Microscopic Level—The Sarcomere
... The fundamental functional unit of muscle is called a sarcomere. One muscle may contain as many as 100,000 of the repeating sarcomere units. In the sarcomere, the myofilaments (thick filaments and thin filaments) are organized into parallel units. Sarcomeres were first identified by imaging (histolo ...
... The fundamental functional unit of muscle is called a sarcomere. One muscle may contain as many as 100,000 of the repeating sarcomere units. In the sarcomere, the myofilaments (thick filaments and thin filaments) are organized into parallel units. Sarcomeres were first identified by imaging (histolo ...
Document
... Sho1p is a protein of 367 amino acids consisting of four predicted transmembrane domains within the Nterminal part, a linker domain, and an SH3 domain for protein-protein interaction. ...
... Sho1p is a protein of 367 amino acids consisting of four predicted transmembrane domains within the Nterminal part, a linker domain, and an SH3 domain for protein-protein interaction. ...
here
... unknown whether it has the same function as for the serine proteases. The serine can act as either a nucleophile or as a base. ...
... unknown whether it has the same function as for the serine proteases. The serine can act as either a nucleophile or as a base. ...
1 Lecture 20: Analysis of Enzyme Inhibition
... In most cases chromatography is performed in long glass tubes filled with a matrix or resin (particle size similar to a fine sand) that is completely immersed in a buffered salt solution. The mixture of proteins is added to the top of this column and buffer is allowed to flow through the column. As ...
... In most cases chromatography is performed in long glass tubes filled with a matrix or resin (particle size similar to a fine sand) that is completely immersed in a buffered salt solution. The mixture of proteins is added to the top of this column and buffer is allowed to flow through the column. As ...
BE.342/442 Tuesday, October 25, 2005 Topic: Biomineralization
... osteoblast layer. The odontoblasts manufacture predentin, which mineralizes into teritubules of dentin. The odontoblast process fills the tubules of predentin produced by odontoblasts, and has relatively little structure inside. The fibril then sprouts predentin, which branches like a tree and becom ...
... osteoblast layer. The odontoblasts manufacture predentin, which mineralizes into teritubules of dentin. The odontoblast process fills the tubules of predentin produced by odontoblasts, and has relatively little structure inside. The fibril then sprouts predentin, which branches like a tree and becom ...
Page 1 Jordan Knoepfel Professor Buns Foundations of Human
... Keeping the samples cold was to ensure there was no decay between extraction and examination. Upon thawing, the tissue was weighed and the protein was precipitated with percloroacetic acid. Once all this was completed the amino acid concentration could be measured. The results showed that for the gr ...
... Keeping the samples cold was to ensure there was no decay between extraction and examination. Upon thawing, the tissue was weighed and the protein was precipitated with percloroacetic acid. Once all this was completed the amino acid concentration could be measured. The results showed that for the gr ...
An acidic amino acid cluster regulates the nucleolar localization and
... entry of rpL22 must be controlled by both its N- and C-terminal regions. By analysis of the amino acid sequence motifs of known nuclear or nucleolar targeting signals [4,9], it was determined that the protein rpL22 carried two potential signals, one around the N-domain and the other at the internal ...
... entry of rpL22 must be controlled by both its N- and C-terminal regions. By analysis of the amino acid sequence motifs of known nuclear or nucleolar targeting signals [4,9], it was determined that the protein rpL22 carried two potential signals, one around the N-domain and the other at the internal ...
msb201347-sup-0001 - Molecular Systems Biology
... proteins in a macromolecular complex (defined by the CORUM database(Ruepp et al, 2010)) that displayed significantly different synthesis/degradation rates than the rest of the proteins in a macromolecular complex. Here, Euclidian distances were calculated among all synthesis/degradation rates of the ...
... proteins in a macromolecular complex (defined by the CORUM database(Ruepp et al, 2010)) that displayed significantly different synthesis/degradation rates than the rest of the proteins in a macromolecular complex. Here, Euclidian distances were calculated among all synthesis/degradation rates of the ...
AP Biology
... 5. Compare and contrast negative and positive feedback. Give an example of each. 6. How many species of organisms have been identified so far? How does this contrast with the number of estimated species on the planet? 7. What are the two important qualities of a scientific hypothesis? Use examples t ...
... 5. Compare and contrast negative and positive feedback. Give an example of each. 6. How many species of organisms have been identified so far? How does this contrast with the number of estimated species on the planet? 7. What are the two important qualities of a scientific hypothesis? Use examples t ...
No Slide Title
... Regulatory Regulatory enzymes In a metabolic pathway, which utilizes numerous enzymes, a regulatory enzyme sets the rate of the overall sequence because it catalyzes the slowest, rate-limiting reaction Characteristics of regulatory enzymes 1. Allosteric control 2. Use of binding proteins 3. Reversib ...
... Regulatory Regulatory enzymes In a metabolic pathway, which utilizes numerous enzymes, a regulatory enzyme sets the rate of the overall sequence because it catalyzes the slowest, rate-limiting reaction Characteristics of regulatory enzymes 1. Allosteric control 2. Use of binding proteins 3. Reversib ...
Functional inferences from reconstructed evolutionary biology
... Homologous proteins have analogous folds. Conversely, nonanalogous folds in two protein families indicate that the two families are not homologous. Thus, if two protein families are predicted to have the same fold, they are more likely to share common ancestry. If two protein families are predicted ...
