Cannabidiol as a Potential Treatment for Anxiety Disorders
... Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effect ...
... Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effect ...
The human nervous system An anatomical viewpoint
... e.g. Sensory areas, all neurons in one unit are activated by the same peripheral stimulus. = a piece of cortex supplied by a single axon from thalamus. (B) Neocortical Areas Are Specialized For Different Functions From clinicopathological studies and animal experiments: Consistent association of som ...
... e.g. Sensory areas, all neurons in one unit are activated by the same peripheral stimulus. = a piece of cortex supplied by a single axon from thalamus. (B) Neocortical Areas Are Specialized For Different Functions From clinicopathological studies and animal experiments: Consistent association of som ...
The Molecular Biology of Memory Storage: A Dialog
... in common with the nervous system and behavior of simpler animals. If so, these fundamental, common principles of neuronal organization might well be studied more profitably in simple animals. The answer to this second question, about commonality, was clear. By 1960, work by students of comparative ...
... in common with the nervous system and behavior of simpler animals. If so, these fundamental, common principles of neuronal organization might well be studied more profitably in simple animals. The answer to this second question, about commonality, was clear. By 1960, work by students of comparative ...
Combination Analysis in Genetic Polymorphisms of Drug
... CYP1A2 activity measured by the rate of caffeine 3-demethylation in Japanese smokers [35]. CYP2C9*2 and CYP2C9*3, the two most common variant alleles, exhibit largely reduced enzymatic activities. The Japanese subjects with the CYP2C9*1/*3 and CYP2C9*3/*3 genotypes have lower warfarin doses than tho ...
... CYP1A2 activity measured by the rate of caffeine 3-demethylation in Japanese smokers [35]. CYP2C9*2 and CYP2C9*3, the two most common variant alleles, exhibit largely reduced enzymatic activities. The Japanese subjects with the CYP2C9*1/*3 and CYP2C9*3/*3 genotypes have lower warfarin doses than tho ...
Development of a Hepatocyte Spheroid Culture Model for Drug
... The use of an appropriate in vitro model is, within the field of clinical pharmacology, highly important for the process of drug development as it gives initial affirmation of a drug to be systemically available and also interact with other drugs. A major problem encountered by several pharmaceutica ...
... The use of an appropriate in vitro model is, within the field of clinical pharmacology, highly important for the process of drug development as it gives initial affirmation of a drug to be systemically available and also interact with other drugs. A major problem encountered by several pharmaceutica ...
Document
... Haloperidol is a potent, orally active central nervous system depressant, sedative, and tranquilizer. However, peak plasma levels are observed between 2 and 6 h after administration. The ester prodrug haloperidol decanoate is injected intramuscularly as a solution in sesame oil, and its antipsychoti ...
... Haloperidol is a potent, orally active central nervous system depressant, sedative, and tranquilizer. However, peak plasma levels are observed between 2 and 6 h after administration. The ester prodrug haloperidol decanoate is injected intramuscularly as a solution in sesame oil, and its antipsychoti ...
Post Operative Nausea & Vomiting
... – Higher doses (50mg) may be effective – Dyskinetic and extrapyramidal side effects ...
... – Higher doses (50mg) may be effective – Dyskinetic and extrapyramidal side effects ...
The use of benzodiazepines within the Traveller community
... gather these figures, they do not highlight the real extent of the problem within the entire community i.e. Travellers who are most likely to fall between the gaps of support services and who may not consider their benzodiazepine use a problem. The Report of the Benzodiazepine Committee acknowledge ...
... gather these figures, they do not highlight the real extent of the problem within the entire community i.e. Travellers who are most likely to fall between the gaps of support services and who may not consider their benzodiazepine use a problem. The Report of the Benzodiazepine Committee acknowledge ...
Review Article Amla (Emblica officinalis) – Medicinal Food and
... Emblica officinalis is a natural, efficacious an antioxidant with the richest natural source of Vitamin C (200‐900 mg per 100 g of edible portion). Numerous studies conducted on Emblica officinalis fruit suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-funga ...
... Emblica officinalis is a natural, efficacious an antioxidant with the richest natural source of Vitamin C (200‐900 mg per 100 g of edible portion). Numerous studies conducted on Emblica officinalis fruit suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-funga ...
IMPROVING THE PREDICTION OF PHARMACOGENES USING
... text-mining-based classifier out-performs the curationbased classifier, with receiver operator characteristic (ROC) curves with area under the curve (AUC) of 0.701 and 0.672 respectively (see Figure 5). Besides having an overall AUC that is slightly higher, the text-miningbased classifier achieves h ...
... text-mining-based classifier out-performs the curationbased classifier, with receiver operator characteristic (ROC) curves with area under the curve (AUC) of 0.701 and 0.672 respectively (see Figure 5). Besides having an overall AUC that is slightly higher, the text-miningbased classifier achieves h ...
Expression of the zebrafish gene hlx
... from hlx-1 and the pax[b] gene. The latter is expressed within two transversal stripes located in the posterior midbrain region which fuse at the dorsal midline in 10 hpf embryos (Krauss et al., 1991b). At later stages, the posterior boundary of the pax[b] expression domain coincides with the furrow ...
... from hlx-1 and the pax[b] gene. The latter is expressed within two transversal stripes located in the posterior midbrain region which fuse at the dorsal midline in 10 hpf embryos (Krauss et al., 1991b). At later stages, the posterior boundary of the pax[b] expression domain coincides with the furrow ...
Dorsal spinal cord stimulation obtunds the capacity of intrathoracic
... power 1401 data acquisition system) and analyzed using the Spike 2 software package (Cambridge Electronics Design). Ganglionic loci were identified from which action potentials with signal-to-noise ratios ⬎ 3:1 could be recorded. The activity generated by individual neuronal somata was identified by ...
