Bioinformatic tools for analysis, mining and modelling large
... individual by identifying the molecular disease signature from a patient and then matching it with the most appropriate treatment[1-3]. For decades, clinicians have offered the same kind of treatment for the same type of cancer, despite being aware that drug treatments only work on a subset of patie ...
... individual by identifying the molecular disease signature from a patient and then matching it with the most appropriate treatment[1-3]. For decades, clinicians have offered the same kind of treatment for the same type of cancer, despite being aware that drug treatments only work on a subset of patie ...
Eye Disease Fact Sheet LEBER CONGENITAL AMAUROSIS
... ERG testing may be done on one or both eyes. Drops are put in the eye and the child must stay in a dark room for at least 30 minutes. Large contact lenses are inserted into the eye and it is exposed to flashes of light. This can be done under anesthesia, if need-be. The eye’s electrical response to ...
... ERG testing may be done on one or both eyes. Drops are put in the eye and the child must stay in a dark room for at least 30 minutes. Large contact lenses are inserted into the eye and it is exposed to flashes of light. This can be done under anesthesia, if need-be. The eye’s electrical response to ...
Preserving information in neural transmission - CNL
... time available for recordings. The signal-to-noise ratio needed to record EPSPs extracellularly meant that the electrode was often very close to, if not touching, the cell. Recordings rarely lasted more than an hour, because the neuron could be injured with even minor relative motion between the ele ...
... time available for recordings. The signal-to-noise ratio needed to record EPSPs extracellularly meant that the electrode was often very close to, if not touching, the cell. Recordings rarely lasted more than an hour, because the neuron could be injured with even minor relative motion between the ele ...
Depressants Sedative Hypnotics
... • Can significantly impair cognitive performance (especially memory) • Decreases academic performance • Reduces psychomotor functioning • Effects can occur for long periods after the drugs are discontinued • Impairments decrease over time (usually) ...
... • Can significantly impair cognitive performance (especially memory) • Decreases academic performance • Reduces psychomotor functioning • Effects can occur for long periods after the drugs are discontinued • Impairments decrease over time (usually) ...
Hypoxia-Induced Respiratory Patterned Activity in Lymnaea
... Inoue, T., Z. Haque, K. Lukowiak, and N. I. Syed. Hypoxiainduced respiratory patterned activity in Lymnaea originates at the periphery. J Neurophysiol 86: 156 –163, 2001. Respiration in Lymnaea is a hypoxia-driven rhythmic behavior, which is controlled by an identified network of central pattern gen ...
... Inoue, T., Z. Haque, K. Lukowiak, and N. I. Syed. Hypoxiainduced respiratory patterned activity in Lymnaea originates at the periphery. J Neurophysiol 86: 156 –163, 2001. Respiration in Lymnaea is a hypoxia-driven rhythmic behavior, which is controlled by an identified network of central pattern gen ...
cont`d. - PSY388
... immediately opens ion channels • Transmitter-gated or ligand-gated channels are channels controlled by a neurotransmitter ...
... immediately opens ion channels • Transmitter-gated or ligand-gated channels are channels controlled by a neurotransmitter ...
Chapter 15. Diuretic Agents
... small contribution, the collecting tubule plays an important role in renal physiology and in diuretic action. As the final site of NaCl reabsorption, the collecting tubule is responsible for volume regulation and for determining the final Na+ concentration of the urine. Furthermore, the collecting t ...
... small contribution, the collecting tubule plays an important role in renal physiology and in diuretic action. As the final site of NaCl reabsorption, the collecting tubule is responsible for volume regulation and for determining the final Na+ concentration of the urine. Furthermore, the collecting t ...
What in the brain tells us that this is pain - HAL
... Knowledge on human cortical pain processing has received tremendous impetus in the last 20 years, through the use of functional brain imaging and electrophysiology combined with stimulus procedures that selectively activate nociceptive pathways. The concept of “Pain Matrix” (PM) arose in the early 9 ...
