Lymphatic System
... swollen. Such swelling is an indication of an active immune response to infection. Histologically, tonsils do not contain a complete capsule, and the epithelial layer invaginates deeply into the interior of the tonsil to form tonsillar crypts. These structures, which accumulate all sorts of material ...
... swollen. Such swelling is an indication of an active immune response to infection. Histologically, tonsils do not contain a complete capsule, and the epithelial layer invaginates deeply into the interior of the tonsil to form tonsillar crypts. These structures, which accumulate all sorts of material ...
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... CD35+ B220+ precursor cell, which is consistent with several observations of binucleate FDCs (Murakami et al., 2007; Allen and Cyster, 2008). Moreover, differentiation of FDCs as a specialized form of myofibroblasts that derive from bone marrow stromal cell progenitors has been also suggested (Munoz ...
... CD35+ B220+ precursor cell, which is consistent with several observations of binucleate FDCs (Murakami et al., 2007; Allen and Cyster, 2008). Moreover, differentiation of FDCs as a specialized form of myofibroblasts that derive from bone marrow stromal cell progenitors has been also suggested (Munoz ...
FVIII Immunity: Early Events and Tolerance Mechanisms to FVIII
... that in vivo, FVIII does not induce the activation and proliferation of hemophilic T cells. Furthermore, infusing FVIII-pulsed immature dendritic cells into hemophilic mice resulted in a long-term reduction in immune reactivity towards FVIII. Also, ...
... that in vivo, FVIII does not induce the activation and proliferation of hemophilic T cells. Furthermore, infusing FVIII-pulsed immature dendritic cells into hemophilic mice resulted in a long-term reduction in immune reactivity towards FVIII. Also, ...
The Development and Survival of Lymphocytes
... the development of a:b T cells, which recognize composite antigens consisting of peptides bound to MHC molecules, because it ensures that an individual’s T cells will be able to respond to peptides bound to his or her MHC molecules. In contrast, lymphocytes with strongly self-reactive receptors must ...
... the development of a:b T cells, which recognize composite antigens consisting of peptides bound to MHC molecules, because it ensures that an individual’s T cells will be able to respond to peptides bound to his or her MHC molecules. In contrast, lymphocytes with strongly self-reactive receptors must ...
T cell activation: Kinetic proofreading, serial
... undergo a training period in the thymus where they are exposed to circulating cells. Those T cells that react strongly are programmed for apoptosis. Therefore, T cells reaching maturity should not be activated by interactions with self pMHC. As described above, T cells are classified into cytotoxic a ...
... undergo a training period in the thymus where they are exposed to circulating cells. Those T cells that react strongly are programmed for apoptosis. Therefore, T cells reaching maturity should not be activated by interactions with self pMHC. As described above, T cells are classified into cytotoxic a ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,
... During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesi ...
... During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesi ...
Phagocytosis and Encapsulation: Cellular Immune Responses in
... but does it contain opsonic factors? The standard test for serum opsonins is (1980) found that a component of Bombyx the addition of serum-treated or untreated mori (L.) serum causes the elongation of test particles (often mammalian erythro- hemocytic filipodia, an action which could cytes) to hemoc ...
... but does it contain opsonic factors? The standard test for serum opsonins is (1980) found that a component of Bombyx the addition of serum-treated or untreated mori (L.) serum causes the elongation of test particles (often mammalian erythro- hemocytic filipodia, an action which could cytes) to hemoc ...
1 of 39 Induction of immune tolerance to FIX by
... Such danger signals elicit the innate immunity of the host, thus stimulating and causing ...
... Such danger signals elicit the innate immunity of the host, thus stimulating and causing ...
Disruption of Dendritic Cell Instruction Virus and Its Avirulent Vaccine
... a result of migration to the lymph nodes or apoptosis (8, 9). Virulent VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essent ...
... a result of migration to the lymph nodes or apoptosis (8, 9). Virulent VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essent ...
Monomers Peptidoglycan, but Not to Peptidoglycan Respond
... fragments are delivered to immune cells, as follows: uptake of monomeric PGN fragments in clathrin-coated pits (14, 15), delivery of monomeric PGN fragments via bacterially-secreted vesicles (16), surface-expressed NOD proteins where monomeric fragments can be detected (17), or NOD ligands generated ...
... fragments are delivered to immune cells, as follows: uptake of monomeric PGN fragments in clathrin-coated pits (14, 15), delivery of monomeric PGN fragments via bacterially-secreted vesicles (16), surface-expressed NOD proteins where monomeric fragments can be detected (17), or NOD ligands generated ...
Immunotoxicity - KSU Faculty Member websites
... negatively selected, has not yet been studied for other drugs, but may not be specific to cyclosporin A. It represents a distinct mechanism of autoimmunity induced by the action of toxic compounds on the immune system, mediated via thymic selection. Although the medullary area is reduced in young ra ...
