John McCarty MD Medical Director Bone Marrow Transplantation
... • 1958: reports of successful identical twin transplants • 1969: Cytoxan added to radiation • 1970: bone marrow harvests perfected to obtain stem cells • 1989: peripheral blood stem cells harvested • 1990: first successful cord blood transplant • 1996: first non-ablative transplant Thomas et al J Cl ...
... • 1958: reports of successful identical twin transplants • 1969: Cytoxan added to radiation • 1970: bone marrow harvests perfected to obtain stem cells • 1989: peripheral blood stem cells harvested • 1990: first successful cord blood transplant • 1996: first non-ablative transplant Thomas et al J Cl ...
Barrier Defenses and the Innate Immune Response
... induced proteins speci c for bacterial cell wall components are mannose-binding protein and C-reactive protein, made in the liver, which bind speci cally to polysaccharide components of the bacterial cell wall. Phagocytes such as macrophages have receptors for these proteins, and they are thus able ...
... induced proteins speci c for bacterial cell wall components are mannose-binding protein and C-reactive protein, made in the liver, which bind speci cally to polysaccharide components of the bacterial cell wall. Phagocytes such as macrophages have receptors for these proteins, and they are thus able ...
Immunology 03 MED
... Main phases of the immune response: induction phase (recognition of antigen), central phase (activation, clonal selection and prolipheration of T and B lymphocytes), effector phase (elimination of antigen mediated by antibodies and effector cells). Immunological memory and tolerance. Lymphocytes: su ...
... Main phases of the immune response: induction phase (recognition of antigen), central phase (activation, clonal selection and prolipheration of T and B lymphocytes), effector phase (elimination of antigen mediated by antibodies and effector cells). Immunological memory and tolerance. Lymphocytes: su ...
Melamede, & Newell
... the immune, endocrine, cardiovascular, digestive, excretory, nervous and reproductive systems. Their predominant, but not exclusive mechanism of action is through G-coupled receptors, CB1 receptors are found mainly in the plasma membrane of nerve tissue, and CB2 receptor is found in immunological c ...
... the immune, endocrine, cardiovascular, digestive, excretory, nervous and reproductive systems. Their predominant, but not exclusive mechanism of action is through G-coupled receptors, CB1 receptors are found mainly in the plasma membrane of nerve tissue, and CB2 receptor is found in immunological c ...
Applications in Dermatology, Dentistry and LASIK Eye Surgery using
... Epidermis – or the uppermost layer of skin is made up of cells called keratinocytes, which are stacked on top of each other, forming different sub-layers. The keratinocytes develop at the bottom and rise to the top, where they are shed from the surface as dead skin cells. The epidermal layer is cons ...
... Epidermis – or the uppermost layer of skin is made up of cells called keratinocytes, which are stacked on top of each other, forming different sub-layers. The keratinocytes develop at the bottom and rise to the top, where they are shed from the surface as dead skin cells. The epidermal layer is cons ...
The Body Defenses
... B cells carry out antibodymediated immunity. • A given lymphocyte has receptors on its surface to recognize one unique antigen. The TLRs of innate effector cells recognize generic traits of all microbes. • Antigens stimulate B cells to convert into plasma cells • that produce antibodies. A plasma c ...
... B cells carry out antibodymediated immunity. • A given lymphocyte has receptors on its surface to recognize one unique antigen. The TLRs of innate effector cells recognize generic traits of all microbes. • Antigens stimulate B cells to convert into plasma cells • that produce antibodies. A plasma c ...
Type III Hypersensitivity - Dow University of Health Sciences
... Poison ivy Metals Latex in gloves and condoms (3% of health care workers) ...
... Poison ivy Metals Latex in gloves and condoms (3% of health care workers) ...
Chemoreception
... stimulus. It plays a major role in the lives of fishes, including feeding, prey detection, predator avoidance, species and sex recognition, sexual behaviour and migration. ...
... stimulus. It plays a major role in the lives of fishes, including feeding, prey detection, predator avoidance, species and sex recognition, sexual behaviour and migration. ...
11-Immunology
... TH activated by AG presented on P-APC -- cytokines needed for TC and B-cell activation TC activated by DC cells & AG presented on infected cell -- kill target cells ...
... TH activated by AG presented on P-APC -- cytokines needed for TC and B-cell activation TC activated by DC cells & AG presented on infected cell -- kill target cells ...
print version
... protection. The second line of defence, the adaptive immune system, provides lifelong immunity; it “remembers” germs or cancers so that it can protect your body against similar attacks in the future. If the immune system is the cancer warrior, then T-cells are the key weapons in its arsenal. They at ...
... protection. The second line of defence, the adaptive immune system, provides lifelong immunity; it “remembers” germs or cancers so that it can protect your body against similar attacks in the future. If the immune system is the cancer warrior, then T-cells are the key weapons in its arsenal. They at ...
‘Research at the Interface’ 2014 Annual Symposium, Friday 9th May 2014
... proteins such as GFP, but not all such constructs tolerate the presence of these bulky substituents without loss of function. Sortases are bacterial transacylases with the remarkable property of having very short recognition motifs in their substrates, and capable of accepting a sheer limitless numb ...
... proteins such as GFP, but not all such constructs tolerate the presence of these bulky substituents without loss of function. Sortases are bacterial transacylases with the remarkable property of having very short recognition motifs in their substrates, and capable of accepting a sheer limitless numb ...
Determining blood cell size
... Microfluidic flow cytometers currently analyze far fewer parameters than conventional flow cytometry or fluorescence activated cell sorting (FACS) in order to minimize cost and complexity. There is a need for microfluidic devices that analyze more and or new cell parameters with compact and minimal ...
