tuberculosis Mycobacterium Early Infection with Dynamic Roles of
... immune responses to intracellular bacteria, including M. tuberculosis. The absolute requirement for IFN-g in the immune control of TB is well established in animal models (3) and humans (4). IFNg–dependent protection is commonly believed to act through increasing the mycobactericidal activity of mac ...
... immune responses to intracellular bacteria, including M. tuberculosis. The absolute requirement for IFN-g in the immune control of TB is well established in animal models (3) and humans (4). IFNg–dependent protection is commonly believed to act through increasing the mycobactericidal activity of mac ...
Normalizing the environment recapitulates adult human immune
... the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immune system, which may account for failures to translate disease tr ...
... the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immune system, which may account for failures to translate disease tr ...
immunology syllabus 2013 - The University of Texas Medical School
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
Food allergy: separating the science from the mythology
... counteract local and peripheral hypersensitivity against innocuous antigens, such as food proteins. The latter strategy is called oral tolerance when induced via the gut. Homeostatic mechanisms also dampen immune responses to commensal bacteria. The mucosal epithelial barrier and immunoregulatory ne ...
... counteract local and peripheral hypersensitivity against innocuous antigens, such as food proteins. The latter strategy is called oral tolerance when induced via the gut. Homeostatic mechanisms also dampen immune responses to commensal bacteria. The mucosal epithelial barrier and immunoregulatory ne ...
clever-1 as an immune suppressive molecule
... system to protect the host against an infection and to protect self-molecules in different pathophysiological conditions. Pregnancy is one of the conditions where the maternal immune system remains resistant against microbes and yet attains tolerance to protect the fetus, whose genetic material diff ...
... system to protect the host against an infection and to protect self-molecules in different pathophysiological conditions. Pregnancy is one of the conditions where the maternal immune system remains resistant against microbes and yet attains tolerance to protect the fetus, whose genetic material diff ...
Immune response on rabbit does of different genetic
... the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. The third study aimed to evaluate differences in the immune response in maternal lines of reproductive rabbit do ...
... the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. The third study aimed to evaluate differences in the immune response in maternal lines of reproductive rabbit do ...
Aspergillus fumigatus conidia induce interferon-b signalling in respiratory epithelial cells C. Beisswenger*
... that the b-glucan receptor dectin-1 is required for the pro-inflammatory responses of alveolar macrophages to swollen and germinating A. fumigatus conidia. Whether respiratory epithelial cells play an active role in the defence against invading fungal pathogens is not well understood. However, in re ...
... that the b-glucan receptor dectin-1 is required for the pro-inflammatory responses of alveolar macrophages to swollen and germinating A. fumigatus conidia. Whether respiratory epithelial cells play an active role in the defence against invading fungal pathogens is not well understood. However, in re ...
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific
... compartments (TLRs 3, 7, 8, 9) [14,25,26]. The endosomal TLRs are responsible for sensing nucleic acids such as bacterial or viral RNAs and DNAs, while the TLRs of the plasma membrane are able to recognize pathogen-derived sugars, lipoproteins, protozoa, or fungal cell wall components. TLR ligand re ...
... compartments (TLRs 3, 7, 8, 9) [14,25,26]. The endosomal TLRs are responsible for sensing nucleic acids such as bacterial or viral RNAs and DNAs, while the TLRs of the plasma membrane are able to recognize pathogen-derived sugars, lipoproteins, protozoa, or fungal cell wall components. TLR ligand re ...
Mucosal Immunity in Mycobacterial Infections Anna Tjärnlund
... of TNF-α may also aid in the activation of macrophages to produce reactive oxygen and nitrogen intermediates, and help granuloma formation (Flynn et al., 1995; Roach et al., 2002). The significance of these toxic nitrogen oxides in the host defense against M. tuberculosis has been well documented, b ...
... of TNF-α may also aid in the activation of macrophages to produce reactive oxygen and nitrogen intermediates, and help granuloma formation (Flynn et al., 1995; Roach et al., 2002). The significance of these toxic nitrogen oxides in the host defense against M. tuberculosis has been well documented, b ...
iiiiiiiiii - Cancer Research
... .Unusually marked rouleau formation with few if any true clumps. Complete absence of agglutinative effect when compared with the same suspension of cells mixed with autogenous serum. ...
... .Unusually marked rouleau formation with few if any true clumps. Complete absence of agglutinative effect when compared with the same suspension of cells mixed with autogenous serum. ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... Pertl, U., A.D. Luster, N.M. Varki, D. Homann, G. Gaedicke, R.A. Reisfeld, H.N. Lode. IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by singlechain IL-12 gene therapy. J. Immunol. 166:6944-6951 (2001) Oldstone, M.B., H. Lewic ...
