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... not only at the level oI chromatin, but also by modiIying transcription Iactors. Additional nitrogen methylations are Iound on the imidazole ring oI histidine, the guanidino moiety oI arginine and the Rgroup amides oI glutamate and aspartate. Methylation oI the oxygen oI the Rgroup carboxylates oI g ...
... not only at the level oI chromatin, but also by modiIying transcription Iactors. Additional nitrogen methylations are Iound on the imidazole ring oI histidine, the guanidino moiety oI arginine and the Rgroup amides oI glutamate and aspartate. Methylation oI the oxygen oI the Rgroup carboxylates oI g ...
::: Gene Set Enrichment Analysis - GSEA
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. The one-sample KS test compares the empirica ...
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. The one-sample KS test compares the empirica ...
a complex voyage to the X chromosome
... system for investigating MSL localization. Recently, high-resolution technologies have enabled the identification of MSL targets at the molecular level. Together, these approaches are beginning to uncover a complex X chromosome targeting mechanism that involves the recognition of DNA elements and tr ...
... system for investigating MSL localization. Recently, high-resolution technologies have enabled the identification of MSL targets at the molecular level. Together, these approaches are beginning to uncover a complex X chromosome targeting mechanism that involves the recognition of DNA elements and tr ...
Affinity Precipitation of a Monoclonal Antibody ELP-Z Stimuli Responsive Biopolymer
... by centrifugation for 30 min at 4,000g to recover the ELP-ZmAb precipitates. The supernatants after centrifugation were collected and analyzed using analytical Protein A chromatography and reversed phase liquid chromatography (RPLC) (discussed below) for the presence of leftover mAb and ELP-Z, respe ...
... by centrifugation for 30 min at 4,000g to recover the ELP-ZmAb precipitates. The supernatants after centrifugation were collected and analyzed using analytical Protein A chromatography and reversed phase liquid chromatography (RPLC) (discussed below) for the presence of leftover mAb and ELP-Z, respe ...
Introns Structure Patterns of Variation in Nucleotide Composition in
... plant genes have prevented a clear understanding of the evolutionary forces acting on it. Moreover, until now, these patterns were usually described without taking into account gene intron number or precise gene architecture. To investigate the potential role of introns in GC-content variation in pl ...
... plant genes have prevented a clear understanding of the evolutionary forces acting on it. Moreover, until now, these patterns were usually described without taking into account gene intron number or precise gene architecture. To investigate the potential role of introns in GC-content variation in pl ...
Branched-chain 2-oxoacids transamination increases
... in a reaction probably catalyzed by a specific branched-chain 2-oxoacid aminotransferase (BCAT) activity [5-8]. Moreover, they can be oxidised to CO2 an acetoacetate [5,9,10] and it has been shown that oxo-4-methylpentanoate (also known as α-ketoisocaproate, KIC) is oxidized at a similar rate to hig ...
... in a reaction probably catalyzed by a specific branched-chain 2-oxoacid aminotransferase (BCAT) activity [5-8]. Moreover, they can be oxidised to CO2 an acetoacetate [5,9,10] and it has been shown that oxo-4-methylpentanoate (also known as α-ketoisocaproate, KIC) is oxidized at a similar rate to hig ...
Emended description of the order Chlamydiales, proposal of
... The current taxonomic classification of Chlamydia is based on limited phenotypic, morphologic and genetic criteria. This classification does not take into account recent analysis of the ribosomal operon or recently identified obligately intracellular organisms that have a chlamydia-like developmenta ...
... The current taxonomic classification of Chlamydia is based on limited phenotypic, morphologic and genetic criteria. This classification does not take into account recent analysis of the ribosomal operon or recently identified obligately intracellular organisms that have a chlamydia-like developmenta ...
The presence of an RHD pseudogene containing a
... No RHD transcript could be detected in D-negative individuals with RHD, probably as a result of nonsense-mediated mRNA decay. Existing PCR-based methods for predicting D phenotype from DNA are not suitable for testing Africans or any population containing a substantial proportion of people with Afr ...
... No RHD transcript could be detected in D-negative individuals with RHD, probably as a result of nonsense-mediated mRNA decay. Existing PCR-based methods for predicting D phenotype from DNA are not suitable for testing Africans or any population containing a substantial proportion of people with Afr ...
Cyclic-‐di-‐AMP: another second messenger enters the fray
... are found in bacterial species but a small number are also present in archaea within the Euryarchaeota group (Box 2)12. In bacteria, DAC domain proteins are most frequently found in the G ...
