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The Science of Onion Flavor Onions are one of the most widely used
The Science of Onion Flavor Onions are one of the most widely used

... Of course, things are not quite as simple as they seem. There are a number of structurally similar (called isomers) thiosulfinates and thiosulfonates produced from isoalliin. In the developing onion bulb isoalliin is formed from a single amino acid called cysteine. Amino acids are the building block ...
an enzyme-coupled biosensor enables (S)
an enzyme-coupled biosensor enables (S)

... lant-specialized metabolites are a rich source of chemical diversity that has given rise to a host of prominent pharmaceuticals1. Despite their widespread use2, many of these compounds are still manufactured from plant extracts because they are too structurally complex to be cost-effectively produce ...
47_Biochemistry of Connective Tissue
47_Biochemistry of Connective Tissue

...  In the spread of cancer cells.  Several diseases (eg: Osteogenesis imperfecta and a number of types of the Ehlers-Danlos syndrome) are due to genetic disturbances of the synthesis of collagen.  Components of proteoglycans are affected in the group of genetic disorders known as the mucopolysaccha ...
Cloning and Functional Characterization of a Phospholipid
Cloning and Functional Characterization of a Phospholipid

... site of the enzymes. These lids have highly variable sequences in lipases and are able to form an amphipatic helix interacting with the lipid interface. It has been suggested that they destabilize the bilayer and facilitate both the binding of the hydrophobic substrate and its diffusion into the act ...
Creation/Evolution
Creation/Evolution

... – The RNA world theory might explain these three components Aminoacyl-tRNA Synthetase, – A protein, thus a product of translation and cannot be explained away by the RNA world theory L Amino Acids ATP - For energy This appears to be an irreducibly complex system ©2000 Timothy G. Standish ...
The Industrial Age of Biocatalytic Transamination
The Industrial Age of Biocatalytic Transamination

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Peroxisome Proliferator-Activated Receptor Activation is
Peroxisome Proliferator-Activated Receptor Activation is

... BHMT, DMGDH and SARDH [25]. However, whether TTA treatment affects the related metabolites has yet to be explored. Also, activation of PPARα has been shown to increase the synthesis of vitamin B3 from tryptophan by regulating key enzymes in this pathway [26], but whether PPAR activation influences t ...
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Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry

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Evolutionary Forces in Shaping the Codon and Amino Acid Usages
Evolutionary Forces in Shaping the Codon and Amino Acid Usages

... codon bias of its genes and it has been argued that growth temperature exerts strong selection on codon usage (25). Symbiotic relationship has great effect on our ecological system as well as on evolution of life on the earth (26). Parasitic relationship is well studied, but the reasons that insist ...
Biosynthesis of Lipids and Hydrocarbons in Algae
Biosynthesis of Lipids and Hydrocarbons in Algae

... the process of binding of CoA (Joyard et al., 2010). Oppositely, fatty acid is necessary to be activated by the binding of ACP for passing through the cell membrane in the cyanobacteria Synechocystis species. In any step, a synthesized carbon chain can be metabolized into various products including ...
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Triacylglycerol Metabolism Gone Bad: A major cause of disease

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Nerve activates contraction
Nerve activates contraction

... sequence of nonoverlapping base triplets, or codons, each of which is translated into a specific amino acid during protein synthesis. ...
11.17.11.ATP.synthase
11.17.11.ATP.synthase

... membrane. When subunit a is in association with this subunit c, this asp is connected through a half channel to either the matrix space or the intermembrane space. When the channel connects to the matrix space, the asp deprotonates because of the H+ gradient. This deprotonation is followed by a conf ...
Biochemistry 304 2014 Student Edition Gluconeogenesis Lectures
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... Lactate produced by active skeletal muscle and erythrocytes is an energy source for other organs. •Skeletal muscle during vigorous exercise produces pyruvate at a rate faster than oxidative metabolism via the citric acid cycle can use it. •Also NADH production is more rapid than its conversion to NA ...
Ribosomes of Mouse Liver following
Ribosomes of Mouse Liver following

... sucrose layers. It has been shown (31) and confirmed in this work (Table 4) that following the 1st centrifugation for sedimentation of free ribosomes some free monomers remain in the overlying 2.0 M sucrose cushion. Therefore, this cushion was removed, diluted, and layered over a new cushion of 2.0 ...
When muscular work starts, the adrenal medulla secretes a
When muscular work starts, the adrenal medulla secretes a

... When a cell receives oxygen at a rate slower than needed, glycolysis can still operate, but the end product is lactate instead of pyruvate. The following reaction is the anaerobic sequence of glucose catabolism: (See figures attached!) So two ATP can still be made by substrate level phosphorylation ...
Conserved Tryptophan Residues within Putative Transmembrane
Conserved Tryptophan Residues within Putative Transmembrane

... different transmembrane helices prediction servers was used to locate the position of TM6 (Table 1). According to the predictions, 24 amino acids from position 257 to 280 of OATP1B1 were selected for alanine-scanning analysis (Fig. 2). These ...
Glucose
Glucose

... one substrate level prosphorylation; • Generation: one FADH2,three NADH+H+,two CO2, one GTP; • Key enzyme:citrate synthase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase complex. ...
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Amino acid synthesis

Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesise all amino acids. Humans are excellent example of this, since humans can only synthesise 11 of the 20 standard amino acids (aka non-essential amino acid), and in time of accelerated growth, arginine, can be considered an essential amino acid.A fundamental problem for biological systems is to obtain nitrogen in an easily usable form. This problem is solved by certain microorganisms capable of reducing the inert N≡N molecule (nitrogen gas) to two molecules of ammonia in one of the most remarkable reactions in biochemistry. Ammonia is the source of nitrogen for all the amino acids. The carbon backbones come from the glycolytic pathway, the pentose phosphate pathway, or the citric acid cycle.In amino acid production, one encounters an important problem in biosynthesis, namely stereochemical control. Because all amino acids except glycine are chiral, biosynthetic pathways must generate the correct isomer with high fidelity. In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. Almost all the transaminases that catalyze these reactions descend from a common ancestor, illustrating once again that effective solutions to biochemical problems are retained throughout evolution.Biosynthetic pathways are often highly regulated such that building-blocks are synthesized only when supplies are low. Very often, a high concentration of the final product of a pathway inhibits the activity of enzymes that function early in the pathway. Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes are similar in functional properties to aspartate transcarbamoylase and its regulators. Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes.
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