Antimicrobial Agents and Chemotherapy
... Amoebiasis is an important public health problem in developing countries. Entamoeba histolytica, the causative agent of amoebiasis, may develop resistance to nitroimidazoles, a group of drugs considered to be the most effective against this parasitic disease. Therefore, research on new drugs for the ...
... Amoebiasis is an important public health problem in developing countries. Entamoeba histolytica, the causative agent of amoebiasis, may develop resistance to nitroimidazoles, a group of drugs considered to be the most effective against this parasitic disease. Therefore, research on new drugs for the ...
Fatty acid methyl esters as a potential therapy against cerebral
... pathogenesis of necrotic or apoptotic cell death (Huang et al., 2014; Kochanek et al., 2015) in the brain. In particular, depletion of ATP during ischemia inhibits the Na+ /K+ pump (Na+ /K+ ATPase) leading to an imbalance of ion (K+ , Na+ , Ca2+ ) gradients (Kochanek et al., 2015). The ionic imbala ...
... pathogenesis of necrotic or apoptotic cell death (Huang et al., 2014; Kochanek et al., 2015) in the brain. In particular, depletion of ATP during ischemia inhibits the Na+ /K+ pump (Na+ /K+ ATPase) leading to an imbalance of ion (K+ , Na+ , Ca2+ ) gradients (Kochanek et al., 2015). The ionic imbala ...
CNS*2004 July 18-22, 2004 Baltimore, Maryland
... COMPUTATIONAL NEUROSCIENCE MEETING CNS*2004 Welcome to CNS*2004! This is the thirteenth annual meeting of an interdisciplinary conference addressing a broad range of research approaches and issues involved in the field of computational neuroscience. These meetings bring together experimental and the ...
... COMPUTATIONAL NEUROSCIENCE MEETING CNS*2004 Welcome to CNS*2004! This is the thirteenth annual meeting of an interdisciplinary conference addressing a broad range of research approaches and issues involved in the field of computational neuroscience. These meetings bring together experimental and the ...
Niosome and Proniosome – Vesicular Structured Dosage Form for
... effects. Drug targeting is the delivery of drugs to receptors or organs or any other specific part of the body to which one wishes to deliver the drugs exclusively.2 The drug’s therapeutic index, as measured by its pharmacological response and safety, relies in the access and specific introduction o ...
... effects. Drug targeting is the delivery of drugs to receptors or organs or any other specific part of the body to which one wishes to deliver the drugs exclusively.2 The drug’s therapeutic index, as measured by its pharmacological response and safety, relies in the access and specific introduction o ...
Drugs Combinations in the Treatment of Obesity
... Another study involving 89 obese women, showed a mean weight loss of 5.5%, 10.2% and 10.6% with orlistat alone, sibutramine alone and combined therapy, respectively, once again with no statistical difference between the latter two groups. Despite these disappointing results, around 14% of obesity sp ...
... Another study involving 89 obese women, showed a mean weight loss of 5.5%, 10.2% and 10.6% with orlistat alone, sibutramine alone and combined therapy, respectively, once again with no statistical difference between the latter two groups. Despite these disappointing results, around 14% of obesity sp ...
Stimulus-Dependent Synchronization of Neuronal Responses in the
... In visual areas of the cerebral cortex, most neurons exhibit preferences for particular features of visual stimuli, but in general, the tuning is broad. Thus, even simple stimuli evoke responses in numerous neurons with differing but overlapping feature preferences, and it is commonly held that a pa ...
... In visual areas of the cerebral cortex, most neurons exhibit preferences for particular features of visual stimuli, but in general, the tuning is broad. Thus, even simple stimuli evoke responses in numerous neurons with differing but overlapping feature preferences, and it is commonly held that a pa ...
Effects of Antidepressants on Inhibitory Avoidance in
... anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as agoraphobia, generalized anxiety disorder, social phobia, obsessive-compulsive disorder and post-traumatic stress disorder (Baldessarini, 2001). Antidepressants are also ...
... anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as agoraphobia, generalized anxiety disorder, social phobia, obsessive-compulsive disorder and post-traumatic stress disorder (Baldessarini, 2001). Antidepressants are also ...
