IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Intrathecal clonidine as an adjuvant to hyperbaric bupivacaine in patients undergoing… incidence of sedation as assessed by sedation score which was higher in the clonidine group than in the control group 3 to 6 hours after injection which was stastically significant (p<0.001). The incidence of hyp ...
... Intrathecal clonidine as an adjuvant to hyperbaric bupivacaine in patients undergoing… incidence of sedation as assessed by sedation score which was higher in the clonidine group than in the control group 3 to 6 hours after injection which was stastically significant (p<0.001). The incidence of hyp ...
- Boehringer Ingelheim (Canada)
... In rats, co-administration of a Vitamin E derivative increased the bleeding effects of tipranavir (see Toxicology section). However, analyses of stored plasma from adults treated with APTIVUS capsules plus low-dose ritonavir, and from paediatric patients treated with APTIVUS capsules or tipranavir ...
... In rats, co-administration of a Vitamin E derivative increased the bleeding effects of tipranavir (see Toxicology section). However, analyses of stored plasma from adults treated with APTIVUS capsules plus low-dose ritonavir, and from paediatric patients treated with APTIVUS capsules or tipranavir ...
Salair Inhaler
... Salbutamol once it reaches the systemic circulation is excreted after undergoing hepatic metabolism. Salbutamol is excreted predominantly in the urine as salbutamol that is ...
... Salbutamol once it reaches the systemic circulation is excreted after undergoing hepatic metabolism. Salbutamol is excreted predominantly in the urine as salbutamol that is ...
SEREVENT DISKUS
... placebo-controlled U.S. trial that compared the safety of salmeterol with placebo added to usual asthma therapy showed an increase in asthma-related deaths in subjects receiving salmeterol (13 deaths out of 13,176 subjects treated for 28 weeks on salmeterol versus 3 deaths out of 13,179 subjects on ...
... placebo-controlled U.S. trial that compared the safety of salmeterol with placebo added to usual asthma therapy showed an increase in asthma-related deaths in subjects receiving salmeterol (13 deaths out of 13,176 subjects treated for 28 weeks on salmeterol versus 3 deaths out of 13,179 subjects on ...
Anti-inflammatory, Antinociceptive, Antipyretic and
... were kept at 4°C till biological tests (8). d = The constant factor between 2 successive doses. Animals: Healthy Sprague-Dawely rats, weighing 130n = Number of animals in each group. 160g and albino mice, weighing 20-25g, were obtained Σ = The sum of (z x d). from the animal house of the National Re ...
... were kept at 4°C till biological tests (8). d = The constant factor between 2 successive doses. Animals: Healthy Sprague-Dawely rats, weighing 130n = Number of animals in each group. 160g and albino mice, weighing 20-25g, were obtained Σ = The sum of (z x d). from the animal house of the National Re ...
BMT CTN PROTOCOL 0403 VERSION 5.0 Study Chairpersons
... Over the last two decades, allogeneic hematopoietic cell transplantation (HCT) has emerged as an important treatment for a number of malignant and non-malignant disorders. Unfortunately, several complications, including graft-versus-host disease (GVHD) and pulmonary dysfunction, limit the utility of ...
... Over the last two decades, allogeneic hematopoietic cell transplantation (HCT) has emerged as an important treatment for a number of malignant and non-malignant disorders. Unfortunately, several complications, including graft-versus-host disease (GVHD) and pulmonary dysfunction, limit the utility of ...
Differential Effects of Ethanol and Midazolam upon the Devaluation
... EtOH's anti-anxiety effects, particularly early in ontogeny. It is still uncertain whether rat pups perceive EtOH's anxiolytic properties and, if so, what mechanisms underlie this phenomenon. This void in the literature can be explained by a lack of appropriate age-related tests. Most of the techniq ...
... EtOH's anti-anxiety effects, particularly early in ontogeny. It is still uncertain whether rat pups perceive EtOH's anxiolytic properties and, if so, what mechanisms underlie this phenomenon. This void in the literature can be explained by a lack of appropriate age-related tests. Most of the techniq ...
