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Arabidopsis Phosphoglycerate Dehydrogenase1 of
Arabidopsis Phosphoglycerate Dehydrogenase1 of

... indicating that the loss of function of PSP or PGDH1 led to embryo lethality (Figure 5D; see Supplemental Figure 5C online). Because we could not obtain homozygous loss-of-function mutants for PGDH1, we generated PGDH1-silenced plants using a microRNA-based approach (Felippes et al., 2012). Transgen ...
THE CITRIC ACID CYCLE
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Regents Biology
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Pyruvate dehydrogenase complex

... The Carbon Atoms of Acetyl-CoA Have Different Fates in the TCA Cycle • Neither of the carbon atoms of a labeled acetate unit is lost as CO2 in the first turn of the cycle • Carbonyl C of acetyl-CoA turns to CO2 only in the second turn of the cycle (following entry of acetyl-CoA ) • Methyl C of acet ...
(Vibrcgen-Zellmiihle, Fa. E. Buhl er,  Tiibingen,  Germany). The  results
(Vibrcgen-Zellmiihle, Fa. E. Buhl er, Tiibingen, Germany). The results

... myceliol dry weight ot 48 hrs). RL-A and RL-a are Rockefeller-Lindegren isolates obtained from J. F. Wilson. It is opporent that a mating type rhws better glycerol growth than doer A for all three strains, except for 41 I-L5-A. When grown on sucrose unde~othewirt identical conditions, little differe ...
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Citric Acid Cycle

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... This is followed by L‐ornithine mono hydrochloride. Chandra  et al  2  ,reported  that  asparagine  and  aspartic  acid  have  been  employed  in  increasing the mycelial growth and fruit body production in Agaricus  bisporus.  Hayes  et  al  15    reported  that  higher  and  lower  concentrations  ...
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Examples from metabolism of xenobiotics

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ANP 204 Main Text - National Open University of Nigeria
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... The glycoside hydrolase family 8 (GH-8) consists of bifunctional cellulase-chitosanases many of which are produced by species of Bacillus. Chitosanolytic enzymes can be useful in producing low molecular weight chitooligosaccharides which have several applications. In addition, a bifunctional enzyme ...
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... inhibited the generation of TNF-␣ in concentrations between 1 and 10 ␮M in lipopolysaccharide-stimulated human monocytes. AKBA was found to be the most active compound. The effect was mediated by a direct inhibitory action on IK B␣ kinases (IKK) conveyed inhibition of NFk B and subsequent down regul ...
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... pathway produces the carbonyl group of acetate?  How do homoacetogens make ATP from the synthesis of acetate?  If catabolism of fructose via glycolysis yields only two molecules of acetate, how can Clostridium aceticum ferment fructose by this pathway and produce three molecules of acetate? ...
GMS BI 555/755 Lecture 3: Techniques for
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... acids in a peptide hydrolysate can be separated by ionexchange chromatography on a sulfonated polystyrene resin (such as Dowex-50). Buffers (in this case, sodium citrate) of increasing pH are used to elute the amino acids from the column. The amount of each amino acid present is determined from the ...
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On the optimality of the genetic code, with the

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... What are the key regulated enzymes in citrate cycle? Isocitrate dehydrogenase - catalyzes the oxidative decarboxylation of isocitrate by transferring two electrons to NAD+ to form NADH, and in the process, releasing CO2, it is activated by ADP and Ca2+ and inhibited by NADH and ATP. α-ketoglutarate ...
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Connection of Propionyl-CoA Metabolism to Polyketide

... the vector pBluescript SK (Stratagene) sequentially to construct the disruption vector pYQ8.4. Plasmid pYQ8.4 was transformed into RRAW7 to delete pcsA by homologous recombination. The fungal transformation technique followed that of Miller et al. (1985) with the modification of embedding the protop ...
SYNTHESIS OF NOVEL ANTIMICROBIAL DERIVATIVES OF 3-SUBSTITUTED PYRROLIDINE2,
SYNTHESIS OF NOVEL ANTIMICROBIAL DERIVATIVES OF 3-SUBSTITUTED PYRROLIDINE2,

... major bacterial protein that is involved in replication & transcription and catalyzes the negative supercoiling of bacterial circular DNA. The DNA gyrase is a known target for antibacterial agents since its blocking induces bacterial death. Hence, the studies are further extended to check probable i ...
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RESPIRATION: SYNTHESIS OF ATP
RESPIRATION: SYNTHESIS OF ATP

... Synthesis of ATP Anaerobic conditions (fermentation) ! Glycolysis depends on a supply of substrates: glucose, ATP, ADP, Pi, NAD+ ! NAD+, FAD present in only small amounts in cell, and NAD+ and FAD are used up in glycolysis and the citric acid cycle. ! Therefore, NAD+ must be regenerated from NADH t ...
Journal of Bacteriology
Journal of Bacteriology

... 42 C; at 30 C it is slightly decreased for strain H-1119 and impaired for strain TKL-46 (Fig. 2). The level and distribution of the alaninecontaining murein precursors in both mutants differ from strain KMBL-146 at both temperatures (Table 1). The low activities of the impaired enzymes limit the rat ...
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Amino acid synthesis

Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesise all amino acids. Humans are excellent example of this, since humans can only synthesise 11 of the 20 standard amino acids (aka non-essential amino acid), and in time of accelerated growth, arginine, can be considered an essential amino acid.A fundamental problem for biological systems is to obtain nitrogen in an easily usable form. This problem is solved by certain microorganisms capable of reducing the inert N≡N molecule (nitrogen gas) to two molecules of ammonia in one of the most remarkable reactions in biochemistry. Ammonia is the source of nitrogen for all the amino acids. The carbon backbones come from the glycolytic pathway, the pentose phosphate pathway, or the citric acid cycle.In amino acid production, one encounters an important problem in biosynthesis, namely stereochemical control. Because all amino acids except glycine are chiral, biosynthetic pathways must generate the correct isomer with high fidelity. In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. Almost all the transaminases that catalyze these reactions descend from a common ancestor, illustrating once again that effective solutions to biochemical problems are retained throughout evolution.Biosynthetic pathways are often highly regulated such that building-blocks are synthesized only when supplies are low. Very often, a high concentration of the final product of a pathway inhibits the activity of enzymes that function early in the pathway. Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes are similar in functional properties to aspartate transcarbamoylase and its regulators. Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes.
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