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Chapter 4. Hard and Soft Acid/Base Theory based on Lewis Acids
Chapter 4. Hard and Soft Acid/Base Theory based on Lewis Acids

... Definitions of Lewis Acid-Base Theory. Lewis acid/base theory (sometimes called donoracceptor theory) is a broad, widely applicable approach to the classification of chemical substances and the analysis of chemical reactions. According to this theory, a base is defined as an electron pair donor, and ...
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Nucleophilic acyl substitution



Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds. In this type of reaction, a nucleophile – such as an alcohol, amine, or enolate – displaces the leaving group of an acyl derivative – such as an acid halide, anhydride, or ester. The resulting product is a carbonyl-containing compound in which the nucleophile has taken the place of the leaving group present in the original acyl derivative. Because acyl derivatives react with a wide variety of nucleophiles, and because the product can depend on the particular type of acyl derivative and nucleophile involved, nucleophilic acyl substitution reactions can be used to synthesize a variety of different products.
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