Wk13-P.aerug.
... activation, 3-oxo-C12-HSL inhibited the release of this cytokine when T cells were stimulated Suggesting that 3-oxo-C12-HSL is acting upstream of IL2 secretion while PQS is preventing proliferation by acting downstream of IL-2 TNF-ά secretion was assessed in assays where LPS was used to drive TNF-ά ...
... activation, 3-oxo-C12-HSL inhibited the release of this cytokine when T cells were stimulated Suggesting that 3-oxo-C12-HSL is acting upstream of IL2 secretion while PQS is preventing proliferation by acting downstream of IL-2 TNF-ά secretion was assessed in assays where LPS was used to drive TNF-ά ...
Chapter 21a
... Our cells are dotted with protein molecules (selfantigens) that are not antigenic to us but are strongly antigenic to others ...
... Our cells are dotted with protein molecules (selfantigens) that are not antigenic to us but are strongly antigenic to others ...
Contribution of Renal Tubule Epithelial Cells in the Innate Immune
... Sanae Ben Mkaddem, PhD; Cecilia Chassin, PhD; Alain Vandewalle, MD, PhD The epithelial cells that line the renal tubule are sometimes severely injured in the course of inflammatory kidney diseases. These renal tubule epithelial cells (RTECs) express some of the Toll-like receptors (TLRs) of the inna ...
... Sanae Ben Mkaddem, PhD; Cecilia Chassin, PhD; Alain Vandewalle, MD, PhD The epithelial cells that line the renal tubule are sometimes severely injured in the course of inflammatory kidney diseases. These renal tubule epithelial cells (RTECs) express some of the Toll-like receptors (TLRs) of the inna ...
Toll-like receptors and immune regulation: their direct and indirect
... The family of Toll-like receptors (TLRs) is a major class of receptors that recognize molecular patterns associated with pathogens including bacteria, viruses, fungi and protozoa. It was commonly accepted that TLR-mediated recognition of specific structures of invading pathogens initiates innate as ...
... The family of Toll-like receptors (TLRs) is a major class of receptors that recognize molecular patterns associated with pathogens including bacteria, viruses, fungi and protozoa. It was commonly accepted that TLR-mediated recognition of specific structures of invading pathogens initiates innate as ...
The role of microRNA-1246 in the regulation of B cell activation and
... Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease which affects multiple organ systems and causes significant morbidity and mortality [1]. One of the hallmarks of SLE is the production of anti-nuclear autoantibodies by uncontrolled over-activated B cells [2]. The au ...
... Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease which affects multiple organ systems and causes significant morbidity and mortality [1]. One of the hallmarks of SLE is the production of anti-nuclear autoantibodies by uncontrolled over-activated B cells [2]. The au ...
Melatonin protects against experimental immune ovarian failure in
... Several ovarian disorders in women including premature ovarian failure [8, 17, 18], polycystic ovary syndrome (in which immunological disturbances may be secondary; [8, 20]), some types of oophoritis [20] or unexplained infertility [8, 17] are associated with autoimmune factors. They have been repor ...
... Several ovarian disorders in women including premature ovarian failure [8, 17, 18], polycystic ovary syndrome (in which immunological disturbances may be secondary; [8, 20]), some types of oophoritis [20] or unexplained infertility [8, 17] are associated with autoimmune factors. They have been repor ...
Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
Host immune responses during Brucella infection
... Brucella spp. by opsonization [74]. Brucella lipoproteins, including lipidated outer membrane protein 19 (L‐Omp 19), can activate human neutrophil functions such as oxidative burst, neutrophil migration and neutrophil survival [77]. In contrast to macrophages, bruce ...
... Brucella spp. by opsonization [74]. Brucella lipoproteins, including lipidated outer membrane protein 19 (L‐Omp 19), can activate human neutrophil functions such as oxidative burst, neutrophil migration and neutrophil survival [77]. In contrast to macrophages, bruce ...
