emboj2009118-sup
... activation upon NRH2 levels. (A) NRH2 knockdown does not alter Trk-mediated pro-survival signals. DRG neurons-infected with CTL or shNRH2-expressing lentivirus were NGF-starved, and then treated with NGF (50 ng/ml) for 0, 15, and 60 min at DIV8. Harvested cell lysates were subjected to immunoblot an ...
... activation upon NRH2 levels. (A) NRH2 knockdown does not alter Trk-mediated pro-survival signals. DRG neurons-infected with CTL or shNRH2-expressing lentivirus were NGF-starved, and then treated with NGF (50 ng/ml) for 0, 15, and 60 min at DIV8. Harvested cell lysates were subjected to immunoblot an ...
cells
... 2. Testing and Removal of Self– Self–Reactive Lymphocytes z The rearrangements of antigen receptor genes are random, which may generate receptors against self antigens. Î Failure of selection can lead to autoimmune diseases z B cells and T cells are maturing and are tested for potential self–reactiv ...
... 2. Testing and Removal of Self– Self–Reactive Lymphocytes z The rearrangements of antigen receptor genes are random, which may generate receptors against self antigens. Î Failure of selection can lead to autoimmune diseases z B cells and T cells are maturing and are tested for potential self–reactiv ...
The predominant surface glycoproteins of thymocytes and
... b e t w e e n m o l e c u l e s on t h e same cell and between the same (or related) molecules on different cells. Cell surface glycoproteins can be labeIled with 3H at sialic acid or galactose residues by reducing with 3H borohydride after oxidation with p e r i o d i c acid, or g a l a c t o s e o ...
... b e t w e e n m o l e c u l e s on t h e same cell and between the same (or related) molecules on different cells. Cell surface glycoproteins can be labeIled with 3H at sialic acid or galactose residues by reducing with 3H borohydride after oxidation with p e r i o d i c acid, or g a l a c t o s e o ...
Cytokines
... Th2 proliferation. • If naïve T cells are triggered to become Th2 cells, they produce IL-10 which shuts down macrophage production of IL-12, removing the stimulus for naïve helper T cells to become Th1 cells. • Thus, each local environment establishes its own balance of Th1 and Th2 cells. ...
... Th2 proliferation. • If naïve T cells are triggered to become Th2 cells, they produce IL-10 which shuts down macrophage production of IL-12, removing the stimulus for naïve helper T cells to become Th1 cells. • Thus, each local environment establishes its own balance of Th1 and Th2 cells. ...
Document
... Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. Within 90 minutes after receiving a single intravenous dose of the drug, all six vo ...
... Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. Within 90 minutes after receiving a single intravenous dose of the drug, all six vo ...
Immunity to parasites
... an initial infection is not eliminated but established, and the host then acquires resistance to invasion by new worms of the same species. ...
... an initial infection is not eliminated but established, and the host then acquires resistance to invasion by new worms of the same species. ...
The immune system
... When things go wrong with the immune system Sometimes the immune system will make a mistake. 1. It may attack your own body as if it were the enemy, eg. insulin dependent diabetes (the type that most often starts in children and young people) is caused by the immune system attacking the cells in the ...
... When things go wrong with the immune system Sometimes the immune system will make a mistake. 1. It may attack your own body as if it were the enemy, eg. insulin dependent diabetes (the type that most often starts in children and young people) is caused by the immune system attacking the cells in the ...
LO 2.29 The student can create representations and
... 2. In the cell‐mediated response, cytotoxic T cells, a type of lymphocytic white blood cell, “target” intracellular pathogens when antigens are displayed on the outside of the cells. 3. In the humoral response, B cells, a type of lymphocytic white blood cell, produce antibodies against specific a ...
... 2. In the cell‐mediated response, cytotoxic T cells, a type of lymphocytic white blood cell, “target” intracellular pathogens when antigens are displayed on the outside of the cells. 3. In the humoral response, B cells, a type of lymphocytic white blood cell, produce antibodies against specific a ...