... are found in bacterial species but a small number are also present in archaea within the Euryarchaeota group (Box 2)12. In bacteria, DAC domain proteins are most frequently found in the G ...
Cellular Biology
... Chromosome aberrations major changes in the entire DNA strand and entire piece missing or an extra chromosome or even an extra complete set examples include Cri – du – chat mising piece of #5 or trisomy 21 Downs syndrome extra 21 chromosome Base pair substitution ...
... Chromosome aberrations major changes in the entire DNA strand and entire piece missing or an extra chromosome or even an extra complete set examples include Cri – du – chat mising piece of #5 or trisomy 21 Downs syndrome extra 21 chromosome Base pair substitution ...
Systems biology of inborn errors of metabolism
... Printing: Háskólaprent, Fálkagata 2, 107 Reykjavik Reykjavik, Iceland, September 2013 ...
... Printing: Háskólaprent, Fálkagata 2, 107 Reykjavik Reykjavik, Iceland, September 2013 ...
Ammonia, urea production and pH regulation
... Long-term regulation of urea-cycle enzymes [20] primarily occurs at the level of transcription [48,49], and several proteins associated with the urea cycle such as ORNT1 [26] or glutaminase [50] are regulated in parallel. mRNA levels for CPS I and ASS also increase immediately following partial hepa ...
... Long-term regulation of urea-cycle enzymes [20] primarily occurs at the level of transcription [48,49], and several proteins associated with the urea cycle such as ORNT1 [26] or glutaminase [50] are regulated in parallel. mRNA levels for CPS I and ASS also increase immediately following partial hepa ...
Vanillin formation from ferulic acid in Vanilla planifolia is catalysed
... demonstrated that the VpVAN sequence contained the three key active site residues required for proteinase activity25. Likewise the VpVAN amino-acid sequence contains the typical processing motif known from cysteine proteinases, indicating that the VpVAN protein when produced in the vanilla pod may b ...
... demonstrated that the VpVAN sequence contained the three key active site residues required for proteinase activity25. Likewise the VpVAN amino-acid sequence contains the typical processing motif known from cysteine proteinases, indicating that the VpVAN protein when produced in the vanilla pod may b ...
Inference of natural selection on quantitative traits
... Genes are the central elements of the genome. Genes serve as the blueprint for proteins, which are biomolecules that perform a vast number of functions in an organism. The coding region of a gene is marked by a characteristic starting sequence, also called promoter, and is read off by a protein call ...
... Genes are the central elements of the genome. Genes serve as the blueprint for proteins, which are biomolecules that perform a vast number of functions in an organism. The coding region of a gene is marked by a characteristic starting sequence, also called promoter, and is read off by a protein call ...
Purification of Arrestin from Bovine Retinas
... freshly bleached phosphorylated rhodopsin occurs rapidly (<200 msec) and quenches the activation of G protein (transducin) (1-4). We have shown that arrestin also acts in the phototransduction process by blocking rapid dephosphorylation of phosphorylated and photolyzed rhodopsin until activated rhod ...
... freshly bleached phosphorylated rhodopsin occurs rapidly (<200 msec) and quenches the activation of G protein (transducin) (1-4). We have shown that arrestin also acts in the phototransduction process by blocking rapid dephosphorylation of phosphorylated and photolyzed rhodopsin until activated rhod ...
213 porters and neurotransmitter transporters
... carriers transport the neurotransmitters across the plasma membrane of neuronal cells and, in some cases, surrounding glial cells. The necessary energy for the neurotransmission cycle is provided by two distinct ATPases. Synaptic vesicles and granules contain a vacuolar H+-ATPase (V-ATPase) that pro ...
... carriers transport the neurotransmitters across the plasma membrane of neuronal cells and, in some cases, surrounding glial cells. The necessary energy for the neurotransmission cycle is provided by two distinct ATPases. Synaptic vesicles and granules contain a vacuolar H+-ATPase (V-ATPase) that pro ...
TaqMan-Based Real-Time PCR for Genotyping Common
... reported, one of which, HP Johnson, occurs at low frequency in various populations (3 ). The molecular weight of the ␣ chain is larger (23 kDa) than that encoded by HP2, and Southern blotting has shown 3 tandem repeats of the same 1.7-kb DNA segment found in the HP2 gene duplication (4 ). Another va ...