... power 1401 data acquisition system) and analyzed using the Spike 2 software package (Cambridge Electronics Design). Ganglionic loci were identified from which action potentials with signal-to-noise ratios ⬎ 3:1 could be recorded. The activity generated by individual neuronal somata was identified by ...
The dynamic spatio-temporal behavior of visual responses in
... evidence accumulated not later than around 1970 [6,57,61,72], indicate that visual information processing must be a process utilizing recurrent loops and involving massive dynamic interactions. It is thus puzzling that visual cortical receptive fields were for a very long time regarded as rather sta ...
... evidence accumulated not later than around 1970 [6,57,61,72], indicate that visual information processing must be a process utilizing recurrent loops and involving massive dynamic interactions. It is thus puzzling that visual cortical receptive fields were for a very long time regarded as rather sta ...
Lysosomal function in macromolecular homeostasis and
... to selectively enter dopaminergic neurons of the substantia nigra based on its size and charge facilitating entry through the dopamine transporter. Upon entering dopaminergic neurons, MPP+ accumulates in mitochondria where it binds to and inhibits complex I, causing ATP depletion, and increasing rea ...
... to selectively enter dopaminergic neurons of the substantia nigra based on its size and charge facilitating entry through the dopamine transporter. Upon entering dopaminergic neurons, MPP+ accumulates in mitochondria where it binds to and inhibits complex I, causing ATP depletion, and increasing rea ...
The homeostatic psyche: Freudian theory and
... if the reflex model, as a rigid connection between sensory and motor systems, has been criticized by physiologists such as Pflüger, it has nevertheless dominated until the 1950s. The Goldstein’s critics can testify of this hegemony, especially concerning the surprising conception on life it leads to. ...
... if the reflex model, as a rigid connection between sensory and motor systems, has been criticized by physiologists such as Pflüger, it has nevertheless dominated until the 1950s. The Goldstein’s critics can testify of this hegemony, especially concerning the surprising conception on life it leads to. ...
Phase II Metabolism of Drugs
... Inducers increase levels of UGT or an enzyme; activators increase the measured catalytic rate of existing enzyme by altering the enzyme in some manner or enhancing a rate-limiting step, eg. access of drug or UDP-GA into the ER of the cell, movement of conjugate out of the cell or perhaps changes in ...
... Inducers increase levels of UGT or an enzyme; activators increase the measured catalytic rate of existing enzyme by altering the enzyme in some manner or enhancing a rate-limiting step, eg. access of drug or UDP-GA into the ER of the cell, movement of conjugate out of the cell or perhaps changes in ...
Can mechanistic explanation be reconciled with
... mathematical framework to accommodate activity on scale-free time-scales. This seems to be the perspective favored by Braun and Marom (this issue). While granting the value of appropriate mathematical representations, I argue for the continued pursuit of mechanistic explanations that impose time-win ...
... mathematical framework to accommodate activity on scale-free time-scales. This seems to be the perspective favored by Braun and Marom (this issue). While granting the value of appropriate mathematical representations, I argue for the continued pursuit of mechanistic explanations that impose time-win ...
NIOSH List of Hazardous Drugs - University of Kansas Medical Center
... Caution: Drugs purchased and used by a facility may have entered the marketplace after the list below was assembled. Therefore, this list may not be all-inclusive. If you use a drug that is not included in the list of examples, check the available literature to see whether the unlisted drug should b ...
... Caution: Drugs purchased and used by a facility may have entered the marketplace after the list below was assembled. Therefore, this list may not be all-inclusive. If you use a drug that is not included in the list of examples, check the available literature to see whether the unlisted drug should b ...
The Benzo Manual
... 1. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals. 2. Market aim: although all benzodiazepines have similar actions, they are usually market ...
... 1. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals. 2. Market aim: although all benzodiazepines have similar actions, they are usually market ...
Introduction - Bowling Green State University
... plasticity and other neural changes are strongly influenced by their activity (Hebb 1949). The most influential hypothesis of DA regulatory function is that it increases the signal-to-noise ratio in striatal areas, enhancing the efficiency of neural networks in elaborating significant signals (Rolls ...
... plasticity and other neural changes are strongly influenced by their activity (Hebb 1949). The most influential hypothesis of DA regulatory function is that it increases the signal-to-noise ratio in striatal areas, enhancing the efficiency of neural networks in elaborating significant signals (Rolls ...
Development of the Nervous System of Carinina ochracea
... could be identified at each stage. Only signals that were consistent in several larvae are documented (Table 1). In many larvae, bilaterally occurring neural structures seem to display immunoreactivity slightly earlier on one side of the body than on the other. Cross reactivity of antibodies was not ...
... could be identified at each stage. Only signals that were consistent in several larvae are documented (Table 1). In many larvae, bilaterally occurring neural structures seem to display immunoreactivity slightly earlier on one side of the body than on the other. Cross reactivity of antibodies was not ...
The Nucleus Basalis of Meynert
... Acetylcholine is synthesized from acetyl CoA and choline by choline acetyltransferase (CAT). It is degraded by acetycholinesterase (AChE), an enzyme present in the synaptic cleft. Hebb et al ' 6 showed that undercutting the cerebral cortex caused a reduction in CAT activity in overlying cortex. This ...
... Acetylcholine is synthesized from acetyl CoA and choline by choline acetyltransferase (CAT). It is degraded by acetycholinesterase (AChE), an enzyme present in the synaptic cleft. Hebb et al ' 6 showed that undercutting the cerebral cortex caused a reduction in CAT activity in overlying cortex. This ...