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Hot Topics in Protein Medicinal Chemistry
Hot Topics in Protein Medicinal Chemistry

... David Tirrell, California Institute of Technology “Non-Canonical Amino Acids as Tools for Protein Medicinal Chemistry” ...
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Reading- HONC While You`re CLPN

... directly involved in making proteins and proteins control the physical characteristics of cells. There are two nucleic acid polymers: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The function of DNA is to store genetic information. RNA, however, is directly involved in making proteins. Nu ...
DNA-RNA-Protein Synthesis
DNA-RNA-Protein Synthesis

... this point on, do work only in the appropriate areas. Discuss with your group where the supplies (parts) you will need should be located in the cell. Have the artist draw it and the recorder write it down. Discuss as a group the process of transcription. Model, draw, and record the process. Remember ...
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... Products of Transcription • Transfer RNA “Translates” the message by bringing a specific amino acid into the correct position on the growing protein chain Has ANTICODON = a group of three nucleotides on a tRNA that recognizes a mRNA codon Has amino acid attachment site ...
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... -Volume increases by the radius cubed. -More material with less exposure to solute.- advantage because fighting for stability against aqueous environment. 2. Exclusion of mutated proteins -If have mutation, subunit will not be incorporated into 4° structure-exception: collagen or other structural pr ...
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... and the ML method is computationally more intensive and requires and explicit model for the process of molecular evolution., although it does not suffer from the same biases as MP method. On the other hand, the site-specific substitution rate also reduces the accuracy of these methods. Model To over ...
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... Here, it can easily be seen that three amino acids are called by six different codons, five amino acids are called by four different codons, one amino acid is called by three different codons, nine amino acids are called by two different codons, and two amino acids have but one codon each. In all ca ...
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... Proteins contain carbon, hydrogen, oxygen, nitrogen, and usually sulphur or phosphorus atoms. Proteins are macromolecules that consist of long, unbranched chains of amino acids. These chains may contain about 20 up to hundreds of amino acids. An example of the size of proteins is the red pigment in ...
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... C. 4 types of organic molecules in living things : 1. Carbohydrates – compounds made up of carbon, hydrogen, & oxygen atoms, usually in a ratio of 1 :2 :1, ex : sugars, starches, & cellulose. **Living things use carbohydrates as their main source of energy.** -Energy for cell activities comes from ...
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Genetic changes - Southington Public Schools

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... Proteins: A large molecule made up of amino acids Amino acid: A small molecule that is made up of Carbon, Hydrogen, Nitrogen, and Oxygen. Proteins are large chains of amino acids that bond together and then fold to create useable cell parts. Proteins also make up enzymes which speed up ...
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... Correction for rate heterogeneity among sites (G [a]+ pinv) Assume neutrality - what if there are biases, or non neutral changes - such as selection? ...
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Expanded genetic code



An expanded genetic code is an artificially modified genetic code in which one or more specific codons have been re-allocated to encode an amino acid that is not among the 22 encoded proteinogenic amino acids.The key prerequisites to expand the genetic code are: the non-standard amino acid to encode, an unused codon to adopt, a tRNA that recognises this codon, and a tRNA synthase that recognises only that tRNA and only the non-standard amino acid.Expanding the genetic code is an area of research of synthetic biology, an applied biological discipline whose goal is to engineer living systems for useful purposes. The genetic code expansion enriches the repertoire of useful tools available to science.
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