Print - Circulation Research
... Exposure to sucrose causes lysosomal derangements in many tissues, including heart.3""6-l5 In fetal mouse hearts, the abnormalities can be observed to appear gradually over a period of 1-3 days.15 In keeping with the rather slow and progressive nature of the development of sucrose-induced lysosomal ...
... Exposure to sucrose causes lysosomal derangements in many tissues, including heart.3""6-l5 In fetal mouse hearts, the abnormalities can be observed to appear gradually over a period of 1-3 days.15 In keeping with the rather slow and progressive nature of the development of sucrose-induced lysosomal ...
Metabolic adaptation of Mycobacterium avium subsp
... compared the protein profiles of clinical strains of MAP prepared from the gastrointestinal tract of diseased cows with the protein profiles of the same strains after they were grown in vitro. LC-MSMS analyses revealed that the principal enzymes for the central carbon metabolic pathways, including g ...
... compared the protein profiles of clinical strains of MAP prepared from the gastrointestinal tract of diseased cows with the protein profiles of the same strains after they were grown in vitro. LC-MSMS analyses revealed that the principal enzymes for the central carbon metabolic pathways, including g ...
BEL β-trefoil: A novel lectin with antineoplastic properties in king
... Proteins of nonimmune origin that selectively bind and recognize carbohydrates without modifying them enzymatically are called lectins (Sharon 2007). In general, ligand binding precedes the fulfillment of an important biological function, which in some cases is still not known. Some members of this f ...
... Proteins of nonimmune origin that selectively bind and recognize carbohydrates without modifying them enzymatically are called lectins (Sharon 2007). In general, ligand binding precedes the fulfillment of an important biological function, which in some cases is still not known. Some members of this f ...
The Role of Nucleoside Diphosphate Kinase in Plant Mitochondria
... Nucleoside Diphosphate Kinase (NDPK) catalyses the transfer of a phosphate from nucleoside triphosphates to a nucleoside diphosphate, is ubiquitously found in all organisms from bacteria to human. It was discovered that the genes nm23 and awd, which encode NDPKs are involved in tumour metastasis and ...
... Nucleoside Diphosphate Kinase (NDPK) catalyses the transfer of a phosphate from nucleoside triphosphates to a nucleoside diphosphate, is ubiquitously found in all organisms from bacteria to human. It was discovered that the genes nm23 and awd, which encode NDPKs are involved in tumour metastasis and ...
Mutational effects on protein structure and function Jonas Carlsson Link¨
... In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. The techniques used are general as demonstrated by applications on metabolic proteins (CYP21, CYP1 ...
... In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. The techniques used are general as demonstrated by applications on metabolic proteins (CYP21, CYP1 ...
HIV-1 Vpr-chloramphenicol acetyltransferase fusion proteins
... molecular weight of the different Vpr-CAT fusion proteins ranged between approximately 29 kDa and 35 kDa. Analysis of viral lysates indicates that Vpr-CAT fusion proteins R1-42CAT, R1-80CAT, R1-88CAT and R1488CAT are packaged into virions at various levels as compared with the wild-type Vpr (Figure ...
... molecular weight of the different Vpr-CAT fusion proteins ranged between approximately 29 kDa and 35 kDa. Analysis of viral lysates indicates that Vpr-CAT fusion proteins R1-42CAT, R1-80CAT, R1-88CAT and R1488CAT are packaged into virions at various levels as compared with the wild-type Vpr (Figure ...
Adenosine signaling mediates hypoxic responses in the chronic
... new drugs do not cure CLL patients. Hence, the identification of drug combinations to treat and ultimately cure the disease is a high priority. Extracellular nucleotides and nucleosides are part of an evolutionarily conserved and highly sophisticated extracellular network that controls scavenging o ...
... new drugs do not cure CLL patients. Hence, the identification of drug combinations to treat and ultimately cure the disease is a high priority. Extracellular nucleotides and nucleosides are part of an evolutionarily conserved and highly sophisticated extracellular network that controls scavenging o ...
- 1 - MOLECULAR CELL BIOLOGY: ESSAY OUTLINE What are
... • Insertion of peroxisomal membrane proteins (PMPs) - Requires Pex3p + Pex19p [ref 7] - PMPs have a peroxisomal membrane targeting signal (mPTS) [ref 7] - Pex19p (which behaves as an import receptor and chaperon) recognises and binds to mPTS on PMP and delivers its PMP protein to the membrane. This ...
