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Current Opinion in Neurobiology (2004)
Current Opinion in Neurobiology (2004)

... had little effect on the proportion of OFC neurons that reversed their selectivity after a reversal of reinforcement contingencies, OFC lesions substantially reduced the proportion of BLA neurons that showed such reversal, consistent with the frequent observation that the OFC is crucial for reversal ...
Viktor`s Notes * Barbiturates
Viktor`s Notes * Barbiturates

... 1. At low doses - potentiation of GABA action on Cl- channel; barbiturates presumably bind to PICROTOXIN BINDING SITE. N.B. barbiturates do not bind to BENZODIAZEPINE RECEPTORS! 2. At higher doses - interference with Na+ and K+ transport across cell membranes → generalized inhibition of polysynaptic ...
to a transcript of this webinar .
to a transcript of this webinar .

... One of the biggest challenges is to get a child to take so many different supplements in large amounts. The current options are either to go through a compounding pharmacy OR to buy the individual components over the counter. The problem with going through a compounding pharmacy is that they are un ...
Vinca Alkaloids
Vinca Alkaloids

... vinca alkaloid, vinflunine that is currently approved in Europe for medicinal treatment.[5,6] ...
Olfactory maps, circuits and computations
Olfactory maps, circuits and computations

... the notion that continuous sensory maps are often built in two-dimensional sheets, raising the possibility that the bulb contains a topographically-organized map for smell not so different from topographic maps for other sensory modalities. Of course, maps are useful only insofar as they are read: t ...
ASYMMETRIC MEMBRANE CAPSULE (AMC): AN USEFUL OSMOTIC DRUG DELIVERY SYSTEM
ASYMMETRIC MEMBRANE CAPSULE (AMC): AN USEFUL OSMOTIC DRUG DELIVERY SYSTEM

... test formulation manually and can be studied for their drug release. Due to this, feasibility of prolonged release of drug can be estimated within short periods of time with small quantities of bulk drugs. 6. The capsules are made of components which have a long history in pharmaceutical excipients. ...
Phantom Limbs and Neural Plasticity
Phantom Limbs and Neural Plasticity

... a “telescoping” of fingers into the stump) for the first time in 10 years. The associated pain in the elbow and wrist also vanished. This may be the first known instance of a successful amputation of a phantom limb! Visual Feedback for Other Neurological Syndromes? Other syndromes such as focal dyst ...
RAMOS - PhD CV 2015 for COCA - New York Institute of Technology
RAMOS - PhD CV 2015 for COCA - New York Institute of Technology

... Department of Psychology, Queens College, City University of New York Major Advisor: Joshua C. Brumberg, Associate Professor of Psychology * Postdoctoral Travel Award, City University of New York 2007 – PhD; Behavioral Neuroscience/Psychology Behavioral Neuroscience Program, Department of Psychology ...
Hereditary Pick’s disease with the G272V tau mutation shows predominant three-repeat
Hereditary Pick’s disease with the G272V tau mutation shows predominant three-repeat

... Upstate, Charlesville) were used (de Silva et al., 2003) to investigate the tau isoform composition of Pick bodies. Sections from the two G272V cases as well as an Alzheimer’s disease and a PSP control were pretreated by pressure-cooking in sodium citrate buffer (pH 6) for 5 min, followed by incubat ...
Neuroimaging and ADHD: fMRI, PET, DTI Findings, and
Neuroimaging and ADHD: fMRI, PET, DTI Findings, and

... by pervasive and developmentally inappropriate levels of inattention, impulsivity, and hyperactivity. There is no conclusive cause of ADHD although a number of etiologic theories have been advanced. Research across neuroanatomical, neurochemical, and genetic disciplines collectively support a physio ...
Long-term neural recording characteristics of wire microelectrode
Long-term neural recording characteristics of wire microelectrode

... Over all of the recording sessions for all of the animals, an average of 1.4 " 0.6 units per active electrode were recorded. This average is relatively consistent as a function of weeks post-implant although the short-term implants had a slightly higher but more variable week-to-week average than th ...
PDF - Department of Neurobiology and Behavior
PDF - Department of Neurobiology and Behavior

