Leukaemia Section t(1;14)(q21;q32) IRTA1/IGH Atlas of Genetics and Cytogenetics in Oncology and Haematology
... The three alternate IRTA1 transcripts give rise to the same putative 515 amino acid protein. The protein shows a signal peptide, four extracellular Ig-type domains carrying three potential asparagaine (N)-linked glycosylation sites, a 16 amino acid transmmbrane and a 106 amino acid cytoplasmic domai ...
... The three alternate IRTA1 transcripts give rise to the same putative 515 amino acid protein. The protein shows a signal peptide, four extracellular Ig-type domains carrying three potential asparagaine (N)-linked glycosylation sites, a 16 amino acid transmmbrane and a 106 amino acid cytoplasmic domai ...
Chapter 18 – Eukaryotic Gene Regulation Cell Differentiation • All
... DNA moves within genome, if it ends up near an active promoter, transcription may increase Amplification of a proto-oncogene increases the number of copies of the gene Point mutations in the proto-oncogene or its control elements can cause an increase in gene expression Tumor-Suppressor Gene ...
... DNA moves within genome, if it ends up near an active promoter, transcription may increase Amplification of a proto-oncogene increases the number of copies of the gene Point mutations in the proto-oncogene or its control elements can cause an increase in gene expression Tumor-Suppressor Gene ...
Gene Section RHOB (ras homolog gene family, member B)
... Plays a pivotal role in the dynamic regulation of the actin cytoskeleton. Involved in intracellular protein trafficking of a number of proteins. Targets PRK1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear traf ...
... Plays a pivotal role in the dynamic regulation of the actin cytoskeleton. Involved in intracellular protein trafficking of a number of proteins. Targets PRK1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear traf ...
cell longevity pathways govern vascular and inflammatory
... Laboratory of Cellular and Molecular Signaling, Cancer Institute of New Jersey, New Jersey Health Sciences University, Newark, NJ, USA More than 170 million individuals world wide are affected by diabetes mellitus (DM). Although complications of DM as a result of oxidative stress are broad in nature ...
... Laboratory of Cellular and Molecular Signaling, Cancer Institute of New Jersey, New Jersey Health Sciences University, Newark, NJ, USA More than 170 million individuals world wide are affected by diabetes mellitus (DM). Although complications of DM as a result of oxidative stress are broad in nature ...
Supplementary table 2: Description of the gene pathways
... muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cisretinoic acid, are ubiquitinated to allow transcription to proceed. Increased intracellul ...
... muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cisretinoic acid, are ubiquitinated to allow transcription to proceed. Increased intracellul ...
Synthetic bile acid derivatives induce apoptosis through a c
... apoptosis including DNA fragmentation, an increased level of proapoptotic protein Bax, and cleavage of poly(ADP-ribose) polymerase were shown when the cells were treated with these synthetic compounds. Nuclear translocation of nuclear transcription factor NF-kappaB was increased and this suggests th ...
... apoptosis including DNA fragmentation, an increased level of proapoptotic protein Bax, and cleavage of poly(ADP-ribose) polymerase were shown when the cells were treated with these synthetic compounds. Nuclear translocation of nuclear transcription factor NF-kappaB was increased and this suggests th ...
Team Publications
... The small GTP-binding protein ADP-ribosylation factor 6 (ARF6) controls the endocytic recycling pathway of several plasma membrane receptors. We analyzed the localization and GDP/GTP cycle of GFP-tagged ARF6 by total internal reflection fluorescent microscopy. We found that ARF6-GFP associates with cl ...
... The small GTP-binding protein ADP-ribosylation factor 6 (ARF6) controls the endocytic recycling pathway of several plasma membrane receptors. We analyzed the localization and GDP/GTP cycle of GFP-tagged ARF6 by total internal reflection fluorescent microscopy. We found that ARF6-GFP associates with cl ...
The Physiology of Beta Cell Mass: Regulation of beta cell
... nutrient flow to the growing fetus, whereas prolactin and placental lactogen counterbalance this resistance and prevent maternal hyperglycemia by driving expansion of the maternal population of insulin-producing beta cells. However, the exact mechanisms by which the lactogenic hormones drive beta ce ...
... nutrient flow to the growing fetus, whereas prolactin and placental lactogen counterbalance this resistance and prevent maternal hyperglycemia by driving expansion of the maternal population of insulin-producing beta cells. However, the exact mechanisms by which the lactogenic hormones drive beta ce ...
Model Description Sheet
... muscle function. Activation of the metabotropic GABAB receptor by GABA influences neuronal activity by coupling with G proteins to activate a signaling cascade that leads to downstream effects including the modulation of various ion channels. The GABAB receptor is a dimer composed of two different s ...
... muscle function. Activation of the metabotropic GABAB receptor by GABA influences neuronal activity by coupling with G proteins to activate a signaling cascade that leads to downstream effects including the modulation of various ion channels. The GABAB receptor is a dimer composed of two different s ...
SI Practice Exam / Review Sheet
... SI Practice Exam / Review Sheet Part 1 Select the appropriate word or words for each of the following. 1. Cells that perform the same function are called a/an _______________, and different types of cells with a similar function make up a/an____________________. 2. Adjacent plant cells are held toge ...
... SI Practice Exam / Review Sheet Part 1 Select the appropriate word or words for each of the following. 1. Cells that perform the same function are called a/an _______________, and different types of cells with a similar function make up a/an____________________. 2. Adjacent plant cells are held toge ...
Leukaemia Section t(4;12)(p16;p13) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... lympthoma with a t(4;12)(p16;p13) chromosomal translocation. ...
