ZOCOR® Product Monograph - Morley Evans Insight
... simvastatin and/or consumed substantial quantities of alcohol. In the Scandinavian Simvastatin Survival Study (see PHARMACOLOGY, Clinical Studies), the number of patients with more than one transaminase elevation to > 3 times the ULN, over the course of the study, was not significantly different bet ...
... simvastatin and/or consumed substantial quantities of alcohol. In the Scandinavian Simvastatin Survival Study (see PHARMACOLOGY, Clinical Studies), the number of patients with more than one transaminase elevation to > 3 times the ULN, over the course of the study, was not significantly different bet ...
study of formulation, characterisation and wound healing potential of
... dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of pre-formulation study is to generate information useful to the formulator in developing stable and bio ava ...
... dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of pre-formulation study is to generate information useful to the formulator in developing stable and bio ava ...
Augmentin SR 1000mg Tablets
... clavulanate can also be detected in breast milk. With the exception of the risk of sensitisation associated with this excretion, there are no known detrimental effects for the breast-fed infant. Reproduction studies in animals have shown that both amoxicillin and clavulanate penetrate the placental ...
... clavulanate can also be detected in breast milk. With the exception of the risk of sensitisation associated with this excretion, there are no known detrimental effects for the breast-fed infant. Reproduction studies in animals have shown that both amoxicillin and clavulanate penetrate the placental ...
A New Crescent-shaped Spindle for Drug Dissolution Testing—But
... variable hydrodynamics, a metal strip based procedure was proposed. The idea behind the metal strip concept was that, not only will it simulate variation in vessel dimensions, within accepted tolerances, but it will also push the positioning of the tablets off-center and enhance spread of the disint ...
... variable hydrodynamics, a metal strip based procedure was proposed. The idea behind the metal strip concept was that, not only will it simulate variation in vessel dimensions, within accepted tolerances, but it will also push the positioning of the tablets off-center and enhance spread of the disint ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Study of anticonvulsant activity of quinidine in albino rats using pentylenetetrazole model tonic clonic seizures act by the first and second mechanism. The drugs active against the absence seizure acts by the third mechanism.3 Various in-vivo models employ diverse animal species including both rod ...
... Study of anticonvulsant activity of quinidine in albino rats using pentylenetetrazole model tonic clonic seizures act by the first and second mechanism. The drugs active against the absence seizure acts by the third mechanism.3 Various in-vivo models employ diverse animal species including both rod ...
Malaria Chemoprophylaxis in the Age of Drug Resistance. I
... the result of gastrointestinal upset and dizziness) than use of placebo. In a recent randomized trial comparing MFQ with AP in 11000 nonimmune travelers, both agents were effective and well tolerated, but AP was better tolerated. The overall discontinuation rate for MFQ was 5%, and 3.9% of MFQ users ...
... the result of gastrointestinal upset and dizziness) than use of placebo. In a recent randomized trial comparing MFQ with AP in 11000 nonimmune travelers, both agents were effective and well tolerated, but AP was better tolerated. The overall discontinuation rate for MFQ was 5%, and 3.9% of MFQ users ...
product monograph
... Suicidal ideation and behaviour Suicidal ideation and behaviour have been reported in patients treated with antiepileptic agents in several indications. All patients treated with antiepileptic drugs, irrespective of indication, should be monitored for signs of suicidal ideation and behaviour and ap ...
... Suicidal ideation and behaviour Suicidal ideation and behaviour have been reported in patients treated with antiepileptic agents in several indications. All patients treated with antiepileptic drugs, irrespective of indication, should be monitored for signs of suicidal ideation and behaviour and ap ...
(PSD) March 2016 PBAC Meeting - (Word 93KB)
... review minimised the impact of any such bias. The COMBI-V trial also allowed cross-over, which the submission acknowledged may bias results. The November 2014 PSD for trametinib (paragraph 6.5) identified COMBI-V as having a low risk of bias and while the possibility of cross-over may have favoured ...
... review minimised the impact of any such bias. The COMBI-V trial also allowed cross-over, which the submission acknowledged may bias results. The November 2014 PSD for trametinib (paragraph 6.5) identified COMBI-V as having a low risk of bias and while the possibility of cross-over may have favoured ...
Erythormycin Ointment Sell Sheet - Akorn
... Staphylococcus aureus, including penicillinase- various salts and esters, at doses that were several producing strains (methicillin-resistant multiples of the usual human dose. No evidence of staphylococci are uniformly resistant to harm to the fetus that appeared related to erythro- ERT00N Rev. 05/ ...
