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Chapter 11: Organization of DNA in Eukaryotes 11.2: mtDNA
Chapter 11: Organization of DNA in Eukaryotes 11.2: mtDNA

... Describe the Endosymbiotic hypothesis. Essentially, modern cells are a product of ancient eukaryotes engulfing free-living mitochondria and/or chloroplasts, allowing these (believed to be) prokaryotes to reside inside of the cytoplasm in a symbiotic relationship. After some time, these mitochondria ...
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... and medicine. The way we think about and practice biology and medicine and the social consequences of work in these fields are changing in an unprecedented manner. These changes have been catalyzed, in large part, by the realization that biology is an informational science” Leroy Hood, M.D., Ph.D. ...
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... 4. The cold viruses used in gene therapy for cystic fibrosis are genetically engineered so they cannot reproduce, and thus cannot cause a viral infection in the patient. Because of this, the therapy does not lead to a permanent cure for cystic fibrosis. Explain why this is the case. ...
Case Study 3: Hutchinson-Gilford’s Progeria Syndrome
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... Approx 1 in 200 people carriers for defective gene Approx 3 in 1,000,000 people have the disease (Slightly higher percentage in Japan) Onset of symptoms early to mid 20’s, Major cause of death—heart attack in mid 40s ...
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... Homozygous:  An  organism  with  two  identical  alleles  at  a  particular  locus.   Heterozygous:  An  organism  with  two  different  alleles  at  a  particular  locus  (at  a   particular  gene).   True-­‐breeding:  A  population  homozyg ...
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...  amino acid sequence in a polypeptide which folds into a ____________ translation  structure and function of the protein (e.g. normal hemoglobin vs. sickle cell hemoglobin)  person's characteristics or traits (e.g. normal health vs. sickle cell anemia) 2. The double helix structure of DNA, transc ...
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... epigenetic modification in cancer, and each tumor type has its own specific pattern. Histone modifications also occur, as does remodeling of chromatin. And disruption of noncoding RNA sequences, the so-called “dark genome,” that code for microRNAs also seems to play a role in how cancer originates a ...
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... where a cell is in the body, so not all proteins are made in every cell. If genes are incorrectly turned on or off, which can happen in genetic diseases, debilitating symptoms can sometimes occur. DNA code is represented as four letters, with each letter indicating a chemical compound, or ‘base’. DN ...
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UNIT 7 TEST DNA TEST BLUEPRINT

... 1. When the __ for insulin is inserted into bacteria, they can be used to mass-produce insulin. a) chromosome b) gene c) fragment d) base 2. Who discovered the structure of DNA and made a model of it? a) Mendel b) Hershey and Chase c) Watson and Crick d) Wilkins and Franklin 3. Which of the followin ...
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... altered. This allows cells to survive for more generations because normally, cells will age and incur chromosomal damage before apoptosis. In cancer, when this occurs, the cells block apoptosis and continue to divide, making the cells capable of infinite cell divisions and tumorigenesis.  Note: the ...
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... If you change only one letter, the entire code will be changed, and therefore the organism will be different!! ...
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... Imprinted genes occur in clusters and may depend on a local control site where de novo methylation occurs unless specifically prevented. ...
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... • Intron removal, mRNA processing, and transcription take place at the same site in the nucleus. • Self-splicing introns happen in some rRNA genes in protists and in mitochondria genes in fungi. • There are alternative processing pathways for processing pre-mRNA. ...
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... •if sequence divergence between humans and horses is scaled for time using fossils •and estimated evolutionary rate, r, is applied to all known protein coding loci •one amino acid substitution has been fixed every second year on average Interpretation: This is too much for selection to have been inf ...
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...  Action: Adds new nucleotides to the exposed bases using the base-pair rule; also proofreads every connection at this time (avg. 1 error per 2 billion nucleotides)  Result: 2 new double DNA strands are created (but still attached) ...
ppt - Language Log
ppt - Language Log

... transport of oxygen from the lungs to body cells. • Like almost all proteins, its structure is part of the code carried by the chromosomes in the nucleus. • How does hemoglobin carry Oxygen? ...
Sticky end in protein synthesis - The School of Molecular and
Sticky end in protein synthesis - The School of Molecular and

... efficiency of protein synthesis in non-neuronal cells, but has a detrimental effect on Purkinje cells. This may be because, as these cells do not divide, there is no ‘dilution’ of the misfolded proteins by cell division. One question not yet addressed is whether the sticky-mouse characteristics aris ...
Gene Hunting
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... • Monogenic -- mutation in one gene leads to disease follows Mendelian inheritance • Polygenic -- mutations in several genes lead to disease follows complex inheritance patterns ...
Quiz 2 Q3 Review Sheet 3/8/11
Quiz 2 Q3 Review Sheet 3/8/11

... (outside the cell) signal that is unable to cross the membrane like a hydrophilic polypeptide or protein is able to turn on or off genes inside the cell. Give an example of such a signal. 36. Compare a proto-oncogene to an oncogene. 37. Compare proto-oncogenes to tumor suppressor genes. Give example ...
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ANSWERS TO REVIEW QUESTIONS

... a. Kary Mullis invented PCR to harness the power of and direct DNA replication to massproduce selected genes. b. RNAi technology uses short synthetic RNA molecules to squelch gene expression. c. Gene targeting through homologous recombination swaps in pieces of DNA into their location in the genome. ...
Unit 1 – Introduction to Biology STUDY GUIDE
Unit 1 – Introduction to Biology STUDY GUIDE

... 12. Based on the Macromolecule Diet Lab, which two macromolecules are most important for energy in our cells? Which of these contains the greatest amount of energy? Explain how you know this. Carbohydrates and Lipids are the most important macromolecules for energy in our cells. Lipids contain more ...
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Point mutation



A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.
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