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Cell Cycle Vignettes The Cell Cycle of Budding Yeast
Cell Cycle Vignettes The Cell Cycle of Budding Yeast

... daughter cell nucleus is not properly pushed into the bud compartment. Molecular cell biology Genetic analysis of the molecular machinery controlling the major events of the cell cycle was begun in budding yeast by Leland Hartwell, who identified dozens of genes that induced the ‘cell division cycle ...
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When epigenetics meets alternative splicing: the roles of DNA
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RNA polymerase II is the key enzyme in the process of transcription
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RNA polymerase II is the key enzyme in the process of transcription
RNA polymerase II is the key enzyme in the process of transcription

... 2. One of the four core histones becomes conjugated with ubiquitin in a process that is coupled to transcriptional activation. Describe briefly this process and explain how this monoubiquitination mark is linked to the formation of another key activation mark on histones. 3. Nuclear bodies are promi ...
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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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