... histograms of activity ⫾200 ms around a syllable boundary include firing rate changes, not only at the zero time point of the boundary of interest, but also over the preceding and following onsets and offsets (Aronov et al. 2008). For this reason, rate histograms of neurons with onset- and offset-lo ...
521 THE CHOLINERGIC LIMBIC SYSTEM: PROJECTIONS TO
521 THE CHOLINERGIC LIMBIC SYSTEM: PROJECTIONS TO

... of the accumbens nucleus, which appears to be an extension of the deep or polymorph layer of the olfactory tubercle, contains cells which are also rich in ChE as well as AChE (PL LXVIII, fig. 5, A). Their axons appear to project to olfactory areas. The main cholinesterase-containing, presumed cholin ...
PAIN & ANALGESIA
PAIN & ANALGESIA

... Sigma(only cause hallucination, euphoria/dysphoria) An opioid agent may act as an agonist (stimulating agent) or antagonist (blocking agent) at each receptor  Some opioid agents are considered mixed agonist/antagonists in that they block one type of receptor and stimulate another or partial agonist ...
Dusano-ISAP-post
Dusano-ISAP-post

... • While measuring the biomarker is straightforward, there are issues about the surrogate endpoint (discussed shortly) • Why do we do reasonably well with identifying exposure-response relationships in antiinfective trials? • The answer is that the MIC gives us a normalizing measure for docking the s ...
The Stimulus Properties of Para-Methoxyamphetamine
The Stimulus Properties of Para-Methoxyamphetamine

... It has been suggested that studies of the stimulus properties of known hallucinogens of various classes may provide a means for identifying, prior to their use in man, those drugs which are likely to be hallucinogenic 1171. In studies by Smythies cta/. [13,141 in which the effects of hallucinogens w ...
Rapid eye movement sleep promotes cortical
Rapid eye movement sleep promotes cortical

... results also further support a role for ERK in ODP, as originally reported in rodents (22). In contrast with our findings, 1 week of continuous RSD or brainstem lesions that reduce ponto-geniculo-occipital (PGO) waves during REM sleep amplify the effects of MD on cell size in the lateral geniculate ...
Code-specific policy gradient rules for spiking neurons
Code-specific policy gradient rules for spiking neurons

... input states are modelled by different firing rate patterns of the input neurons. The probability of choosing the actions is proportional to the spike counts of two output neurons: p(ak |s) = Nk /(N1 + N2 ). B Learning curves of the 2-armed bandit. Blue: Spike count learning rule (7), Red: Full spik ...
The Case Against Antipsychotics
The Case Against Antipsychotics

... There are many problems that can be identified with the relapse literature. (An indepth review of Leucht’s study, and its limitations, can be found here.) But for the purposes of the larger question being investigated in this paper, which is the effect of antipsychotics on long-term outcomes, the s ...
Managing weight gain as a side effect of
Managing weight gain as a side effect of

... unexpected increases in body weight occur during long-term treatment as opposed to shortterm treatment with SSRIs.18 In its revised practice guideline for the treatment of major depressive disorder,19 the American Psychiatric Association acknowledges that the literature differs as to whether patient ...
Supranuclear control of ocular motility
Supranuclear control of ocular motility

... undergo concurrent activation. The descending ocular motor connections differ from those of the skeletal motor system in that they do not perpetrate the usual “upper motor neuron–lower motor neuron” sequence. Cortical neurons do not project directly to ocular motoneurons in the brainstem. For both s ...
Stress-induced enhancement of response inhibition
Stress-induced enhancement of response inhibition

... immediately before and about 30 min after the stop-signal task. Saliva samples were stored at 20 8C until analysis. From saliva we analyzed cortisol concentrations using an immunoassay (IBL International). Inter- and intraassay coefficients of variance were below 10%. 2.2.3. Stop-signal task Thirty ...
Cortical modulation of pain
Cortical modulation of pain



... have a hypotensive action and to stimulate uterine contraction in rabbits .(3) The latter two actions were thought to involve a cholinergic mechanism . The action of corn silk extract on experimental periodontolysis in hamsters has been documented .(4 Cryptoxanthin is stated to possess vitamin A act ...
Micardis HCT - Boehringer Ingelheim
Micardis HCT - Boehringer Ingelheim

... MICARDIS HCT (telmisartan and hydrochlorothiazide) is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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