... • Insertion of peroxisomal membrane proteins (PMPs) - Requires Pex3p + Pex19p [ref 7] - PMPs have a peroxisomal membrane targeting signal (mPTS) [ref 7] - Pex19p (which behaves as an import receptor and chaperon) recognises and binds to mPTS on PMP and delivers its PMP protein to the membrane. This ...
A Quick Look at Biochemistry: Lipid Metabolism
... Introduction Lipids are a group of naturally occurring compounds and hydrophobic or amphiphilic molecules that form structures such as vesicles, liposomes or membranes in an aqueous environment. They are a large and diverse group of organic macromolecules; hence, it is always difficult for scientist ...
... Introduction Lipids are a group of naturally occurring compounds and hydrophobic or amphiphilic molecules that form structures such as vesicles, liposomes or membranes in an aqueous environment. They are a large and diverse group of organic macromolecules; hence, it is always difficult for scientist ...
De Novo Pyrimidine Nucleotide Synthesis Mainly
... by adding the nucleobase uracil (Chen and Slocum, 2008). In general, it is assumed that pyrimidine de novo synthesis is exclusively located in plastids with the exception of the reaction catalyzed by dihydroorotate dehydrogenase (DHODH) (Slocum, 2005). However, direct experimental evidence for this ...
... by adding the nucleobase uracil (Chen and Slocum, 2008). In general, it is assumed that pyrimidine de novo synthesis is exclusively located in plastids with the exception of the reaction catalyzed by dihydroorotate dehydrogenase (DHODH) (Slocum, 2005). However, direct experimental evidence for this ...
Activation of Peroxisome Proliferator-Activated Receptors
... expressed in liver, is responsible for the proDepartment of Biology, Boston University, Boston, Massachusetts liferative effects of chemical peroxisome Trichloroethylene (TCE) and related hydrocarbons constitute an important class of environmental proliferators such as clofibrate (5). By conpollutan ...
... expressed in liver, is responsible for the proDepartment of Biology, Boston University, Boston, Massachusetts liferative effects of chemical peroxisome Trichloroethylene (TCE) and related hydrocarbons constitute an important class of environmental proliferators such as clofibrate (5). By conpollutan ...
Characterizing the Grape Transcriptome
... in common use for viticulture, as shown by example in Figure 1 (for complete detail, see Supplemental Table II). The vocabulary was used to generate an online query tool (http://cgf.ucdavis.edu/) to facilitate identification of genes that may be differentially or uniquely expressed under specified c ...
... in common use for viticulture, as shown by example in Figure 1 (for complete detail, see Supplemental Table II). The vocabulary was used to generate an online query tool (http://cgf.ucdavis.edu/) to facilitate identification of genes that may be differentially or uniquely expressed under specified c ...
Expression of vascular endothelial growth factor
... phobic signal sequence, would consist of 120 (VEGF2), 164 (VEGF-1) or 188 (VEGF-3) amino acid residues (Fig. 2). The direct protein sequence analysis of the amino-terminal end of the putative murine VEGF (Plouet et al., 1989) is in agreement with the sequence obtained from the cDNA clones. However, ...
... phobic signal sequence, would consist of 120 (VEGF2), 164 (VEGF-1) or 188 (VEGF-3) amino acid residues (Fig. 2). The direct protein sequence analysis of the amino-terminal end of the putative murine VEGF (Plouet et al., 1989) is in agreement with the sequence obtained from the cDNA clones. However, ...
Plasma membrane
... The hydrogen atoms are delivered to enzymes and coenzymes of the cristae which catalyze the synthesis of ATP from ADP and phosphate. At the end of this process, oxygen combines with the hydrogen atoms to form ...
... The hydrogen atoms are delivered to enzymes and coenzymes of the cristae which catalyze the synthesis of ATP from ADP and phosphate. At the end of this process, oxygen combines with the hydrogen atoms to form ...
PrionPPSatBlack
... analyses Some mutations have been associated with prion diseases. By mapping these onto structures, propose a hypothesis to explain this. Most of the variation seems to be in the Nterminal region. Is there homology to this region in other proteins? ...
... analyses Some mutations have been associated with prion diseases. By mapping these onto structures, propose a hypothesis to explain this. Most of the variation seems to be in the Nterminal region. Is there homology to this region in other proteins? ...
