Production kinetics
... other behavior: general inhibition of protein chain elongation (by cycloheximide) or inhibition of ribosomal RNA (rRNA) synthesis (by actinomycin D) each slowed both growth and the specific MAb production rate, leading to net "positive" growth associated MAb production rates. ...
... other behavior: general inhibition of protein chain elongation (by cycloheximide) or inhibition of ribosomal RNA (rRNA) synthesis (by actinomycin D) each slowed both growth and the specific MAb production rate, leading to net "positive" growth associated MAb production rates. ...
GLUCOCORTICOID AND MINERALOCORTICOID RECEPTORS
... Distinguishing GR- and MR-Mediated Responses In in vitro cotransfection systems, GR and MR appear to have equivalent transcriptional activity at a classical (canonical) HRE when activated by an appropriate ligand (14); moreover, MR are equivalently activated by cortisol and aldosterone in some studi ...
... Distinguishing GR- and MR-Mediated Responses In in vitro cotransfection systems, GR and MR appear to have equivalent transcriptional activity at a classical (canonical) HRE when activated by an appropriate ligand (14); moreover, MR are equivalently activated by cortisol and aldosterone in some studi ...
Intercellular adhesion, signalling and the cytoskeleton
... Insights into actin dynamics and intercellular adhesion have also come from the use of green fluorescent protein (GFP)-tagged E-cadherin and real time microscopy to study the mechanism of adhesion in Madin Darby Canine Kidney (MDCK) epithelial cells18. At the initial stages of calcium-induced interc ...
... Insights into actin dynamics and intercellular adhesion have also come from the use of green fluorescent protein (GFP)-tagged E-cadherin and real time microscopy to study the mechanism of adhesion in Madin Darby Canine Kidney (MDCK) epithelial cells18. At the initial stages of calcium-induced interc ...
Module 1: Review of General and Organic Chemistry
... e. Will either isozyme work near its maximal rate under normal blood glucose levels? If so, which one and why? ...
... e. Will either isozyme work near its maximal rate under normal blood glucose levels? If so, which one and why? ...
Human Complement Component C1s Antibody
... The classical complement pathway plays a major role in innate immunity against infection. This pathway is triggered by C1, a multimolecular complex composed of the recognition protein C1q and two serine proteases, C1r and C1s. Following the C1q recognition, C1r is autoactivated, and in turn activat ...
... The classical complement pathway plays a major role in innate immunity against infection. This pathway is triggered by C1, a multimolecular complex composed of the recognition protein C1q and two serine proteases, C1r and C1s. Following the C1q recognition, C1r is autoactivated, and in turn activat ...
The taste perception is an important function for living organisms to
... 1. Background of research ...
... 1. Background of research ...
O 2
... (a) results in the formation of the substrate complex (b). The ferric P450 then accepts the first electron from CPR (cytochrome P450 reductase), thereby being reduced to the ferrous intermediate (c). This intermediate then binds an oxygen molecule to form oxycomplex (d), which is further reduced to ...
... (a) results in the formation of the substrate complex (b). The ferric P450 then accepts the first electron from CPR (cytochrome P450 reductase), thereby being reduced to the ferrous intermediate (c). This intermediate then binds an oxygen molecule to form oxycomplex (d), which is further reduced to ...
Platelet-Derived Growth Factor Receptor Activation Promotes the
... PDGFR-ab was specifically phosphorylated in FLS from RA patients. Phosphorylation of PDGFR-ab was also elevated in RA synovial tissues. Interference with PDGFR activation or PDGF neutralization inhibited invadosome formation in RA synoviocytes, indicating the presence of an autocrine PDGFR activatio ...
... PDGFR-ab was specifically phosphorylated in FLS from RA patients. Phosphorylation of PDGFR-ab was also elevated in RA synovial tissues. Interference with PDGFR activation or PDGF neutralization inhibited invadosome formation in RA synoviocytes, indicating the presence of an autocrine PDGFR activatio ...
