Predicting outcomes and drug resistance with standardised treatment of active tuberculosis O. Oxlade*
... spontaneous cure rate as untreated cases in Europe in the preantibiotic era [19]). The remainder of MDR cases failed (42%). We assumed that all failures and relapses would be detected and receive the standardised retreatment regimen. Those who required retreatment were reclassified according to thei ...
... spontaneous cure rate as untreated cases in Europe in the preantibiotic era [19]). The remainder of MDR cases failed (42%). We assumed that all failures and relapses would be detected and receive the standardised retreatment regimen. Those who required retreatment were reclassified according to thei ...
Formulation Development of Chlorpheniramine Maleate Tablet by
... order to get the correct medicinal benefits. This directly compressible formulation was compared with three leading marketed brands for efficiency and competence. These marketed brands are manufactured through wet granulation technique. The majority of pharmaceutical industries have been using wet g ...
... order to get the correct medicinal benefits. This directly compressible formulation was compared with three leading marketed brands for efficiency and competence. These marketed brands are manufactured through wet granulation technique. The majority of pharmaceutical industries have been using wet g ...
Cyclosporine population pharmacokinetics and - HAL
... the first month and around 150 ng/mL thereafter for the first year. Corticosteroids were administered according to the standard administration regimen of each center. Classically high doses were administered at the time of transplantation, close to 2mg/kg/day at day one and progressively reduced ove ...
... the first month and around 150 ng/mL thereafter for the first year. Corticosteroids were administered according to the standard administration regimen of each center. Classically high doses were administered at the time of transplantation, close to 2mg/kg/day at day one and progressively reduced ove ...
CELEXA PM MKT Control 149419 10Jan2012 En
... discontinuation. The risk of discontinuation symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), agitation or anx ...
... discontinuation. The risk of discontinuation symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), agitation or anx ...
Package Insert-Amiloride Tablets-5mg
... should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets of amiloride HCl daily usually are not needed, and there is little controlled experience with such doses. If persistent hy ...
... should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets of amiloride HCl daily usually are not needed, and there is little controlled experience with such doses. If persistent hy ...
economics TB Drug Development t he o f
... Within the pharmaceutical industry, serious drug development for treating TB virtually stopped some 30 years ago, in part because it was perceived that TB was defeated. The Global Alliance for TB Drug Development believes that activity remains low, at least in part, because the real size of the mark ...
... Within the pharmaceutical industry, serious drug development for treating TB virtually stopped some 30 years ago, in part because it was perceived that TB was defeated. The Global Alliance for TB Drug Development believes that activity remains low, at least in part, because the real size of the mark ...
Additivity Versus Synergy: A Theoretical Analysis of - Area-c54
... BACKGROUND: Inhaled anesthetics have been postulated to act at multiple receptors, with modest action at each site summing to produce immobility to noxious stimulation. Recent experimental results affirm prior findings that inhaled anesthetics interact additively. Synergy implies multiple sites of a ...
... BACKGROUND: Inhaled anesthetics have been postulated to act at multiple receptors, with modest action at each site summing to produce immobility to noxious stimulation. Recent experimental results affirm prior findings that inhaled anesthetics interact additively. Synergy implies multiple sites of a ...
12146005
... Oral sustained release drug delivery system is being widely used for the past two decades as a means to provide a drug with improved therapeutic efficacy and also to assure rational drug therapy. The sustained release dosage form allows slow release of the drug followed by the maintenance of a const ...
... Oral sustained release drug delivery system is being widely used for the past two decades as a means to provide a drug with improved therapeutic efficacy and also to assure rational drug therapy. The sustained release dosage form allows slow release of the drug followed by the maintenance of a const ...
(PSD) November 2015 PBAC Meeting
... Restriction Section 100: Public and private hospital authority required Clinical Patient must have a documented history of severe chronic idiopathic urticaria (CIU), criteria AND Patient must demonstrate, at the time of application, an adequate response to their most recent course of treatment with ...
