceding the molecular biology era and based on breeding experiments in plants (first by Gregor Mendel in 1866) and animals. At the beginning of the 20th century Mendel’s genes were identified with ...
Imprinted gene expression in hybrids: perturbed
... ‘Imprinting control regions’: essential regulatory DMRs, which have germ line-derived, mono-allelic ...
... ‘Imprinting control regions’: essential regulatory DMRs, which have germ line-derived, mono-allelic ...
PDF - Hormones.gr
... participate in the physiologic function of almost all organs and play a fundamental role in the stress response.5 Glucocorticoids exert their pleiotropic effects through their cognate receptor, which belongs to the steroid receptor family of the nuclear receptor superfamily.6 The glucocorticoid rece ...
... participate in the physiologic function of almost all organs and play a fundamental role in the stress response.5 Glucocorticoids exert their pleiotropic effects through their cognate receptor, which belongs to the steroid receptor family of the nuclear receptor superfamily.6 The glucocorticoid rece ...
HbF inducers
... ● Some studies have been carried out using valproic acid, a compound related to short fatty acid derivatives, reported increased HbF levels ...
... ● Some studies have been carried out using valproic acid, a compound related to short fatty acid derivatives, reported increased HbF levels ...
Neuroimaging findings in post-traumatic stress disorder Systematic
... localised functional changes include increased activation of the amygdala after symptom provocation (which may reflect its role in emotional memory) and decreased activity of Broca’s area atthe same time (which may explain the difficulty patients have in labelling their experiences). Conclusions Evi ...
... localised functional changes include increased activation of the amygdala after symptom provocation (which may reflect its role in emotional memory) and decreased activity of Broca’s area atthe same time (which may explain the difficulty patients have in labelling their experiences). Conclusions Evi ...
Gene methylation in gastric cancer
... aberrant methylation of several tumor-related genes is significantly associated with the age in gastric cancer, such as CDH1 and DAPK [31]. However, it is noteworthy that age-related methylation of tumor-suppressor genes applies mostly to exonic or far upstream regions within a promoter CGI, and that ...
... aberrant methylation of several tumor-related genes is significantly associated with the age in gastric cancer, such as CDH1 and DAPK [31]. However, it is noteworthy that age-related methylation of tumor-suppressor genes applies mostly to exonic or far upstream regions within a promoter CGI, and that ...
Chromatin DNA Methylayion
... Agents that inhibit DNA methyltransferase such as 5-aza-CdR stimulate tumor invasion and metastasis. ...
... Agents that inhibit DNA methyltransferase such as 5-aza-CdR stimulate tumor invasion and metastasis. ...
Fulltext PDF - Indian Academy of Sciences
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
Functional significance of the discordance between
... Characterization of tTA-TRAF2 mice. Figure 1 shows that the tTA-TRAF2 mice develop a dilated HF phenotype at 12 weeks, characterized by an increased heart weight–to–body weight (HW/BW) ratio (P < 0.05), increased LV dilation (P < 0.05), decreased fractional shortening, and adverse LV remodeling as d ...
... Characterization of tTA-TRAF2 mice. Figure 1 shows that the tTA-TRAF2 mice develop a dilated HF phenotype at 12 weeks, characterized by an increased heart weight–to–body weight (HW/BW) ratio (P < 0.05), increased LV dilation (P < 0.05), decreased fractional shortening, and adverse LV remodeling as d ...
PDF
... whereas the paternally inherited chromosome is methylated (Takada et al., 2002). Deletion of the IG-DMR on the maternal chromosome silences expression of MEGs and activated maternal alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The ...
... whereas the paternally inherited chromosome is methylated (Takada et al., 2002). Deletion of the IG-DMR on the maternal chromosome silences expression of MEGs and activated maternal alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The ...
Imprinting and Seed Development
... Imprinting exists in placental mammals as well as in angiosperms. Unsuccessful attempts to create mouse embryos from two female pronuclei first revealed parent-of-origin effects on embryogenesis in mammals (McGrath and Solter, 1984; Surani et al., 1984). Mammalian androgenetic and gynogenetic embryo ...
... Imprinting exists in placental mammals as well as in angiosperms. Unsuccessful attempts to create mouse embryos from two female pronuclei first revealed parent-of-origin effects on embryogenesis in mammals (McGrath and Solter, 1984; Surani et al., 1984). Mammalian androgenetic and gynogenetic embryo ...
Journal Club Pack - Circulation Research
... pELK-1, KLF4, and HDAC2, with the latter contributing to histone hypo-acetylation, chromatin remodeling, and transcriptional silencing. Studies provide novel evidence that phenotypic switching of SMC in vivo is mediated, at least in part, by binding of the stem cell pluripotency factor KLF4 to a G/C ...
... pELK-1, KLF4, and HDAC2, with the latter contributing to histone hypo-acetylation, chromatin remodeling, and transcriptional silencing. Studies provide novel evidence that phenotypic switching of SMC in vivo is mediated, at least in part, by binding of the stem cell pluripotency factor KLF4 to a G/C ...
DNA Microarrays in Brain Research
... Degree: BS, PhD program at Anthropology Institution: Psychiatry and Anthropology, U of Pittsburgh Research Project: Gene expression changes in response to antipsychotic medication Current Position: Faculty at U of Michigan Role in training: Major advisor for gene expression work Name: Christos Colov ...