Lect 9: BioMacromolecular Visualization I: Principles - BIDD
... Protein sequence-structure-function relationship ...
... Protein sequence-structure-function relationship ...
Unfinished business from April 4!
... Figure 1 Metabolic transformation of sugars into fatty acids. a, Conversion of hexose phosphate to pentose phosphate through the non-oxidative steps of the pentose phosphate pathway and the subsequent formation of PGA by Rubisco bypasses the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogena ...
... Figure 1 Metabolic transformation of sugars into fatty acids. a, Conversion of hexose phosphate to pentose phosphate through the non-oxidative steps of the pentose phosphate pathway and the subsequent formation of PGA by Rubisco bypasses the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogena ...
Activin Receptor IIB human (A9579) - Datasheet - Sigma
... recognized as a unique compound. Activins and inhibins are members of the TGF-β superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-β ...
... recognized as a unique compound. Activins and inhibins are members of the TGF-β superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-β ...
Protein Structure
... Marfan’s Syndrom and Ehler’s-Danlos syndromes - inherited disorder of connective tissue which affects many organ systems, including the skeleton, lungs, eyes, heart and blood vessels. All resulting from various mutation in collagen and other fibril associated proteins, ultimately affecting the struc ...
... Marfan’s Syndrom and Ehler’s-Danlos syndromes - inherited disorder of connective tissue which affects many organ systems, including the skeleton, lungs, eyes, heart and blood vessels. All resulting from various mutation in collagen and other fibril associated proteins, ultimately affecting the struc ...
Protein synthesis
... The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
... The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
In silico Study of Target Proteins for Mycobacterium
... targets. Availability of the genome sequence of pathogens has provided a tremendous amount of information that can be useful in drug target and vaccine target identification. Thus essential genes provide selectivity and yield a drug which is highly selective against pathogen with respect to human ho ...
... targets. Availability of the genome sequence of pathogens has provided a tremendous amount of information that can be useful in drug target and vaccine target identification. Thus essential genes provide selectivity and yield a drug which is highly selective against pathogen with respect to human ho ...
Full-Text PDF
... is a synergistic interaction with ethylene in the induction of a large group of genes related to defense. The signaling pathways mediated by SA act mainly during biotrophic and hemibiotrophic pathogen attack and determine the establishment of so-called systemic acquired resistance [29]. The signalin ...
... is a synergistic interaction with ethylene in the induction of a large group of genes related to defense. The signaling pathways mediated by SA act mainly during biotrophic and hemibiotrophic pathogen attack and determine the establishment of so-called systemic acquired resistance [29]. The signalin ...
Alternative Pathways to Cellular Respiration!
... calvin cycle When pyruvate is left after the CO2 breaks off the malate, it takes ATP to rearrange the pyruvate into PEP. ...
... calvin cycle When pyruvate is left after the CO2 breaks off the malate, it takes ATP to rearrange the pyruvate into PEP. ...
Biochemistry/Proteins/Introduction
... Amino acids polymerize via peptide bonds, which is a type of amide bond. A peptide bond is formed upon the dehydration of the carboxy-terminus of one amino acid with the amine terminus of a second amino acid. The resulting carbonyl group's carbon atom is directly bound to the nitrogen atom of a seco ...
... Amino acids polymerize via peptide bonds, which is a type of amide bond. A peptide bond is formed upon the dehydration of the carboxy-terminus of one amino acid with the amine terminus of a second amino acid. The resulting carbonyl group's carbon atom is directly bound to the nitrogen atom of a seco ...
D (+)-Glucose, anhydrous
... Glucose is one of the major components of nutritional supplement solutions used in fed-batch biomanufacturing of recombinant proteins, monoclonal antibodies, viral vectors for gene therapy and viral vaccines from mammalian and insect cell cultures. Addition of such glucose containing supplements in ...