Immune responses in viral infections
... The immune system has developed to protect the host from pathogens and other foreign substances, self/non-self discrimination is one of the hallmarks of the immune system. Most pathogens can elicit both an antibody (humoral) and a cell-mediated response, both of which may contribute to ridding the h ...
... The immune system has developed to protect the host from pathogens and other foreign substances, self/non-self discrimination is one of the hallmarks of the immune system. Most pathogens can elicit both an antibody (humoral) and a cell-mediated response, both of which may contribute to ridding the h ...
Immunology_lecture13Transplantation
... • Cause fast and strong rejection • Difference of HLA types is the main cause of human grafts rejection ...
... • Cause fast and strong rejection • Difference of HLA types is the main cause of human grafts rejection ...
The HPV life cycle has implications for the immune response
... the L1 capsid protein is type-specific and longlasting (over 10 years). The IgA response may be as long lived • Antibodies are neutralizing and are directed to conformational epitopes on L1. • The humoral immune response protects against reinfection, but does not cause regression of existing papillo ...
... the L1 capsid protein is type-specific and longlasting (over 10 years). The IgA response may be as long lived • Antibodies are neutralizing and are directed to conformational epitopes on L1. • The humoral immune response protects against reinfection, but does not cause regression of existing papillo ...
Slide 1
... -cytokine that plays a key role in the thymus in lymphocyte development and survival -in the periphery it is important for T-cell homeostasis and is required for homeostatic proliferation of CD4+ and CD8+ Tcells When used in cancer patients it preferentially expanded naïve T-cells In a phase I/IIa c ...
... -cytokine that plays a key role in the thymus in lymphocyte development and survival -in the periphery it is important for T-cell homeostasis and is required for homeostatic proliferation of CD4+ and CD8+ Tcells When used in cancer patients it preferentially expanded naïve T-cells In a phase I/IIa c ...
tolerance
... immature tolerized the relevant lymphocytes. * Medewar subsequently investigated the effects of transferring hemopoietic cells from histoincompatible mice at different times after birth. He found that if the cells were transferred in the first few days of life (but not later) the recipient mouse acq ...
... immature tolerized the relevant lymphocytes. * Medewar subsequently investigated the effects of transferring hemopoietic cells from histoincompatible mice at different times after birth. He found that if the cells were transferred in the first few days of life (but not later) the recipient mouse acq ...
Biochemistry of the immune system
... immunity. They have T-cell receptors (TCRs) on their surface for glycolipid antigen recognition. They also have natural killer (NK) cell receptors. – Through the cytokines they produce once activated, iNKT cells are essential in both innate and adaptive immune protection against pathogens and tumors ...
... immunity. They have T-cell receptors (TCRs) on their surface for glycolipid antigen recognition. They also have natural killer (NK) cell receptors. – Through the cytokines they produce once activated, iNKT cells are essential in both innate and adaptive immune protection against pathogens and tumors ...
the immune system - Regenerative Medicine Partnership in Education
... caused by many different types of viruses that all cause the same symptoms. This is why you can “catch a cold” more than once. Because there are so many types of viruses that cause the common cold, there is no vaccine for the common cold. Vaccines work by showing your body what a single germ looks l ...
... caused by many different types of viruses that all cause the same symptoms. This is why you can “catch a cold” more than once. Because there are so many types of viruses that cause the common cold, there is no vaccine for the common cold. Vaccines work by showing your body what a single germ looks l ...
Ralph Steinman and the Discovery of Dendritic Cells Dec. 7 , 2011
... on the widely held view that the major antigen presenting cells were the far more numerous macrophages and on the uncertainty that many immunologists had about the assay that Steinman and Cohn used to establish the function of their dendritic cells. “ ...
... on the widely held view that the major antigen presenting cells were the far more numerous macrophages and on the uncertainty that many immunologists had about the assay that Steinman and Cohn used to establish the function of their dendritic cells. “ ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.