Leukaemia Section t(14;19)(q32;q13) in acute lymphoblastic leukaemia Atlas of Genetics and Cytogenetics
... The involvement of the IGH gene located at 14q32 has been demonstrated via FISH using the LSI IGH Dual Colour Break Apart Rearrangement Probe in all cases tested. Metaphase and interphase FISH using probes flanking the BCL3 gene have ruled out the involvement of this gene; thus distinguishing it fro ...
... The involvement of the IGH gene located at 14q32 has been demonstrated via FISH using the LSI IGH Dual Colour Break Apart Rearrangement Probe in all cases tested. Metaphase and interphase FISH using probes flanking the BCL3 gene have ruled out the involvement of this gene; thus distinguishing it fro ...
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... • Question basic assumptions about biochemistry, physiology and evolution • Understand the power and limitations of bioinformatics ...
... • Question basic assumptions about biochemistry, physiology and evolution • Understand the power and limitations of bioinformatics ...
PowerPoint Presentation - Documented Gene Transfer in Bacteria
... • Definition: Segments of DNA that are able to move from one location to another • Properties – “Random” movement – Not capable of self replication – Transposition mediated by site-specific recombination • Transposase – Transposition may be accompanied by duplication ...
... • Definition: Segments of DNA that are able to move from one location to another • Properties – “Random” movement – Not capable of self replication – Transposition mediated by site-specific recombination • Transposase – Transposition may be accompanied by duplication ...
Genetics Option - Worked Examples
... Positive identification is less certain, even if there is a perfect match between two DNA samples. At best, this can provide an extremely high probability that the samples came from the same source. The reason for this is that a number of people may show the same patterns on a DNA test. The probabi ...
... Positive identification is less certain, even if there is a perfect match between two DNA samples. At best, this can provide an extremely high probability that the samples came from the same source. The reason for this is that a number of people may show the same patterns on a DNA test. The probabi ...
Diffuse Nonepidermolytic Palmoplantar Keratoderma Caused by a
... achieved toward a better understanding of the molecular basis of these disorders. Mutations in more than 20 distinct genes have been described in various forms of PPK. Many of these genes code for structural proteins (eg, keratins) or components of the desmosomal plaque, which are all known to play ...
... achieved toward a better understanding of the molecular basis of these disorders. Mutations in more than 20 distinct genes have been described in various forms of PPK. Many of these genes code for structural proteins (eg, keratins) or components of the desmosomal plaque, which are all known to play ...
Annotation Practice Activity [Based on materials from the GEP
... The Genome browser will find closely related D. melanogaster genes to sequences contained in contig 36. Twinscan, SGP, Gene ID Genes and Genscan Genes are different computer programs that create gene models. Each region of the image shows in graphical form the results of some computer program ...
... The Genome browser will find closely related D. melanogaster genes to sequences contained in contig 36. Twinscan, SGP, Gene ID Genes and Genscan Genes are different computer programs that create gene models. Each region of the image shows in graphical form the results of some computer program ...
Genetic susceptibility to Hodgkin`s lymphoma and to secondary
... HL and NHL, pre-alloSCT a significantly high level of monoallelic replication of both loci was observed after evaluation of bone marrow (BM) and peripheral blood (PB) samples. Similarly high levels of mono-allelic replication were observed in normal donors that received 5 days of subcutaneous inject ...
... HL and NHL, pre-alloSCT a significantly high level of monoallelic replication of both loci was observed after evaluation of bone marrow (BM) and peripheral blood (PB) samples. Similarly high levels of mono-allelic replication were observed in normal donors that received 5 days of subcutaneous inject ...
Cancer Prone Disease Section Beckwith-Wiedemann syndrome Atlas of Genetics and Cytogenetics
... expression is primarily confined to skeletal and cardiac muscle; other tissues are down-regulated postnatal but re-expressed in tumours that express the gene during embryogenesis. Function: Putative tumour suppressor; proposed regulatory function for IGF2 expression (under debate). Mutations Germina ...
... expression is primarily confined to skeletal and cardiac muscle; other tissues are down-regulated postnatal but re-expressed in tumours that express the gene during embryogenesis. Function: Putative tumour suppressor; proposed regulatory function for IGF2 expression (under debate). Mutations Germina ...