Immunological Methods and their Application
... Define auto-immunity and explain origin of autoimmune diseases Describe MHC of man and role in tissue/graft rejection Define allergy/hypersensitivity and differentiate the different types of hyper sensitivity reactions. Explain the basic principles of immunological methods and state their applicatio ...
... Define auto-immunity and explain origin of autoimmune diseases Describe MHC of man and role in tissue/graft rejection Define allergy/hypersensitivity and differentiate the different types of hyper sensitivity reactions. Explain the basic principles of immunological methods and state their applicatio ...
Differential In Situ Cytokine Profiles of Langerhans
... Fig 2. Identification of cellular origin of cytokines in LCH biopsies. Double immunohistochemical labeling was used to determine cytokine profiles of T cells and LCH cells in frozen sections of LCH biopsies. IL-1a (red) is not produced by CD31 T cells (blue), as shown by the absence of intermediate ...
... Fig 2. Identification of cellular origin of cytokines in LCH biopsies. Double immunohistochemical labeling was used to determine cytokine profiles of T cells and LCH cells in frozen sections of LCH biopsies. IL-1a (red) is not produced by CD31 T cells (blue), as shown by the absence of intermediate ...
Innate Immune Cells: Key Regulators of Homeostasis and
... SIGIRR expression is reduced in intestinal epithelial cells in order to ensure proper TLR signaling [31]. Moreover, expression of the TLR4 adaptor molecule MD2 is supposedly low in intestinal epithelial cells in order to reduce inflammatory reactivity to bacterial cell wall components [27]. Macropha ...
... SIGIRR expression is reduced in intestinal epithelial cells in order to ensure proper TLR signaling [31]. Moreover, expression of the TLR4 adaptor molecule MD2 is supposedly low in intestinal epithelial cells in order to reduce inflammatory reactivity to bacterial cell wall components [27]. Macropha ...
Probiotic Induce Macrophage Cytokine Production via Activation of
... process antigens for presentation to T cells on MHCII molecule; ultimately, the expression of molecules such as MHC 1 and MHC 11 and co-stimulatory molecules, B7-1 (CD80) and B7-2(CD86) by macrophages due it to involve in antigen processing and presentation leading to direct adaptive immunity [2]. H ...
... process antigens for presentation to T cells on MHCII molecule; ultimately, the expression of molecules such as MHC 1 and MHC 11 and co-stimulatory molecules, B7-1 (CD80) and B7-2(CD86) by macrophages due it to involve in antigen processing and presentation leading to direct adaptive immunity [2]. H ...
lec 9-17
... Bursa of fabricius (organ for development of B cells in chickens) T cells are found in walls of gut and respiratory tract have Payer’s patches (aggregates of lymphocytes), epithelial layer that protects is 1 layer thick, secrete IgA (gut and respiratory bulk of infx) IgA – secretory immunoglobin th ...
... Bursa of fabricius (organ for development of B cells in chickens) T cells are found in walls of gut and respiratory tract have Payer’s patches (aggregates of lymphocytes), epithelial layer that protects is 1 layer thick, secrete IgA (gut and respiratory bulk of infx) IgA – secretory immunoglobin th ...
Dynamics of Lymphocytic Subpopulations in
... to FLY (1 1), but the role of the host immune response to FLY is still uncertain. In the responses of mice to leukemia and sarcoma virus induced tumors, several different cell-mediated immune mech anisms have been demonstrated in vitro (17—19),but the in vivo roles and relative importances of thes ...
... to FLY (1 1), but the role of the host immune response to FLY is still uncertain. In the responses of mice to leukemia and sarcoma virus induced tumors, several different cell-mediated immune mech anisms have been demonstrated in vitro (17—19),but the in vivo roles and relative importances of thes ...
Seasonal Allergies and Histamine Response
... who have seasonal allergies tend to see a worsening of these symptoms during spring time. Decreasing high histamine One supplement is not always effective in decreasing histamine levels. A combination of supplements is typically required to help keep the behavioral, mental and physical symptoms of h ...
... who have seasonal allergies tend to see a worsening of these symptoms during spring time. Decreasing high histamine One supplement is not always effective in decreasing histamine levels. A combination of supplements is typically required to help keep the behavioral, mental and physical symptoms of h ...
