Proteomics of
... both the fertilizing ability of spermatozoa and exert important effects on the female reproductive physiology. Seminal plasma proteins are involved in the control of molecular mechanisms accompanying sperm transport in the female reproductive tract, suppression of the immune response against sperm a ...
... both the fertilizing ability of spermatozoa and exert important effects on the female reproductive physiology. Seminal plasma proteins are involved in the control of molecular mechanisms accompanying sperm transport in the female reproductive tract, suppression of the immune response against sperm a ...
Regulation of nitrogen metabolism in gram
... TnrA/GlnR site upstream of orthologous genes in at least two genomes. Another 11 operons lacked the conserved TnrA-binding site, but their products were involved in nitrogen assimilation (Fig. 3). In all genomes analyzed, the conserved TnrAbinding site was observed upstream of the nrgAB operon. In B ...
... TnrA/GlnR site upstream of orthologous genes in at least two genomes. Another 11 operons lacked the conserved TnrA-binding site, but their products were involved in nitrogen assimilation (Fig. 3). In all genomes analyzed, the conserved TnrAbinding site was observed upstream of the nrgAB operon. In B ...
as a PDF
... Interestingly, during growth on oxygen plus heme, the respiratory chain expulses protons, allowing growth rescue of an ATPase mutant (4). Respiration may thus protect cells against a decrease in intracellular pH during growth. The clear distinctions between L. lactis and respiratory bacteria like E. ...
... Interestingly, during growth on oxygen plus heme, the respiratory chain expulses protons, allowing growth rescue of an ATPase mutant (4). Respiration may thus protect cells against a decrease in intracellular pH during growth. The clear distinctions between L. lactis and respiratory bacteria like E. ...
Substrate Specificity and Mechanism from the Structure of
... bacterial sepsis. Galactokinase deficiency (galactosemia II; MIM 230200) in man is an inborn error of galactose metabolism and is linked to development of cataracts during the first months of life and also pre-senile cataracts, the onset of which is between 20 and 50 years of age.3 Over 20 mutations ...
... bacterial sepsis. Galactokinase deficiency (galactosemia II; MIM 230200) in man is an inborn error of galactose metabolism and is linked to development of cataracts during the first months of life and also pre-senile cataracts, the onset of which is between 20 and 50 years of age.3 Over 20 mutations ...
Full-Text PDF
... unfavorable conditions [11–14]. This observation coupled with the wide metabolic diversity of SRB suggests their versatility in adapting to extreme pH and high temperature conditions, such as those present in seawater cooling tower systems and seawater injection pipelines used for oil recovery. SRBs ...
... unfavorable conditions [11–14]. This observation coupled with the wide metabolic diversity of SRB suggests their versatility in adapting to extreme pH and high temperature conditions, such as those present in seawater cooling tower systems and seawater injection pipelines used for oil recovery. SRBs ...
Plant Peroxisomes: Biogenesis and Function
... for peroxisome biogenesis. The growth and division paradigm was challenged by demonstrations that mutant yeast and mammalian cells lacking certain PEX genes, such as PEX3 and PEX19, were devoid of any obvious peroxisomal structures, yet the organelles appeared after reintroduction of the wild-type g ...
... for peroxisome biogenesis. The growth and division paradigm was challenged by demonstrations that mutant yeast and mammalian cells lacking certain PEX genes, such as PEX3 and PEX19, were devoid of any obvious peroxisomal structures, yet the organelles appeared after reintroduction of the wild-type g ...
View - OhioLINK Electronic Theses and Dissertations Center
... complement-mediated lysis. LVSG and LVSR are variant strains derived from LVS that have altered surface carbohydrate structures and are susceptible to complement-mediated lysis in serum. C3b deposition, however, occurs on each strain tested, indicating that complement is not solely activated by var ...
... complement-mediated lysis. LVSG and LVSR are variant strains derived from LVS that have altered surface carbohydrate structures and are susceptible to complement-mediated lysis in serum. C3b deposition, however, occurs on each strain tested, indicating that complement is not solely activated by var ...
Balancing between respiration and fermentation - UvA-DARE
... Thee most simple explanation for the petite-negative phenotype of K. lactis would be that this yeastt needs a functional respiratory chain and therefore does not tolerate mutations in the mitochondriall genome. This explanation is not tenable however, since K. lactis is able to grow onn glucose in t ...
... Thee most simple explanation for the petite-negative phenotype of K. lactis would be that this yeastt needs a functional respiratory chain and therefore does not tolerate mutations in the mitochondriall genome. This explanation is not tenable however, since K. lactis is able to grow onn glucose in t ...
Regulation of Ketone Body Metabolism and the Role of PPAR
... lipids stored in adipose tissue and break down of triglycerides to free fatty acids and glycerol [1,2]. These two components are subsequently catabolized in liver: fatty acids undergo β-oxidation to produce acetyl-CoA and glycerol is a substrate for glucose synthesis via gluconeogenesis. Acetyl-CoA ...
