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Indian Journal of Clinical Medicine Monoclonal Antibodies: A tool in
Indian Journal of Clinical Medicine Monoclonal Antibodies: A tool in

... Abstract: Monoclonal antibodies (MAbs) are an old immunological tool with applications in the fields of immunology, biotechnology, biochemistry, and applied biology. Production of monoclonal antibodies using hybridoma technology was discovered in 1975 by Georges Kohler of West Germany and Cesar Mils ...
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... (B) Epidemiological studies have shown that the risk of developing multiple sclerosis is linked to particular HLA Class I molecules (C) Like most people, this individual has T-cells that recognize self antigens in the CNS, but unlike most people, these T-cell clones have expanded (D) The lesion see ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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