Cutaneous Lymphomas - Abdel Hamid Derm Atlas
... constantly circulate in the naïve form (virgin, not exposed to antigens) in blood and peripheral lymphoid organs. When T lymphocytes are presented, in the lymph nodes, to antigens coming from the skin (effector lymphocytes, memory lymphocytes) they express markers on their surface, which turns them ...
... constantly circulate in the naïve form (virgin, not exposed to antigens) in blood and peripheral lymphoid organs. When T lymphocytes are presented, in the lymph nodes, to antigens coming from the skin (effector lymphocytes, memory lymphocytes) they express markers on their surface, which turns them ...
Antibodies used for the detection of leukocyte subsets - HAL
... accumulation in the SNpc following MPTP intoxication is beneficial or harmful to DNs, we compared the effects of the toxin in T-cell antigen receptor beta gene mutant mice lacking mature T lymphocytes (Tcrb-/-) (15) and in their wild-type (WT) littermates. We found that whereas only 72% of the nigra ...
... accumulation in the SNpc following MPTP intoxication is beneficial or harmful to DNs, we compared the effects of the toxin in T-cell antigen receptor beta gene mutant mice lacking mature T lymphocytes (Tcrb-/-) (15) and in their wild-type (WT) littermates. We found that whereas only 72% of the nigra ...
Mast Cells in Autoimmune Disease - Direct-MS
... the antibodies that they produce, may also be important, although this is still under debate. Numerous studies, dating as far back as 100 years, have reported a correlation between the number and/or distribution of mast cells and the development of multiple sclerosis or EAE (reviewed in ref. 17). Ev ...
... the antibodies that they produce, may also be important, although this is still under debate. Numerous studies, dating as far back as 100 years, have reported a correlation between the number and/or distribution of mast cells and the development of multiple sclerosis or EAE (reviewed in ref. 17). Ev ...
Airway smooth muscle cells respond directly to inhaled
... www.smw.ch – Early Online Publication, 4. May 2010 ...
... www.smw.ch – Early Online Publication, 4. May 2010 ...
A minimum of two distinct heritable factors are required to explain
... of the interdivisional variation or its significance is still not known. Cells undergoing apoptosis also show variation in times to die that are consistent with a stochastic internal process that is at least partly the result of a balance of anti- and pro-apoptotic molecules (Hawkins et al. 2007; Spe ...
... of the interdivisional variation or its significance is still not known. Cells undergoing apoptosis also show variation in times to die that are consistent with a stochastic internal process that is at least partly the result of a balance of anti- and pro-apoptotic molecules (Hawkins et al. 2007; Spe ...
Current Perspective on In Vivo Molecular Imaging of Immune Cells
... macrophages. Macrophages that reside inside or in close proximity to tumors and assist tumor progression are primarily classified as tumor-associated macrophages (TAMs). They facilitate formation of tumors by secreting pro-angiogenic factors and tumor immune evasion, promoting metastasis and neoplas ...
... macrophages. Macrophages that reside inside or in close proximity to tumors and assist tumor progression are primarily classified as tumor-associated macrophages (TAMs). They facilitate formation of tumors by secreting pro-angiogenic factors and tumor immune evasion, promoting metastasis and neoplas ...
Antoine Roquilly, MD (1-2), Alexis Broquet, PhD (1), Cedric Jacqueline,... Gautreau, PhD (3-4), Jean Pierre Segain, PhD (5), Pierre de... TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural...
... pneumonia [2]. This post-traumatic susceptibility to sepsis has been related to a state of immunosuppression lasting 7 to 10 days followed by an immunological recovery [3]. Dendritic cells (DCs) play a major role in linking innate and adaptive immune responses through production of cytokines as well ...
... pneumonia [2]. This post-traumatic susceptibility to sepsis has been related to a state of immunosuppression lasting 7 to 10 days followed by an immunological recovery [3]. Dendritic cells (DCs) play a major role in linking innate and adaptive immune responses through production of cytokines as well ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.