... Restriction Section 100: Public and private hospital authority required Clinical Patient must have a documented history of severe chronic idiopathic urticaria (CIU), criteria AND Patient must demonstrate, at the time of application, an adequate response to their most recent course of treatment with ...
cannabis or hashish - KSU Faculty Member websites
... man to discover the ability of some plants to relieve pain, change the mood, alter perception or produce euphoria. Such plants included Opium in China and India, Mescal buttons in Mexico, Coca in Peru, Cannabis in China and Teonanctal mushroom in Mexico and South West USA. Furthermore some of these ...
... man to discover the ability of some plants to relieve pain, change the mood, alter perception or produce euphoria. Such plants included Opium in China and India, Mescal buttons in Mexico, Coca in Peru, Cannabis in China and Teonanctal mushroom in Mexico and South West USA. Furthermore some of these ...
IIH:WT Trial Protocol - University of Birmingham
... Principal Investigator Signature Page Principal Investigator: I have read and agree to the protocol, as detailed in this document. I agree to adhere to the protocol as outlined and agree that any suggested changes to the protocol must be approved by the Trial Steering Committee prior to seeking appr ...
... Principal Investigator Signature Page Principal Investigator: I have read and agree to the protocol, as detailed in this document. I agree to adhere to the protocol as outlined and agree that any suggested changes to the protocol must be approved by the Trial Steering Committee prior to seeking appr ...
Concomitant Administration of Clopidogrel With Statins or Calcium
... consultant for Aegerion, Amgen, AstraZeneca/Bristol-Myers Squibb Alliance, Intarcia, Pfizer, Sanofi-aventis, and Vertex. Dr. O’Donoghue has received research funding from GlaxoSmithKline and AstraZeneca and is a consultant for Aegerion. All other authors have reported that ...
... consultant for Aegerion, Amgen, AstraZeneca/Bristol-Myers Squibb Alliance, Intarcia, Pfizer, Sanofi-aventis, and Vertex. Dr. O’Donoghue has received research funding from GlaxoSmithKline and AstraZeneca and is a consultant for Aegerion. All other authors have reported that ...
Ritodrine (Systemic)
... enhance fetal lung maturity; however, intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. Intravenous ritodrine further increases plasma volume and may cause overhydration. One possible result of overhydration is maternal pulmonary ed ...
... enhance fetal lung maturity; however, intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. Intravenous ritodrine further increases plasma volume and may cause overhydration. One possible result of overhydration is maternal pulmonary ed ...
Paracetamol and Ibuprofen for Paediatric Pain and Fever
... Up to 90 mg/kg per day under medical supervision with review 10 mg/kg 3 or 4 times a day after 48 hours; single doses of 30 mg/kg for night-time dosing ...
... Up to 90 mg/kg per day under medical supervision with review 10 mg/kg 3 or 4 times a day after 48 hours; single doses of 30 mg/kg for night-time dosing ...
revised clinical study protocol 1
... Study design This is a Phase II, multicentre, randomised, double-blind, placebo-controlled, dose escalation study to assess the safety, tolerability, PK and PD of multiple intravenous (IV) infusions of two different doses of AZD9773 in Japanese patients with severe sepsis and/or septic shock (as soo ...
... Study design This is a Phase II, multicentre, randomised, double-blind, placebo-controlled, dose escalation study to assess the safety, tolerability, PK and PD of multiple intravenous (IV) infusions of two different doses of AZD9773 in Japanese patients with severe sepsis and/or septic shock (as soo ...
How fast and how often: The pharmacokinetics of drug use are
... Amongst people who use drugs, some keep control over their drug use while others develop addiction. What accounts for this differential vulnerability? Like any complex disease, “the development of addiction depends on the interaction of agent, host and environment” (O’Brien, 2008). With this reality ...
... Amongst people who use drugs, some keep control over their drug use while others develop addiction. What accounts for this differential vulnerability? Like any complex disease, “the development of addiction depends on the interaction of agent, host and environment” (O’Brien, 2008). With this reality ...
Warfarin Therapy in Haemodialysis patients. doc
... evidence to prevent dysfunction of tunnelled cuffed dialysis catheters (TCCs) dysfunction or arterio-venous dialysis access. (Willm, L. & Vercaigne, L. 2008) Warfarin therapy management is complicated in the HD population. Platelet dysfunction, anticoagulation for the extracorporeal dialysis circuit ...