... reported, one of which, HP Johnson, occurs at low frequency in various populations (3 ). The molecular weight of the ␣ chain is larger (23 kDa) than that encoded by HP2, and Southern blotting has shown 3 tandem repeats of the same 1.7-kb DNA segment found in the HP2 gene duplication (4 ). Another va ...
Mutational Analysis of the Drosophila Sister-Chromatid
... of all chromosomesin both male and female DrosophThe urd gene is required for proper segregation ila meiosis. Herewe describe the isolation of a null urd allele and examine the consequences of ablating urd function. Cytologically, meiotic sister-chromatid cohesion is severely disrupted in flies lack ...
... of all chromosomesin both male and female DrosophThe urd gene is required for proper segregation ila meiosis. Herewe describe the isolation of a null urd allele and examine the consequences of ablating urd function. Cytologically, meiotic sister-chromatid cohesion is severely disrupted in flies lack ...
GSEA - Bioinformatics Unit
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. ...
... The Kolmogorov–Smirnov test is used to determine whether two underlying one-dimensional probability distributions differ, or whether an underlying probability distribution differs from a hypothesized distribution, in either case based on finite samples. ...
Presence of multiple group I introns closely 23S rRNAs of lichen-forming
... LAGLIDADG family of HE comprises more than 200 proteins and is the most diverse of the HE families since its members are present in the genomes of plant and algal chloroplasts, fungal and protozoan mitochondria, bacteria, and archaea [37]. One reason for the wide distribution of these proteins appea ...
... LAGLIDADG family of HE comprises more than 200 proteins and is the most diverse of the HE families since its members are present in the genomes of plant and algal chloroplasts, fungal and protozoan mitochondria, bacteria, and archaea [37]. One reason for the wide distribution of these proteins appea ...
Glutamate Dehydrogenases: Enzymology, Physiological
... therefore, totally dependent on other organisms to convert oxidized forms of nitrogen into forms available for the organism, as well as to provide some essential amino acids (Figure 2). These are supplied in the diet or are provided by bacteria from the intestinal tract. In plants and microorganisms ...
... therefore, totally dependent on other organisms to convert oxidized forms of nitrogen into forms available for the organism, as well as to provide some essential amino acids (Figure 2). These are supplied in the diet or are provided by bacteria from the intestinal tract. In plants and microorganisms ...
The genetics of Caenorhabditis elegans.
... stored in liquid nitrogen, provided that glycerol was present and that the initial freezing took place slowly. The standard method used is as follows: worms are washed off the surface of a petri dish culture using about 1.5 m l of S o r M 9 buffer. To 1 ml of this suspension is added 1 ml of a 30% s ...
... stored in liquid nitrogen, provided that glycerol was present and that the initial freezing took place slowly. The standard method used is as follows: worms are washed off the surface of a petri dish culture using about 1.5 m l of S o r M 9 buffer. To 1 ml of this suspension is added 1 ml of a 30% s ...
The KetelD Dominant-Negative Mutations Identify
... times but instead of separation they organize rudimentary asters of MTs along with a general decay of the egg cytoplasm. (Behavior of the polar body nuclei was not different in wild-type and in Ketel D eggs and served as a reference for timing the initial events of embryogenesis.) The Ketel D mutant ...
... times but instead of separation they organize rudimentary asters of MTs along with a general decay of the egg cytoplasm. (Behavior of the polar body nuclei was not different in wild-type and in Ketel D eggs and served as a reference for timing the initial events of embryogenesis.) The Ketel D mutant ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... ATF2 is activated by stress kinases, including JNK (MAPK8, MAPK9, MAPK10) and p38 (MAPK1, MAPK11, MAPK12, MAPK13, MAPK14) and is implicated in transcriptional regulation of immediate early genes regulating stress and DNA damage responses (Gupta et al., 1995; van Dam et al., 1995) and cell cycle cont ...
... ATF2 is activated by stress kinases, including JNK (MAPK8, MAPK9, MAPK10) and p38 (MAPK1, MAPK11, MAPK12, MAPK13, MAPK14) and is implicated in transcriptional regulation of immediate early genes regulating stress and DNA damage responses (Gupta et al., 1995; van Dam et al., 1995) and cell cycle cont ...
Charles K. Wairuri , Jacquie E. van der Waals
... pili (Fig. 1B). As indicated earlier, these include a relatively short mature pilin (44 aa) and a ...
... pili (Fig. 1B). As indicated earlier, these include a relatively short mature pilin (44 aa) and a ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.