... lympthoma with a t(4;12)(p16;p13) chromosomal translocation. ...
powerpoint
... How are the hormone receptor and AC coupled? • Purified AC and purified receptor, when recombined, are not coupled. • Rodbell showed that GTP is required for hormonal activation of AC • In 1977, Elliott Ross and Alfred Gilman at Univ. of Virginia discovered a GTP-binding protein which restored hor ...
... How are the hormone receptor and AC coupled? • Purified AC and purified receptor, when recombined, are not coupled. • Rodbell showed that GTP is required for hormonal activation of AC • In 1977, Elliott Ross and Alfred Gilman at Univ. of Virginia discovered a GTP-binding protein which restored hor ...
Chapter 11. Review Notes [10-2
... Type II binds TGF-B or Smad Family of CYTOKINES Function as Hetero-dimers: Type-I and Type-II Receptors form a I-II dimer for activity ...
... Type II binds TGF-B or Smad Family of CYTOKINES Function as Hetero-dimers: Type-I and Type-II Receptors form a I-II dimer for activity ...
StellARray Predefined Flyer
... • Compatible with most real time thermocyclers and any SYBR® Green or EvaGreen® master mix to fit seamlessly into your lab; • 96-, 384- and 4x96-well plate formats provide flexibility in gene and sample number tested; • Dried down format is ready to use or guaranteed for one year. Global Pattern Rec ...
... • Compatible with most real time thermocyclers and any SYBR® Green or EvaGreen® master mix to fit seamlessly into your lab; • 96-, 384- and 4x96-well plate formats provide flexibility in gene and sample number tested; • Dried down format is ready to use or guaranteed for one year. Global Pattern Rec ...
Attachment 2
... • Very tiny compared to red and white blood cells • Does not have a nucleus • Travel in blood to find cuts and scrapes on your skin • “plug” the cuts and scrapes to stop them from bleeding and help them heal • Made in your bone marrow (soft tissue inside your bones) ...
... • Very tiny compared to red and white blood cells • Does not have a nucleus • Travel in blood to find cuts and scrapes on your skin • “plug” the cuts and scrapes to stop them from bleeding and help them heal • Made in your bone marrow (soft tissue inside your bones) ...
A: Ca 2+
... the catecholamines (epinephrine and norepinephrine). Growth factors are involved in mitogenesis, whereas cytokines play critical roles in the differentiation, proliferation and function of various cell lineages.. Interaction of such ligands with their membrane, cell-specific receptors or intracellul ...
... the catecholamines (epinephrine and norepinephrine). Growth factors are involved in mitogenesis, whereas cytokines play critical roles in the differentiation, proliferation and function of various cell lineages.. Interaction of such ligands with their membrane, cell-specific receptors or intracellul ...
Document
... the catecholamines (epinephrine and norepinephrine). Growth factors are involved in mitogenesis, whereas cytokines play critical roles in the differentiation, proliferation and function of various cell lineages.. Interaction of such ligands with their membrane, cell-specific receptors or intracellul ...
... the catecholamines (epinephrine and norepinephrine). Growth factors are involved in mitogenesis, whereas cytokines play critical roles in the differentiation, proliferation and function of various cell lineages.. Interaction of such ligands with their membrane, cell-specific receptors or intracellul ...
Answers to End-of-Chapter Questions – Brooker et al ARIS site
... thereby keeping the effects very local. An example of this is found in the nervous system, where signaling chemicals called neurotransmitters communicate specific messages to target cells. Hormone signaling This form of signaling acts over long distances. Certain cells secrete hormones that are ca ...
... thereby keeping the effects very local. An example of this is found in the nervous system, where signaling chemicals called neurotransmitters communicate specific messages to target cells. Hormone signaling This form of signaling acts over long distances. Certain cells secrete hormones that are ca ...
Cell Communication
... (a) Cell junctions. animals cells have cell junctions that allow molecules to pass readily between adjacent cells without crossing plasma membranes. ...
... (a) Cell junctions. animals cells have cell junctions that allow molecules to pass readily between adjacent cells without crossing plasma membranes. ...
G-protein linked receptor
... cAMP levels rise rapidly in response to extracellular signal Assay fluorescence of protein that binds cAMP 5 X 10 ...
... cAMP levels rise rapidly in response to extracellular signal Assay fluorescence of protein that binds cAMP 5 X 10 ...
CHEM523 Exam2
... E) There exist >100 orphan GPCRs in the human genome with no known ligand. 22. Which of the following is not involved in signal transduction by the -adrenergic receptor pathway? ...
... E) There exist >100 orphan GPCRs in the human genome with no known ligand. 22. Which of the following is not involved in signal transduction by the -adrenergic receptor pathway? ...
PowerPoint 簡報
... Chemical Signals and Cellular Receptors • Different types of chemical signals can be received by cells • Receptor binding involves specific interactions between ligands and their receptors • Receptor binding activates a sequence of signal transduction events within the cell ...
... Chemical Signals and Cellular Receptors • Different types of chemical signals can be received by cells • Receptor binding involves specific interactions between ligands and their receptors • Receptor binding activates a sequence of signal transduction events within the cell ...
Cell Signaling
... • Calcium ions also act as second messengers. One example is activating an enzyme phospholipase C to produce two more messengers which will open Ca channels. The signal receptor may be a G protein or a tyrosine kinase receptor. ...
... • Calcium ions also act as second messengers. One example is activating an enzyme phospholipase C to produce two more messengers which will open Ca channels. The signal receptor may be a G protein or a tyrosine kinase receptor. ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.