Drug action
... Elsevier items and derived items © 2009 by Saunders, an imprint of Elsevier Inc. Some material was previously published. ...
... Elsevier items and derived items © 2009 by Saunders, an imprint of Elsevier Inc. Some material was previously published. ...
SEGMENTATION OF NEURONS BASED ON ONE
... set that allows determining how similar an unlabeled voxel is to the voxels in the background class. Finally, foreground voxels are assigned as those unlabeled voxels that are not classified as background. Our method was qualitatively and quantitatively evaluated on several dataset to demonstrate it ...
... set that allows determining how similar an unlabeled voxel is to the voxels in the background class. Finally, foreground voxels are assigned as those unlabeled voxels that are not classified as background. Our method was qualitatively and quantitatively evaluated on several dataset to demonstrate it ...
الشريحة 1
... ineffective in gout). Since aspirin, the original NSAID, has a number of adverse effects, many other NSAIDs have been developed in attempts to improve upon aspirin's efficacy and decrease its toxicity. ...
... ineffective in gout). Since aspirin, the original NSAID, has a number of adverse effects, many other NSAIDs have been developed in attempts to improve upon aspirin's efficacy and decrease its toxicity. ...
Alcohol-Induced c-Fos Expression in the Edinger
... of the opioid system was first tested with the pretreatment of saline or the opioid antagonist naltrexone (Sigma-Aldrich). Naltrexone was dissolved in saline and was administered 10 min before 2.4 g/kg alcohol (n ⫽ 4 – 8/group). The effects of morphine on c-Fos expression in EW were also tested. Mor ...
... of the opioid system was first tested with the pretreatment of saline or the opioid antagonist naltrexone (Sigma-Aldrich). Naltrexone was dissolved in saline and was administered 10 min before 2.4 g/kg alcohol (n ⫽ 4 – 8/group). The effects of morphine on c-Fos expression in EW were also tested. Mor ...
Zn2 Slows Down CaV3.3 Gating Kinetics: Implications for
... recorded in nRT cells (Huguenard and Prince 1992). As these different isoforms have specific kinetic properties, neuron behavior will depend on the type of T-current it expresses. Specifically, because slow inactivating CaV3.3 channels are required to fire action potentials at a high frequency and f ...
... recorded in nRT cells (Huguenard and Prince 1992). As these different isoforms have specific kinetic properties, neuron behavior will depend on the type of T-current it expresses. Specifically, because slow inactivating CaV3.3 channels are required to fire action potentials at a high frequency and f ...
Untitled
... It is our great pleasure to welcome you here in Helsinki at GPEN 2014. About one year of organizing and planning lies behind us and finally the 10th biennial meeting of the Globalization of Pharmaceutics Education Network (GPEN) has arrived. It has been both a demanding and rewarding time and we are ...
... It is our great pleasure to welcome you here in Helsinki at GPEN 2014. About one year of organizing and planning lies behind us and finally the 10th biennial meeting of the Globalization of Pharmaceutics Education Network (GPEN) has arrived. It has been both a demanding and rewarding time and we are ...
Laminar Differences in Dendritic Structure of Pyramidal Neurons in
... Pyramidal cell structure varies between different cortical areas and species, indicating that the cortical circuits that these cells participate in are likely to be characterized by different functional capabilities. Structural differences between cortical layers have been traditionally reported usi ...
... Pyramidal cell structure varies between different cortical areas and species, indicating that the cortical circuits that these cells participate in are likely to be characterized by different functional capabilities. Structural differences between cortical layers have been traditionally reported usi ...
GAP-43 Expression in Primary Sensory Neurons following Central
... ganglia (DRG). Dorsal root section had no effect on GAP-43 mRNA levels in the dorsal horn or in neighboring intact DRG. It also failed to alter the laminar boundaries of the GAP-43 central terminal labeling produced by peripheral nerve section, even though vacant synaptic sites were produced in unst ...
... ganglia (DRG). Dorsal root section had no effect on GAP-43 mRNA levels in the dorsal horn or in neighboring intact DRG. It also failed to alter the laminar boundaries of the GAP-43 central terminal labeling produced by peripheral nerve section, even though vacant synaptic sites were produced in unst ...