... Knowledge on human cortical pain processing has received tremendous impetus in the last 20 years, through the use of functional brain imaging and electrophysiology combined with stimulus procedures that selectively activate nociceptive pathways. The concept of “Pain Matrix” (PM) arose in the early 9 ...
ACTELION`S NEW DUAL OREXIN RECEPTOR ANTAGONIST
... Actelion has significant expertise in the discovery and development of DORAs ...
... Actelion has significant expertise in the discovery and development of DORAs ...
Granulomatous Meningoencephalomyelitis in Dogs
... with accumulation of pigment and adhesions to the underlying choroid may also occur.13,14 Occasionally, classic perivascular lesions may extend into the sclera.15,17 The origin of inflammatory cells in GME is controversial. These cells may result from the migration of blood-derived inflammatory cell ...
... with accumulation of pigment and adhesions to the underlying choroid may also occur.13,14 Occasionally, classic perivascular lesions may extend into the sclera.15,17 The origin of inflammatory cells in GME is controversial. These cells may result from the migration of blood-derived inflammatory cell ...
Bounded Integration in Parietal Cortex Underlies
... In many instances, a decision between alternatives must also incorporate a rule for terminating the decision process, in effect stopping the deliberation and committing to a choice. A large body of theoretical and experimental work supports the idea that a single mechanism accounts for both the term ...
... In many instances, a decision between alternatives must also incorporate a rule for terminating the decision process, in effect stopping the deliberation and committing to a choice. A large body of theoretical and experimental work supports the idea that a single mechanism accounts for both the term ...
Infant Feeding Guidelines for Drug Using Mothers
... alcohol and will ask for advice. Parents should be informed that for most drugs the benefits of breastfeeding far outweigh the disadvantages, even with continued drug use. It is important to reassure the mother that the actual amount of drugs passed to the baby through breast milk is usually minimal ...
... alcohol and will ask for advice. Parents should be informed that for most drugs the benefits of breastfeeding far outweigh the disadvantages, even with continued drug use. It is important to reassure the mother that the actual amount of drugs passed to the baby through breast milk is usually minimal ...
Audition, the Body Senses, and the Chemical Senses
... • The stimuli • The cutaneous senses respond to several different types of stimuli: pressure, vibration, heating, cooling, and events that cause tissue damage (and hence pain). • Some receptors report changes in _______________ to the brain; providing our sense of ______________. • Additional recept ...
... • The stimuli • The cutaneous senses respond to several different types of stimuli: pressure, vibration, heating, cooling, and events that cause tissue damage (and hence pain). • Some receptors report changes in _______________ to the brain; providing our sense of ______________. • Additional recept ...
Ophthalmic adverse drug reactions to systemic drugs
... Ophthalmology are rare, some ADRs might be extremely frequent (such as cornea verticillata caused by amiodarone8), but require specific ophthalmological examination for its detection. Every ocular structure might be affected by an ADR. There is a need for performing specific systematic reviews of opht ...
... Ophthalmology are rare, some ADRs might be extremely frequent (such as cornea verticillata caused by amiodarone8), but require specific ophthalmological examination for its detection. Every ocular structure might be affected by an ADR. There is a need for performing specific systematic reviews of opht ...
Inotropes
... ischemia. There is a pressing need for new inotropic agents that avoid these harmful effects. This review describes the mechanism of action and the clinical utility of some of the older inotropic agents, which are still commonly used, and provides an update for physicians on the development of newer ...
... ischemia. There is a pressing need for new inotropic agents that avoid these harmful effects. This review describes the mechanism of action and the clinical utility of some of the older inotropic agents, which are still commonly used, and provides an update for physicians on the development of newer ...
2nd T. 4th L. Updated
... 3. Hepatotoxicity and renal toxicity occur less frequently 4. With higher doses, patients may experience salicylism (vomiting, tinnitus, decreased hearing, and vertigo) reversible by reducing the dosage 5. Still larger doses of salicylates cause hyperpnea through a direct effect on the medulla. At t ...
