Antiarrhythmic therapy in patients with atrial fibrillation
... as well as emerging reports associated with adverse effects (17-19), underline the leading role of the principle of “safety first”. Therefore, it was considered as a valuable observation that in some patients, for example in those with increased risk connected with treatment, a shortterm antiarrhyth ...
... as well as emerging reports associated with adverse effects (17-19), underline the leading role of the principle of “safety first”. Therefore, it was considered as a valuable observation that in some patients, for example in those with increased risk connected with treatment, a shortterm antiarrhyth ...
Molecular Targets and Cancer Therapeutics
... a broad characterization of the cancer. We have developed and optimized a large next generation sequencing (NGS) panel covering the coding regions of over 500 genes. Using this panel, we sequenced cell free DNA from plasma and matched tumor DNA in patients with early stage breast cancer, late stage ...
... a broad characterization of the cancer. We have developed and optimized a large next generation sequencing (NGS) panel covering the coding regions of over 500 genes. Using this panel, we sequenced cell free DNA from plasma and matched tumor DNA in patients with early stage breast cancer, late stage ...
Cell type-specific activation of p38 MAPK in the brain regions of
... Activation of p38 mitogen-activated protein kinase (p38 MAPK) has been implicated as a mechanism of ischemia/hypoxia-induced cerebral injury. The current study was designed to explore the involvement of p38 MAPK in the development of cerebral hypoxic preconditioning (HPC) by observing the changes in ...
... Activation of p38 mitogen-activated protein kinase (p38 MAPK) has been implicated as a mechanism of ischemia/hypoxia-induced cerebral injury. The current study was designed to explore the involvement of p38 MAPK in the development of cerebral hypoxic preconditioning (HPC) by observing the changes in ...
How do dendrites take their shape?
... as length, diameter, growth rate and molecular composition that are different from those characteristics in axons12. Second, dendrites extend in a defined direction and increase in diameter as they undergo the third step, formation of branches at defined intervals. Fourth, as dendrites elaborate, ma ...
... as length, diameter, growth rate and molecular composition that are different from those characteristics in axons12. Second, dendrites extend in a defined direction and increase in diameter as they undergo the third step, formation of branches at defined intervals. Fourth, as dendrites elaborate, ma ...
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system
... dependence is an important component in the abuse of drugs as opioids, cannabis, ethanol and nicotine (Nestler et al., 2001). 1.2.2. Emotional and motivational aspects of dependence. The emotional and motivational component of drug dependence is manifested by withdrawal symptoms such as anhedonia, d ...
... dependence is an important component in the abuse of drugs as opioids, cannabis, ethanol and nicotine (Nestler et al., 2001). 1.2.2. Emotional and motivational aspects of dependence. The emotional and motivational component of drug dependence is manifested by withdrawal symptoms such as anhedonia, d ...
Development and application of highly sensitive high−performance
... In recent years, many kinds of drugs of abuse have been used worldwide and caused serious social problems. Among these, methamphetamine (MP) is the most popular drug of abuse in Japan. In addition to MP illegal designer drugs, 3,4−methylenedioxymethamphetamine and 3,4−methylendioxyamphetamine have b ...
... In recent years, many kinds of drugs of abuse have been used worldwide and caused serious social problems. Among these, methamphetamine (MP) is the most popular drug of abuse in Japan. In addition to MP illegal designer drugs, 3,4−methylenedioxymethamphetamine and 3,4−methylendioxyamphetamine have b ...
Psychopharmacology - Where can my students do assignments that
... • Transition to smoking or IV is often a significant event in drug history – Much greater high – Often develop cocaine binges • Bouts of drug use lasting from hours to days • Nothing is more important than maintaining the high – 3-day freebasing binge could involve consuming as much as 150 g of coca ...
... • Transition to smoking or IV is often a significant event in drug history – Much greater high – Often develop cocaine binges • Bouts of drug use lasting from hours to days • Nothing is more important than maintaining the high – 3-day freebasing binge could involve consuming as much as 150 g of coca ...
Attention-Deficit Hyperactivity Disorder
... Perry, 2003, p.409). This gave strong support for it’s positive effects in individuals with ADHD. It also shows the difference between MPH and atomoxetine. MPH increases both extracellular norepinephrine and dopamine levels in the prefrontal cortex, as well as the nucleus accumbens and the striatum, ...
