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CS325 Artificial Intelligence Chs. 9, 12 – Knowledge Representation
CS325 Artificial Intelligence Chs. 9, 12 – Knowledge Representation

... Chs. 9, 12 – Knowledge Representation and Inference Cengiz Günay, Emory Univ. ...
Functional Specialization Within the Cat Red Nucleus
Functional Specialization Within the Cat Red Nucleus

... by RNm stimulation. Although the shoulder muscles, sd and ss, were more likely to be facilitated by RNp stimulation (49 vs. 21%), the overall pattern of muscle activation between RNm and RNp was not significantly different (␹2 ⫽ 2.9, 6 df, P ⬎ 0.50). Therefore stimulation within RN did not support a ...
Author`s personal copy
Author`s personal copy

... criteria (including cytoarchitecture, myeloarchitecture, and connectivity patterns) and functional criteria such as tuning properties [13,21,24,25]. A logical consequence of this principle is that any individual anatomically or functionally defined area will contain no more than a single representat ...
lead paint litigation - American Bar Association
lead paint litigation - American Bar Association

... resulting in cognitive deficits. Physicians may also testify that damage to the central nervous system is proof of an injury. Moreover, plaintiffs’ experts may testify that lead impairs nerve cells’ ability to communicate with one another. Lead also interferes with mitochondria, which are organelles ...
Bursting Neurons Signal Input Slope
Bursting Neurons Signal Input Slope

... frequencies. Figure 3D shows the mean slope of the stimuli preceding bursts at a range of frequencies. The maximal positive slopes (dark red) always precede bursts. Note, that at ⬎10 Hz there is a frequency-dependent delay of bursts up to ⬃20 msec. This frequency-dependent delay could degrade the te ...
powerpoint lecture
powerpoint lecture

... Four Generalizations of Cerebral Cortex • Functional areas – Motor areas—control voluntary movement – Sensory areas—conscious awareness of sensation – Association areas—integrate diverse information ...
Effect of cranberry dietary supplements with
Effect of cranberry dietary supplements with

... caused a mechanism-based inhibition during CYP3A-mediated oxidation of nifedipine both in human liver and rat intestinal microsomes (Uesawa and Mohri, 2006). The authors suggested that a component or components present in cranberry juice inhibit human CYP3A-mediated metabolism of nifedipine. Inhibit ...
Fatal intoxication due to tramadol alone Case report and review of
Fatal intoxication due to tramadol alone Case report and review of

... as high as 175 IU/l, a liver biopsy was performed the next day, showing both steatosis and centrolobular necrosis. Therapy was mainly supportive including the initiation of antibiotics, pulmonary artery catheter guided fluid management, inotropics and vasopressor therapy, enemas with lactulose becau ...
Tyrosine phosphorylation at the MET catalytic doamin and
Tyrosine phosphorylation at the MET catalytic doamin and

... murine cell infiltration and a resulting increase in murine protein content were contributing to the apparent decline in absolute MET levels as tumors grew larger (14). Normalization of MET levels to human DNA content was partially effective in countering this variability (Figure S5D, E). Note also ...
Principles of Neural Science - Weizmann Institute of Science
Principles of Neural Science - Weizmann Institute of Science

... The region of the retina from which the ganglion cell axons exit, the optic disc, contains no photoreceptors and therefore is insensitive to light—a blind spot in the retina. Since the disc is nasal to the fovea in each eye (Figure 27-1), light coming from a single point in the binocular zone never ...
(2012) Prediction of economic choice by primate amygdala neurons
(2012) Prediction of economic choice by primate amygdala neurons

... and it is involved in value-guided behavior. Damage to the amygdala in humans is related to changes in decision-making under conditions of ambiguity (1) and risk (2). In monkeys and rats, amygdala lesions impair reward-related and affective behavior (3, 4). Individual amygdala neurons respond to bas ...
Article 5  - Graduate Program in Neuroscience | UBC
Article 5 - Graduate Program in Neuroscience | UBC

... and unrewarded movement. A red square trigger stimulus presented at 2.5–3.5 s after instruction onset required the animal to execute or withhold a reaching movement according to the trial type. The trigger stimulus was the same in all three trial types. In rewarded movement trials, the animal releas ...
safety reporting requirements for clinical drug trials
safety reporting requirements for clinical drug trials