... lipids stored in adipose tissue and break down of triglycerides to free fatty acids and glycerol [1,2]. These two components are subsequently catabolized in liver: fatty acids undergo β-oxidation to produce acetyl-CoA and glycerol is a substrate for glucose synthesis via gluconeogenesis. Acetyl-CoA ...
Defining the Schistosoma haematobium kinome enables the
... focused on protein kinases13,14, because they are involved in signalling cascades of essential regulatory and developmental processes15–17, particular kinase groups have relatively conserved structures18, and also because drugs targeting these enzymes in humans have shown particular potential for th ...
... focused on protein kinases13,14, because they are involved in signalling cascades of essential regulatory and developmental processes15–17, particular kinase groups have relatively conserved structures18, and also because drugs targeting these enzymes in humans have shown particular potential for th ...
Proteins - The Open University
... Chemical catalysis Enzymes, which are responsible for catalysing biological reactions, are the largest functional group of proteins. Whilst there are thousands of different enzymes, all catalysing different reactions, they do have some features in common and can often be identified as members of a p ...
... Chemical catalysis Enzymes, which are responsible for catalysing biological reactions, are the largest functional group of proteins. Whilst there are thousands of different enzymes, all catalysing different reactions, they do have some features in common and can often be identified as members of a p ...
Carbon Metabolism in Spores of the Arbuscular Mycorrhizal Fungus
... colonize the roots of over 80% of plants in all terrestrial environments. Understanding why AM fungi do not complete their life cycle under free-living conditions has significant implications for the management of one of the world’s most important symbioses. We used 13C-labeled substrates and nuclea ...
... colonize the roots of over 80% of plants in all terrestrial environments. Understanding why AM fungi do not complete their life cycle under free-living conditions has significant implications for the management of one of the world’s most important symbioses. We used 13C-labeled substrates and nuclea ...
Diversity and origins of anaerobic metabolism in mitochondria and
... homologues of many of the proteins found in T. vaginalis hydrogenosomes, including HYD proteins, PFO, SCS, ASCT, chaperones, CI subunits and Fe–S cluster biosynthesis proteins [41]. Interestingly, Sawyeria appears to encode enzymes for a variety of canonical mitochondrial pathways linked to amino ac ...
... homologues of many of the proteins found in T. vaginalis hydrogenosomes, including HYD proteins, PFO, SCS, ASCT, chaperones, CI subunits and Fe–S cluster biosynthesis proteins [41]. Interestingly, Sawyeria appears to encode enzymes for a variety of canonical mitochondrial pathways linked to amino ac ...
Cooperative and independent functions of FGF and Wnt signaling
... Consistent with a role of Wnt signaling in otic fate decisions, otic vesicles are reduced in size when Wnt signaling is inhibited [14, 15, 21, 22]. Early ectopic activation of Wnt signaling results in the formation of enlarged or supernumerary otic vesicles due to posteriorization of the embryo lead ...
... Consistent with a role of Wnt signaling in otic fate decisions, otic vesicles are reduced in size when Wnt signaling is inhibited [14, 15, 21, 22]. Early ectopic activation of Wnt signaling results in the formation of enlarged or supernumerary otic vesicles due to posteriorization of the embryo lead ...
Emerging therapeutic roles for NAD+ metabolism in mitochondrial
... in regulating cellular metabolism and energy homeostasis. NAD+ in its reduced form (i.e. NADH) serves as the primary electron donor in mitochondrial respiratory chain, which involves adenosine triphosphate production by oxidative phosphorylation. The NAD+/NADH ratio also regulates the activity of va ...
... in regulating cellular metabolism and energy homeostasis. NAD+ in its reduced form (i.e. NADH) serves as the primary electron donor in mitochondrial respiratory chain, which involves adenosine triphosphate production by oxidative phosphorylation. The NAD+/NADH ratio also regulates the activity of va ...
Document
... of the 3rd phase of Glucose Aerobic oxidation • Stage I The acetyl-CoA is completely oxidized into CO2, with electrons collected by NAD and FAD via a cyclic pathway (tricarboxylic acid cycle) • Stage II Electrons of NADH and FADH2 are transferred to O2 via a series carriers, producing H2O and a H+ g ...
... of the 3rd phase of Glucose Aerobic oxidation • Stage I The acetyl-CoA is completely oxidized into CO2, with electrons collected by NAD and FAD via a cyclic pathway (tricarboxylic acid cycle) • Stage II Electrons of NADH and FADH2 are transferred to O2 via a series carriers, producing H2O and a H+ g ...
Mechanisms and applications of disulfide bond formation
... these proteins contain disulfide bonds in their native state, covalent links formed between the thiol groups of cysteine residues. In many proteins, disulfide bonds play an essential role in folding, stabilizing structure and the function of the protein. Therefore, understanding the pathways of disu ...
