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Cortex, Cognition and the Cell: New Insights into the Pyramidal
Cortex, Cognition and the Cell: New Insights into the Pyramidal

... Lessons from Sensory Cortex Of all cortical regions in the brain, the most extensively studied is sensory cortex. In particular, the visual cortex of the macaque monkey has been the focus of much interest due to its parallels with the human visual system (Kaas, 1992). Visual cortex, like other senso ...
ENDURING ISSUES ENDURING ISSUES (con`t) ENDURING
ENDURING ISSUES ENDURING ISSUES (con`t) ENDURING

... myelin  sheath  -­‐  white  faWy  covering  found  on  some   axons.   ...
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The Structure and Plasticity of the Proximal Axon of Hippocampal
The Structure and Plasticity of the Proximal Axon of Hippocampal

... Dendrites are one of two types of neuronal processes which emerge from the soma. Dendrites receive chemical signals from other neurons through neurotransmitter receptors. In response to afferent information, they integrate the synaptic inputs and generate electrical signals. As far as morphology is ...
1 Socioeconomic Status and Neurocognitive Development
1 Socioeconomic Status and Neurocognitive Development

... selective attention were observed electrophysiologically despite similar behavioral performance between the low and middle SES children, and provide direct evidence for socioeconomic differences in early stages of executive function processing. D’Anguilli and colleagues (2008) have found similar SES ...
The Cerebellum - krigolson teaching
The Cerebellum - krigolson teaching

... Jansen 1972.) ...
Mechanical Response Properties of A and C Primary Afferent
Mechanical Response Properties of A and C Primary Afferent

... ␹2 test for proportion of mechanically insensitive units: slow A ⬍ C, P ⫽ 0.0077; C ⬍ fast A, P ⫽ 0.01). This percentage was close to 0 among the slow A’s (3%, 2/59), but it increased sharply among neurons with CVs ⬎5 m/s (33%, 33/99). This difference in the percentage of mechanically insensitive un ...
GHB
GHB

... Cartridge Cleaner, Plant Food, Fingernail Polish Remover, Paint Stripper. There are more than 80 known names for GHB and its equally deadly analogs. ...
mGluR-dependent persistent firing in entorhinal cortex layer III neurons SYNAPTIC MECHANISMS Motoharu Yoshida,
mGluR-dependent persistent firing in entorhinal cortex layer III neurons SYNAPTIC MECHANISMS Motoharu Yoshida,

... On the other hand, recent in vivo findings have shown an involvement of group I metabotropic glutamate receptors (mGluRs) in working memory (Naie & Manahan-Vaughan, 2004; Hayashi et al., 2007; Mikami et al., 2007). It has also been shown that group I mGluRs can modulate ICAN and transient receptor po ...
MAY 5, 2000 Submitted to the Annual Review of Neuroscience AN
MAY 5, 2000 Submitted to the Annual Review of Neuroscience AN

... patterns of activity that represent goals and the means to achieve them. They provide bias signals throughout much of the rest of the brain, affecting not only visual processes, but also other sensory modalities, as well as systems responsible for response execution, memory retrieval, emotional eval ...
Choline Signal Changes after Choline
Choline Signal Changes after Choline

... et. al (16) concluded that the striatum was bilaterally involved as revealed by the NAA/Cr ratio, approximately 20–25% neurons in the globus pallidus may have died or may be severely dysfunctional on ADHD-children. The role of Glutamate-Glutamine (Glu-Gln) metabolism in ADHDpatients has also been st ...
PDF
PDF

... produce F1 hybrids. This transgenic mouse was used to observe activity of entire V1 because of its uniform expression of GCaMP3 over the cortex, and because it was difficult to entirely cover the V1 by tilling injections of OGB-1 AM. On the other hand, this transgenic line is not suitable for cellul ...
An Overview of the Topical Antimicrobial Agents Used
An Overview of the Topical Antimicrobial Agents Used

... cream is not associated with electrolyte disturbances. Absorption of cerium has been documented in patients with large burns treated continuously with it for several weeks, but is minimal. Gentamicin (Garamycin, Gentamar, et al). Gentamicin is usually applied as a 0.1% in a water miscible ointment. ...
Review: Side Effects of Some Commonly Used Allergy Medications
Review: Side Effects of Some Commonly Used Allergy Medications

... stroke, intracranial bleed, arrhythmias, and myocardial infarction [3,6,7]. Although decongestants may lead to hyper excitability and an increased risk of seizure, a recent animal study showed a paradoxical effect in which phenylephrine potentiates the anticonvulsant effect and neutralizes the sedat ...
- MIRACALUS PHARMA PVT. LTD.
- MIRACALUS PHARMA PVT. LTD.