... 3. Hepatotoxicity and renal toxicity occur less frequently 4. With higher doses, patients may experience salicylism (vomiting, tinnitus, decreased hearing, and vertigo) reversible by reducing the dosage 5. Still larger doses of salicylates cause hyperpnea through a direct effect on the medulla. At t ...
The Řie-Tozer Model of Drug D
... However, more detailed mechanism-based distribution models should be used in pre-clinical and clinical settings for drugs that exhibit more complex pharmacokinetic behavior. ...
... However, more detailed mechanism-based distribution models should be used in pre-clinical and clinical settings for drugs that exhibit more complex pharmacokinetic behavior. ...
ART 2015 AdvAnced ReTinAl TheRApy
... Angiographic OCT in retinal diagnosis is a brilliant example of improving practicality for patients and knowledge for doctors. The modality has therefore rapidly gained acceptance in the clinics. It is now the responsibility of ophthalmologists to extract as much diagnostic features as possible, but ...
... Angiographic OCT in retinal diagnosis is a brilliant example of improving practicality for patients and knowledge for doctors. The modality has therefore rapidly gained acceptance in the clinics. It is now the responsibility of ophthalmologists to extract as much diagnostic features as possible, but ...
Deep Brain stimulation in the Treatment of Dystonia – The
... Externus] Adapted from Breakefield et al.2 ...
... Externus] Adapted from Breakefield et al.2 ...
Adverse Effects of Antiepileptic Drugs
... is not universal, and a list of AED adverse effects may include terms taken from other sources, such as the World Health Organization’s Adverse Reaction Terminology (WHO-ART), International Classification of Diseases (ICD) 9, and ICD9-CM. To improve the terminology used to describe adverse effects, ...
... is not universal, and a list of AED adverse effects may include terms taken from other sources, such as the World Health Organization’s Adverse Reaction Terminology (WHO-ART), International Classification of Diseases (ICD) 9, and ICD9-CM. To improve the terminology used to describe adverse effects, ...
pharmacology basic principles
... o A receptors affinity for a drug determines conc of drug required to form significant no of drug-receptor complexes o Total no of receptors limits max effect a drug can produce Receptors determine selectivity of drug action o Change in chemical structure of drug change affinities for diff classes ...
... o A receptors affinity for a drug determines conc of drug required to form significant no of drug-receptor complexes o Total no of receptors limits max effect a drug can produce Receptors determine selectivity of drug action o Change in chemical structure of drug change affinities for diff classes ...
Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo NEUROSYSTEMS
... Fig. 3. Hyperpolarizing current stimulation at specific input phases of the oscillation increased the probability of subsequent spikes at the peak of the oscillation in some neurons. (A) Polar plot of the input phase of hyperpolarizing current stimulation that elicited subsequent spikes of a putative ...
... Fig. 3. Hyperpolarizing current stimulation at specific input phases of the oscillation increased the probability of subsequent spikes at the peak of the oscillation in some neurons. (A) Polar plot of the input phase of hyperpolarizing current stimulation that elicited subsequent spikes of a putative ...
Network effects of deep brain stimulation
... STN stimulation for the treatment of PD. Unless otherwise stated, the studies reviewed in the STN sections below involve DBS of the sensorimotor territory of the STN for PD. A current hypothesis for the therapeutic effects of STN DBS in PD is that STN stimulation decreases pathological synchronizati ...
... STN stimulation for the treatment of PD. Unless otherwise stated, the studies reviewed in the STN sections below involve DBS of the sensorimotor territory of the STN for PD. A current hypothesis for the therapeutic effects of STN DBS in PD is that STN stimulation decreases pathological synchronizati ...
body proportions in infancy and early childhood
... – Brain cells that are specialized to communicate with one another to make it possible for people to sense the world, think, move their body, and carry out their lives ...
... – Brain cells that are specialized to communicate with one another to make it possible for people to sense the world, think, move their body, and carry out their lives ...