Synchronisation and control of proliferation in cycling cell
... group, this has been demonstrated by comparing tumour growth curves. These observations were confirmed and supported by measurements of clock gene expression by quantitative real time polymerase chain reaction (qRTPCR). Furthermore, it was shown that in the disrupted clock group, a partial correctio ...
... group, this has been demonstrated by comparing tumour growth curves. These observations were confirmed and supported by measurements of clock gene expression by quantitative real time polymerase chain reaction (qRTPCR). Furthermore, it was shown that in the disrupted clock group, a partial correctio ...
The Usefulness of a Closed-system Device for the Mixing of
... Introduction To ensure the safety of medical professionals, it is extremely important to assess their exposure in the handling of anticancer drugs in terms of preparation techniques, as well as to establish appropriate methods of preparation. The process by which contamin ation coming from antican ...
... Introduction To ensure the safety of medical professionals, it is extremely important to assess their exposure in the handling of anticancer drugs in terms of preparation techniques, as well as to establish appropriate methods of preparation. The process by which contamin ation coming from antican ...
Cognition The Cognitive Science Approach 1) The Atkinson
... 55) One reason cognitive psychologists moved away from the strict information-processing approach was the evidence that multiple mental processing can occur in parallel. Answer: TRUE 56) Each hemisphere of the brain is a single sheet of neural tissue, the lobes are merely separated by larger folds a ...
... 55) One reason cognitive psychologists moved away from the strict information-processing approach was the evidence that multiple mental processing can occur in parallel. Answer: TRUE 56) Each hemisphere of the brain is a single sheet of neural tissue, the lobes are merely separated by larger folds a ...
Inhalant Abuse - National Drug Court Resource Center
... nhalants are volatile substances that produce chemical vapors that can be inhaled to induce a psychoactive, or mind-altering, effect. Although other abused substances can be inhaled, the term “inhalants” is used to describe a variety of substances whose main common characteristic is that they are ra ...
... nhalants are volatile substances that produce chemical vapors that can be inhaled to induce a psychoactive, or mind-altering, effect. Although other abused substances can be inhaled, the term “inhalants” is used to describe a variety of substances whose main common characteristic is that they are ra ...
Reward-Related Neuronal Activity During Go - Research
... indicating a response transfer from primary reward to the rewardpredicting instruction, possibly reflecting the temporal unpredictability of reward. In conclusion, orbitofrontal neurons report stimuli associated with reinforcers are concerned with the expectation of reward and detect reward delivery ...
... indicating a response transfer from primary reward to the rewardpredicting instruction, possibly reflecting the temporal unpredictability of reward. In conclusion, orbitofrontal neurons report stimuli associated with reinforcers are concerned with the expectation of reward and detect reward delivery ...
Elicited Behavior and Classical Conditioning
... – These effects occur primarily with acetylated salicylates (i.e., aspirin). Because nonacetylated salicylates lack the ability to acetylate cyclooxygenase and thereby irreversibly inhibit its activity, they are weaker inhibitors than aspirin. – Aspirin-induced gastric bleeding sometimes is painless ...
... – These effects occur primarily with acetylated salicylates (i.e., aspirin). Because nonacetylated salicylates lack the ability to acetylate cyclooxygenase and thereby irreversibly inhibit its activity, they are weaker inhibitors than aspirin. – Aspirin-induced gastric bleeding sometimes is painless ...
individual trait Variability of perceptual multistability: from
... changing interpretations of a single but ambiguous meaningful input pattern. Neural findings from binocular rivalry may hence to an unknown extent also reflect different mechanisms than in paradigms where the dynamics of perception depend exclusively on inference, as for instance ambiguous figures a ...
... changing interpretations of a single but ambiguous meaningful input pattern. Neural findings from binocular rivalry may hence to an unknown extent also reflect different mechanisms than in paradigms where the dynamics of perception depend exclusively on inference, as for instance ambiguous figures a ...
Asymmetric Neuroblast Divisions Producing Apoptotic Cells Require
... dynamics. We report here that GRP-1, the sole Caenorhabditis elegans cytohesin, controls the asymmetric divisions of certain neuroblasts that divide to produce a larger neuronal precursor or neuron and a smaller cell fated to die. In the Q neuroblast lineage, loss of GRP-1 led to the production of d ...
