Macrophage Cell Surface CD4 Type 1 HIV gp120 Induced Loss of A
... Ag gp120 are skewed away from VH3 bearing IgGs, which are normally protective against pathogens (4). Autoimmune responses are also a feature (5, 6) including those against CD4 molecules (7–9). HIV-1 is able to infect CD4⫹ T cells and CD4⫹ APCs, including macrophages and DC, (10 –12). There is also e ...
... Ag gp120 are skewed away from VH3 bearing IgGs, which are normally protective against pathogens (4). Autoimmune responses are also a feature (5, 6) including those against CD4 molecules (7–9). HIV-1 is able to infect CD4⫹ T cells and CD4⫹ APCs, including macrophages and DC, (10 –12). There is also e ...
determining the innate and adaptive immune responses to vesicular
... The purpose of a vaccine is to provide immunity to a target pathogen. How that immunity is developed depends on how the vaccine is designed. One method is to use a live attenuated virus. Current examples would be the measles, mumps, rubella vaccine, the live attenuated influenza vaccine (LAIV), and ...
... The purpose of a vaccine is to provide immunity to a target pathogen. How that immunity is developed depends on how the vaccine is designed. One method is to use a live attenuated virus. Current examples would be the measles, mumps, rubella vaccine, the live attenuated influenza vaccine (LAIV), and ...
UNIVERSITAT DE BARCELONA IMMUNE PROFILING OF OPERATIONAL TOLERANCE IN LIVER TRANSPLANTATION
... Medicine for his demonstration that renal autografts in dogs survived indefinitely while renal allografts rapidly ceased to function [1, 2]. This pioneering work led to the concept of histocompatibility, which refers to the fact that even within a same species there are polymorphic tissue antigens ( ...
... Medicine for his demonstration that renal autografts in dogs survived indefinitely while renal allografts rapidly ceased to function [1, 2]. This pioneering work led to the concept of histocompatibility, which refers to the fact that even within a same species there are polymorphic tissue antigens ( ...
Responses of Bovine Endometrial Epithelial Cells to Pathogens
... stimulated proliferation of bEEC (maximum observed at 8 µg/mL LPS). The strong increase in cell numbers by 72 h was not associated with an increase in apoptosis, but this occurred with higher LPS doses. Analysis of protein pro-files revealed deregulation of 38 proteins belonging to many pathways, so ...
... stimulated proliferation of bEEC (maximum observed at 8 µg/mL LPS). The strong increase in cell numbers by 72 h was not associated with an increase in apoptosis, but this occurred with higher LPS doses. Analysis of protein pro-files revealed deregulation of 38 proteins belonging to many pathways, so ...
Chapter 1: Masters Thesis Literature Review
... vivo. ManLAM treatment of bone marrow derived DCs (BMDCs) prevents their phenotypic maturation reduces the expression of MHC class II and CD1d. BMDCs stimulated with ManLAM also exhibit altered phagocytic capacity and the inability to stimulate naïve CD4+ T-cell proliferation. The anti-inflammatory ...
... vivo. ManLAM treatment of bone marrow derived DCs (BMDCs) prevents their phenotypic maturation reduces the expression of MHC class II and CD1d. BMDCs stimulated with ManLAM also exhibit altered phagocytic capacity and the inability to stimulate naïve CD4+ T-cell proliferation. The anti-inflammatory ...
Early Life Microbiota, Neonatal Immune Maturation and
... Hematopoietic stem cells from the fetal liver seed the fetal spleen and bone marrow in perinatal phase. Granulocytosis in neonate mice and man just after birth is a natural event of early life hematopoiesis and likely contributes to elevated counts of neutrophil-like cells in the peripheral blood of ...
... Hematopoietic stem cells from the fetal liver seed the fetal spleen and bone marrow in perinatal phase. Granulocytosis in neonate mice and man just after birth is a natural event of early life hematopoiesis and likely contributes to elevated counts of neutrophil-like cells in the peripheral blood of ...
Initiation and Regulation of Type 2 Immunity and Inflammation at
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
Nature Medicine 10, 1307
... controlled the activity of phagocytes, many now see adaptive immunity as beholden to a subset of the latter (DCs) for guidance on how to best assist the host in resisting infections (Fig. 2b). Although these results have given us a framework for one major aspect of Tlr function, many questions remai ...
... controlled the activity of phagocytes, many now see adaptive immunity as beholden to a subset of the latter (DCs) for guidance on how to best assist the host in resisting infections (Fig. 2b). Although these results have given us a framework for one major aspect of Tlr function, many questions remai ...
O MHC - Fernando Pessoa University
... of each type of MHC molecule • The rate of replication by pathogenic microorganisms is faster than human reproduction • In a given time a pathogen can mutate genes more frequently than humans and can easily evade changes in MHC molecules • The number of types of MHC molecules are limited ...
... of each type of MHC molecule • The rate of replication by pathogenic microorganisms is faster than human reproduction • In a given time a pathogen can mutate genes more frequently than humans and can easily evade changes in MHC molecules • The number of types of MHC molecules are limited ...
B cell fate following immunization: from memory B cells to plasma cells
... not to be the case; rather we observed intrinsic animal variation and that the frequency of plasma cells correlated with the age of the animals. In Paper IV, we described cell markers that better characterize BM plasma cells. We found that functional BM plasma cells that constitutively secrete IgG, ...
... not to be the case; rather we observed intrinsic animal variation and that the frequency of plasma cells correlated with the age of the animals. In Paper IV, we described cell markers that better characterize BM plasma cells. We found that functional BM plasma cells that constitutively secrete IgG, ...