Structural Basis for Pharmacology of Voltage
... activation of voltage-gated calcium channels in heart and vascular smooth muscle by acting at an allosteric modulatory site located outside of the pore (Hess et al., 1984; Kokubun and Reuter, 1984; Kokubun et al., 1986). Their binding is highly voltage dependent, and the calcium antagonist drugs use ...
... activation of voltage-gated calcium channels in heart and vascular smooth muscle by acting at an allosteric modulatory site located outside of the pore (Hess et al., 1984; Kokubun and Reuter, 1984; Kokubun et al., 1986). Their binding is highly voltage dependent, and the calcium antagonist drugs use ...
Setor 11. Farmacologia Clínica, Farmacocinética
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
Investigating pain networks in the spinal cord using functional MRI
... cord gives poor image quality owing to the inhomogeneous magnetic field environment caused by bone–tissue interfaces within the spine. The image quality is further degraded when echo-planar imaging (EPI) schemes are used to achieve short image acquisition times, with the trade-off being high sensiti ...
... cord gives poor image quality owing to the inhomogeneous magnetic field environment caused by bone–tissue interfaces within the spine. The image quality is further degraded when echo-planar imaging (EPI) schemes are used to achieve short image acquisition times, with the trade-off being high sensiti ...
Vexing Pediatric Anesthesia Issues for the Generalist Anesthesiologist
... to varying concentrations of halothane from the time of conception to PND28 had a decrease in synaptic density and that these exposed animals also demonstrated behavioral disturbances (1). More recent investigations with newborn animal models have reported apoptosis in multiple areas of the central ...
... to varying concentrations of halothane from the time of conception to PND28 had a decrease in synaptic density and that these exposed animals also demonstrated behavioral disturbances (1). More recent investigations with newborn animal models have reported apoptosis in multiple areas of the central ...
New horizons in pulmonary arterial hypertension therapies
... 6MWD continued to improve with a mean increase in the overall cohort (n5214) of 48¡72 m compared with baseline [39]. Functional class also continued to improve and 68% of the overall cohort were in functional class I/II after 1 year of treatment (versus 38–49% at baseline); 36% and 57% of patients s ...
... 6MWD continued to improve with a mean increase in the overall cohort (n5214) of 48¡72 m compared with baseline [39]. Functional class also continued to improve and 68% of the overall cohort were in functional class I/II after 1 year of treatment (versus 38–49% at baseline); 36% and 57% of patients s ...
Polyscias balfouriana
... Rishiraj College of Pharmacy, Sanwer Road, Indore, Madhya Pradesh, India ...
... Rishiraj College of Pharmacy, Sanwer Road, Indore, Madhya Pradesh, India ...
Compound analgesics and the management of pain
... 200 top prescribers only nine opioid/acetaminophen/NSAID combinations were recommended by WHO for treatment of moderate severe pain. SA is the country with the most multi-substance analgesics in the world. It contains analgesics and many other substances. Almost every firm produces its own version o ...
... 200 top prescribers only nine opioid/acetaminophen/NSAID combinations were recommended by WHO for treatment of moderate severe pain. SA is the country with the most multi-substance analgesics in the world. It contains analgesics and many other substances. Almost every firm produces its own version o ...
The effects of herbal teas on drug permeability
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
50 animal models relevant to schizophrenia disorders
... the model is intended to reflect only the efficacy of known therapeutic agents and so lead to the discovery of related pharmacotherapies. Because the explicit purpose of the model is to predict treatment efficacy, the principle guiding this approach has been termed pharmacologic isomorphism (2). The ...
... the model is intended to reflect only the efficacy of known therapeutic agents and so lead to the discovery of related pharmacotherapies. Because the explicit purpose of the model is to predict treatment efficacy, the principle guiding this approach has been termed pharmacologic isomorphism (2). The ...
Selective visual attention and perceptual coherence
... initiated by transient switch signals that ‘reset’ or ‘nudge’ the brain out of the current attractor state, allowing a new coherence field to be formed based on input from the sensory environment and from working memory, where current task goals are maintained. Attention biases competition for repre ...