... these proteins contain disulfide bonds in their native state, covalent links formed between the thiol groups of cysteine residues. In many proteins, disulfide bonds play an essential role in folding, stabilizing structure and the function of the protein. Therefore, understanding the pathways of disu ...
Chem*3560 Lecture 9: Glycogen phosphorylase
... kinase in the PKA driven cascade already described. Phosphate is removed from serine in phosphorylase b kinase as well as from phosphorylase a by phosphoprotein phosphatase 1. Glycogen phosphorylase is a dimer of two identical subunits, with a slight difference in the liver and muscle versions. The ...
... kinase in the PKA driven cascade already described. Phosphate is removed from serine in phosphorylase b kinase as well as from phosphorylase a by phosphoprotein phosphatase 1. Glycogen phosphorylase is a dimer of two identical subunits, with a slight difference in the liver and muscle versions. The ...
Analysis of structural robustness of metabolic
... mutants of micro-organisms are still able to grow, some with almost the same growth rate as the wild type. This has been shown, for example, by a systematic study on single knockout mutants of virtually all genes in baker’s yeast [1, 2]. In many cells, there are parallel and thus redundant metabolic ...
... mutants of micro-organisms are still able to grow, some with almost the same growth rate as the wild type. This has been shown, for example, by a systematic study on single knockout mutants of virtually all genes in baker’s yeast [1, 2]. In many cells, there are parallel and thus redundant metabolic ...
NIH Public Access
... lacking activation (Fig. 2C). The ability of SIRT1 to be activated by resveratrol was attenuated in one mutant that substituted a lysine for a glutamate at position 230 (E230K), whether an AMC-tagged substrate (Fig. 2D) or a natural amino acid substrate was used (fig. S8A). Substitution of Glu230 wi ...
... lacking activation (Fig. 2C). The ability of SIRT1 to be activated by resveratrol was attenuated in one mutant that substituted a lysine for a glutamate at position 230 (E230K), whether an AMC-tagged substrate (Fig. 2D) or a natural amino acid substrate was used (fig. S8A). Substitution of Glu230 wi ...
Tetrahymena Contain Two Distinct and Unusual High Mobility Group
... each other or any other macronuclear polypeptide in immunoblotting analyses. As well, LG-1 and LG-2 antibodies do not react with calf thymus, chicken, or yeast HMG proteins. Consistent with these results, a 47 amino-terminal sequence of LG-1 has been determined that shows limited homology to both ca ...
... each other or any other macronuclear polypeptide in immunoblotting analyses. As well, LG-1 and LG-2 antibodies do not react with calf thymus, chicken, or yeast HMG proteins. Consistent with these results, a 47 amino-terminal sequence of LG-1 has been determined that shows limited homology to both ca ...
PDF - Oxford Academic - Oxford University Press
... plants of other TORC1-related proteins would shed light on the dynamic molecular mechanisms involved in the induction of autophagy. After the assembly of the Atg1–Atg13 kinase complex, subsequent activation of the complex induces several steps during autophagosome formation, although we still do not ...
... plants of other TORC1-related proteins would shed light on the dynamic molecular mechanisms involved in the induction of autophagy. After the assembly of the Atg1–Atg13 kinase complex, subsequent activation of the complex induces several steps during autophagosome formation, although we still do not ...
Glycogen Earth organisms use three major forms of - Rose
... branches may also have a role in altering the rate of breakdown of the molecule; phosphorylase can only cleave to within about 5 residues of a branch-point, and therefore must coordinate with debranching enzyme to allow complete degradation of glycogen. (Note that roughly half of the glucose residue ...
... branches may also have a role in altering the rate of breakdown of the molecule; phosphorylase can only cleave to within about 5 residues of a branch-point, and therefore must coordinate with debranching enzyme to allow complete degradation of glycogen. (Note that roughly half of the glucose residue ...
University of Groningen Stress responses and sugar metabolism in
... and acsA [282]. In the latter case, affinity of CcpA for the cre site was also dependent on the composition of the nucleotides flanking cre. In chapter 5 the ydhMNOPQRST operon and the ycgN gene are identified as novel CcpA‐repressed targets, for which putative cre sites were detected upstream of ...
... and acsA [282]. In the latter case, affinity of CcpA for the cre site was also dependent on the composition of the nucleotides flanking cre. In chapter 5 the ydhMNOPQRST operon and the ycgN gene are identified as novel CcpA‐repressed targets, for which putative cre sites were detected upstream of ...
Beta-Cell Function and Failure in Type 1 Diabetes
... are approximately 70% to 80% of the total islet cells. Beta-cells are responsible for secreting insulin in response to rises in blood nutrient levels during the postprandial state. Glucose is the most important nutrient for insulin secretion. The process by which glucose promotes insulin secretion r ...
... are approximately 70% to 80% of the total islet cells. Beta-cells are responsible for secreting insulin in response to rises in blood nutrient levels during the postprandial state. Glucose is the most important nutrient for insulin secretion. The process by which glucose promotes insulin secretion r ...