Candida
... susceptible women, promoting pathological inflammation without affecting fungal burden. Evidence to date in the mouse model suggests that a similar acute PMN migration into the vagina is mediated by chemotactic S100A8 and S100A9 alarmins produced by vaginal epithelial cells in response to Candida. B ...
... susceptible women, promoting pathological inflammation without affecting fungal burden. Evidence to date in the mouse model suggests that a similar acute PMN migration into the vagina is mediated by chemotactic S100A8 and S100A9 alarmins produced by vaginal epithelial cells in response to Candida. B ...
High Level Expression of HLA-A*0203
... mixing the biotinylated monomer with streptavidin-PE at a ratio of 4:1. Flow cytometry showed that this tetramer could specifically react with antigen-specific CD8+ T cells, indicating that it was biologically functional. These results provide a foundation for further characterization of antigen-spe ...
... mixing the biotinylated monomer with streptavidin-PE at a ratio of 4:1. Flow cytometry showed that this tetramer could specifically react with antigen-specific CD8+ T cells, indicating that it was biologically functional. These results provide a foundation for further characterization of antigen-spe ...
Fundamentals of Immunology
... 3. The first decision or branch point, is whether the cell will go myeloid or lymphoid: a. CMP- If it turns into a common myeloid-erythroid progenitor, it may develop into a huge number of types including different types of white blood cells, red blood cells and platelet-producing megakaryocytes. b ...
... 3. The first decision or branch point, is whether the cell will go myeloid or lymphoid: a. CMP- If it turns into a common myeloid-erythroid progenitor, it may develop into a huge number of types including different types of white blood cells, red blood cells and platelet-producing megakaryocytes. b ...
Here - European Macrophage and Dendritic Cell Society
... the category “immunology, microbiology and virology”. All this is meant to emphasize that immunology is very close to our hearts. Needless to say that many of us have had a strong and long-standing interest in macrophages and dendritic cells. This year´s EMDS meeting focusses on the interaction of m ...
... the category “immunology, microbiology and virology”. All this is meant to emphasize that immunology is very close to our hearts. Needless to say that many of us have had a strong and long-standing interest in macrophages and dendritic cells. This year´s EMDS meeting focusses on the interaction of m ...
Immune tolerance by interferon-alpha in experimental arthritis Jaya Prakash Chalise Linköping University
... exhibited higher suppressive activity against mBSA-stimulated proliferation of responder T cells. The enhancing effect of IFN-α on Treg cell numbers was observed in blood, spleen, LNs and also in ex-vivo cultures of leucocytes re-stimulated with mBSA and IFN-α. Although IFN-α clearly increased the s ...
... exhibited higher suppressive activity against mBSA-stimulated proliferation of responder T cells. The enhancing effect of IFN-α on Treg cell numbers was observed in blood, spleen, LNs and also in ex-vivo cultures of leucocytes re-stimulated with mBSA and IFN-α. Although IFN-α clearly increased the s ...
How Mycobacterium tuberculosis Manipulates Innate and Adaptive Immunity: New Views of
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade
... to exposed hyaluronan at the injury site. These fully mature macrophages rapidly proliferate and adopt an alternative activation phenotype once they are located in the afflicted tissue. Intravital imaging revealed that these cells dismantle nuclei from necrotic cells and help to fully revascularize ...
... to exposed hyaluronan at the injury site. These fully mature macrophages rapidly proliferate and adopt an alternative activation phenotype once they are located in the afflicted tissue. Intravital imaging revealed that these cells dismantle nuclei from necrotic cells and help to fully revascularize ...
Immunogenicity of B16 melanoma cells after
... cytokine secretion when gathered from melanoma cells treated with RT, DTIC and HT in combination with zVAD-fmk .............................................................................................. 60 ...
... cytokine secretion when gathered from melanoma cells treated with RT, DTIC and HT in combination with zVAD-fmk .............................................................................................. 60 ...
Sinusoid-lining cells are novel myeloid- endothelial innate cells that form splenic
... diversified antigen receptors that mediate slow but specific protection8. A third category of immune effector cells includes lymphocytes that blur the conventional boundaries between the innate and adaptive immune systems. These “in-betweeners” include T cells, NKT cells, B-1 cells and MZ B cells ...
... diversified antigen receptors that mediate slow but specific protection8. A third category of immune effector cells includes lymphocytes that blur the conventional boundaries between the innate and adaptive immune systems. These “in-betweeners” include T cells, NKT cells, B-1 cells and MZ B cells ...
Protective Anti-Helicobacter Immunity Is Induced with Aluminum
... considered to be protected if there was a complete absence of detectable Helicobacter organisms in silver-stained sections. Additionally, cultures were performed on gastric biopsy samples from H. pylori–challenged mice to confirm the presence or absence of bacteria. Two biopsy samples (2 ⫻ 2 mm) fro ...
... considered to be protected if there was a complete absence of detectable Helicobacter organisms in silver-stained sections. Additionally, cultures were performed on gastric biopsy samples from H. pylori–challenged mice to confirm the presence or absence of bacteria. Two biopsy samples (2 ⫻ 2 mm) fro ...
ACTIVATION OF HUMAN NATURAL KILLER CELLS BY
... The sexual phase of the life-cycle takes place in the mosquito and the asexual phase in the human. When an infected mosquito bites, it inserts sporozoites into the bloodstream; sporozoites are small, motile forms of the parasite and are able to find their way to the liver. Once in the liver, the spo ...
... The sexual phase of the life-cycle takes place in the mosquito and the asexual phase in the human. When an infected mosquito bites, it inserts sporozoites into the bloodstream; sporozoites are small, motile forms of the parasite and are able to find their way to the liver. Once in the liver, the spo ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.