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... nervous system. The way a drug is taken helps determine speed and extent of reaction. In the central nervous system, most psychoactive drugs affect neurotransmitters. Drugs can stimulate, inhibit, or halt the release of neurotransmitters. For example, some neurotransmitters inhibit rather than conve ...
NIDA Research Report - MDMA
NIDA Research Report - MDMA

... cognition, emotion, and motor function. However, improved imaging technologies and more research are needed to confirm these findings and to elucidate the exact nature of the effects of MDMA on the human brain. It is also important to keep in mind that many users of ecstasy may unknowingly be taking ...
Multiplicative Gain Changes Are Induced by Excitation or Inhibition
Multiplicative Gain Changes Are Induced by Excitation or Inhibition

... variance of the conductance, and ␹ (t) is a Gaussian random variable with 0 mean and a SD of 1. Parameters were chosen by beginning with the parameters used by Palmer and Miller (2002) and adjusting these to produce membrane potential fluctuations of ⬃5 mV at rest and a rest potential of approximate ...
The stress-coping (mis)match hypothesis for nature×nurture
The stress-coping (mis)match hypothesis for nature×nurture

... A model par example for nature × nurture interactions in psychiatry is the serotonin transporter-linked polymorphic region (5-HTTLPR) in humans. It consists of two allelic variants, of which the low activity (short; s) allele is associated with reduced transcription of the Slc6A4 gene compared to lo ...
Spinal cord and reflexes
Spinal cord and reflexes

...  In addition to motor impulses: – dorsal, ventral, and white rami also carry sensory information ...
neonatal convulsions
neonatal convulsions

... • Need for resuscitation in the labor room, low Apgar scores (<3 at 1 and/ or 5 minutes) and • abnormal cord pH (≤7) and base deficit (> 10 mEq/L) should be ...
Spinal cord and reflexes
Spinal cord and reflexes

...  In addition to motor impulses: – dorsal, ventral, and white rami also carry sensory information ...
Early-life social adversity and developmental processes in
Early-life social adversity and developmental processes in

... Adolescent and adult macaques exposed to ELSA have lower 5-HIAA titers, implying reduced serotonergic tone [26,39,40], cf. [41]. Modification of CSF levels as a consequence of ELSA for other monoamine metabolites and corticotropin-releasing hormone has also been documented [12,22,40,42]. As is the c ...


... These findings led neuroscientists at that time to emphatically search for specific brain regions associated with each cognitive, motor or sensory function. The Brodmann areas,3 for example, are used daily in the attempt to localize brain functions. The importance of these studies was recently the s ...
Express Results CLIA-Waived Integrated Cup
Express Results CLIA-Waived Integrated Cup

... drug company for the treatment of obesity.8 Those who take the drug frequently report adverse effects, such as increased muscle tension and sweating. MDMA is not clearly a stimulant, although it has, in common with amphetamine drugs, a capacity to increase blood pressure and heart rate. MDMA does pr ...
Vaccine pharmacotherapy for the treatment of
Vaccine pharmacotherapy for the treatment of

... Addictions, especially alcohol dependence, have been treated largely as behavioral disorders. Weaknesses in will, character, or faith were among the factors believed to contribute to an addicted person's dependence. Consequently, for decades, treatment has centered on psychological or behavioral the ...
Systemic Antibiotics
Systemic Antibiotics

... otics may cause the loss of an autolysin inhibitor. Saturation of at least two of the three essential PBPs leads to a fast killing rate. The activity of β-lactam antibiotics depends also on the density of the bacterial population and the timing of the infection. They are more effective against small ...
Central Nervous System Depressant, Analgesic and Antidiarrheal
Central Nervous System Depressant, Analgesic and Antidiarrheal

... decrease may be intimately related to sedation resulting from depression of the CNS [24]. ...
Report to SACATM
Report to SACATM

... stimulus. A muscarinic receptor agonist does a similar thing. They developed a semiquantitative movement index: no movement (DMSO) = -10, constant movement = 0, therefore, hyperactivity during stimulus would be positive. They have created a similar coding for several characteristic behaviors and hav ...
Normalization as a canonical neural computation
Normalization as a canonical neural computation

... in the primary visual cortex 17–19. Similar computations20 had been proposed previously to explain light adaptation in the retina21–24, size invariance in the fly visual system25 and associative memory in the hippocampus26. Evidence that has accumulated since then suggests that normalization plays a ...
Serum Transaminase Elevations as Indicators of - UNC
Serum Transaminase Elevations as Indicators of - UNC

... populations is the underlying incidence of mildly abnormal results in a classical panel of liver tests used in routine monitoring of asymptomatic, unaffected individuals. These may be associated with population characteristics previously discussed and are not usually encountered in preclinical anima ...
Oxcarbazepine (TrileptalTM)
Oxcarbazepine (TrileptalTM)

... The FDA, however, does not indicate that a generic drug can be substituted by another generic drug for a brand name drug product even though both of the generic drugs have been shown to be bioequivalent to the same brand name drug. Bioequivalence studies are generally performed on a limited number o ...
CNB12 Plus
CNB12 Plus

... metabolism and neural-motor control. Methylcobalamin has been shown specifically to protect against glutamateinduced neural toxicity caused by L-dopa. This means that supplementation with methylcobalamin could protect those patients with Parkinson’s disease from glutamate-induced toxicity caused by ...
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)

... benzodiazepines can induce brief episodes of EEG and clinical seizure activity (Table 5). In general, the benzodiazepines used in anesthetic practice possess potent anticonvulsant properties in both humans and animals. In humans, diazepam (191) and lorazepam (192,193) have been widely used to termin ...
Trauma: Head/Brain Injuries
Trauma: Head/Brain Injuries

... Subarachnoid hemorrhage, into the subarachnoid space, may result from diffuse brain injury and may be associated with other injuries, such as extensive intraventricular hemorrhage or extensive contusions. Subarachnoid hemorrhage may result in diffuse spread or localized hematoma. Traumatic subarach ...
This article was downloaded by:[EBSCOHost EJS Content Distribution]
This article was downloaded by:[EBSCOHost EJS Content Distribution]

... This article was downloaded by:[EBSCOHost EJS Content Distribution] On: 18 February 2008 ...
Cortical sensorimotor alterations classify clinical phenotype and
Cortical sensorimotor alterations classify clinical phenotype and

... focal dystonia have been previously reported to exhibit altered resting-state connectivity [17–21]. Classification algorithms represent a powerful tool for identification of single traits or a combination of features that characterize and separate two or more classes of objects or subjects. Algorithmi ...
Topical Review
Topical Review

... system, and with specific therapies, in the spinal cord and optic nerve.19 –22 In these sites, sprouting neurons activate specific molecular elements of a growth program to elaborate a growth cone, extend an axon and form new synapses. Nervous system injury also induces glial and meningeal growth-in ...
Nasal Drug Delivery in EMS
Nasal Drug Delivery in EMS

... Are absorbed via the rich vascular plexus of the nose and directly enter the circulation. Avoid the stomach and small intestine so are not destroyed by acid and digestive enzymes, nor delayed in their absorption to the blood stream. Avoid the portal circulation, so are not subject to extensive destr ...
Handouts Day 2
Handouts Day 2

... Activity to develop activities and individual programs that encourage balance ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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