... Perry, 2003, p.409). This gave strong support for it’s positive effects in individuals with ADHD. It also shows the difference between MPH and atomoxetine. MPH increases both extracellular norepinephrine and dopamine levels in the prefrontal cortex, as well as the nucleus accumbens and the striatum, ...
Lipid Excipients in Self Emulsifying Drug
... Self emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants and co-surfactants can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be orally administered in soft or hard gelatin capsul ...
... Self emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants and co-surfactants can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be orally administered in soft or hard gelatin capsul ...
Mammalian Models of CNS Regeneration - Wiley-VCH
... high affinity and specificity to two major brain gangliosides, GD1a and GT1b, that are expressed prominently on axons (Calderon et al., 1995). MAG was originally shown to be a promoter of neurite outgrowth from immature dorsal root ganglion (DRG) neurons (Johnson et al., 1989), but subsequently it was ...
... high affinity and specificity to two major brain gangliosides, GD1a and GT1b, that are expressed prominently on axons (Calderon et al., 1995). MAG was originally shown to be a promoter of neurite outgrowth from immature dorsal root ganglion (DRG) neurons (Johnson et al., 1989), but subsequently it was ...
Basal Ganglia Functional Connectivity Based on
... Functional connectivity thus defined does not necessarily rely upon direct (monosynaptic) anatomical connections. Conversely, anatomical connectivity does not necessarily imply functional connectivity, as 2 anatomically connected areas may coactivate only during certain specific cognitive acts (e.g., ...
... Functional connectivity thus defined does not necessarily rely upon direct (monosynaptic) anatomical connections. Conversely, anatomical connectivity does not necessarily imply functional connectivity, as 2 anatomically connected areas may coactivate only during certain specific cognitive acts (e.g., ...
Mietzsch U, McKenna J 3rd, Reith RM, Way SW, Gambello MJ. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013 Nov. 521(16):3817-31.
... differences in disease severity. Several brain-specific mouse models of TSC have made it possible to study the roles of hamartin and tuberin in both normal brain development and in the neuropathology of TSC (Uhlmann et al., 2002; Meikle et al., 2007; Way et al., 2009; Carson et al., 2012). In partic ...
... differences in disease severity. Several brain-specific mouse models of TSC have made it possible to study the roles of hamartin and tuberin in both normal brain development and in the neuropathology of TSC (Uhlmann et al., 2002; Meikle et al., 2007; Way et al., 2009; Carson et al., 2012). In partic ...
- Journal of Vestibular Research
... mammalian species (Table 3). Reactive synaptogenesis has often been suggested as a possible explanation for vestibular compensation; although there is evidence to support its occurrence in frog (for example, 66,67), the evidence from lower mammalian species (for example, 5 ,68) suggests that these c ...
... mammalian species (Table 3). Reactive synaptogenesis has often been suggested as a possible explanation for vestibular compensation; although there is evidence to support its occurrence in frog (for example, 66,67), the evidence from lower mammalian species (for example, 5 ,68) suggests that these c ...
A neurocomputational model of the mammalian fear
... their functions [37]. It is a particularly interesting case study because of how well linked it is to learning and memory; fearful experiences have a strong effect on an animal’s future behaviour [37]. This link provides a potential avenue of investigation into how low-level reward and punishment sys ...
... their functions [37]. It is a particularly interesting case study because of how well linked it is to learning and memory; fearful experiences have a strong effect on an animal’s future behaviour [37]. This link provides a potential avenue of investigation into how low-level reward and punishment sys ...
EFFECT OF ELECTRICAL STIMULATIONS ON EEG Harikanth1
... Abstract: Generally, Electro Enchephalo Graphic signals (electrical activity of the brain, EEG) are complex in its structure and nature. The observation and analysis of EEG is also difficult because it is highly subjective, random in nature and not able to predict the signal pattern. But, proper EEG ...
... Abstract: Generally, Electro Enchephalo Graphic signals (electrical activity of the brain, EEG) are complex in its structure and nature. The observation and analysis of EEG is also difficult because it is highly subjective, random in nature and not able to predict the signal pattern. But, proper EEG ...