... Staphylococcus aureus, including penicillinase- various salts and esters, at doses that were several producing strains (methicillin-resistant multiples of the usual human dose. No evidence of staphylococci are uniformly resistant to harm to the fetus that appeared related to erythro- ERT00N Rev. 05/ ...
ROPINIROLE-GA PRODUCT INFORMATION (ropinirole) NAME OF
... somnolence while on ropinirole, some perceived that they had no warning signs such as excessive drowsiness, and believed that they were alert immediately prior to the event. Some of these events have been reported as late as 1 year after initiation of treatment. In controlled clinical trials, somnol ...
... somnolence while on ropinirole, some perceived that they had no warning signs such as excessive drowsiness, and believed that they were alert immediately prior to the event. Some of these events have been reported as late as 1 year after initiation of treatment. In controlled clinical trials, somnol ...
BIOAVAILABILITY OF ORAL PROPOFOL IN HUMANS Victor
... rate and a reduction in body temperature. Righting reflex was not lost in any animal at this dose.” The same investigators noted that the median intravenous hypnotic dose of propofol on the mouse was 12.8 mg/kg.13 Thus, propofol is at least 23 times less potent when administered orally in mice than ...
... rate and a reduction in body temperature. Righting reflex was not lost in any animal at this dose.” The same investigators noted that the median intravenous hypnotic dose of propofol on the mouse was 12.8 mg/kg.13 Thus, propofol is at least 23 times less potent when administered orally in mice than ...
MS Contin - Purdue Pharma
... Addiction, Abuse and Misuse Like all opioids, MS Contin is a potential drug of abuse and misuse, which can lead to overdose and death. Therefore, MS Contin should be prescribed and handled with caution. Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being ...
... Addiction, Abuse and Misuse Like all opioids, MS Contin is a potential drug of abuse and misuse, which can lead to overdose and death. Therefore, MS Contin should be prescribed and handled with caution. Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being ...
Abbott-4100-PCA+2-Op.. - Elite Medical Equipment
... The PCA PLUS II infuser can be programmed to deliver either PCA doses deliver only a continuous background infusion with no PCA doses permitted (CONTINUOUS mode), or to deliver a continuous rate and allow PCA doses (PCA+CONTINUOUS mode). Analgesic drugs may be delivered through LifeCare PCA Plus II ...
... The PCA PLUS II infuser can be programmed to deliver either PCA doses deliver only a continuous background infusion with no PCA doses permitted (CONTINUOUS mode), or to deliver a continuous rate and allow PCA doses (PCA+CONTINUOUS mode). Analgesic drugs may be delivered through LifeCare PCA Plus II ...
A Clinically Oriented Review of the Landmark Clinical Trials
... inter-patient dose variability [5-7]. Because of these limitations, large surveys indicate that at least one third of patients who are considered to be ideal candidates for anticoagulation therapy are not receiving it [8-10]. Therefore, VKAs are often not started in patients who would benefit from t ...
... inter-patient dose variability [5-7]. Because of these limitations, large surveys indicate that at least one third of patients who are considered to be ideal candidates for anticoagulation therapy are not receiving it [8-10]. Therefore, VKAs are often not started in patients who would benefit from t ...
urticaria
... Tricyclic antidepressants are potent blockers of histamine H1 and H2 receptors. When taken in dosages between 10 and 25 mg three times a day doxepin is effective for the treatment of chronic idiopathic urticaria. Doxepin is a good alternative for patients with chronic urticaria not controlled with c ...
... Tricyclic antidepressants are potent blockers of histamine H1 and H2 receptors. When taken in dosages between 10 and 25 mg three times a day doxepin is effective for the treatment of chronic idiopathic urticaria. Doxepin is a good alternative for patients with chronic urticaria not controlled with c ...
The effects of chlorpromazine and pimozide in reinforcement
... six reinforcers according to the contingency that every fifth response or a 10-s interval without a response operated the dipper. The warm-up period was signalled by the houselight and was followed by a 120-s time-out period. During this time-out and the 500-s time-out periods between reinforcement ...
... six reinforcers according to the contingency that every fifth response or a 10-s interval without a response operated the dipper. The warm-up period was signalled by the houselight and was followed by a 120-s time-out period. During this time-out and the 500-s time-out periods between reinforcement ...