... Degree: BS, PhD program at Anthropology Institution: Psychiatry and Anthropology, U of Pittsburgh Research Project: Gene expression changes in response to antipsychotic medication Current Position: Faculty at U of Michigan Role in training: Major advisor for gene expression work Name: Christos Colov ...
American Journal of Public Health Research
... situated bilaterally deep within the medial temporal lobes of the brain play vital roles in the processing of emotions by modulating stress response mechanisms particularly when feelings of anxiety or fear are involved (Roozendaal et al, 2009) while the Hippocampus which is situated just below each ...
... situated bilaterally deep within the medial temporal lobes of the brain play vital roles in the processing of emotions by modulating stress response mechanisms particularly when feelings of anxiety or fear are involved (Roozendaal et al, 2009) while the Hippocampus which is situated just below each ...
Mary Ann Osley*, Alastair Fleming, and Cheng
... transcriptionally active euchromatin through the targeted recruitment of SAGA to gene promoters{Henry, 2003 #170}. As discussed below (III.2.1), the antagonistic activities of Rad6-Bre1 and Ubp8 during transcription promote transient accumulation of ub-H2B at the promoters of the GAL1 and PHO5 genes ...
... transcriptionally active euchromatin through the targeted recruitment of SAGA to gene promoters{Henry, 2003 #170}. As discussed below (III.2.1), the antagonistic activities of Rad6-Bre1 and Ubp8 during transcription promote transient accumulation of ub-H2B at the promoters of the GAL1 and PHO5 genes ...
Antioxidant Enzymes in Brain Cortex of Rats
... The results show that acute stress by immobilization elevated activities of both SOD enzymes in brain cortex. This observation is in accordance with the findings of ªAHIN and GÜMܪLÜ (2004) and it differs from our previous study of acute stress effects in hippocampus. In that brain region, we found ...
... The results show that acute stress by immobilization elevated activities of both SOD enzymes in brain cortex. This observation is in accordance with the findings of ªAHIN and GÜMܪLÜ (2004) and it differs from our previous study of acute stress effects in hippocampus. In that brain region, we found ...
Replication timing as an epigenetic mark
... timing, chromatin structure and transcriptional activity. By the mid 1970’s it was already known that late-replicating DNA coincided with AT-rich, Giemsa-dark, G-bands on metaphase chromosomes with low transcriptional activity, while early-replicating DNA coincided with GC-rich, R-bands with high tr ...
... timing, chromatin structure and transcriptional activity. By the mid 1970’s it was already known that late-replicating DNA coincided with AT-rich, Giemsa-dark, G-bands on metaphase chromosomes with low transcriptional activity, while early-replicating DNA coincided with GC-rich, R-bands with high tr ...
How Neuroscience Predicts The Spontaneous Remission Of Addiction
... Adolescence To Adulthood To Old Age--Maturity And Risk Avoidance Research shows us that people become progressively more risk averse with age. Dr. Julia Deakin and her research team had 177 subjects aged between 17 and 73 take part in a computer based gambling task and found that risk taking behavio ...
... Adolescence To Adulthood To Old Age--Maturity And Risk Avoidance Research shows us that people become progressively more risk averse with age. Dr. Julia Deakin and her research team had 177 subjects aged between 17 and 73 take part in a computer based gambling task and found that risk taking behavio ...
Gene Regulatory Network of Ikaros in T cell development and
... Ikaros is a master regulator of lymphogenesis, especially critical for lymphoid differentiation and maturation. Recurrent genomic lesions of Ikaros have been found associated with high risks of relapse of leukemia and poor outcome of therapy. However, it remains unclear about the gene regulatory net ...
... Ikaros is a master regulator of lymphogenesis, especially critical for lymphoid differentiation and maturation. Recurrent genomic lesions of Ikaros have been found associated with high risks of relapse of leukemia and poor outcome of therapy. However, it remains unclear about the gene regulatory net ...
Waddington`s Legacy in Development and
... Edinburgh, coupled with a Chair in Genetics at the University of Edinburgh. As Robertson (1977) recounts, in the early days of the Institute, all the staff lived essentially in a "commune," although admittedly the commune was a country house, an arrangement that lasted from 1947 to 1953. By his fift ...
... Edinburgh, coupled with a Chair in Genetics at the University of Edinburgh. As Robertson (1977) recounts, in the early days of the Institute, all the staff lived essentially in a "commune," although admittedly the commune was a country house, an arrangement that lasted from 1947 to 1953. By his fift ...
State of the art
... 6 hours per night.19 Reduced sleep duration was reported to be associated with increased body mass and obesity in the NHANES study.20 Sleep deprivation also causes cognitive impairment. The brain is the master regulator of the neuroendocrine, autonomic, and immune systems, along with behaviors that ...
... 6 hours per night.19 Reduced sleep duration was reported to be associated with increased body mass and obesity in the NHANES study.20 Sleep deprivation also causes cognitive impairment. The brain is the master regulator of the neuroendocrine, autonomic, and immune systems, along with behaviors that ...
Behavioral epigenetics
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal (including human) behaviour. It is an experimental science that seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviour, cognition personality, and mental health.Epigenetic gene regulation involves changes other than to the sequence of DNA and includes changes to histones (proteins around which DNA is wrapped) and DNA methylation. These epigenetic changes can influence the growth of neurons in the developing brain as well as modify activity of the neurons in the adult brain. Together, these epigenetic changes on neuron structure and function can have a marked influence on an organism's behavior.