Yr7 - NVT Online
... field, combinations of two or more Yr genes were developed by crossing single gene NILs ...
... field, combinations of two or more Yr genes were developed by crossing single gene NILs ...
Activity #3a - Center for Occupational Research and Development
... In Activities #1 and #2, you learned the scientific basis for how DNA microarray technology works and how it can be used to illustrate variations in gene expression by examining the gene expression data from two mythological creatures. Different gene expression results in different characteristics. ...
... In Activities #1 and #2, you learned the scientific basis for how DNA microarray technology works and how it can be used to illustrate variations in gene expression by examining the gene expression data from two mythological creatures. Different gene expression results in different characteristics. ...
Part VI - OCCC.edu
... In the disease Hemoglobin Saverne, the A in triplet CAC #143 is deleted, causing a frameshift mutation. Delete that A in triplet #143, and reorder the remaining bases downstream as triplets, three at a time, without that A. The new DNA would then read: ...
... In the disease Hemoglobin Saverne, the A in triplet CAC #143 is deleted, causing a frameshift mutation. Delete that A in triplet #143, and reorder the remaining bases downstream as triplets, three at a time, without that A. The new DNA would then read: ...
Automatic Annotation of Gene Lists from Literature Analysis
... 1) For a gene i, if the term count xi is significantly higher than expected by chance (determined by λ0 and di), then the term may be related to the gene i; 2) If there are many genes related to the term, then this term is enriched in the given gene list. ...
... 1) For a gene i, if the term count xi is significantly higher than expected by chance (determined by λ0 and di), then the term may be related to the gene i; 2) If there are many genes related to the term, then this term is enriched in the given gene list. ...
A History of Genetics and Genomics
... direct attack on preeminence of selection as the driving force of evolution. The theory suggests that most mutations are neutral and are fixed by genetic drift and not selection. It is debated whether the evolution of species is driven more by neutral effects or selection. Some feel the two theories ...
... direct attack on preeminence of selection as the driving force of evolution. The theory suggests that most mutations are neutral and are fixed by genetic drift and not selection. It is debated whether the evolution of species is driven more by neutral effects or selection. Some feel the two theories ...
Use of DNA Polymorphisms to Predict Offender
... extremely broad, narrow, or asymmetrically shaped skulls. Point mutations in six genes have been identified that cause craniosynostosis syndromes [19]. A SNP that shows association with a decrease in the cephalic index, the standard measure of head shape, was identified in FGFR, one of the genes cau ...
... extremely broad, narrow, or asymmetrically shaped skulls. Point mutations in six genes have been identified that cause craniosynostosis syndromes [19]. A SNP that shows association with a decrease in the cephalic index, the standard measure of head shape, was identified in FGFR, one of the genes cau ...
Leukaemia Section t(11;21)(q21;q22) Atlas of Genetics and Cytogenetics
... resorption and stimulates prostate cancer cell migration (Chen and Kroog, 2010). ...
... resorption and stimulates prostate cancer cell migration (Chen and Kroog, 2010). ...
HapMap PROJECT - Faculty of Science at Bilkent University
... • Problem: there are not that many functional SNPs. • Uncharacterized de novo mutations??? ...
... • Problem: there are not that many functional SNPs. • Uncharacterized de novo mutations??? ...
SDL 13- Brain Tumors II Ganglioglioma Well differentiated, slowly
... Malignant embryonal CNS tumor in children, composed of rhabdoid cells (resemble primitive skeletal muscle cells) 2% CNS tumors in patients 18 and less (generally <5 years)- male:female is 1.4:1 50% in posterior fossa, rest in supratentorial location Many patients have disseminated tumor within the c ...
... Malignant embryonal CNS tumor in children, composed of rhabdoid cells (resemble primitive skeletal muscle cells) 2% CNS tumors in patients 18 and less (generally <5 years)- male:female is 1.4:1 50% in posterior fossa, rest in supratentorial location Many patients have disseminated tumor within the c ...
Lecture 1: Meiosis and Recombination
... Based on the unique ability of a portion of single stranded DNA, i.e. a probe, to anneal with its complementary target sequence wherever it is located on a metaphase spread. ...
... Based on the unique ability of a portion of single stranded DNA, i.e. a probe, to anneal with its complementary target sequence wherever it is located on a metaphase spread. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.