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Chapter 12 - Nervous Tissue
Chapter 12 - Nervous Tissue

... __________________ - most common glial cell, similar to astrocytes but with shorter & fewer processes. Functions: 1) Guide development of _________ in the CNS 2) Produce ______________ (lipid & protein) around CNS neuron axons, which insulates axon, increasing speed of nerve impulse conduction. 3) _ ...
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Neurons and Nervous System

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Nervous System - Calgary Christian School
Nervous System - Calgary Christian School

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Chapter 19 The Neurological System
Chapter 19 The Neurological System

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Attenuating GABAA Receptor Signaling in Dopamine Neurons
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The Nervous System
The Nervous System

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Neurotoxin



Neurotoxins are substances that are poisonous or destructive to nerve tissue. Neurotoxins are an extensive class of exogenous chemical neurological insults that can adversely affect function in both developing and mature nervous tissue. The term can also be used to classify endogenous compounds, which, when abnormally contact, can prove neurologically toxic. Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems. Common examples of neurotoxins include lead, ethanol (drinking alcohol), Manganese glutamate, nitric oxide (NO), botulinum toxin (e.g. Botox), tetanus toxin, and tetrodotoxin. Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations.Neurotoxins inhibit neuron control over ion concentrations across the cell membrane, or communication between neurons across a synapse. Local pathology of neurotoxin exposure often includes neuron excitotoxicity or apoptosis but can also include glial cell damage. Macroscopic manifestations of neurotoxin exposure can include widespread central nervous system damage such as intellectual disability, persistent memory impairments, epilepsy, and dementia. Additionally, neurotoxin-mediated peripheral nervous system damage such as neuropathy or myopathy is common. Support has been shown for a number of treatments aimed at attenuating neurotoxin-mediated injury, such as antioxidant, and antitoxin administration.
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