Document
... • Cells are the smallest units that perform all vital physiological functions • Each cell maintains homeostasis at the cellular level ...
... • Cells are the smallest units that perform all vital physiological functions • Each cell maintains homeostasis at the cellular level ...
Nitrogen Balance and Protein Requirements: Definition and
... cannot, by definition, be synthesised by the body, they must be introduced with the diet in a proportion that will fit with the organism’s metabolic needs. On the other hand, in the absence of dietary NEAA, despite the theoretical capability of the body to synthesise them, nitrogen will be needed fo ...
... cannot, by definition, be synthesised by the body, they must be introduced with the diet in a proportion that will fit with the organism’s metabolic needs. On the other hand, in the absence of dietary NEAA, despite the theoretical capability of the body to synthesise them, nitrogen will be needed fo ...
Chapter 3 powerpoint File - District 196 e
... The hydrogen atoms are delivered to enzymes and coenzymes of the cristae which catalyze the synthesis of ATP from ADP and phosphate. At the end of this process, oxygen combines with the hydrogen atoms to form ...
... The hydrogen atoms are delivered to enzymes and coenzymes of the cristae which catalyze the synthesis of ATP from ADP and phosphate. At the end of this process, oxygen combines with the hydrogen atoms to form ...
UNIT 11. CATABOLISM OF GLUCOSE • Aerobic glycolysis: scheme
... Glycolysis is an oxidative specific pathway by which one mole of glucose is enzymatically split into two moles of pyruvate. It occurs in cytosol of all cells of the body. The principle function of glycolysis is the generation of ATP. Glycolysis also provides precursors for fatty acids biosynthesis, ...
... Glycolysis is an oxidative specific pathway by which one mole of glucose is enzymatically split into two moles of pyruvate. It occurs in cytosol of all cells of the body. The principle function of glycolysis is the generation of ATP. Glycolysis also provides precursors for fatty acids biosynthesis, ...
Synthetic human prion protein octapeptide repeat binds to the
... The octapeptide repeats in prion proteins are also a region capable of binding to heparin and heparan sulphate (HS) [12]. HS is expressed in neural and other cell types. It modulates the activity of growth factors and cytokines [13]. Cellular glycosaminoglycans play a role in the biogenesis of PrPSc ...
... The octapeptide repeats in prion proteins are also a region capable of binding to heparin and heparan sulphate (HS) [12]. HS is expressed in neural and other cell types. It modulates the activity of growth factors and cytokines [13]. Cellular glycosaminoglycans play a role in the biogenesis of PrPSc ...
Possibilities for feeding low-protein diets to weanling and growing pigs
... AA for maintenance rather than lean protein synthesis. The ideal ratio for maintenance is different from the ideal ratio for lean meat production, and as a greater proportion of the dietary AA are used for maintenance, the ideal profile of the entire diet will change. Once the ideal ratios have been ...
... AA for maintenance rather than lean protein synthesis. The ideal ratio for maintenance is different from the ideal ratio for lean meat production, and as a greater proportion of the dietary AA are used for maintenance, the ideal profile of the entire diet will change. Once the ideal ratios have been ...
revised Protein and polypeptide hormones
... second messengers are cAMP, Ca2+, inositol triphosphate (IP3) , and diacylglycerol (DAG) . Proteins are phosphorylated on serine and threonine by cAMP-dependent protein kinase (PKA) and DAG-activated protein kinase C (PKC). Additionally a series of membrane-associated and intracellular tyrosine kina ...
... second messengers are cAMP, Ca2+, inositol triphosphate (IP3) , and diacylglycerol (DAG) . Proteins are phosphorylated on serine and threonine by cAMP-dependent protein kinase (PKA) and DAG-activated protein kinase C (PKC). Additionally a series of membrane-associated and intracellular tyrosine kina ...
The p101 subunit of PI3Kγ restores activation by Gβ mutants
... signals into the principle product PtdIns(3,4,5)P3 in order to control a plethora of fundamental cellular responses, including proliferation, differentiation, growth and chemotaxis [1–8]. On the basis of their structural features and modes of regulation, class I PI3Ks have been grouped into the clas ...
... signals into the principle product PtdIns(3,4,5)P3 in order to control a plethora of fundamental cellular responses, including proliferation, differentiation, growth and chemotaxis [1–8]. On the basis of their structural features and modes of regulation, class I PI3Ks have been grouped into the clas ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.