... negatively selected, has not yet been studied for other drugs, but may not be specific to cyclosporin A. It represents a distinct mechanism of autoimmunity induced by the action of toxic compounds on the immune system, mediated via thymic selection. Although the medullary area is reduced in young ra ...
Human T-Cell Leukemia Virus Type I Induces Adult T
... with cellular proteins that are transcriptional factors or modulators of cellular functions. In addition to this transcriptional regulation, it is also known that Tax can functionally inactivate p53, p16INK4A, and mitotic arrest deficient (MAD) 1. The PDZ domain-binding motif (PBM) in the C terminus ...
... with cellular proteins that are transcriptional factors or modulators of cellular functions. In addition to this transcriptional regulation, it is also known that Tax can functionally inactivate p53, p16INK4A, and mitotic arrest deficient (MAD) 1. The PDZ domain-binding motif (PBM) in the C terminus ...
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... an important mechanism of action [60–62]. This is mediated primarily through local inflammation induced by virus infection, which stimulates the maturation of DCs and causes them to migrate to the draining lymph nodes, where they can cross-present tumor antigens to naïve T cells [63]. OV-mediated ce ...
... an important mechanism of action [60–62]. This is mediated primarily through local inflammation induced by virus infection, which stimulates the maturation of DCs and causes them to migrate to the draining lymph nodes, where they can cross-present tumor antigens to naïve T cells [63]. OV-mediated ce ...
Local Immune Responses in Human Tuberculosis: Learning From
... monocytes and effector T cells as well as regulatory T (Treg) cells migrate from the blood and accumulate in the area of bacterial replication. The proportion of M. tuberculosis–specific effector T cells producing cytokines and antimicrobial effector molecules are significantly higher at the disease ...
... monocytes and effector T cells as well as regulatory T (Treg) cells migrate from the blood and accumulate in the area of bacterial replication. The proportion of M. tuberculosis–specific effector T cells producing cytokines and antimicrobial effector molecules are significantly higher at the disease ...
HIC1 links retinoic acid signalling to group 3 innate
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
dependent regulation of intestinal immunity and homeostasis
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
Regulatory T cells
... -R cells inhibit E cell activation and production of IL2 by a mechanism requiring their colocalized activation at the APCs -R cells constitutively over express the Alpha chain of IL2R (CD25), while E cells up regulate this molecule transiently after activation. -The main sources of IL2 in vivo are t ...
... -R cells inhibit E cell activation and production of IL2 by a mechanism requiring their colocalized activation at the APCs -R cells constitutively over express the Alpha chain of IL2R (CD25), while E cells up regulate this molecule transiently after activation. -The main sources of IL2 in vivo are t ...
Th17 Cell Frequency and IL-17 Concentration Correlate
... egeneration of the human intervertebral disk (IVD) is a widespread and debilitating disorder characterized by pronounced anatomic and biological changes in a process that is strongly associated with aging.1 Low back pain in humans, which is an increasingly common and costly health problem, is mainly ...
... egeneration of the human intervertebral disk (IVD) is a widespread and debilitating disorder characterized by pronounced anatomic and biological changes in a process that is strongly associated with aging.1 Low back pain in humans, which is an increasingly common and costly health problem, is mainly ...
The potential protective immune responses to synthetic peptides
... Induction of' humoral immune response in guinea-pigs ufter immunisution with P . gingivalis Jimbriae or their qxthetic peptide segments P . ginyicalis strain 38 1 fimbriae (10-500 pg/animal) with or without 500 pg of the semi-synthetic adjuvant GM-53 in FIA were administered in the left hind footpad ...
... Induction of' humoral immune response in guinea-pigs ufter immunisution with P . gingivalis Jimbriae or their qxthetic peptide segments P . ginyicalis strain 38 1 fimbriae (10-500 pg/animal) with or without 500 pg of the semi-synthetic adjuvant GM-53 in FIA were administered in the left hind footpad ...
RNA released from necrotic synovial fluid cells activates rheumatoid
... We also found that activation of synovial fibroblasts in culture with TLR-2 ligands results in the up-regulation of TLR-2 expression and the production of proinflammatory cytokines (6). Moreover, a variety of chemokines typically found in the synovial fluid of RA patients were found to be secreted b ...
... We also found that activation of synovial fibroblasts in culture with TLR-2 ligands results in the up-regulation of TLR-2 expression and the production of proinflammatory cytokines (6). Moreover, a variety of chemokines typically found in the synovial fluid of RA patients were found to be secreted b ...
Lymphatic System - El Camino College
... diseases like Pneumonia attack and kill the person. Memory T-cells live for long periods and alert the immune system when an invader enters the body after 1st infection or vaccination. Recap 1 Lymphatic System 1. Lymphatic system begins as a peripheral network of lymphatic vessels and ends at connec ...
... diseases like Pneumonia attack and kill the person. Memory T-cells live for long periods and alert the immune system when an invader enters the body after 1st infection or vaccination. Recap 1 Lymphatic System 1. Lymphatic system begins as a peripheral network of lymphatic vessels and ends at connec ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.