... Homologous proteins have analogous folds. Conversely, nonanalogous folds in two protein families indicate that the two families are not homologous. Thus, if two protein families are predicted to have the same fold, they are more likely to share common ancestry. If two protein families are predicted ...
a pdf of this article as it appeared in Projects in Scientific
... As a further step, the researchers aligned the aminoacid sequences of eight different forms of importin to identify likely “hot spots” for FG-Nup binding. With this combination of MD simulations and sequence alignment, their computations confirmed three out of four FGNup binding sites on importin th ...
... As a further step, the researchers aligned the aminoacid sequences of eight different forms of importin to identify likely “hot spots” for FG-Nup binding. With this combination of MD simulations and sequence alignment, their computations confirmed three out of four FGNup binding sites on importin th ...
The cytoplasm of living cells: a functional mixture of thousands of
... faster. Section 3 will discuss how we can understand and even calculate some aspects of the phase behaviour of models of the cytoplasm, even in the absence of hard data on even one of the millions of interactions that occur in the cytoplasm. In the remainder of this introduction we will consider som ...
... faster. Section 3 will discuss how we can understand and even calculate some aspects of the phase behaviour of models of the cytoplasm, even in the absence of hard data on even one of the millions of interactions that occur in the cytoplasm. In the remainder of this introduction we will consider som ...
The Membrane: Overview
... This molecular structure is what allows phospholipids to form membranes ...
... This molecular structure is what allows phospholipids to form membranes ...
Document
... Organic Molecules = Living Molecules Defined by the Presence of Carbon that acts to Hold Together these large, complex molecules. ...
... Organic Molecules = Living Molecules Defined by the Presence of Carbon that acts to Hold Together these large, complex molecules. ...
FOOD-CHEMISTRY-CARBOHYDRATES-BY
... * The disaccharide units contain either of two modified sugars--- Nacetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc) and a uronic acid such as glucuronate or iduronate. GAGs are highly negatively charged molecules, with extended conformation that imparts high viscosity to the solution. ...
... * The disaccharide units contain either of two modified sugars--- Nacetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc) and a uronic acid such as glucuronate or iduronate. GAGs are highly negatively charged molecules, with extended conformation that imparts high viscosity to the solution. ...
Cellular Structures I
... b. Some will be signaling molecules that respond to growth factors or hormones c. Some of these signaling proteins will be associated with G-proteins d. Many surface receptors are kinases (kinases phosphorylate proteins) e. Some will be receptors for steroids and cytokines f. Overall: they are recei ...
... b. Some will be signaling molecules that respond to growth factors or hormones c. Some of these signaling proteins will be associated with G-proteins d. Many surface receptors are kinases (kinases phosphorylate proteins) e. Some will be receptors for steroids and cytokines f. Overall: they are recei ...
RAMACHANDRAN PLOT
... EXCEPTION : Cis configuration is seen in peptide bonds to approximately 10% of Proline residues as in that case the steric interference is reduced ...
... EXCEPTION : Cis configuration is seen in peptide bonds to approximately 10% of Proline residues as in that case the steric interference is reduced ...
[edit]More recent updates
... frequently used instead of protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations, driven by a number of non-covalent interactions such as hydrogen bonding, ionic interactions, Van Der Waals forces, and hydrophobicpacking. To understan ...
... frequently used instead of protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations, driven by a number of non-covalent interactions such as hydrogen bonding, ionic interactions, Van Der Waals forces, and hydrophobicpacking. To understan ...
Scholars Research Library Study the modern biochemical analysis
... examples are the alpha helix and beta sheet. Tertiary structure: the overall shape of a single protein molecule; the spatial relationship of the secondary structure to one another. Tertiary structure is generally stabilized by non local interactions, most commonly the formation of a hydrophobic core ...
... examples are the alpha helix and beta sheet. Tertiary structure: the overall shape of a single protein molecule; the spatial relationship of the secondary structure to one another. Tertiary structure is generally stabilized by non local interactions, most commonly the formation of a hydrophobic core ...
Electrophoresis Chapter 10 +
... Most commonly by “Coomassie Brilliant Blue” (0.1% w/v) mixed with Methanol (Ethanol), H2O, Acetic acid. More sensitive is Silver staining, silver-ions are reduced to silver on the protein (Limit of detection is approx 1 ng protein bands) Glycoproteines can be stained with periodic acid-Schiff (PAS) ...
... Most commonly by “Coomassie Brilliant Blue” (0.1% w/v) mixed with Methanol (Ethanol), H2O, Acetic acid. More sensitive is Silver staining, silver-ions are reduced to silver on the protein (Limit of detection is approx 1 ng protein bands) Glycoproteines can be stained with periodic acid-Schiff (PAS) ...
Commentaries on Cutting Edge Science
... al showed that Thbs1, which is in a different subfamily and structurally somewhat different than Thbs4, also facilitated ATF6 activation, it is apparent that other members of the Thbs family activate ATF6. In terms of determining the relative importance of intracellular and extracellular Thbs, Lynch ...
... al showed that Thbs1, which is in a different subfamily and structurally somewhat different than Thbs4, also facilitated ATF6 activation, it is apparent that other members of the Thbs family activate ATF6. In terms of determining the relative importance of intracellular and extracellular Thbs, Lynch ...
Structure and dynamics of the crenarchaeal nucleoid
... proteins. Sso7c is another protein that has been suggested to be involved in chromatin organization [12,19]. It forms a dimer in solution and binds non-specifically to the major groove of DNA. Whether this protein indeed functions in chromatin organization and compaction is currently unclear. At the ...
... proteins. Sso7c is another protein that has been suggested to be involved in chromatin organization [12,19]. It forms a dimer in solution and binds non-specifically to the major groove of DNA. Whether this protein indeed functions in chromatin organization and compaction is currently unclear. At the ...
Cyclol
The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.