... Microfluidic flow cytometers currently analyze far fewer parameters than conventional flow cytometry or fluorescence activated cell sorting (FACS) in order to minimize cost and complexity. There is a need for microfluidic devices that analyze more and or new cell parameters with compact and minimal ...
The ORT Times - Office of Research Trainees
... presence of excess activated T cells. Previously, the authors found that there is a genetic polymorphism that biases T cell development towards the production of more pro-inflammatory T cells than usual. In this study, the authors discovered that this is further exacerbated by functionally abnormal ...
... presence of excess activated T cells. Previously, the authors found that there is a genetic polymorphism that biases T cell development towards the production of more pro-inflammatory T cells than usual. In this study, the authors discovered that this is further exacerbated by functionally abnormal ...
plasma cells
... respectively), and then circulate through the blood to secondary lymphoid organs (lymph nodes, spleen, regional lymphoid tissues such as mucosa-associated lymphoid tissues). Fully mature T cells leave the thymus, but immature B cells leave the bone marrow and complete their maturation in secondary l ...
... respectively), and then circulate through the blood to secondary lymphoid organs (lymph nodes, spleen, regional lymphoid tissues such as mucosa-associated lymphoid tissues). Fully mature T cells leave the thymus, but immature B cells leave the bone marrow and complete their maturation in secondary l ...
Module 023806: Advanced topics in Immunology
... Immature APCs express low levels of MHC II and other costimulatory molecules. As such they do not activate efficient T cell priming. This important in maintaining tolerance. Not activated via their TLRs, therefore they do not see self antigens as dangerous. However, in autoimmune conditions TLRs a ...
... Immature APCs express low levels of MHC II and other costimulatory molecules. As such they do not activate efficient T cell priming. This important in maintaining tolerance. Not activated via their TLRs, therefore they do not see self antigens as dangerous. However, in autoimmune conditions TLRs a ...
The Basics of Cancer Biology
... – CD4 T-cells of the Treg variety (FOXP3 positive, produce cytokines that suppress CD8 and CD4 Th1 cells) – CD4 T-cells of the Th2 variety (produce cytokines that stimulate B-cells and drive an antibody response rather than a cytotoxic response) – CD4 T-cells of the Th17 variety (produce IL-17 and a ...
... – CD4 T-cells of the Treg variety (FOXP3 positive, produce cytokines that suppress CD8 and CD4 Th1 cells) – CD4 T-cells of the Th2 variety (produce cytokines that stimulate B-cells and drive an antibody response rather than a cytotoxic response) – CD4 T-cells of the Th17 variety (produce IL-17 and a ...
The Physiology of Lymphocyte Migration
... necessarily to be the case. Lymphocytes may be preferentially recirculated, and are able home in and target specific tissues. In addition, memory lymphocytes show different migration behaviour to na ve lymphocytes. The immune system maintains a pool of recirculating lymphocytes that cycle around the ...
... necessarily to be the case. Lymphocytes may be preferentially recirculated, and are able home in and target specific tissues. In addition, memory lymphocytes show different migration behaviour to na ve lymphocytes. The immune system maintains a pool of recirculating lymphocytes that cycle around the ...
Powerpoint - Blood Journal
... Binding of LL2-onconase conjugate to Daudi cells.Competitive binding analysis of LL2 or LL2onconase inhibition of binding of [125I]-labeled LL2 IgG2a antibody to human Daudi lymphoma cells expressing the CD22 antigen. ...
... Binding of LL2-onconase conjugate to Daudi cells.Competitive binding analysis of LL2 or LL2onconase inhibition of binding of [125I]-labeled LL2 IgG2a antibody to human Daudi lymphoma cells expressing the CD22 antigen. ...
Document
... Cytotoxic T cells (TC cells or CTLs) • Only recognize antigens presented by various cells with MHC class I proteins on their surface • Some T cells become memory T cells o Live for many years and can quickly initiate immune response to an antigen previously present in the body TO PREVIOUS SLIDE ...
... Cytotoxic T cells (TC cells or CTLs) • Only recognize antigens presented by various cells with MHC class I proteins on their surface • Some T cells become memory T cells o Live for many years and can quickly initiate immune response to an antigen previously present in the body TO PREVIOUS SLIDE ...
BCBio12_Chapter10_immunity
... Cytotoxic T cells (TC cells or CTLs) • Only recognize antigens presented by various cells with MHC class I proteins on their surface • Some T cells become memory T cells o Live for many years and can quickly initiate immune response to an antigen previously present in the body TO PREVIOUS SLIDE ...
... Cytotoxic T cells (TC cells or CTLs) • Only recognize antigens presented by various cells with MHC class I proteins on their surface • Some T cells become memory T cells o Live for many years and can quickly initiate immune response to an antigen previously present in the body TO PREVIOUS SLIDE ...
CELLULAR AND HUMORAL IMMUNITY The Immune Response
... How Do B Cells Produce Antibodies? – B cells develop from stem cells in the bone marrow of adults (liver of fetuses). – After maturation B cells migrate to lymphoid organs (lymph node or spleen). – Clonal Selection: When a B cell encounters an antigen it recognizes, it is stimulated and divides into ...
... How Do B Cells Produce Antibodies? – B cells develop from stem cells in the bone marrow of adults (liver of fetuses). – After maturation B cells migrate to lymphoid organs (lymph node or spleen). – Clonal Selection: When a B cell encounters an antigen it recognizes, it is stimulated and divides into ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.