Peroxisomes: family of versatile organelles
... complex system for regulation of lipid metabolism. ...
... complex system for regulation of lipid metabolism. ...
Predicting functional linkages from gene fusions with
... are described, of which 117 apply to E. coli. Example KEGG categories are shown in Table 1. Unfortunately, the KEGG functional categories also suffer from certain limitations. Primarily, they are not defined according to objective criteria—some categories represent not pathways, but homologous prote ...
... are described, of which 117 apply to E. coli. Example KEGG categories are shown in Table 1. Unfortunately, the KEGG functional categories also suffer from certain limitations. Primarily, they are not defined according to objective criteria—some categories represent not pathways, but homologous prote ...
Oxidized LDL-Containing Immune Complexes Induce Fc Gamma
... Abstract—Our previous studies have shown that Fc gamma receptor (FcgR)-mediated uptake of LDL-containing immune complexes (oxLDL-ICs) by human monocyte-derived macrophages leads to not only transformation of macrophages into foam cells but also macrophage activation and release of cytokines. It has ...
... Abstract—Our previous studies have shown that Fc gamma receptor (FcgR)-mediated uptake of LDL-containing immune complexes (oxLDL-ICs) by human monocyte-derived macrophages leads to not only transformation of macrophages into foam cells but also macrophage activation and release of cytokines. It has ...
Gene Section MAP2 (microtubule associated protein 2) -
... 3' UTR. Local expression within dendrites is hypothesized to be more suited to regulate need based synthesis. Tubulin, a protein expressed in both axons and dendrites is known to be expressed in the cytoplasm of the cell body showing that location specific expression of proteins is important to the ...
... 3' UTR. Local expression within dendrites is hypothesized to be more suited to regulate need based synthesis. Tubulin, a protein expressed in both axons and dendrites is known to be expressed in the cytoplasm of the cell body showing that location specific expression of proteins is important to the ...
Protein Molecules in Solution
... in compounds such as tyrosine. On the other hand, Cu is bound more strongly to amine nitrogens or to mereaptan groups. An interesting case not shown in table 3 is Pb ion which, like Zn or Cu, is bound strongly to mereaptan groups. On the other hand, Pb shows a much greater affinity for carboxyl than ...
... in compounds such as tyrosine. On the other hand, Cu is bound more strongly to amine nitrogens or to mereaptan groups. An interesting case not shown in table 3 is Pb ion which, like Zn or Cu, is bound strongly to mereaptan groups. On the other hand, Pb shows a much greater affinity for carboxyl than ...
Dynamics of Protein Tyrosine Nitration and
... In vitro, selectively of ONOO- mediated tyrosine nitration is mostly seen at N-terminal region of the tau molecule (Y18, Y29) and less at Y197 and Y394. Nitration at Y310 was rarely observed, probably because of its location within the hydrophobic microtubule binding repeat of tau [66]. Generation o ...
... In vitro, selectively of ONOO- mediated tyrosine nitration is mostly seen at N-terminal region of the tau molecule (Y18, Y29) and less at Y197 and Y394. Nitration at Y310 was rarely observed, probably because of its location within the hydrophobic microtubule binding repeat of tau [66]. Generation o ...
LDL
... PPARα increases the entry of FA into the hepatocyte and favors their activation, intracellular transport and catabolism via the β-oxidation cycle thus diminishing FA pool and TG production. PPARα also increases ketone body (KB) synthesis and TG clearance by modulating the expression of genes implic ...
... PPARα increases the entry of FA into the hepatocyte and favors their activation, intracellular transport and catabolism via the β-oxidation cycle thus diminishing FA pool and TG production. PPARα also increases ketone body (KB) synthesis and TG clearance by modulating the expression of genes implic ...
Macromolecular Crystallography in India, IUCr, 2017
... crystallography and electron cryo-‐microscopy, complemented by single-‐molecule biophysical studies. ...
... crystallography and electron cryo-‐microscopy, complemented by single-‐molecule biophysical studies. ...
Receptor-mediated sorting of soluble vacuolar proteins: myths, facts
... MPRs are prevented from interacting in the early secretory pathway (ER and cis/medial-Golgi cisternae) with their cargo ligands, which are ‘capped’ by the addition of GlcNac1-phosphate to α-1,6-linked terminal mannose residues. The ligands only become ‘demasked’ at the TGN through the action of a so ...