... further evaluation and counseling. Lenalidomide is contraindicated in any patients who have demonstrated hypersensitivity to the drug or its components. WARNINGS Pregnancy Category Lenalidomide is an analogue of thalidomide. Thalidomide is a known human teratogen that causes life-threatening human b ...
Head-Direction Cells Recorded from the Postsubiculum in Freely
Head-Direction Cells Recorded from the Postsubiculum in Freely

... idal neuronsin the hippocampusof freely moving rats discharge in relation to the animal’s location within the environment (O’Keefe and Dostrovsky, 1971; O’Keefe, 1976; Muller et al., 1987). These neurons are called place cells becausetheir firing is primarily location-specific and may be independent ...
Anti-inflammatory activity of hydroalcoholic extract of Quisqualis
Anti-inflammatory activity of hydroalcoholic extract of Quisqualis

... adverse effects. Exploring the healing power of plants is an ancient concept. For centuries people have been trying to alleviate and treat disease with different plant extracts and formulations5. Quisqualis indica Linn. (Combreteceae) is a strong climber, ligneous vine that can reach from 2.5 meters ...
Higginbotham H, Eom TY, Mariani LE, Bachleda A, Hirt J, Gukassyan V, Cusack CL, Lai C, Caspary T, Anton ES. Developmental Cell. 2012, Nov 13 23(5):925-38. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex.
Higginbotham H, Eom TY, Mariani LE, Bachleda A, Hirt J, Gukassyan V, Cusack CL, Lai C, Caspary T, Anton ES. Developmental Cell. 2012, Nov 13 23(5):925-38. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex.

... (A and B) GFP-labeled coronal hemisections show interneuron migration defects in Arl13bLox/Lox;Dlx5/6-CIE mutants, with clusters of cells stuck at the pallialsubpallial boundary (5B, arrow). (C and D) Loss of characteristic interneuronal migratory streams in Arl13bLox/Lox;Dlx5/6-CIE cortex. Arrowhea ...
Glycine Binding Sites of Presynaptic NMDA Receptors May
Glycine Binding Sites of Presynaptic NMDA Receptors May

... of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. ...
The stress-coping (mis)match hypothesis for nature×nurture
The stress-coping (mis)match hypothesis for nature×nurture

... A model par example for nature × nurture interactions in psychiatry is the serotonin transporter-linked polymorphic region (5-HTTLPR) in humans. It consists of two allelic variants, of which the low activity (short; s) allele is associated with reduced transcription of the Slc6A4 gene compared to lo ...
Interspike Intervals, Receptive Fields, and Information Encoding in
Interspike Intervals, Receptive Fields, and Information Encoding in

... preceded by ISIs ⬎38 msec are often fired in response to spatially uniform stimuli that reverse contrast over time. The third question, concerning the ways in which these different messages are decoded, is not addressed directly by our experiments. We note at the outset that this question is concept ...
Multiplicative Gain Changes Are Induced by Excitation or Inhibition
Multiplicative Gain Changes Are Induced by Excitation or Inhibition

... variance of the conductance, and ␹ (t) is a Gaussian random variable with 0 mean and a SD of 1. Parameters were chosen by beginning with the parameters used by Palmer and Miller (2002) and adjusting these to produce membrane potential fluctuations of ⬃5 mV at rest and a rest potential of approximate ...
Ethnopsychopharmacology for Asians
Ethnopsychopharmacology for Asians

... Pre-lecture Examination Questions 1 Which of the following statements are correct? 1. Pharmacogenetic profile can influence both the pharmacokinetics and the pharmacodynamics of a given medication. 2. Pharmacokinetics refers the way in which the body handles drugs. This includes absorption, distrib ...
MIrror neuRons based RObot Recognition - LIRA-Lab
MIrror neuRons based RObot Recognition - LIRA-Lab

... visual responses (“visual neurons” and “bimodal neurons”), 41% respond to the observations of actions made by another individual. One third of them, however, similarly to STS neurons, do not appear to have motor-related activity. The other two-third discharge also during the monkey movement and, in ...
NIDA Research Report - MDMA
NIDA Research Report - MDMA

... cognition, emotion, and motor function. However, improved imaging technologies and more research are needed to confirm these findings and to elucidate the exact nature of the effects of MDMA on the human brain. It is also important to keep in mind that many users of ecstasy may unknowingly be taking ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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