... Pertl, U., A.D. Luster, N.M. Varki, D. Homann, G. Gaedicke, R.A. Reisfeld, H.N. Lode. IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by singlechain IL-12 gene therapy. J. Immunol. 166:6944-6951 (2001) Oldstone, M.B., H. Lewic ...
The role of peanut-specific T cell
... response to a food allergen (such as the antigen presenting cells) as well as processes that take place later in the immune response and involve B cells and other effectors, but it is the multiple T cell subsets which orchestrate the overall immune response to antigens, including food allergens, as ...
... response to a food allergen (such as the antigen presenting cells) as well as processes that take place later in the immune response and involve B cells and other effectors, but it is the multiple T cell subsets which orchestrate the overall immune response to antigens, including food allergens, as ...
Molecular and functional characterization of the immunoreceptors CD300d and CD300f
... evolution, the innate immune system appeared before the adaptive immune system 3 and the same innate immunity molecular modules are found in plants and animals, meaning that it arose before the split into these two kingdoms 4. Innate immunity operates through the intertwined action of several cell t ...
... evolution, the innate immune system appeared before the adaptive immune system 3 and the same innate immunity molecular modules are found in plants and animals, meaning that it arose before the split into these two kingdoms 4. Innate immunity operates through the intertwined action of several cell t ...
Gene, environment, microbiome and mucosal immune tolerance in
... their components are only able to activate the innate immune system. The gut commensal segmented filamentous bacterium (SFB), for example, is sufficient to activate Th17 cells in the lamina propria [47] and eventually trigger autoimmunity and inflammatory arthritis [48] (see section Environmental an ...
... their components are only able to activate the innate immune system. The gut commensal segmented filamentous bacterium (SFB), for example, is sufficient to activate Th17 cells in the lamina propria [47] and eventually trigger autoimmunity and inflammatory arthritis [48] (see section Environmental an ...
HEVs, lymphatics and homeostatic immune cell trafficking in lymph
... bulk of lymphocyte trafficking to lymph nodes. During homeostasis, HEVs are found only in lymphoid organs, but they can develop in non-lymphoid tissues during chronic inflammatory diseases6,24 and cancer 25, and they are associated with high levels of lymphocyte infiltration into these tissues (BOX ...
... bulk of lymphocyte trafficking to lymph nodes. During homeostasis, HEVs are found only in lymphoid organs, but they can develop in non-lymphoid tissues during chronic inflammatory diseases6,24 and cancer 25, and they are associated with high levels of lymphocyte infiltration into these tissues (BOX ...
Induction of protective immunity to Cryptococcal infection in mice by
... pathogen and the resolution of the fungal infection (7–9). It is well established that cell-mediated immunity (CMI) plays a critical role in anticryptococcal defense, as is evident from the higher prevalence of cryptococcal infections in immunocompromised patients (1). This is recapitulated in anima ...
... pathogen and the resolution of the fungal infection (7–9). It is well established that cell-mediated immunity (CMI) plays a critical role in anticryptococcal defense, as is evident from the higher prevalence of cryptococcal infections in immunocompromised patients (1). This is recapitulated in anima ...
Thesis - KI Open Archive
... Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal d ...
... Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal d ...
The vitamin D receptor and T cell function
... naïve T cells followed by migration of the resulting effector T cells to the site of infection. Antigen-specific triggering of TCRs expressed on the surface of antigen-naïve T cells together with co-stimulation induces intracellular signaling events that promote upregulation of the VDR (Provvedini e ...
... naïve T cells followed by migration of the resulting effector T cells to the site of infection. Antigen-specific triggering of TCRs expressed on the surface of antigen-naïve T cells together with co-stimulation induces intracellular signaling events that promote upregulation of the VDR (Provvedini e ...
ABSTRACT Title of Document:
... 2.4 Cell culture ..........................................................................................................51 2.5 T cell purification.................................................................................................51 2.6 Estimation of T cell purity by flow cytometry . ...
... 2.4 Cell culture ..........................................................................................................51 2.5 T cell purification.................................................................................................51 2.6 Estimation of T cell purity by flow cytometry . ...
The level of monocyte turnover predicts disease progression in the
... immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression.1 It has also been shown that chronic immune activation predicts ...
... immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression.1 It has also been shown that chronic immune activation predicts ...
Apoptotic Debris Accumulates on Hematopoietic Cells and
... with their deposits in the kidneys and their ability to activate complement (C3) in lupus nephritis (22, 23). However, later studies showed that deposits of IgG and complement persist in the kidneys of lupus-prone mice when proteinuria and morbidity were diminished by blockade or genetic ablation of ...
... with their deposits in the kidneys and their ability to activate complement (C3) in lupus nephritis (22, 23). However, later studies showed that deposits of IgG and complement persist in the kidneys of lupus-prone mice when proteinuria and morbidity were diminished by blockade or genetic ablation of ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.