... MPRs are prevented from interacting in the early secretory pathway (ER and cis/medial-Golgi cisternae) with their cargo ligands, which are ‘capped’ by the addition of GlcNac1-phosphate to α-1,6-linked terminal mannose residues. The ligands only become ‘demasked’ at the TGN through the action of a so ...
GENE NOMENCLATURE OF DIFFERENT TYPES OF SPINOCEREBELLAR ATAXIA (SCA) AND
... of Spinocerebellar ataxia and a computational work on Spinocerebellar ataxia type 1 (SCA1) are done in this study. SCA1 is a progressive, degenerative and often fatal neurodegenerative disorders. There is no known effective treatment or cure. It is caused by either a recessive or dominant gene. Many ...
... of Spinocerebellar ataxia and a computational work on Spinocerebellar ataxia type 1 (SCA1) are done in this study. SCA1 is a progressive, degenerative and often fatal neurodegenerative disorders. There is no known effective treatment or cure. It is caused by either a recessive or dominant gene. Many ...
Wine Proteins and Protein Stability
... increase with increasing grape maturity. Protein synthesis proceeds rapidly after véraison and parallels the rapid accumulation of sugar. The protein level of the fruit is frequently higher in warmer regions. Low crop levels have also been associated with higher protein and higher total nitrogen. ...
... increase with increasing grape maturity. Protein synthesis proceeds rapidly after véraison and parallels the rapid accumulation of sugar. The protein level of the fruit is frequently higher in warmer regions. Low crop levels have also been associated with higher protein and higher total nitrogen. ...
Essentials of Glycobiology Lecture 13 April 25th. 2000
... Alternate Pathways for Trafficking of Lysosomal Enzymes In I-cell disease, some cells and tissues (e.g. liver, Blymphoblast lines and circulating granulocytes) have essentially normal levels of lysosomal enzymes. Two soluble lysosomal enzymes, acid phosphatase and ß-glucocerebrosidase are not a ...
... Alternate Pathways for Trafficking of Lysosomal Enzymes In I-cell disease, some cells and tissues (e.g. liver, Blymphoblast lines and circulating granulocytes) have essentially normal levels of lysosomal enzymes. Two soluble lysosomal enzymes, acid phosphatase and ß-glucocerebrosidase are not a ...
Protein Modeling Challenge Science Olympiad Trial Event
... Lending Library - Introduction to Protein StructureITOPS (www) Challenge: Download the 1ZAA pdb file, create an image in RasMol, identify key structural features, and fold a Mini-Toober model (change to new zinc finger folding kit activities) ...
... Lending Library - Introduction to Protein StructureITOPS (www) Challenge: Download the 1ZAA pdb file, create an image in RasMol, identify key structural features, and fold a Mini-Toober model (change to new zinc finger folding kit activities) ...
Human Metabolism: Macronutrients Instructors: Rosalind Coleman
... is to help you use and integrate information covered in the course. These sessions will help you understand disorders related to nutrition. You may be asked to participate in class. If you do not wish to be called on, please tell Dr. Coleman. Exams will cover information from assignments. Course Pol ...
... is to help you use and integrate information covered in the course. These sessions will help you understand disorders related to nutrition. You may be asked to participate in class. If you do not wish to be called on, please tell Dr. Coleman. Exams will cover information from assignments. Course Pol ...
Biochemistry I, Spring Term 2004 - Second Exam:
... 2. What is the purpose of a Scatchard plot? When is it appropriate to use it and when is it not? ...
... 2. What is the purpose of a Scatchard plot? When is it appropriate to use it and when is it not? ...
Biochemistry I, Spring Term 2004 - Second Exam:
... B6 (10 pts): Do one of the following three choices: Choice A: Biochem Bob is trying to purify a single protein from a complex mixture of proteins. He knows the protein that he is trying to purify has a large number of Aspartic and Glutamic acid residues, and no Lysine, Arginine, or Histidine residue ...
... B6 (10 pts): Do one of the following three choices: Choice A: Biochem Bob is trying to purify a single protein from a complex mixture of proteins. He knows the protein that he is trying to purify has a large number of Aspartic and Glutamic acid residues, and no Lysine, Arginine, or Histidine residue ...
Adaptation Processes in Alakaliphiles When Cell Wall
... distributed among the alkaliphilic isolates of Bacillus spp. although they are not found in neutrophilic strains. One half of the isolates produce teichuronopeptide, with each strain having a specific amino acid composition. The facultative alkaliphile strain C-125 produces teichuronic acid and teic ...
