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Severe axonal Charcot-Marie-Tooth disease with proximal
Severe axonal Charcot-Marie-Tooth disease with proximal

... muscles (including hip flexors) being weaker than extensor muscles. Clinical presentation is summarized in Table 1. Photographs of the patient are shown in Fig. 1. Nerve conduction studies results are summarized in Table 2. The patient has been tested, since 2001, for PMP22 duplication/deletion and S ...
Fall 2009
Fall 2009

... 24. The cell membrane is made up of ___layer and is said to be ____________ ______________, which means it, allows some but, not all materials to cross. Scientists have developed the _________ ___________ _________, which describes the arrangement of the molecules that make up the cell membrane. Eac ...
I. Genetics
I. Genetics

... -the passing of traits from parent to offspring ...
Supplementary Documents (doc 60K)
Supplementary Documents (doc 60K)

... kinases that regulate gene expression.3 As before, the top 10 TFs that regulate the DE genes were identified in each dataset and then Genes2Networks4 was used to link these 10 TFs in each dataset to their regulatory networks by known protein-protein interactions.5 The Human Protein Reference Databas ...
Novel Molecular Methods for Discovery and Engineering of
Novel Molecular Methods for Discovery and Engineering of

... biocatalysts from uncultured marine microorganisms. Discovery of marine biocatalysts by this approach, in general, involves four main steps. First, a metagenomic library containing a pool of biocatalyst-encoding genes is constructed from a marine environment, which can be done by various methods, in ...
HIV treatments
HIV treatments

... membrane ensures the full inclusion of viral proteins ...
Remember those chromosomes?
Remember those chromosomes?

... specific to humans, organisms vary in their chromosome #’s. ...
Drosophila
Drosophila

... male. • The worm C. elegans: it is achieved by a halving of the activity of genes on both of the X chromosomes in the female • Placental mammals: genes on one of the X chromosomes in the female are inactivated creating Barr body ...
Advanced Environmental Biotechnology II
Advanced Environmental Biotechnology II

... criteria for the quality and suitability of RNA extraction protocols are the yield, the integrity, and the purity of the RNA. ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

... Discuss the salient features of Crick and Watson model for the structure of DNA. ...
Restriction Enzymes
Restriction Enzymes

... • Restriction enzymes are endonucleases which catalyze the cleavage of the phosphodiester bonds within both strands of DNA. • They require Mg+2 for activity and generate a 5 prime (5') phosphate and a 3 prime (3') hydroxyl group at the point of cleavage. • The distinguishing feature of restriction e ...
Genetics Study Guide
Genetics Study Guide

... A male sex cell A female sex cell The process that occurs in sex cells by which the number of chromosomes is reduced by half. A change in a gene or chromosome. ...
General Biology Program for Secondary
General Biology Program for Secondary

... 13. A.4c Describe how scientific knowledge, explanations and technological designs may change with new information over time (e.g., the understanding of DNA, the design of computers). ...
Nucleic Acids
Nucleic Acids

... DNA replication “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” James Watson Francis Crick ...
protein
protein

... delivered to the cells by the blood vessels. Inside the cells, they are used for anabolism (building) of proteins or undergo deamination (removal of the amine functional group) for ATP production in cellular respiration. ...
Marvelous Macromolecules
Marvelous Macromolecules

... next 20 amino acid monomers make thousands of proteins Joined together by dehydration reaction that removes hydroxyl group from one and amino group of another to make a peptide bond ...
Why teach a course in bioinformatics?
Why teach a course in bioinformatics?

... Technologies have allowed highthroughput ‘transcriptome’ analysis. That capability was introduced in the ’90s, but since then, it has become much more powerful as the genome project progressed. There are now many transcriptome centers already set up or being established. People are using this techno ...
Lec 01 - History of Microbiology True or False 1. Robert Koch is the
Lec 01 - History of Microbiology True or False 1. Robert Koch is the

... 1.Besides providing strong evidence toward the disproof of spontaneous generation, Louis Pasteur made many other contributions toward the advancement of microbiology. Which of the following is not one of Pasteur’s contributions? (a) Provided evidence for the germ theory with his association of speci ...
Genetics Study Guide
Genetics Study Guide

... A male sex cell A female sex cell The process that occurs in sex cells by which the number of chromosomes is reduced by half. A change in a gene or chromosome. ...
Total genomic DNA of non-treated and DHPA
Total genomic DNA of non-treated and DHPA

... Figure S1 - MSAP analysis of DNA samples isolated from tobacco seedlings treated with 0 μM (DHPA 0), 10 μM (DHPA 10) and 100 μM (DHPA 100) 9-(S)-(2,3dihydroxypropyl)-adenine (DHPA; [1]). DHPA preferentially induces hypomethylation of CHG sequences and also some CG sequences at elevated concentra ...
Course Review
Course Review

... 3. Compare DNA and RNA and outline their similarities and differences. 4. In a hypothetical situation, 85 amino acids exist and there are still only 4 nucleotides found in nucleic acid. Calculate the minimum number of nucleotides required to code for this large number of amino acids. What is the max ...
Control Mechanism of Gene Expression During Development of
Control Mechanism of Gene Expression During Development of

... strand. In prokaryotic cells, this process causes destabilization of RNA. I investigated the effects of pcnB gene deletion on the level of expression of crucial viral genes (xis, cIII, N, cI, cro, cII, oop, O, Q, R) after prophage induction. I observed that shortly after treatment of lysogenic cell ...
Complex Traits
Complex Traits

... IBD regions among many affected sib pairs. Usually results in a large region, a significant fraction of an entire chromosome: too big for positional cloning. Also: if more than one gene causes the trait, the necessary large amount of data will never converge to a single chromosome region. ...
you can view a sample report here.
you can view a sample report here.

... Variants Found production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylMultiple have considered riboflavin and shown that the MTHFR 677that TTWhen genoMTRR studies MTRR attaches a methyl group tostatus B12 considered and variants here will slow thesho ...
Genetic Disorders - Sarah E. Goode STEM Academy
Genetic Disorders - Sarah E. Goode STEM Academy

... Genetic Disorders A person can inherit genes that contain a mutation, or abnormality. The mutation may have little or no effect. It also may result in a birth defect or may increase the person’s likelihood of developing a disease. ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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