Health Psychology From Ideas to Efficacy
... a pilot study is often conducted to determine the feasibility and acceptability of a trial protocol in preparation for the Phase III efficacy trial, where the drug’s impact on clinically meaningful endpoints such as disease onset, progression and mortality is evaluated (Friedman et al., 1998; Lipsky ...
... a pilot study is often conducted to determine the feasibility and acceptability of a trial protocol in preparation for the Phase III efficacy trial, where the drug’s impact on clinically meaningful endpoints such as disease onset, progression and mortality is evaluated (Friedman et al., 1998; Lipsky ...
navigating the fda
... 3 different dose levels, 2+ species, observed 2 – 12 weeks Estimate what human dosages will be Especially note liver, kidneys and nervous system Chronic toxicity 3 – 24 months At least 6 months before human studies Carcinogenic effects, 6 months, 2+ species, same route of administration as humans Te ...
... 3 different dose levels, 2+ species, observed 2 – 12 weeks Estimate what human dosages will be Especially note liver, kidneys and nervous system Chronic toxicity 3 – 24 months At least 6 months before human studies Carcinogenic effects, 6 months, 2+ species, same route of administration as humans Te ...
Guidance for FDA Reviewers and Sponsors
... Distribution of these products can also be a challenge due to stability issues and the frequently short dating period of many cellular products, which may necessitate release of the final product for administration to a patient before certain test results are available. This guidance finalizes the d ...
... Distribution of these products can also be a challenge due to stability issues and the frequently short dating period of many cellular products, which may necessitate release of the final product for administration to a patient before certain test results are available. This guidance finalizes the d ...
Xanax - Erowid
... XANAX. These include a spectrum of withdrawal symptoms; the most important is seizure (see DRUG ABUSE AND DEPENDENCE). Even after relatively short-term use at the doses recommended for the treatment of transient anxiety and anxiety disorder (ie, 0.75 to 4.0 mg per day), there is some risk of depende ...
... XANAX. These include a spectrum of withdrawal symptoms; the most important is seizure (see DRUG ABUSE AND DEPENDENCE). Even after relatively short-term use at the doses recommended for the treatment of transient anxiety and anxiety disorder (ie, 0.75 to 4.0 mg per day), there is some risk of depende ...
Why Do We Use 600 mg of Rifampicin in
... isoniazid-pyrazinamide regimens over equally active isoniazid-rifampicin regimens as rifampicin cost more than £110 for 6 months, which was .4 times the cost of pyrazinamide. The benefit of their study was formulated giving ‘‘good prospects of developing practical short-course regimens which do not ...
... isoniazid-pyrazinamide regimens over equally active isoniazid-rifampicin regimens as rifampicin cost more than £110 for 6 months, which was .4 times the cost of pyrazinamide. The benefit of their study was formulated giving ‘‘good prospects of developing practical short-course regimens which do not ...
Dr. Yarascavitch - Toronto Academy of Dentistry
... well as consideration of any other factors that may after his/her suitability for sedation must be made prior to its administration.” (#5, p.2) ...
... well as consideration of any other factors that may after his/her suitability for sedation must be made prior to its administration.” (#5, p.2) ...
Bayer Aspirin Complex 500mg/30mg Granules for Oral Suspension
... hypertension); - renal dysfunction, which may progress to renal failure with oligo-hydroamniosis; the mother and the neonate, at the end of pregnancy, to: - possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses. - inhibition of uterine contractions ...
... hypertension); - renal dysfunction, which may progress to renal failure with oligo-hydroamniosis; the mother and the neonate, at the end of pregnancy, to: - possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses. - inhibition of uterine contractions ...
CHRONOTHERAPY OF CANCER:
... use today. The most widely used anthracycline, doxorubicin, is a potent therapeutic agent against a wide spectrum of malignancies, but it causes substantial acute and chronic toxicity [29]. Profound myelosuppression, stomatitis, mucositis and gastrointestinal disturbances are commonly observed acute ...
... use today. The most widely used anthracycline, doxorubicin, is a potent therapeutic agent against a wide spectrum of malignancies, but it causes substantial acute and chronic toxicity [29]. Profound myelosuppression, stomatitis, mucositis and gastrointestinal disturbances are commonly observed acute ...
classification of sedating antihistamines
... which is interpreted as early EEG sign of sedation, was observed after chlorpheniramine or cetirizine 20mg. Witek et al. conducted two single dose, cross over studies. In the first, the authors validated their methodology in 18 healthy subjects by examining the response to diphenhydramine 50mg, te ...
