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Immune System - Dr. Annette M. Parrott
Immune System - Dr. Annette M. Parrott

... 2. In the cell-mediated response, cytotoxic T cells, a type of lymphocytic white blood cell, “target” intracellular pathogens when antigens are displayed on the outside of the cells. 3. In the humoral response, B cells, a type of lymphocytic white blood cell, produce antibodies against specific anti ...
3. Immunology
3. Immunology

... As well as being in the plasma, IgA is the major immunoglobulin of the external secretory system and is found in saliva, tears, colostrum breast milk and in nasal, bronchial and intestinal secretions. IgA is present in large quantities in colostrum and breast milk and can be transferred across the g ...
3 slides
3 slides

...  Anaphylactic Shock = can be fatal. 2) Autoimmune Disease: Body mistakes own cells as invaders  Diabetes mellitus (Type I): Destruction of pancreatic cells  Multiple Sclerosis: Destruction of neuron insulation (myelin) ...
Immunity
Immunity

... cytokines that stimulate the activity of other immune cells, including B lymphocytes and other T cells Cytotoxic T lymphocytes (TC or CD8+ T cells) destroy virally-infected cells and tumor cells, and are responsible for transplant rejection Regulatory T lymphocytes (Treg cells) help to mediate ...
3. Immunology
3. Immunology

... Foreign nature - The body is tolerant of its own components and does not initiate immune response against these. ...
Immune System Crossword PARA3002
Immune System Crossword PARA3002

... system, and reacts with immune cells or their products. 22. Type of T lymphocyte that directly kills foreign cells, cancer cells, or virus-infected body cells by inducing apoptosis. 23. A protein molecule that is released by a plasma cell (a daughter cell of an activated B lymphocyte) and that binds ...
Document
Document

... Ig (immunoglobulin) G- active in blood against bacteria and viruses helps activate complement helps phagocytes eliminate antigens most common antibody in the blood IgM- reacts with certain antigens, usually on first exposure IgA- most common in mucosa ...
Immune Response to HIV Infection
Immune Response to HIV Infection

... the immune system to signal activation and proliferation of the appropriate components of the immune response. IL-1 is released from macrophages and signals activation of T cells. Activated T cells produce IL-2 which signals proliferation of T cell clones and also helps B cells to start secreting an ...
NOTES: Specific Defenses / Immunity (Ch 14, part 3)
NOTES: Specific Defenses / Immunity (Ch 14, part 3)

... cell CLONES itself to make lots of copies of the correct antigen fighting cell** **Therefore, each type of T cell or B cell has a particular type of antigen receptor that can respond only to a SPECIFIC antigen** ...
Lymphatic System Part 2
Lymphatic System Part 2

... Passive Immunity  Monoclonal antibodies  Antibodies prepared for clinical testing or diagnostic services  Produced from descendents of a single cell line  Examples of uses for monoclonal antibodies  Diagnosis of pregnancy  Treatment after exposure to hepatitis and rabies ...
Paper 2 - Soalan-Percubaan-STPM
Paper 2 - Soalan-Percubaan-STPM

... NO (b) ...
Immunoglobulins
Immunoglobulins

... To reduce vulnerability to microbial proteases the hinge region of IgA2 is truncated. In IgA1 the hinge is heavily glycosylated. IgA is inefficient at causing inflammation and elicits protection by excluding, binding, crosslinking microorganisms and facilitating phagocytosis ...
Specific Resistance = Immunity
Specific Resistance = Immunity

... 5) These signals stimulate specific B cells to proliferate and mature to antibody secreting plasma cells (see details below for T-dependent antigens). 6) These signals also stimulate specific Tc cells to proliferate and activate. The Tc cells involved have their own receptors bound to class I - MHC. ...
HISTORY- Antibody production
HISTORY- Antibody production

... molecular scale, the proteins are relatively large, so they cannot be recognized as a whole; instead, their segments, called epitopes, can be recognized.[1] An epitope comes in contact with a very small region (of 15–22 amino acids) of the antibody molecule; this region is known as the paratope In t ...
b cells - immunology.unideb.hu
b cells - immunology.unideb.hu

... Some key questions: 1) How cab the immune system respond to so any different pathogens…. 2) Specific antibodies can be made to almost any antigens. How is this possible? 3) How many genes do we (humans) have? 4) How many species of pathogens and antigens are out there? 5) Does a single B cell recog ...
Translating Biological Complexity Into More Powerful
Translating Biological Complexity Into More Powerful

... statements may include, but are not limited to, statements concerning the company’s anticipated performance, including revenue and profit expectations; development and implementation of our collaborations; duration; size; scope and revenue associated with collaboration partnerships; benefits provide ...
Lymphatic System
Lymphatic System

... What is an antigen? • Antigen = “antibody generating” molecule – any chemical substance that, when introduced into the body, causes the body to produce specific antibodies that can react with the antigen ...
Lymphatic System Chapter 22 10/28/11 Introduction
Lymphatic System Chapter 22 10/28/11 Introduction

... What is an antigen? •  Antigen = “antibody generating” molecule –  any chemical substance that, when introduced into the body, causes the body to produce specific antibodies that can react with the antigen ...
Monoclonal Versus Polyclonal Antibodies: Distinguishing
Monoclonal Versus Polyclonal Antibodies: Distinguishing

... antibodies (MAbs1) are antibodies produced by a single B lymphocyte clone. MAbs were first recognized in sera of patients with multiple myeloma in which clonal expansion of malignant plasma cells produce high levels of an identical antibody resulting in a monoclonal gammopathy. In the mid-1970s, Kö ...
The Lymphatic System
The Lymphatic System

... produced by another individual; person does not have an immune response, so immunity is shortterm Occurs naturally when antibodies pass from ...
AMA 180 powerpoint
AMA 180 powerpoint

... water, dissolved proteins, sugar, wastes, salts, hormones, etc. Erythrocytes: red blood cells that contain hemoglobin (protein) that enable them to carry oxygen. ...
Quiz: Body Defenses
Quiz: Body Defenses

... 20. Suppose a pathogen infects and kills macrophage cells. How will this pathogen affect B Cell activity? T Cell activity? The ability to produce a fever? 21. Of what benefit is a fever during a bacterial infection? 22. Discuss antibodies with respect to each of the following: a. Specificity b. Shap ...
Microsoft Word
Microsoft Word

... 20. Suppose a pathogen infects and kills macrophage cells. How will this pathogen affect B Cell activity? T Cell activity? The ability to produce a fever? 21. Of what benefit is a fever during a bacterial infection? 22. Discuss antibodies with respect to each of the following: a. Specificity b. Shap ...
T cells
T cells

... in secondary lymph organs meet antigens -B cells are activated when their surface Igs bind to a specific epitope on an antigen -TH cytokines may also be required -Activation results in clonal expansion and differentiation into plasma and memory cells -Plasma cells produce soluble antibodies against ...
NoB2ch08QUICKcheck-ed
NoB2ch08QUICKcheck-ed

... would have killed the invading organism. This is most likely to have occurred before the person’s immune system had time to react fully to the invading organism. It is unlikely that there was sufficient time for memory cells to be produced. In the absence of memory cells, no immunity exists against ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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