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... phenotypes being observed in rep strains are related to a general DNA replication problem, rather than due to some uncharacterized rep weirdness. There is more linear DNA in the absence of recBCD (recall that recBCD eats linear DNA) Observe: deletion of ruvC suppresses the linear DNA phenotype, just ...
Lecture 2 Turunen 14.9. - MyCourses
Lecture 2 Turunen 14.9. - MyCourses

Review of "A proposed structure for the nucleic acids" by Pauling
Review of "A proposed structure for the nucleic acids" by Pauling

... expect for the fundamental building block of life. Would such a structure be expected to form spontaneously? Particularly troubling for me is the fact that the phosphates are inaccessible to divalent cations, and one would expect that divalent cations would actually inhibit the formation of this str ...
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on January 24, 2017 Downloaded from

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CHAPTER 17 FROM GENE TO PROTEIN Section A: The

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i3 dna cloning - ชีวเคมี กำแพงแสน Biochemistry KU KPS

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senior biology - School of Medical Sciences

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A Recipe for Traits - Teach Genetics Website

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... sample size of eighty persons with belief constructs on consciousness behavior. The Pearson’s coefficient thus obtained is then compared with DNA coefficient. A logical justification is made for the comparison of these two values. The coefficient values are found to tally but with an error margin of ...
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Deoxyribozyme



Deoxyribozymes, also called DNA enzymes, DNAzymes, or catalytic DNA, are DNA oligonucleotides that are capable of catalyzing specific chemical reactions, similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA).However, in contrast to the abundance of protein enzymes in biological systems and the discovery of biological ribozymes in the 1980s,there are no known naturally occurring deoxyribozymes.Deoxyribozymes should not be confused with DNA aptamers which are oligonucleotides that selectively bind a target ligand, but do not catalyze a subsequent chemical reaction.With the exception of ribozymes, nucleic acid molecules within cells primarily serve as storage of genetic information due to its ability to form complementary base pairs, which allows for high-fidelity copying and transfer of genetic information. In contrast, nucleic acid molecules are more limited in their catalytic ability, in comparison to protein enzymes, to just three types of interactions: hydrogen bonding, pi stacking, and metal-ion coordination. This is due to the limited number of functional groups of the nucleic acid monomers: while proteins are built from up to twenty different amino acids with various functional groups, nucleic acids are built from just four chemically similar nucleobases. In addition, DNA lacks the 2'-hydroxyl group found in RNA which limits the catalytic competency of deoxyribozymes even in comparison to ribozymes.In addition to the inherent inferiority of DNA catalytic activity, the apparent lack of naturally occurring deoxyribozymes may also be due to the primarily double-stranded conformation of DNA in biological systems which would limit its physical flexibility and ability to form tertiary structures, and so would drastically limit the ability of double-stranded DNA to act as a catalyst; though there are a few known instances of biological single-stranded DNA such as multicopy single-stranded DNA (msDNA), certain viral genomes, and the replication fork formed during DNA replication. Further structural differences between DNA and RNA may also play a role in the lack of biological deoxyribozymes, such as the additional methyl group of the DNA base thymidine compared to the RNA base uracil or the tendency of DNA to adopt the B-form helix while RNA tends to adopt the A-form helix. However, it has also been shown that DNA can form structures that RNA cannot, which suggests that, though there are differences in structures that each can form, neither is inherently more or less catalytic due to their possible structural motifs.
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