Microglia and neurodegeneration C Cummingham
... and inducible nitric oxide synthase (iNOS). Alternatively activated macrophages (M2a) are driven by the influence of IL-4 and IL-13, typically from Th2 cells, resulting in an anti-inflammatory, profibrogenic profile. The M2b phenotype is driven by immune complex formation and TLR or IL-1b activation ...
... and inducible nitric oxide synthase (iNOS). Alternatively activated macrophages (M2a) are driven by the influence of IL-4 and IL-13, typically from Th2 cells, resulting in an anti-inflammatory, profibrogenic profile. The M2b phenotype is driven by immune complex formation and TLR or IL-1b activation ...
Anti-epileptic drugs and osteoporosis
... the body needs to absorb and use calcium in the bones. Although it is not completely understood how these anti-epileptic drugs affect bone density, there is some evidence that phenytoin, carbamazepine and primidone may stimulate an enzyme which destroys vitamin D, reducing the amount of vitamin D in ...
... the body needs to absorb and use calcium in the bones. Although it is not completely understood how these anti-epileptic drugs affect bone density, there is some evidence that phenytoin, carbamazepine and primidone may stimulate an enzyme which destroys vitamin D, reducing the amount of vitamin D in ...
Narcotics and the Anesthetist: Professional Hazards
... "to apply habitually, as one's mind to speculation; to give (oneself) up or over as to versifying as a constant practice." The noun is defined as "one who is addicted to a habit, especially to the taking of some drug." The term addicted has become commonly used when referring to bad habits and the t ...
... "to apply habitually, as one's mind to speculation; to give (oneself) up or over as to versifying as a constant practice." The noun is defined as "one who is addicted to a habit, especially to the taking of some drug." The term addicted has become commonly used when referring to bad habits and the t ...
Lymphatic transport of orally administered drugs
... The in vitro determination of digestion profiles and phase behavior of the lipids used in the lipid drug formulations, may be useful in predicting the fate of drug during the phase of lipid digestion. (i.e. the preabsorptive phase). The rate and extent of digestion and phase behavior of the lipolyti ...
... The in vitro determination of digestion profiles and phase behavior of the lipids used in the lipid drug formulations, may be useful in predicting the fate of drug during the phase of lipid digestion. (i.e. the preabsorptive phase). The rate and extent of digestion and phase behavior of the lipolyti ...
Brain asymmetry is encoded at the level of axon terminal morphology
... axonal projection within the FR, from the rHb to the IPN. (b) A single R habenular neuron labeled by focal electroporation and visualized by anti-GFP immunostaining (brown). The image shows the dorsal diencephalon of a dissected brain of a 4 dpf larva. Dotted lines show the borders of the habenulae ...
... axonal projection within the FR, from the rHb to the IPN. (b) A single R habenular neuron labeled by focal electroporation and visualized by anti-GFP immunostaining (brown). The image shows the dorsal diencephalon of a dissected brain of a 4 dpf larva. Dotted lines show the borders of the habenulae ...
Case # 5
... emergency physicians and toxicologists, it is not well described in the medical literature. There are absolutely no data on the incidence, severity, or exact physiology of this syndrome. Only 2 anecdotal reports appear in the literature. Although known for years, the exact physiology is unknown; how ...
... emergency physicians and toxicologists, it is not well described in the medical literature. There are absolutely no data on the incidence, severity, or exact physiology of this syndrome. Only 2 anecdotal reports appear in the literature. Although known for years, the exact physiology is unknown; how ...
to our information package
... Gabapentin is similar in structure to the neurotransmitter GABA but is not believed to act on the same brain receptors. Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage-gated calcium ion channels. Clinical uses Gabapentin has also ...
... Gabapentin is similar in structure to the neurotransmitter GABA but is not believed to act on the same brain receptors. Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage-gated calcium ion channels. Clinical uses Gabapentin has also ...
NIDA Research Report - MDMA
... cognition, emotion, and motor function. However, improved imaging technologies and more research are needed to confirm these findings and to elucidate the exact nature of the effects of MDMA on the human brain. It is also important to keep in mind that many users of ecstasy may unknowingly be taking ...
... cognition, emotion, and motor function. However, improved imaging technologies and more research are needed to confirm these findings and to elucidate the exact nature of the effects of MDMA on the human brain. It is also important to keep in mind that many users of ecstasy may unknowingly be taking ...