... distributed among the alkaliphilic isolates of Bacillus spp. although they are not found in neutrophilic strains. One half of the isolates produce teichuronopeptide, with each strain having a specific amino acid composition. The facultative alkaliphile strain C-125 produces teichuronic acid and teic ...
Exam 2 Practice Questions
... What is the percent composition of peptidoglycan in gram positive and then gram negative? Positive is 90% or less and negative is 10% or less T/F: the glycan portion is different on gram positive vs gram negative False, it is the same on both T/F: the glycan portion is best described as a heteropoly ...
... What is the percent composition of peptidoglycan in gram positive and then gram negative? Positive is 90% or less and negative is 10% or less T/F: the glycan portion is different on gram positive vs gram negative False, it is the same on both T/F: the glycan portion is best described as a heteropoly ...
Sphingolipid homeostasis in the web of metabolic routes
... human diseases generated by the defects in these pathways [3]. 2.3. Regulation of sphingolipid synthesis Although SLs are essential players in cell homeostasis the regulatory mechanisms controlling this pathway have only recently begun to emerge. The initial advances in the network of enzymatic cont ...
... human diseases generated by the defects in these pathways [3]. 2.3. Regulation of sphingolipid synthesis Although SLs are essential players in cell homeostasis the regulatory mechanisms controlling this pathway have only recently begun to emerge. The initial advances in the network of enzymatic cont ...
Tertiary and Quaternary Structure
... Define the terms domain and subunit as they relate to protein structure. Be able to recognize different domains in a ribbon diagram of a single polypeptide chain with 2 or more domains. Describe in general terms the structure of the polypeptide chain of myoglobin. Describe the structure of the struc ...
... Define the terms domain and subunit as they relate to protein structure. Be able to recognize different domains in a ribbon diagram of a single polypeptide chain with 2 or more domains. Describe in general terms the structure of the polypeptide chain of myoglobin. Describe the structure of the struc ...
Evolutionary rate at the protein domain level is
... theoretical framework for understanding the molecular clock as well as the apparent differences in the rate of evolution that arise within proteins and across different lineages [13]. Because the mechanism of DNA replication is prone to some small level of error, mutations repeatedly arise in the ge ...
... theoretical framework for understanding the molecular clock as well as the apparent differences in the rate of evolution that arise within proteins and across different lineages [13]. Because the mechanism of DNA replication is prone to some small level of error, mutations repeatedly arise in the ge ...
Chem*3560 Lecture 11: Regulation by proteolytic cleavage
... is structurally equivalent to Lys6 and Ile7 in trypsinogen. The newly exposed N-terminal Ile is similarly positioned to make an ion pair with Asp 194, and the mechanism of activation is the same as for trypsin. The immediate product is called π -chymotrypsin and is fully active as a protease. Self-e ...
... is structurally equivalent to Lys6 and Ile7 in trypsinogen. The newly exposed N-terminal Ile is similarly positioned to make an ion pair with Asp 194, and the mechanism of activation is the same as for trypsin. The immediate product is called π -chymotrypsin and is fully active as a protease. Self-e ...
Intrinsic Disorder in Cell-signaling and Cancer
... many tumors.16 A large number of protooncogenes (i.e. c-jun, c-fos, c-myc ) code for transcription factors required for cell-cycle progression and cell differentiation. Experimental evidence of disorder in signaling and oncoproteins further support our disorder predictions. For example, the N termin ...
... many tumors.16 A large number of protooncogenes (i.e. c-jun, c-fos, c-myc ) code for transcription factors required for cell-cycle progression and cell differentiation. Experimental evidence of disorder in signaling and oncoproteins further support our disorder predictions. For example, the N termin ...
The Carboxyl-Terminal Region of Protein C Is
... Construction of carboxyl-terminal deletion mutants. Complementary DNA (cDNA) fragments coding for wtPC and PCN were ligated into the multicloning site of the pBluescript II KS (1) (Stratagene, La Jolla, CA) as described previously,4 and designated pBPC and pBPCN, respectively. The carboxyl-terminal ...
... Construction of carboxyl-terminal deletion mutants. Complementary DNA (cDNA) fragments coding for wtPC and PCN were ligated into the multicloning site of the pBluescript II KS (1) (Stratagene, La Jolla, CA) as described previously,4 and designated pBPC and pBPCN, respectively. The carboxyl-terminal ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.