... dynamics. We report here that GRP-1, the sole Caenorhabditis elegans cytohesin, controls the asymmetric divisions of certain neuroblasts that divide to produce a larger neuronal precursor or neuron and a smaller cell fated to die. In the Q neuroblast lineage, loss of GRP-1 led to the production of d ...
Pharmacokinetics, Pharmacodynamics, and
... The distribution of a drug depends largely on the drug’s hydrophilicity and its acid dissociation constant, which affects its binding to proteins and other macromolecules. Only a free drug, unbound by protein, can diffuse across tissue and have physiologic effect. Many acidic drugs are bound to albu ...
... The distribution of a drug depends largely on the drug’s hydrophilicity and its acid dissociation constant, which affects its binding to proteins and other macromolecules. Only a free drug, unbound by protein, can diffuse across tissue and have physiologic effect. Many acidic drugs are bound to albu ...
Morphological Studies of Wobbler Mouse Dorsal Root Ganglia
... degeneration results in the denervation of skeletal muscles and eventually to progressive paralysis leading to respiratory arrest. Since first being described by Charcot in 1896, ALS has been investigated intensively and many cellular defects found in animal models have been suggested to cause these ...
... degeneration results in the denervation of skeletal muscles and eventually to progressive paralysis leading to respiratory arrest. Since first being described by Charcot in 1896, ALS has been investigated intensively and many cellular defects found in animal models have been suggested to cause these ...
Environmental and Drug Effects on Patients With
... of cellular telephones. Although no recent studies that systematically test the effect of household microwave energy on implanted devices have been performed, it is widely believed and accepted that all modern pacemakers are adequately shielded from microwave energy produced by today’s appliances. P ...
... of cellular telephones. Although no recent studies that systematically test the effect of household microwave energy on implanted devices have been performed, it is widely believed and accepted that all modern pacemakers are adequately shielded from microwave energy produced by today’s appliances. P ...
Parallel Processing of Appetitive Short- and Long
... [22, 24] and in ab neurons to form LTM [24], suggesting an independence of these two memory phases. However, several results suggest that aversive STM and LTM are not processed by fully independent neuronal pathways. Thus, a more efficient rescue of rut STM or LTM defect is observed when RUT is expr ...
... [22, 24] and in ab neurons to form LTM [24], suggesting an independence of these two memory phases. However, several results suggest that aversive STM and LTM are not processed by fully independent neuronal pathways. Thus, a more efficient rescue of rut STM or LTM defect is observed when RUT is expr ...
Circuits of emotion in the primate brain
... elimination, even immune function is coordinated directly from the brainstem. The brainstem also contains a reticular system that plays an important role in vigilance and behavioral activation in response to both emotional and neutral stimuli. Based on the collateral signals it receives from all the ...
... elimination, even immune function is coordinated directly from the brainstem. The brainstem also contains a reticular system that plays an important role in vigilance and behavioral activation in response to both emotional and neutral stimuli. Based on the collateral signals it receives from all the ...
Pharmacotherapeutic action of Dasanga Guggulu
... Hyperlipidaemia, one of major health issue, is being developed globally in this century. It is defined as elevated concentrations of any or all the lipids in the plasma, including hypertriglyceridemia, hypercholesterolemia, etc1. Less physical activities, sedentary life style and mental stress are n ...
... Hyperlipidaemia, one of major health issue, is being developed globally in this century. It is defined as elevated concentrations of any or all the lipids in the plasma, including hypertriglyceridemia, hypercholesterolemia, etc1. Less physical activities, sedentary life style and mental stress are n ...
Metabolic Activation and Idiosycratic Drug Toxicity
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause ...
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause ...
Reactive Metabolites - New England Drug Metabolism Discussion
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause for ...
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause for ...
The Nervous System
... Electrical energy is stored across the plasma membrane of a resting neuron. There are more negatively charged compounds just inside the membrane than outside of it. As a result, the inside of the cell is negatively charged relative to the outside. The charge difference creates a form of stored energ ...
... Electrical energy is stored across the plasma membrane of a resting neuron. There are more negatively charged compounds just inside the membrane than outside of it. As a result, the inside of the cell is negatively charged relative to the outside. The charge difference creates a form of stored energ ...