... initiated by transient switch signals that ‘reset’ or ‘nudge’ the brain out of the current attractor state, allowing a new coherence field to be formed based on input from the sensory environment and from working memory, where current task goals are maintained. Attention biases competition for repre ...
Wide field-of-view, twin-region two-photon imaging across extended
... areas (PM, AM, A, RL, AL, LM, and LI). (b) To examine activity in multiple cortical areas, it is necessary to have a large field of view. Conventional two-photon imaging is limited to narrow border regions that fail to cover significant portions of mouse cortical areas. By contrast, a expanded field ...
... areas (PM, AM, A, RL, AL, LM, and LI). (b) To examine activity in multiple cortical areas, it is necessary to have a large field of view. Conventional two-photon imaging is limited to narrow border regions that fail to cover significant portions of mouse cortical areas. By contrast, a expanded field ...
Medical Management of Parkinson`s disease
... cholinergic input. In addition to suppressing central cholinergic activity, these agents may also inhibit the reuptake and storage of dopamine at the central dopamine receptors, thereby prolonging the action of dopamine. They were the standard antiparkinsonian treatment until the late 1960's, when n ...
... cholinergic input. In addition to suppressing central cholinergic activity, these agents may also inhibit the reuptake and storage of dopamine at the central dopamine receptors, thereby prolonging the action of dopamine. They were the standard antiparkinsonian treatment until the late 1960's, when n ...
The Role of Kisspeptin Signaling in Reproduction
... rectifying potassium channel (Kir) (66, 84). Thus kisspeptins act directly on GnRH neurons to induce a sustained depolarization event and increase the rate of action potential firing (37, 88). The number of GnRH neurons that can respond to kisspeptins increases during puberty even though the express ...
... rectifying potassium channel (Kir) (66, 84). Thus kisspeptins act directly on GnRH neurons to induce a sustained depolarization event and increase the rate of action potential firing (37, 88). The number of GnRH neurons that can respond to kisspeptins increases during puberty even though the express ...
Categorical perception of somesthetic stimuli: psychophysical
... the evoked activity of the somatosensory (SI) cortex, and the neural signals associated with the animal’s decision. We have recorded the responses of neurons of SI cortex with receptive fields on the finger tips during the categorization of the stimulus speeds (Romo et al., 1996). The results indica ...
... the evoked activity of the somatosensory (SI) cortex, and the neural signals associated with the animal’s decision. We have recorded the responses of neurons of SI cortex with receptive fields on the finger tips during the categorization of the stimulus speeds (Romo et al., 1996). The results indica ...
Cardiorespiratory fitness: A predictor of cortical plasticity in multiple
... relationships. Consequently, development of strategies to maintain or enhance cognitive function in MS is an important public health goal. In addition to the necessity of developing training programs that target amelioration of cognitive deficits in the MS population, recent neuroimaging studies hav ...
... relationships. Consequently, development of strategies to maintain or enhance cognitive function in MS is an important public health goal. In addition to the necessity of developing training programs that target amelioration of cognitive deficits in the MS population, recent neuroimaging studies hav ...
EEG & Sleep
... • It is characterized by emotional outburst such as abnormal rage,anxiety,fear or discomfort. • There is amnesia or confused mental state for some period. • The cause, are the abnormalities in temporal lobe & tumor in hypothalamus and limbic system. ...
... • It is characterized by emotional outburst such as abnormal rage,anxiety,fear or discomfort. • There is amnesia or confused mental state for some period. • The cause, are the abnormalities in temporal lobe & tumor in hypothalamus and limbic system. ...
ARCI-011-020 Medications and Prohibited Substances
... (d) Drugs with prominent CNS depressant action; (e) Antidepressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects; (f) Muscle blocking drugs which have a direct neuromuscular blocking action; (g) Local anesthetics which have a reasonable potential for use as ...
... (d) Drugs with prominent CNS depressant action; (e) Antidepressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects; (f) Muscle blocking drugs which have a direct neuromuscular blocking action; (g) Local anesthetics which have a reasonable potential for use as ...