... evidence to prevent dysfunction of tunnelled cuffed dialysis catheters (TCCs) dysfunction or arterio-venous dialysis access. (Willm, L. & Vercaigne, L. 2008) Warfarin therapy management is complicated in the HD population. Platelet dysfunction, anticoagulation for the extracorporeal dialysis circuit ...
Prescription Drug Cost Sharing - Associations With Medication and
... not control for other factors that might be changing, including observations before and after a benefit change with no control group. These designs include (but are not limited to) many international studies in which co-payments changed for the entire population.* Some of the studies found relativel ...
... not control for other factors that might be changing, including observations before and after a benefit change with no control group. These designs include (but are not limited to) many international studies in which co-payments changed for the entire population.* Some of the studies found relativel ...
Management of Oral Anticoagulation Therapy: A Review of Principles
... increased risk of serious and life-threatening bleeding events when receiving warfarin therapy: eg, *2/*2, *2/*3, or *3/*3. Because different alleles contribute to variability in warfarin dose requirements among individual patients, screening for these variants in different patient populations may h ...
... increased risk of serious and life-threatening bleeding events when receiving warfarin therapy: eg, *2/*2, *2/*3, or *3/*3. Because different alleles contribute to variability in warfarin dose requirements among individual patients, screening for these variants in different patient populations may h ...
Extract from the Clinical Evaluation Report for Elosulfase alfa (rch)
... The words [Information redacted], where they appear in this document, indicate that confidential information has been deleted. ...
... The words [Information redacted], where they appear in this document, indicate that confidential information has been deleted. ...
Cephalosporins and Related Antibiotics Therapeutic Class Review (TCR) January 7, 2014
... patient worsens or fails to improve with watchful waiting, therapy with amoxicillin should begin.19 (Update to this guideline is in progress, no expected date of publication given at this time.) If treatment failure is observed following seven days of antibiotic therapy, a nonbacterial cause or infe ...
... patient worsens or fails to improve with watchful waiting, therapy with amoxicillin should begin.19 (Update to this guideline is in progress, no expected date of publication given at this time.) If treatment failure is observed following seven days of antibiotic therapy, a nonbacterial cause or infe ...
Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis
... induced the expression of drug-metabolizing enzymes and transporters. Administration of Wu Wei Zi and Gan Cao extracts in rats resulted in an increased metabolism of warfarin. Our results suggest that caution should be taken when using TCM herbs to avoid unwanted excessive PXR activation and the res ...
... induced the expression of drug-metabolizing enzymes and transporters. Administration of Wu Wei Zi and Gan Cao extracts in rats resulted in an increased metabolism of warfarin. Our results suggest that caution should be taken when using TCM herbs to avoid unwanted excessive PXR activation and the res ...
Product Information Ledipasvir / Sofosbuvir
... (78%) while 3.5% was recovered as sofosbuvir. This data indicate that renal clearance is the major elimination pathway for GS-331007. The median terminal half-lives of sofosbuvir and GS331007 were 0.4 and 27 hours, respectively. Effect of food Relative to fasting conditions, the administration of a ...
... (78%) while 3.5% was recovered as sofosbuvir. This data indicate that renal clearance is the major elimination pathway for GS-331007. The median terminal half-lives of sofosbuvir and GS331007 were 0.4 and 27 hours, respectively. Effect of food Relative to fasting conditions, the administration of a ...
study of formulation, characterisation and wound healing potential of
... dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of pre-formulation study is to generate information useful to the formulator in developing stable and bio ava ...
... dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of pre-formulation study is to generate information useful to the formulator in developing stable and bio ava ...
AusPAR: Pitavastatin - Therapeutic Goods Administration
... In vitro studies showed that pitavastatin inhibited cholesterol synthesis in HepG2, skeletal muscle cells and hepatocytes with IC50s of 5.8, 3.4 and 24.5nM, respectively. The IC50 ratio of 1/3/6 obtained for pitavastatin, simvastatin and atorvastatin in HepG2 cells is close to the respective clinica ...
... In vitro studies showed that pitavastatin inhibited cholesterol synthesis in HepG2, skeletal muscle cells and hepatocytes with IC50s of 5.8, 3.4 and 24.5nM, respectively. The IC50 ratio of 1/3/6 obtained for pitavastatin, simvastatin and atorvastatin in HepG2 cells is close to the respective clinica ...