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... To investigate brain substrates of spatial memory, the cellular expression of c-Fos protein in rats was studied after training the animals to perform a spatial reference memory task and a working reference memory task in a Morris water maze. The number of c-Fos positive neuronal nuclei was quantifie ...
Lower activation in the right frontoparietal network during a counting
Lower activation in the right frontoparietal network during a counting

... test done at the clinic before patients participated in the scanning session. Three and two subjects were excluded from the control group and the cocaine group, respectively, as they had a positive urine test (one patient), MRI technical issues (one control) and excessive movement during fMRI acquis ...
Lecture 2: Structure and function of the NS
Lecture 2: Structure and function of the NS

... The neuronal cell body is the site of synthesis of nearly all the neuron’s enzymes, structural proteins, membrane components, and organelles, as well as some of its chemical messengers. Its structure (Fig. 1-9) reflects this function. The nucleus is large and pale-staining, with most of its chromati ...
CLM  UMR-S 839 INSERM/UPMC Institut du Fer a Moulin
CLM UMR-S 839 INSERM/UPMC Institut du Fer a Moulin

Algorithms in nature: the convergence of systems biology and
Algorithms in nature: the convergence of systems biology and

... as molecular data have rapidly accumulated. Computational tools for searching large databases, including BLAST (Altschul et al, 1990), are now routinely used by experimentalists. Genome sequencing and assembly rely heavily on algorithms to speed up data accumulation and analysis (Gusfield, 1997; Trap ...
Anatomical identification of primary auditory cortex in the developing
Anatomical identification of primary auditory cortex in the developing

... easy to breed, easy to train, and more interestingly, it is born with a brain in a rather immature state (1). Nevertheless, gerbil’s brain anatomy descriptions or atlases are not easy to find in the literature, neither adult nor young, and therefore developing auditory cortex in vivo is hard to be l ...
Magnetic resonance imaging indicators of blood
Magnetic resonance imaging indicators of blood

... Results: In nonhydrocephalic rats, water content decreased progressively from age 3 to 7 weeks. T1 and T2 and apparent diffusion coefficients did not exhibit parallel changes and there was no evidence of BBB permeability to tracers. The cerebral ventricles enlarged progressively in the weeks followi ...
The speed of learning instructed stimulus
The speed of learning instructed stimulus

... response is initiated when all neurons in a pool of m neurons have fired their first spike after input onset. Values of m=2 or 3 were consistent with the experimental data. The proposed model is the simplest solution consistent with neurophysiological knowledge. Additional experiments are suggested ...
Structural and functional brain network correlates of depressive
Structural and functional brain network correlates of depressive

... Abstract: Depression is common in premanifest Huntington’s disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using ...
Amelioration of Delayed Neuronal Death in the Hippocampus by
Amelioration of Delayed Neuronal Death in the Hippocampus by

q-gram Based Database Searching Using a Suffix Array (QUASAR)
q-gram Based Database Searching Using a Suffix Array (QUASAR)

... from the database where the query sequence possibly occurs with a high level of similarity. These positions can later be inspected in more depth with a standard alignment algorithm. The crucial point in the approach we use for QUASAR was therefore the design of the lter which combines some already ...
Mutations affecting the development of the embryonic zebrafish brain
Mutations affecting the development of the embryonic zebrafish brain

... Embryonic development of the vertebrate brain involves several steps. First, the neural plate forms on the dorsal side of the embryo and is regionalized along the anterior-posterior and dorsal-ventral axes. The formation of the neural tube from the neural plate and the development of brain ventricle ...
BIIIG : Enabling Business Intelligence with Integrated Instance Graphs
BIIIG : Enabling Business Intelligence with Integrated Instance Graphs

... objects to better understand the causes of certain results, e.g., in which way certain employees contribute to profit. Such relationships are frequently recorded in the underlying information systems but are not transferred to the data warehouse due to the typical focus on simple dimensional relatio ...
5104-c2
5104-c2

... • These data suggest that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them. ...
Beyond the classical receptive field: The effect of contextual stimuli
Beyond the classical receptive field: The effect of contextual stimuli

... transition from local to global processing by using information from beyond the classical RF. Surfaces enclosed by boundaries, rather than edge effects, have become the main focus of interest. A cellular basis for these mechanisms will have to be sought in cortical visual areas rather than in intera ...
Brain-implantable biomimetic electronics as the next era in neural
Brain-implantable biomimetic electronics as the next era in neural

... initially appear somewhat daunting, there is a rational approach to the problem. Information in the hippocampus and all other parts of the brain is coded in terms of variation in the sequence of all-or-none, point-process (spike) events, or temporal pattern (for multiple neurons, variation in the sp ...
The Biological Perspective
The Biological Perspective