... Glucose is one of the major components of nutritional supplement solutions used in fed-batch biomanufacturing of recombinant proteins, monoclonal antibodies, viral vectors for gene therapy and viral vaccines from mammalian and insect cell cultures. Addition of such glucose containing supplements in ...
Folds
... protein “salting in” results from protein-counter ion binding and the consequently higher net protein charge and solvation; it occurs where the protein has little net charge near its pI primarily by weakly hydrated anions. protein solubility is minimal at the pI (net charge is zero), below or above ...
... protein “salting in” results from protein-counter ion binding and the consequently higher net protein charge and solvation; it occurs where the protein has little net charge near its pI primarily by weakly hydrated anions. protein solubility is minimal at the pI (net charge is zero), below or above ...
Research Focused Undergraduate Education
... and not found in plants. Naturally produced 1H-indol-3-acetic acid, is unstable to both heat and light. • Naturally produced in apical and root meristems seeds and developing fruit • Alters proton pump and ATP production in target cells • Induces cell elongation • Suppresses lateral bud growth and s ...
... and not found in plants. Naturally produced 1H-indol-3-acetic acid, is unstable to both heat and light. • Naturally produced in apical and root meristems seeds and developing fruit • Alters proton pump and ATP production in target cells • Induces cell elongation • Suppresses lateral bud growth and s ...
PowerPoint 演示文稿 - Shandong University
... • VG Ca2+ channels open. – Ca2+ enters bouton down concentration gradient. – Inward diffusion triggers rapid fusion of synaptic vesicles and release of NTs. ...
... • VG Ca2+ channels open. – Ca2+ enters bouton down concentration gradient. – Inward diffusion triggers rapid fusion of synaptic vesicles and release of NTs. ...
Serum Total Protein
... Introduction • The key roles which plasma proteins play in bodily function, together with the relative ease of assaying them, makes their determination a valuable diagnostic tool as well as a way to monitor clinical progress. • In very general terms, variations in plasma protein concentrations can ...
... Introduction • The key roles which plasma proteins play in bodily function, together with the relative ease of assaying them, makes their determination a valuable diagnostic tool as well as a way to monitor clinical progress. • In very general terms, variations in plasma protein concentrations can ...
Pentose Phosphate Pathway - Lectures For UG-5
... The nonoxidative reactions of the pentose phosphate pathway occur in all cell types synthesizing nucleotides and nucleic acids. These reactions catalyze the interconversion of three-, four-, five-, six-, and seven-carbon sugars (Figure 13.2). These reversible reactions permit ribulose 5-phosphate (p ...
... The nonoxidative reactions of the pentose phosphate pathway occur in all cell types synthesizing nucleotides and nucleic acids. These reactions catalyze the interconversion of three-, four-, five-, six-, and seven-carbon sugars (Figure 13.2). These reversible reactions permit ribulose 5-phosphate (p ...
AIS: Androgen Insensitivity Disorder
... Androgen receptor is highly conserved in mammals and higher organisms but does not have a direct homolog in more distantly related organisms – Should not be used a to determine speciation events, example, chimpanzee and cattle ...
... Androgen receptor is highly conserved in mammals and higher organisms but does not have a direct homolog in more distantly related organisms – Should not be used a to determine speciation events, example, chimpanzee and cattle ...
Environmental stresses activate a tomato SNF1
... mixture containing 1 m g of total RNA, 2.5 m M oligodT15–18, each 0.5 mM sNTPs, 40 unit of cloned RNase inhibitor and 200 unit of M-MLV reverse transcriptase (TaKaRa) in the standard buffer condition was incubated at 42°C for 60 min after annealing. Amplification was carried out in the program Temp ...
... mixture containing 1 m g of total RNA, 2.5 m M oligodT15–18, each 0.5 mM sNTPs, 40 unit of cloned RNase inhibitor and 200 unit of M-MLV reverse transcriptase (TaKaRa) in the standard buffer condition was incubated at 42°C for 60 min after annealing. Amplification was carried out in the program Temp ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.