... other appropriate people aware of new, important information on serious reactions. Therefore, such reporting will generally involve events previously unobserved or undocumented, and a guideline is needed on how to define an event as “unexpected” or “expected” (expected/unexpected from the perspectiv ...
Prescribing Information
Prescribing Information

... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety assessment is based on al ...
Grapefruit-medication interactions: Forbidden fruit or avoidable
Grapefruit-medication interactions: Forbidden fruit or avoidable

... dose.6 In other words, felodipine has low innate bioavailability. For this reason, it is subject to a potentially dramatic increase in systemic exposure and associated higher risk of overdose with grapefruit as a result of diminished CYP3A4 activity, primarily in the small intestine rather than in t ...
pdf
pdf

... Female rats show enhanced maternal responsiveness toward their young if they have had maternal experiences before. This kind of maternal experience-based memory is critically dependent on the mesolimbic dopamine (DA) system, especially the nucleus accumbens (NA) shell. However, the relative contribu ...
RECENT ADVANCES IN PAIN MANAGEMENT: RECENT
RECENT ADVANCES IN PAIN MANAGEMENT: RECENT

... GI ulcers or ulcer complications (such as perforations or bleeding) 29% less chance of having nausea 22% less chance of abdominal pain Increase risk for heart attack , thrombosis & stroke by a relative increase in thromboxane . PARACETAMOL: PARACETAMOL Central antinociceptive effect & potential mech ...
Chapter 12 PowerPoint - Hillsborough Community College
Chapter 12 PowerPoint - Hillsborough Community College

... Clinical – Homeostatic Imbalance 12.1 • Muscle strength or ability to perform discrete individual movements is not impaired; only control over movements is lost – Example: damage to premotor area controlling movement of fingers would still allow fingers to move, but voluntary control needed to type ...
transcutaneous drug delivery system: a comprehensive review
transcutaneous drug delivery system: a comprehensive review

... At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks – namely poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high ...
Resting-state functional connectivity in neuropsychiatric disorders
Resting-state functional connectivity in neuropsychiatric disorders

... is made up of several regions, including the posterior cingulate cortex, the posterolateral parietal cortices, and the medial temporal lobes/hippocampi that are known from PET studies to be targeted early in the course of Alzheimer’s disease [23,24]. We reported reduced connectivity within the DMN, ...
'  STATE OF WISCONSIN DEPARTMENT OF JUSTICE
' STATE OF WISCONSIN DEPARTMENT OF JUSTICE

... and attached documents . (CPR 2001, pp. i-9 (Petition and attachments .) It confirmed more than five years ago - that relevant, peer-reviewed scientific literature had established all FDA criteria for the requested switch : First, EC is safe for self-medication because it is not toxic to the woman ( ...
Caenorhabditis elegans: A versatile platform for drug discovery
Caenorhabditis elegans: A versatile platform for drug discovery

... in vitro assays and mammalian models since it allows high-throughput approaches, while still providing relevant physiological information. How MOA studies are performed in C. elegans is depicted in Fig. 2. In the past decades, small-molecule drug discovery has been mostly based on target-specific ap ...
Computation with Spikes in a Winner-Take-All Network
Computation with Spikes in a Winner-Take-All Network

... the excitatory connections from excitatory neurons to interneurons and the inhibitory connections from interneurons to excitatory neurons. In our model, we assume the forward connections between the excitatory and the inhibitory neurons to be strong, so that each spike of an excitatory neuron trigge ...
Pharmaceutical and Medical Pharmaceutical and Medical
Pharmaceutical and Medical Pharmaceutical and Medical

... The USP 33 – NF 28 features more than 4200 monographs in a new uniform design, cross-references, and updated and concise language, making it easier to find and follow standards information. It also offers harmonized material and more than 200 General Chapters with current guidelines for the full rang ...
Age-dependent effect of cholinergic lesion on dendritic morphology
Age-dependent effect of cholinergic lesion on dendritic morphology

... 1. Introduction Plasticity has long been known to be a property of developing nervous systems. Although originally considered to be a developmental phenomenon, plasticity extends into adulthood as well, underlying a variety of processes, including learning and memory as well as recovery from injury. ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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