... which is interpreted as early EEG sign of sedation, was observed after chlorpheniramine or cetirizine 20mg. Witek et al. conducted two single dose, cross over studies. In the first, the authors validated their methodology in 18 healthy subjects by examining the response to diphenhydramine 50mg, te ...
GLUCOVANCE (Glyburide and Metformin HCl) - Products
... metformin, or placebo, but the differences from glyburide and metformin did not reach statistical significance. Changes in the lipid profile associated with GLUCOVANCE treatment were similar to those seen with glyburide, metformin, and placebo. The double-blind, placebo-controlled trial described ab ...
... metformin, or placebo, but the differences from glyburide and metformin did not reach statistical significance. Changes in the lipid profile associated with GLUCOVANCE treatment were similar to those seen with glyburide, metformin, and placebo. The double-blind, placebo-controlled trial described ab ...
Evaluation of rat ultrasonic vocalizations as predictors of the
... [0.36±0.23; t(17)=2.61, P<0.05] but not the low dose of NAL (3.87±1.23) emitted fewer 50 kHz USVs in the drug-paired compartment, relative to VEH-conditioned animals (3.25±1.26). Analysis of percentage 50 kHz USVs emitted in the drug-paired chamber, covarying for percentage time spent in the drug-pa ...
... [0.36±0.23; t(17)=2.61, P<0.05] but not the low dose of NAL (3.87±1.23) emitted fewer 50 kHz USVs in the drug-paired compartment, relative to VEH-conditioned animals (3.25±1.26). Analysis of percentage 50 kHz USVs emitted in the drug-paired chamber, covarying for percentage time spent in the drug-pa ...
Prodrugs—from Serendipity to Rational Design
... V. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... V. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of
... addressed in a previous parameter.(3) There were several reasons for this decision. First, we felt that the newer AEDs, less familiar to the practicing physician, were the cause of the most practice variance and confusion. Secondly, the evidence available on the use of the older AEDs is vast, and th ...
... addressed in a previous parameter.(3) There were several reasons for this decision. First, we felt that the newer AEDs, less familiar to the practicing physician, were the cause of the most practice variance and confusion. Secondly, the evidence available on the use of the older AEDs is vast, and th ...
SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS
... patients, especially those suffering from respiratory diseases. Most DPI formulations contain a carrier to improve the handling of the powder and to control the deposition of the drug into the lungs.1,2 Excipients like lactose, mannitol, sorbitol, erythritol, anhydrous glucose, trehalose and fumaryl ...
... patients, especially those suffering from respiratory diseases. Most DPI formulations contain a carrier to improve the handling of the powder and to control the deposition of the drug into the lungs.1,2 Excipients like lactose, mannitol, sorbitol, erythritol, anhydrous glucose, trehalose and fumaryl ...
Formulation and evaluation of fluconazole and ichthammol ointment
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
MEDICATION GUIDE ZEGERID® (ze ger id) (omeprazole / sodium
... Avoid concomitant use of ZEGERID with clopidogrel. Clopidogrel is a prodrug. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as omeprazole, that ...
... Avoid concomitant use of ZEGERID with clopidogrel. Clopidogrel is a prodrug. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as omeprazole, that ...
FDA Approved Labeling 12.19.08 3pm NovaDel Pharma Inc.
... administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional over-dosage is more common in this group of patients; therefore, the least amount of drug that is feasible should ...
... administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional over-dosage is more common in this group of patients; therefore, the least amount of drug that is feasible should ...
http://www.fda.gov/downloads/Drugs/G.../ucm073389.pdf
... includes safety considerations. The level of any degradation product present in a new drug product that has been adequately tested in safety and/or clinical studies would be considered qualified. Therefore, it is useful to include any available information on the actual content of degradation produc ...
... includes safety considerations. The level of any degradation product present in a new drug product that has been adequately tested in safety and/or clinical studies would be considered qualified. Therefore, it is useful to include any available information on the actual content of degradation produc ...