European Heart Rhythm Association Practical patients with non-valvular atrial fibrillation
... proposed in Figure 1, is intended to document each planned visit, each relevant observation or examination, and any medication change, so that every person following up the patient is well-informed. Moreover, written communication between the different (para)medical players is required to inform the ...
... proposed in Figure 1, is intended to document each planned visit, each relevant observation or examination, and any medication change, so that every person following up the patient is well-informed. Moreover, written communication between the different (para)medical players is required to inform the ...
Balsalazide disodium for the treatment of ulcerative colitis Drug Profile
... The pharmacokinetic properties of balsalazide have been well described [19]. Values were studied in 54 patients who were taking 3–6 g/day of balsalazide for 1 year, normalized to a statim dose of 3.43 mmol. The peak plasma concentration (Cmax) was 0.324 µmol/l, trough plasma concentration (Cmin) 0.0 ...
... The pharmacokinetic properties of balsalazide have been well described [19]. Values were studied in 54 patients who were taking 3–6 g/day of balsalazide for 1 year, normalized to a statim dose of 3.43 mmol. The peak plasma concentration (Cmax) was 0.324 µmol/l, trough plasma concentration (Cmin) 0.0 ...
PRODUCT MONOGRAPH PrLINCOCIN® Lincomycin injection USP
... and compared with a control group of 65 children born at the same time in the same hospital. LINCOCIN treatment did not result in any drug related abnormalities (physical, dental or developmental) when compared with the control group. The lincomycin injection formulation contains benzyl alcohol. The ...
... and compared with a control group of 65 children born at the same time in the same hospital. LINCOCIN treatment did not result in any drug related abnormalities (physical, dental or developmental) when compared with the control group. The lincomycin injection formulation contains benzyl alcohol. The ...
Nasacort® AQ (triamcinolone acetonide)
... Spray well before each use. 2.1 Adults and Adolescents 12 Years of Age and Older The recommended starting and maximum dose is 220 mcg per day as two sprays in each nostril once daily. Titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. When the maxi ...
... Spray well before each use. 2.1 Adults and Adolescents 12 Years of Age and Older The recommended starting and maximum dose is 220 mcg per day as two sprays in each nostril once daily. Titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. When the maxi ...
European Heart Rhythm Association Practical Guide on the use of
... the different AF anticoagulation trials, there are still many under-explored aspects of NOAC that are relevant already today when these drugs are used by cardiologists, neurologists, geriatricians, and general practitioners. Each of the new NOACs entering the market will be accompanied by tools for ...
... the different AF anticoagulation trials, there are still many under-explored aspects of NOAC that are relevant already today when these drugs are used by cardiologists, neurologists, geriatricians, and general practitioners. Each of the new NOACs entering the market will be accompanied by tools for ...
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... • Nintedanib reduced the decline in FVC, which is consistent with a slowing of disease progression • Nintedanib was frequently associated with diarrhea, which led to discontinuation of the study medication in less than 5% of patients ...
... • Nintedanib reduced the decline in FVC, which is consistent with a slowing of disease progression • Nintedanib was frequently associated with diarrhea, which led to discontinuation of the study medication in less than 5% of patients ...
The Effects of the Preferential 5
... Schizophrenia patients exhibit impairments in prepulse inhibition (PPI) of the startle response. Hallucinogenic 5-HT2A receptor agonists are used for animal models of schizophrenia because they mimic some symptoms of schizophrenia in humans and induce PPI deficits in animals. Nevertheless, one repor ...
... Schizophrenia patients exhibit impairments in prepulse inhibition (PPI) of the startle response. Hallucinogenic 5-HT2A receptor agonists are used for animal models of schizophrenia because they mimic some symptoms of schizophrenia in humans and induce PPI deficits in animals. Nevertheless, one repor ...
GYNO-DAKTARIN™ Janssen Pharma
... occur, the treatment should be discontinued. Appropriate therapy is indicated when the sexual partner is also infected. GYNO-DAKTARIN products do not stain skin or clothes. The concurrent use of latex condoms or diaphragms with vaginal anti-infective preparations may decrease the effectiveness of la ...
... occur, the treatment should be discontinued. Appropriate therapy is indicated when the sexual partner is also infected. GYNO-DAKTARIN products do not stain skin or clothes. The concurrent use of latex condoms or diaphragms with vaginal anti-infective preparations may decrease the effectiveness of la ...