Biological Foundations of Behaviour
Biological Foundations of Behaviour

... Many axons that transmit information throughout the brain and spinal cord are covered by a tubelike myelin sheath, a fatty, whitish insulation layer derived from glial cells during development. The myelin sheath is interrupted at regular intervals by the nodes of Ranvier, where the myelin is either ...
Effect of pH on Metabolism and Ultrastructure of Guinea Pig
Effect of pH on Metabolism and Ultrastructure of Guinea Pig

... As the rates of oxygen and glucose consumption were shown statistically not to be affected by the three slice levels or by the incubation times of 20, 30 or 40 minutes, each value is a mean ± SE of nine observations, except in case of pH 9.0 and its control, where 18 observations were made consideri ...
The Red Nucleus: Past, Present, and Future
The Red Nucleus: Past, Present, and Future

... to development of the cerebellum. A primitive level of RN organization is present in amphibians with only one cerebellar nucleus and no evidence of a rubro-olivary projection. Limbed reptiles demonstrate a more advanced level of organization with lateral and medial cerebellar nuclei showing projecti ...
Structural Abnormalities of the Central Auditory Pathway in Infants
Structural Abnormalities of the Central Auditory Pathway in Infants

... emission (TEOAE) screening, and air conduction auditory brain stem–evoked response (ABR) hearing threshold acquisition with click stimuli. Thirty-three infants with active middle ear disease (diagnosed otitis media or abnormal tympanograms in one or both ears) or with a history of recurrent (three t ...
new techniques for imaging, digitization and analysis of
new techniques for imaging, digitization and analysis of

Molecular and anatomical signatures of sleep deprivation in the
Molecular and anatomical signatures of sleep deprivation in the

... The identification of the genes and anatomical regions activated during sleep and responsive to SD could be important to defining the function of sleep in biochemical and molecular terms, as well as in understanding the mechanisms underlying sleep homeostasis. The goals of the current study were thr ...
EXTINCTION LEARNING - Ruhr
EXTINCTION LEARNING - Ruhr

... relevance for unraveling neural dysfunctions and improving therapies in anxiety disorders. The amygdala, a conserved part of the limbic system in vertebrates, receives sensory information from the outside world and is a key structure for emotional stimulus-associations and storage of fear memories. ...
KISHORE Aswathy - School of Computing
KISHORE Aswathy - School of Computing

... a simple coloured object, the brain stores information about it using what is called a ‘compositional representation’. Accordingly, different features of the object such as shape, texture and colour will be represented in different parts of the brain. Hence, in order to have a complete representatio ...
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Neuroinformatics

Neuroinformatics is a research field concerned with the organization of neuroscience data by the application of computational models and analytical tools. These areas of research are important for the integration and analysis of increasingly large-volume, high-dimensional, and fine-grain experimental data. Neuroinformaticians provide computational tools, mathematical models, and create interoperable databases for clinicians and research scientists. Neuroscience is a heterogeneous field, consisting of many and various sub-disciplines (e.g., Cognitive Psychology, Behavioral Neuroscience, and Behavioral Genetics). In order for our understanding of the brain to continue to deepen, it is necessary that these sub-disciplines are able to share data and findings in a meaningful way; Neuroinformaticians facilitate this.Neuroinformatics stands at the intersection of neuroscience and information science. Other fields, like genomics, have demonstrated the effectiveness of freely-distributed databases and the application of theoretical and computational models for solving complex problems. In Neuroinformatics, such facilities allow researchers to more easily quantitatively confirm their working theories by computational modeling. Additionally, neuroinformatics fosters collaborative research—an important fact that facilitates the field's interest in studying the multi-level complexity of the brain.There are three main directions where neuroinformatics has to be applied: the development of tools and databases for management and sharing of neuroscience data at all levels of analysis, the development of tools for analyzing and modeling neuroscience data, the development of computational models of the nervous system and neural processes.In the recent decade, as vast amounts of diverse data about the brain were gathered by many research groups, the problem was raised of how to integrate the data from thousands of publications in order to enable efficient tools for further research. The biological and neuroscience data are highly interconnected and complex, and by itself, integration represents a great challenge for scientists.Combining informatics research and brain research provides benefits for both fields of science. On one hand, informatics facilitates brain data processing and data handling, by providing new electronic and software technologies for arranging databases, modeling and communication in brain research. On the other hand, enhanced discoveries in the field of neuroscience will invoke the development of new methods in information technologies (IT).
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